6VWC
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![BU of 6vwc by Molmil](/molmil-images/mine/6vwc) | Crystal structure of Bcl-xL in complex with tetrahydroisoquinoline-pyridine based inhibitors | 分子名称: | 6-{8-[(1,3-benzothiazol-2-yl)carbamoyl]-3,4-dihydroisoquinolin-2(1H)-yl}-3-{1-[(pyridin-4-yl)methyl]-1H-pyrazol-4-yl}pyridine-2-carboxylic acid, Bcl-2-like protein 1 | 著者 | Judge, R.A, Judd, A.S. | 登録日 | 2020-02-19 | 公開日 | 2020-10-21 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.604 Å) | 主引用文献 | Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-X L Inhibitor. Acs Med.Chem.Lett., 11, 2020
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7TB4
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4C13
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![BU of 4c13 by Molmil](/molmil-images/mine/4c13) | x-ray crystal structure of Staphylococcus aureus MurE with UDP-MurNAc- Ala-Glu-Lys | 分子名称: | CHLORIDE ION, MAGNESIUM ION, PHOSPHATE ION, ... | 著者 | Ruane, K.M, Roper, D.I, Fulop, V, Barreteau, H, Boniface, A, Dementin, S, Blanot, D, Mengin-Lecreulx, D, Gobec, S, Dessen, A, Dowson, C.G, Lloyd, A.J. | 登録日 | 2013-08-09 | 公開日 | 2013-10-02 | 最終更新日 | 2021-03-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy. Nat.Chem.Biol., 2021
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4ZPV
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![BU of 4zpv by Molmil](/molmil-images/mine/4zpv) | Structure of MERS-Coronavirus Spike Receptor-binding Domain (England1 Strain) in Complex with Vaccine-Elicited Murine Neutralizing Antibody D12 (Crystal Form 2) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, D12 Fab Heavy chain, D12 Fab light chain, ... | 著者 | Joyce, M.G, Mascola, J.R, Graham, B.S, Kwong, P.D. | 登録日 | 2015-05-08 | 公開日 | 2015-10-21 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Evaluation of candidate vaccine approaches for MERS-CoV. Nat Commun, 6, 2015
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4ZPW
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![BU of 4zpw by Molmil](/molmil-images/mine/4zpw) | Structure of unbound MERS-CoV spike receptor-binding domain (England1 strain). | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHATE ION, Spike glycoprotein | 著者 | Joyce, M.G, Mascola, J.R, Graham, B.S, Kwong, P.D. | 登録日 | 2015-05-08 | 公開日 | 2015-08-12 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.023 Å) | 主引用文献 | Evaluation of candidate vaccine approaches for MERS-CoV. Nat Commun, 6, 2015
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5U1A
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![BU of 5u1a by Molmil](/molmil-images/mine/5u1a) | Ferritin with Gc MtrE loop 1 inserted at His34 | 分子名称: | CHLORIDE ION, FE (III) ION, Ferritin,MtrE protein chimera, ... | 著者 | Wang, S. | 登録日 | 2016-11-28 | 公開日 | 2017-10-11 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure-based design of ferritin nanoparticle immunogens displaying antigenic loops of Neisseria gonorrhoeae. FEBS Open Bio, 7, 2017
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5U1B
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4ZZ3
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![BU of 4zz3 by Molmil](/molmil-images/mine/4zz3) | Human GAR transformylase in complex with GAR and pemetrexed | 分子名称: | GLYCINAMIDE RIBONUCLEOTIDE, N-{4-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid, Trifunctional purine biosynthetic protein adenosine-3 | 著者 | Deis, S.M, Dann III, C.E. | 登録日 | 2015-05-22 | 公開日 | 2015-12-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.504 Å) | 主引用文献 | 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor alpha and the Proton-Coupled Folate Transporter in Human Tumors. J.Med.Chem., 58, 2015
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4ZZ1
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![BU of 4zz1 by Molmil](/molmil-images/mine/4zz1) | HUMAN GAR TRANSFORMYLASE IN COMPLEX WITH GAR AND (S)-2-({4-[3-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)-PROPYL]-THIOPHENE-2-CARBONYL}-AMINO)-PENTANEDIOIC ACID | 分子名称: | (S)-2-({4-[3-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-propyl]-thiophene-2-carbonyl}-amino)-pentanedioic acid, GLYCINAMIDE RIBONUCLEOTIDE, Trifunctional purine biosynthetic protein adenosine-3 | 著者 | Deis, S.M, Dann III, C.E. | 登録日 | 2015-05-22 | 公開日 | 2015-12-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.351 Å) | 主引用文献 | 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor alpha and the Proton-Coupled Folate Transporter in Human Tumors. J.Med.Chem., 58, 2015
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4ZZ2
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![BU of 4zz2 by Molmil](/molmil-images/mine/4zz2) | HUMAN GAR TRANSFORMYLASE IN COMPLEX WITH GAR AND (S)-2-({5-[3-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)-PROPYL]-THIOPHENE-3-CARBONYL}-AMINO)-PENTANEDIOIC ACID | 分子名称: | (S)-2-({5-[3-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-propyl]-thiophene-3-carbonyl}-amino)-pentanedioic acid, GLYCINAMIDE RIBONUCLEOTIDE, Trifunctional purine biosynthetic protein adenosine-3 | 著者 | Deis, S.M, Dann III, C.E. | 登録日 | 2015-05-22 | 公開日 | 2015-12-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.451 Å) | 主引用文献 | 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor alpha and the Proton-Coupled Folate Transporter in Human Tumors. J.Med.Chem., 58, 2015
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6C6Z
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7DWC
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8SBD
