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Crystal structure of IDH1 R132H mutant in complex with compound 24
分子名称:	4-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-2-methoxybenzonitrile, BETA-MERCAPTOETHANOL, Isocitrate dehydrogenase [NADP] cytoplasmic, ...
著者	Toms, A.V, Lin, J.
登録日	2019-02-25
公開日	2019-06-26
最終更新日	2024-03-13
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors. J.Med.Chem., 62, 2019

6ORO

Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab874NHP
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab874NHP antibody Fab heavy chain, ...
著者	Abernathy, M.E, Gristick, H.B, Bjorkman, P.J.
登録日	2019-04-30
公開日	2019-06-12
最終更新日	2020-07-29
実験手法	ELECTRON MICROSCOPY (3.9 Å)
主引用文献	Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. Nature, 570, 2019

6ORN

Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch bNAb 10-1074
分子名称:	10-1074 antibody Fab heavy chain, 10-1074 antibody Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者	Abernathy, M.E, Gristick, H.B, Bjorkman, P.J.
登録日	2019-04-30
公開日	2019-06-12
最終更新日	2020-07-29
実験手法	ELECTRON MICROSCOPY (4.05 Å)
主引用文献	Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. Nature, 570, 2019

6ORQ

Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab275MUR
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab275MUR antibody Fab heavy chain, ...
著者	Abernathy, M.E, Gristick, H.B, Bjorkman, P.J.
登録日	2019-04-30
公開日	2019-06-12
最終更新日	2020-07-29
実験手法	ELECTRON MICROSCOPY (4.4 Å)
主引用文献	Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. Nature, 570, 2019

6ORP

Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab897NHP
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab897NHP antibody Fab heavy chain, ...
著者	Abernathy, M.E, Gristick, H.B, Bjorkman, P.J.
登録日	2019-04-30
公開日	2019-06-12
最終更新日	2020-07-29
実験手法	ELECTRON MICROSCOPY (4.4 Å)
主引用文献	Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. Nature, 570, 2019

8ZVF

AtALMT9 plus high malate in low pH
分子名称:	1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, Aluminum-activated malate transporter 9
著者	Gong, D.S.
登録日	2024-06-11
公開日	2024-09-25
実験手法	ELECTRON MICROSCOPY (3.59 Å)
主引用文献	Structural insight into the Arabidopsis vacuolar anion channel ALMT9 shows clade specificity. Cell Rep, 43, 2024

5WXH

Crystal structure of TAF3 PHD finger bound to H3K4me3
分子名称:	Histone H3K4me3, Transcription initiation factor TFIID subunit 3, ZINC ION
著者	Zhao, S, Huang, J, Li, H.
登録日	2017-01-07
公開日	2017-08-16
最終更新日	2017-09-13
実験手法	X-RAY DIFFRACTION (1.297 Å)
主引用文献	Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology Proc. Natl. Acad. Sci. U.S.A., 114, 2017

5WXG

Structure of TAF PHD finger domain binds to H3(1-15)K4ac
分子名称:	Histone H3K4ac, MAGNESIUM ION, Transcription initiation factor TFIID subunit 3, ...
著者	Zhao, S, Li, H.
登録日	2017-01-07
公開日	2017-08-16
最終更新日	2017-09-13
実験手法	X-RAY DIFFRACTION (1.703 Å)
主引用文献	Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology Proc. Natl. Acad. Sci. U.S.A., 114, 2017

5Y6N

Zika virus helicase in complex with ADP
分子名称:	ADENOSINE-5'-DIPHOSPHATE, Helicase domain from Genome polyprotein, MANGANESE (II) ION
著者	Yang, X.Y, Chen, C, Tian, H.L, Chi, H, Mu, Z.Y, Zhang, T.Q, Yang, K.L, Zhao, Q, Liu, X.H, Wang, Z.F, Ji, X.Y, Yang, H.T.
登録日	2017-08-12
公開日	2018-07-04
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (1.571 Å)
主引用文献	Mechanism of ATP hydrolysis by the Zika virus helicase. FASEB J., 32, 2018

