1EVA
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7VJN
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7XG2
| CryoEM structure of type IV-A NTS-nicked dsDNA bound Csf-crRNA ternary complex | 分子名称: | Csf1, Csf2, Csf3, ... | 著者 | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | 登録日 | 2022-04-02 | 公開日 | 2023-08-09 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment. Mol.Cell, 83, 2023
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7XG0
| CryoEM structure of type IV-A Csf-crRNA-dsDNA ternary complex | 分子名称: | Csf1, Csf2, Csf3, ... | 著者 | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | 登録日 | 2022-04-02 | 公開日 | 2023-08-09 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment. Mol.Cell, 83, 2023
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6A52
| Oxidase ChaP-H1 | 分子名称: | FE (II) ION, dioxidase ChaP-H1 | 著者 | Zhang, B, Ge, H.M. | 登録日 | 2018-06-21 | 公開日 | 2018-08-29 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis. J. Am. Chem. Soc., 140, 2018
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6A4X
| Oxidase ChaP-H2 | 分子名称: | Bleomycin resistance protein, FE (II) ION | 著者 | Zhang, B, Wang, Y.S, Ge, H.M. | 登録日 | 2018-06-21 | 公開日 | 2018-08-29 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis. J. Am. Chem. Soc., 140, 2018
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6A4Z
| Oxidase ChaP | 分子名称: | ChaP protein, FE (II) ION | 著者 | Zhang, B, Ge, H.M. | 登録日 | 2018-06-21 | 公開日 | 2018-08-29 | 最終更新日 | 2018-09-19 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis. J. Am. Chem. Soc., 140, 2018
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5TVT
| Structure of Maternal Embryonic Leucine Zipper Kinase | 分子名称: | 9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3-methyl-3,4-dihydropyrimido[5,4-c][1,5]naphthyridin-2(1H)-one, Maternal embryonic leucine zipper kinase | 著者 | Seo, H.-Y, Huang, H, Gray, N.S, Dhe-Paganon, S. | 登録日 | 2016-11-10 | 公開日 | 2017-11-15 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Structure of Maternal Embryonic Leucine Zipper Kinase To Be Published
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2HX4
| Rat nNOS heme domain complexed with 4-N-(Nw-nitro-L-argininyl)-trans-4-hydroxyamino-L-proline amide | 分子名称: | (4R)-4-(HYDROXY{N~5~-[IMINO(NITROAMINO)METHYL]-L-ORNITHYL}AMINO)-L-PROLINAMIDE, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... | 著者 | Igarashi, J, Li, H, Poulos, T.L. | 登録日 | 2006-08-02 | 公開日 | 2007-04-24 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structure-Based Design and Synthesis of N(omega)-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water. J.Med.Chem., 50, 2007
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2HX2
| Bovine eNOS heme domain complexed with (4S)-N-{4-Amino-5-[(2-aminoethyl)-hydroxyamino]-pentyl}-N'-nitroguanidine | 分子名称: | (4S)-N-{4-AMINO-5-[(2-AMINOETHYL)(HYDROXYAMINO]-PENTYL}-N'-NITROGUANIDINE, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... | 著者 | Igarashi, J, Li, H, Poulos, T.L. | 登録日 | 2006-08-02 | 公開日 | 2007-04-24 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure-Based Design and Synthesis of N(omega)-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water. J.Med.Chem., 50, 2007
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2HX3
| Rat nNOS heme domain complexed with (4S)-N-{4-Amino-5-[(2-aminoethyl)-hydroxyamino]-pentyl}-N'-nitroguanidine | 分子名称: | (4S)-N-{4-AMINO-5-[(2-AMINOETHYL)(HYDROXYAMINO]-PENTYL}-N'-NITROGUANIDINE, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... | 著者 | Igarashi, J, Li, H, Poulos, T.L. | 登録日 | 2006-08-02 | 公開日 | 2007-04-24 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure-Based Design and Synthesis of N(omega)-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water. J.Med.Chem., 50, 2007
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3V6D
| Crystal structure of HIV-1 reverse transcriptase (RT) cross-linked with AZT-terminated DNA | 分子名称: | DNA (5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(ATM))-3'), DNA (5'-D(*AP*TP*GP*GP*AP*AP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'), HIV-1 REVERSE TRANSCRIPTASE P51 subunit, ... | 著者 | Das, K, Martinez, S.E, Arnold, E. | 登録日 | 2011-12-19 | 公開日 | 2012-01-18 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.7048 Å) | 主引用文献 | HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism. Nat.Struct.Mol.Biol., 19, 2012
