2OAZ
 
 | | Human Methionine Aminopeptidase-2 Complexed with SB-587094 | | 分子名称: | COBALT (II) ION, N-(2-ISOPROPYLPHENYL)-3-[(2-THIENYLMETHYL)THIO]-1H-1,2,4-TRIAZOL-5-AMINE, human Methionine Amino Peptidase 2 | | 著者 | Marino Jr, J.P, Fisher, P.W, Hofmann, G.A, Kirkpatrick, R, Janson, C.A, Johnson, R.K, Ma, C, Mattern, M, Meek, T.D, Ryan, D, Schulz, C, Smith, W.W, Tew, D.G, Tomazek Jr, T.A, Veber, D.F, Xiong, W.C, Yamamoto, Y, Yamashita, K, Yang, G, Thompson, S.K. | | 登録日 | 2006-12-18 | | 公開日 | 2007-06-19 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore.
J.Med.Chem., 50, 2007
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6IYC
 | | Recognition of the Amyloid Precursor Protein by Human gamma-secretase | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhou, R, Yang, G, Guo, X, Zhou, Q, Lei, J, Shi, Y. | | 登録日 | 2018-12-14 | | 公開日 | 2019-01-23 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Recognition of the amyloid precursor protein by human gamma-secretase.
Science, 363, 2019
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7YD3
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7EQ7
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7YI6
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8IOY
 | | Structure of ATP7B C983S/C985S/D1027A mutant with AMP-PNP | | 分子名称: | Copper-transporting ATPase 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | 著者 | Yang, G, Xu, L, Guo, J, Wu, Z. | | 登録日 | 2023-03-13 | | 公開日 | 2023-04-26 | | 最終更新日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structures of the human Wilson disease copper transporter ATP7B.
Cell Rep, 42, 2023
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1B6I
 | | T4 LYSOZYME MUTANT WITH CYS 54 REPLACED BY THR, CYS 97 REPLACED BY ALA, THR 21 REPLACED BY CYS AND LYS 124 REPLACED BY CYS (C54T,C97A,T21C,K124C) | | 分子名称: | 2-HYDROXYETHYL DISULFIDE, PROTEIN (LYSOZYME) | | 著者 | Vetter, I.R, Baase, W.A, Snow, S, Matthews, B.W. | | 登録日 | 1999-01-14 | | 公開日 | 2000-01-12 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Solid-state synthesis and mechanical unfolding of polymers of T4 lysozyme.
Proc.Natl.Acad.Sci.USA, 97, 2000
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5EHT
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7D39
 | | FLR-apo | | 分子名称: | Cd1, FLAVIN MONONUCLEOTIDE | | 著者 | Hong, S, Yang, G.H, Zhang, P. | | 登録日 | 2020-09-18 | | 公開日 | 2021-03-03 | | 実験手法 | X-RAY DIFFRACTION (2.198 Å) | | 主引用文献 | Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria.
Nat Commun, 12, 2021
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7D38
 | | flavone reductase | | 分子名称: | Cd1, FLAVIN MONONUCLEOTIDE, chrysin | | 著者 | Hong, S, Yang, G.H, Zhang, P. | | 登録日 | 2020-09-18 | | 公開日 | 2021-03-03 | | 実験手法 | X-RAY DIFFRACTION (2.649 Å) | | 主引用文献 | Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria.
Nat Commun, 12, 2021
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7D3B
 | | flavone reductase | | 分子名称: | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, Cd1, FLAVIN MONONUCLEOTIDE | | 著者 | Hong, S, Yang, G.H, Zhang, P. | | 登録日 | 2020-09-18 | | 公開日 | 2021-03-03 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria.
Nat Commun, 12, 2021
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7D3A
 | | flavone reductase | | 分子名称: | 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, Cd1, FLAVIN MONONUCLEOTIDE | | 著者 | Hong, S, Yang, G.H, Zhang, P. | | 登録日 | 2020-09-18 | | 公開日 | 2021-03-03 | | 最終更新日 | 2021-09-29 | | 実験手法 | X-RAY DIFFRACTION (2.552 Å) | | 主引用文献 | Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria.
Nat Commun, 12, 2021
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4N0S
 | | Complex of ERK2 with caffeic acid | | 分子名称: | CAFFEIC ACID, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | | 著者 | Kurinov, I, Malakhova, M. | | 登録日 | 2013-10-02 | | 公開日 | 2014-08-27 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.7992 Å) | | 主引用文献 | Caffeic Acid Directly Targets ERK1/2 to Attenuate Solar UV-Induced Skin Carcinogenesis.
Cancer Prev Res (Phila), 7, 2014
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7XUK
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7XUO
 | | Structure of ATP7B C983S/C985S/D1027A mutant with cisplatin in presence of ATOX1 | | 分子名称: | Copper-transporting ATPase 2, PLATINUM (II) ION | | 著者 | Yang, G, Xu, L, Chang, S, Guo, J, Wu, Z. | | 登録日 | 2022-05-19 | | 公開日 | 2023-04-26 | | 最終更新日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structures of the human Wilson disease copper transporter ATP7B.
Cell Rep, 42, 2023
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7XUN
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7XUM
 | | Structure of ATP7B C983S/C985S/D1027A mutant with Cu+ in presence of ATOX1 | | 分子名称: | COPPER (II) ION, Copper-transporting ATPase 2 | | 著者 | Yang, G, Xu, L, Chang, S, Guo, J, Wu, Z. | | 登録日 | 2022-05-19 | | 公開日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structures of the human Wilson disease copper transporter ATP7B.
Cell Rep, 42, 2023
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3L4A
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3L47
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3L4L
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5FA5
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5FN2
 | | Cryo-EM structure of gamma secretase in complex with a drug DAPT | | 分子名称: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | | 著者 | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | | 登録日 | 2015-11-10 | | 公開日 | 2015-12-16 | | 最終更新日 | 2019-09-04 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Sampling the conformational space of the catalytic subunit of human gamma-secretase.
Elife, 4, 2015
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5FN4
 | | Cryo-EM structure of gamma secretase in class 2 of the apo- state ensemble | | 分子名称: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | | 著者 | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | | 登録日 | 2015-11-10 | | 公開日 | 2015-12-16 | | 最終更新日 | 2019-09-11 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Sampling the conformational space of the catalytic subunit of human gamma-secretase.
Elife, 4, 2015
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5FN5
 | | Cryo-EM structure of gamma secretase in class 3 of the apo- state ensemble | | 分子名称: | Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ... | | 著者 | Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W. | | 登録日 | 2015-11-10 | | 公開日 | 2015-12-16 | | 最終更新日 | 2019-09-11 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Sampling the conformational space of the catalytic subunit of human gamma-secretase.
Elife, 4, 2015
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8I71
 | | Hepatitis B virus core protein Y132A mutant in complex with Linvencorvir (RG7907), a Hepatitis B Virus (HBV) Core Protein Allosteric Modulator (CpAM) | | 分子名称: | 3-[(8~{a}~{S})-7-[[5-ethoxycarbonyl-4-(3-fluoranyl-2-methyl-phenyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]-3-oxidanylidene-5,6,8,8~{a}-tetrahydro-1~{H}-imidazo[1,5-a]pyrazin-2-yl]-2,2-dimethyl-propanoic acid, CHLORIDE ION, Capsid protein, ... | | 著者 | Zhou, Z, Xu, Z.H. | | 登録日 | 2023-01-30 | | 公開日 | 2023-03-22 | | 最終更新日 | 2023-04-05 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection.
J.Med.Chem., 66, 2023
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