5Y6M

Zika virus helicase in complex with ADP-AlF3
分子名称:	ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Helicase domain from Genome polyprotein, ...
著者	Yang, X.Y, Chen, C, Tian, H.L, Chi, H, Mu, Z.Y, Zhang, T.Q, Yang, K.L, Zhao, Q, Liu, X.H, Wang, Z.F, Ji, X.Y, Yang, H.T.
登録日	2017-08-12
公開日	2018-07-04
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (2.002 Å)
主引用文献	Mechanism of ATP hydrolysis by the Zika virus helicase. FASEB J., 32, 2018

8HOG

Crystal structure of Bcl-2 in complex with sonrotoclax
分子名称:	Apoptosis regulator Bcl-2, ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
著者	Liu, J, Xu, M, Feng, Y, Hong, Y, Liu, Y.
登録日	2022-12-10
公開日	2024-01-17
最終更新日	2024-05-15
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy. Blood, 143, 2024

8HOH

Crystal structure of Bcl-2 G101V in complex with sonrotoclax
分子名称:	Apoptosis regulator Bcl-2, ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
著者	Liu, J, Xu, M, Feng, Y, Hong, Y, Liu, Y.
登録日	2022-12-10
公開日	2024-01-17
最終更新日	2024-05-15
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy. Blood, 143, 2024

8HOI

Crystal structure of Bcl-2 D103Y in complex with sonrotoclax
分子名称:	Apoptosis regulator Bcl-2, FORMIC ACID, ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
著者	Liu, J, Xu, M, Feng, Y, Hong, Y, Liu, Y.
登録日	2022-12-10
公開日	2024-01-17
最終更新日	2024-05-15
実験手法	X-RAY DIFFRACTION (2.25 Å)
主引用文献	Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy. Blood, 143, 2024

4IVM

Structure of human protoporphyrinogen IX oxidase(R59G)
分子名称:	5-[2-CHLORO-4-(TRIFLUOROMETHYL)PHENOXY]-2-NITROBENZOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ...
著者	Xiaohong, Q, Baifan, W.
登録日	2013-01-23
公開日	2013-03-06
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.769 Å)
主引用文献	Quantitative structural insight into human variegate porphyria disease. J.Biol.Chem., 288, 2013

8K3K

The crystal structure of nanobody Nb4 in complex with receptor binding domain (RBD) of BA.1 Spike protein
分子名称:	Nanobody Nb4, Spike protein S1
著者	Wang, H.Y, Xu, W.Q.
登録日	2023-07-16
公開日	2024-01-24
実験手法	X-RAY DIFFRACTION (2.43 Å)
主引用文献	A potent and broad-spectrum neutralizing nanobody for SARS-CoV-2 viruses, including all major Omicron strains. MedComm (2020), 4, 2023

4IVO

Structure of human protoporphyrinogen IX oxidase(R59Q)
分子名称:	5-[2-CHLORO-4-(TRIFLUOROMETHYL)PHENOXY]-2-NITROBENZOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ...
著者	Xiaohong, Q, Baifan, W.
登録日	2013-01-23
公開日	2013-03-06
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.597 Å)
主引用文献	Quantitative structural insight into human variegate porphyria disease. J.Biol.Chem., 288, 2013

4IA0

Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors
分子名称:	5-bromo-2-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-6-octylpyrimidin-4(3H)-one, MAGNESIUM ION, ZINC ION, ...
著者	Ren, J, Chen, T, Xu, Y.
登録日	2012-12-05
公開日	2014-01-01
実験手法	X-RAY DIFFRACTION (2.17 Å)
主引用文献	Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5. Bioorg.Med.Chem.Lett., 23, 2013

4I9Z

Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors
分子名称:	5-bromo-2-{5-[(4-methylpiperazin-1-yl)acetyl]-2-propoxyphenyl}-6-(propan-2-yl)pyrimidin-4(3H)-one, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ...
著者	Ren, J, Chen, T, Xu, Y.
登録日	2012-12-05
公開日	2014-01-01
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (2.08 Å)
主引用文献	Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5. Bioorg.Med.Chem.Lett., 23, 2013