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3V4I
| Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and AZTTP | 分子名称: | 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(ATM))-3'), DNA (5'-D(*AP*TP*GP*GP*AP*AP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'), ... | 著者 | Das, K, Martinez, S.E, Arnold, E. | 登録日 | 2011-12-15 | 公開日 | 2012-01-18 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.7983 Å) | 主引用文献 | HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism. Nat.Struct.Mol.Biol., 19, 2012
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3V81
| Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and the nonnucleoside inhibitor nevirapine | 分子名称: | 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, DNA (5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(ATM))-3'), DNA (5'-D(*AP*TP*GP*GP*AP*AP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'), ... | 著者 | Das, K, Martinez, S.E, Arnold, E. | 登録日 | 2011-12-22 | 公開日 | 2012-01-18 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.8503 Å) | 主引用文献 | HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism. Nat.Struct.Mol.Biol., 19, 2012
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3A5U
| Promiscuity and specificity in DNA binding to SSB: Insights from the structure of the Mycobacterium smegmatis SSB-ssDNA complex | 分子名称: | DNA (31-MER), Single-stranded DNA-binding protein | 著者 | Kaushal, P.S, Manjunath, G.P, Sekar, K, Muniyappa, K, Vijayan, M. | 登録日 | 2009-08-12 | 公開日 | 2010-08-18 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Promiscuity and specificity in DNA binding to SSB: Insights from the structure of the Mycobacterium smegmatis SSB-ssDNA complex. To be Published, 2009
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2JR7
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7CNA
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6HP9
| Structure of the kinase domain of human DDR1 in complex with a 2-Amino-2,3-Dihydro-1H-Indene-5-Carboxamide-based inhibitor | 分子名称: | (2~{R})-~{N}-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-2-(pyrimidin-5-ylamino)-2,3-dihydro-1~{H}-indene-5-carboxamide, Epithelial discoidin domain-containing receptor 1 | 著者 | Pinkas, D.M, Fox, A.E, Kupinska, K, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N, Structural Genomics Consortium (SGC) | 登録日 | 2018-09-19 | 公開日 | 2019-01-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | 2-Amino-2,3-dihydro-1H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy. J.Med.Chem., 62, 2019
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6LE0
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6LOX
| Crystal Structure of human glutaminase with macrocyclic inhibitor | 分子名称: | (E)-15,22-Dioxa-4,11-diaza-5(2,5)-thiadiazola-10(3,6)-pyridazina-1,14(1,3)-dibenzenacyclodocosaphan-18-ene-3,12-dione, Glutaminase kidney isoform, mitochondrial | 著者 | Bian, J, Li, Z, Xu, X, Wang, J, Li, L. | 登録日 | 2020-01-07 | 公開日 | 2021-01-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structure-Enabled Discovery of Novel Macrocyclic Inhibitors Targeting Glutaminase 1 Allosteric Binding Site. J.Med.Chem., 64, 2021
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7WK1
| Mouse Pendrin bound chloride in inward state | 分子名称: | CHLORIDE ION, Pendrin | 著者 | Liu, Q.Y, Zhang, X, Sun, L, Chen, Z.G. | 登録日 | 2022-01-08 | 公開日 | 2023-04-12 | 最終更新日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Asymmetric pendrin homodimer reveals its molecular mechanism as anion exchanger. Nat Commun, 14, 2023
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7WL7
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7WLA
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7WL2
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7WL9
| Mouse Pendrin in chloride and bicarbonate in asymmetric state | 分子名称: | CHLORIDE ION, Pendrin | 著者 | Liu, Q.Y, Zhang, X, Sun, L, Chen, Z.G. | 登録日 | 2022-01-12 | 公開日 | 2023-04-12 | 最終更新日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | 主引用文献 | Asymmetric pendrin homodimer reveals its molecular mechanism as anion exchanger. Nat Commun, 14, 2023
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