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![BU of 8sbd by Molmil](/molmil-images/mine/8sbd) | Cryo-EM structure of insulin amyloid-like fibril that is composed of two antiparallel protofilaments | 分子名称: | Insulin A chain, Insulin B chain | 著者 | Wang, L.W, Hall, C, Uchikawa, E, Chen, D.L, Choi, E, Zhang, X.W, Bai, X.C. | 登録日 | 2023-04-03 | 公開日 | 2023-08-30 | 最終更新日 | 2023-09-27 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis of insulin fibrillation. Sci Adv, 9, 2023
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6C6Y
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![BU of 6c6y by Molmil](/molmil-images/mine/6c6y) | Crystal structure of Middle-East Respiratory Syndrome (MERS) coronavirus neutralizing antibody JC57-14 isolated from a vaccinated rhesus macaque in complex with MERS Receptor Binding Domain | 分子名称: | JC57-14 Heavy chain, JC57-14 Light chain, SULFATE ION, ... | 著者 | Joyce, M.G, Mascola, J.R, Graham, B.S, Kwong, P.D. | 登録日 | 2018-01-19 | 公開日 | 2018-03-07 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.32 Å) | 主引用文献 | Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape. J. Virol., 92, 2018
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6C6X
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![BU of 6c6x by Molmil](/molmil-images/mine/6c6x) | Crystal structure of Middle-East Respiratory Syndrome (MERS) coronavirus neutralizing antibody JC57-14 isolated from a vaccinated rhesus macaque. | 分子名称: | JC57-14 Heavy chain, JC57-14 Light chain | 著者 | Joyce, M.G, Mascola, J.R, Graham, B.S, Kwong, P.D. | 登録日 | 2018-01-19 | 公開日 | 2018-02-28 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape. J. Virol., 92, 2018
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6EGF
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6EGD
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![BU of 6egd by Molmil](/molmil-images/mine/6egd) | |
7WTK
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![BU of 7wtk by Molmil](/molmil-images/mine/7wtk) | SARS-CoV-2 Omicron variant spike in complex with Fab XGv286 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of XGv286, ... | 著者 | Wang, X, Fu, W. | 登録日 | 2022-02-04 | 公開日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Selection and structural bases of potent broadly neutralizing antibodies from 3-dose vaccinees that are highly effective against diverse SARS-CoV-2 variants, including Omicron sublineages. Cell Res., 32, 2022
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7WTJ
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![BU of 7wtj by Molmil](/molmil-images/mine/7wtj) | SARS-CoV-2 Omicron variant spike RBD in complex with Fab XGv286 | 分子名称: | Heavy chain of XGv286, Light chain of XGv286, Spike protein S1 | 著者 | Wang, X, Fu, W. | 登録日 | 2022-02-04 | 公開日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Selection and structural bases of potent broadly neutralizing antibodies from 3-dose vaccinees that are highly effective against diverse SARS-CoV-2 variants, including Omicron sublineages. Cell Res., 32, 2022
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7WTG
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![BU of 7wtg by Molmil](/molmil-images/mine/7wtg) | SARS-CoV-2 Omicron variant spike RBD in complex with Fab XGv051 | 分子名称: | Heavy chain of XGv051, Light chain of XGv051, Spike protein S1 | 著者 | Wang, X, Fu, W. | 登録日 | 2022-02-04 | 公開日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Selection and structural bases of potent broadly neutralizing antibodies from 3-dose vaccinees that are highly effective against diverse SARS-CoV-2 variants, including Omicron sublineages. Cell Res., 32, 2022
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7WTH
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![BU of 7wth by Molmil](/molmil-images/mine/7wth) | SARS-CoV-2 Omicron variant spike RBD in complex with Fab XGv264 | 分子名称: | Heavy chain of XGv264, Light chain of XGv264, Spike protein S1 | 著者 | Wang, X, Fu, W. | 登録日 | 2022-02-04 | 公開日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Selection and structural bases of potent broadly neutralizing antibodies from 3-dose vaccinees that are highly effective against diverse SARS-CoV-2 variants, including Omicron sublineages. Cell Res., 32, 2022
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7WTF
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![BU of 7wtf by Molmil](/molmil-images/mine/7wtf) | SARS-CoV-2 Omicron variant spike in complex with Fab XGv051 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of XGv051, ... | 著者 | Wang, X, Fu, W. | 登録日 | 2022-02-04 | 公開日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Selection and structural bases of potent broadly neutralizing antibodies from 3-dose vaccinees that are highly effective against diverse SARS-CoV-2 variants, including Omicron sublineages. Cell Res., 32, 2022
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7WTI
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![BU of 7wti by Molmil](/molmil-images/mine/7wti) | SARS-CoV-2 Omicron variant spike in complex with Fab XGv264 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of XGv264, Light chain of XGv264, ... | 著者 | Wang, X, Fu, W. | 登録日 | 2022-02-04 | 公開日 | 2022-12-21 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Selection and structural bases of potent broadly neutralizing antibodies from 3-dose vaccinees that are highly effective against diverse SARS-CoV-2 variants, including Omicron sublineages. Cell Res., 32, 2022
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6EGE
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6UY0
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![BU of 6uy0 by Molmil](/molmil-images/mine/6uy0) | |