3CYO

Structure of a longer thermalstable core domain of HIV-1 GP41 containing the enfuvirtide resistance mutation N43D and complementary mutation E137K
分子名称:	Transmembrane protein
著者	Wang, Z.M, Dwyer, J.J.
登録日	2008-04-25
公開日	2008-06-17
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Impact of the enfuvirtide resistance mutation N43D and the associated baseline polymorphism E137K on peptide sensitivity and six-helix bundle structure. Biochemistry, 47, 2008

7ESX

Crystal structure of Wolbachia cytoplasmic incompatibility factor CidA from wPip
分子名称:	Bacteria factor 1
著者	Xiao, Y.J, Wang, W, Chen, X, Ji, X.Y, Yang, H.T.
登録日	2021-05-12
公開日	2021-11-10
最終更新日	2024-05-29
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Structural and mechanistic insights into the complexes formed by Wolbachia cytoplasmic incompatibility factors. Proc.Natl.Acad.Sci.USA, 118, 2021

7ESY

Crystal structure of the complex formed by Wolbachia cytoplasmic incompatibility factors CidA and CidBND1-ND2 from wPip
分子名称:	Bacteria factor 1, CALCIUM ION, ULP_PROTEASE domain-containing protein
著者	Xiao, Y.J, Wang, W, Chen, X, Ji, X.Y, Yang, H.T.
登録日	2021-05-12
公開日	2021-11-10
最終更新日	2024-05-29
実験手法	X-RAY DIFFRACTION (2.297 Å)
主引用文献	Structural and mechanistic insights into the complexes formed by Wolbachia cytoplasmic incompatibility factors. Proc.Natl.Acad.Sci.USA, 118, 2021

7ESZ

Crystal structure of the complex formed by Wolbachia cytoplasmic incompatibility factors CinA and CinB with Mn2+ from wPip
分子名称:	BACTERIA FACTOR A, BACTERIA FACTOR B, MANGANESE (II) ION
著者	Xiao, Y.J, Wang, W, Chen, X, Ji, X.Y, Yang, H.T.
登録日	2021-05-12
公開日	2021-11-10
最終更新日	2024-05-29
実験手法	X-RAY DIFFRACTION (2.476 Å)
主引用文献	Structural and mechanistic insights into the complexes formed by Wolbachia cytoplasmic incompatibility factors. Proc.Natl.Acad.Sci.USA, 118, 2021

7ET0

Crystal structure of the complex formed by Wolbachia cytoplasmic incompatibility factors CinA and CinB from wPip
分子名称:	Bacteria factor A, Bacteria factor B
著者	Xiao, Y.J, Wang, W, Chen, X, Ji, X.Y, Yang, H.T.
登録日	2021-05-12
公開日	2021-11-10
最終更新日	2024-05-29
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Structural and mechanistic insights into the complexes formed by Wolbachia cytoplasmic incompatibility factors. Proc.Natl.Acad.Sci.USA, 118, 2021

7FIV

Crystal structure of the complex formed by Wolbachia cytoplasmic incompatibility factors CidA and CidBND1-ND2 from wPip(Tunis)
分子名称:	CidA_I gamma/2 protein, CidB_I b/2 protein
著者	Xiao, Y.J, Wang, W, Chen, X, Ji, X.Y, Yang, H.T.
登録日	2021-08-01
公開日	2022-04-06
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (2.59 Å)
主引用文献	Crystal Structures of Wolbachia CidA and CidB Reveal Determinants of Bacteria-induced Cytoplasmic Incompatibility and Rescue. Nat Commun, 13, 2022

7FIW

Crystal structure of the complex formed by Wolbachia cytoplasmic incompatibility factors CidAwMel(ST) and CidBND1-ND2 from wPip(Pel)
分子名称:	ULP_PROTEASE domain-containing protein, bacteria factor 4,CidA I(Zeta/1) protein
著者	Xiao, Y.J, Wang, W, Chen, X, Ji, X.Y, Yang, H.T.
登録日	2021-08-01
公開日	2022-04-06
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (2.16 Å)
主引用文献	Crystal Structures of Wolbachia CidA and CidB Reveal Determinants of Bacteria-induced Cytoplasmic Incompatibility and Rescue. Nat Commun, 13, 2022

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