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8IT9
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BU of 8it9 by Molmil
Co-crystal structure of FTO bound to 22
分子名称: 2-OXOGLUTARIC ACID, 2-[(2,6-diethyl-4-pyridin-4-yl-phenyl)amino]-6-(1,4-oxazepan-4-ylmethyl)benzoic acid, Alpha-ketoglutarate-dependent dioxygenase FTO
著者Yang, C.-G, Gan, J.H.
登録日2023-03-22
公開日2024-02-14
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Rational Design of RNA Demethylase FTO Inhibitors with Enhanced Antileukemia Drug-Like Properties.
J.Med.Chem., 66, 2023
8HGK
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BU of 8hgk by Molmil
Crystal structure of human ClpP in complex with ZK53
分子名称: 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide, ATP-dependent Clp protease proteolytic subunit, mitochondrial, ...
著者Yang, C.-G, Gan, J.H, Zhou, L.-L.
登録日2022-11-14
公開日2023-09-27
最終更新日2024-04-17
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma.
Nat Commun, 14, 2023
7VP9
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BU of 7vp9 by Molmil
Crystal structure of human ClpP in complex with ZG111
分子名称: (6S,9aS)-N-[(4-bromophenyl)methyl]-6-[(2S)-butan-2-yl]-8-(naphthalen-1-ylmethyl)-4,7-bis(oxidanylidene)-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide, ATP-dependent Clp protease proteolytic subunit, mitochondrial, ...
著者Wang, P.Y, Gan, J.H, Yang, C.-G.
登録日2021-10-15
公開日2022-06-08
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.552 Å)
主引用文献Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma.
Cell Chem Biol, 29, 2022
3O1U
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BU of 3o1u by Molmil
Iron-Catalyzed Oxidation Intermediates Captured in A DNA Repair Dioxygenase
分子名称: Alpha-ketoglutarate-dependent dioxygenase AlkB, DNA (5'-D(*AP*AP*CP*GP*GP*TP*AP*TP*TP*AP*CP*CP*T)-3'), DNA (5'-D(*AP*GP*GP*TP*AP*AP*(MDV)P*AP*CP*CP*GP*T)-3'), ...
著者Yi, C, Jia, G, Hou, G, Dai, Q, Zhang, W, Zheng, G, Jian, X, Yang, C.-G, Cui, Q, He, C.
登録日2010-07-22
公開日2010-11-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase.
Nature, 468, 2010
3O1S
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BU of 3o1s by Molmil
Iron-Catalyzed Oxidation Intermediates Captured in A DNA Repair Dioxygenase
分子名称: Alpha-ketoglutarate-dependent dioxygenase AlkB, DNA (5'-D(*AP*AP*CP*GP*GP*TP*AP*TP*TP*AP*CP*CP*T)-3'), DNA (5'-D(*AP*GP*GP*TP*AP*AP*(MDQ)P*AP*CP*CP*GP*T)-3'), ...
著者Yi, C, Jia, G, Hou, G, Dai, Q, Zhang, W, Zheng, G, Jian, X, Yang, C.-G, Cui, Q, He, C.
登録日2010-07-22
公開日2010-11-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase.
Nature, 468, 2010
3O1T
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BU of 3o1t by Molmil
Iron-Catalyzed Oxidation Intermediates Captured in A DNA Repair Dioxygenase
分子名称: Alpha-ketoglutarate-dependent dioxygenase AlkB, DNA (5'-D(*AP*AP*CP*GP*GP*TP*AP*TP*TP*AP*CP*CP*T)-3'), DNA (5'-D(*AP*GP*GP*TP*AP*AP*(MDU)P*AP*CP*CP*GP*T)-3'), ...
著者Yi, C, Jia, G, Hou, G, Dai, Q, Zhang, W, Zheng, G, Jian, X, Yang, C.-G, Cui, Q, He, C.
登録日2010-07-22
公開日2010-11-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase.
Nature, 468, 2010
3O1M
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BU of 3o1m by Molmil
Iron-Catalyzed Oxidation Intermediates Captured in A DNA Repair Dioxygenase
分子名称: 2-OXOGLUTARIC ACID, Alpha-ketoglutarate-dependent dioxygenase AlkB, DNA (5'-D(*AP*AP*CP*GP*GP*TP*AP*TP*TP*AP*CP*CP*T)-3'), ...
著者Yi, C, Jia, G, Hou, G, Dai, Q, Zhang, W, Zheng, G, Jian, X, Yang, C.-G, Cui, Q, He, C.
登録日2010-07-21
公開日2010-11-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase.
Nature, 468, 2010
3O1V
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BU of 3o1v by Molmil
Iron-Catalyzed Oxidation Intermediates Captured in A DNA Repair Dioxygenase
分子名称: Alpha-ketoglutarate-dependent dioxygenase AlkB, DNA (5'-D(*AP*AP*CP*GP*GP*TP*AP*TP*TP*AP*CP*CP*T)-3'), DNA (5'-D(*AP*GP*GP*TP*AP*AP*(MDJ)P*AP*CP*CP*GP*T)-3'), ...
著者Yi, C, Jia, G, Hou, G, Dai, Q, Zhang, W, Zheng, G, Jian, X, Yang, C.-G, Cui, Q, He, C.
登録日2010-07-22
公開日2010-11-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase.
Nature, 468, 2010
3O1P
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BU of 3o1p by Molmil
Iron-Catalyzed Oxidation Intermediates Captured in A DNA Repair Dioxygenase
分子名称: 2-OXOGLUTARIC ACID, Alpha-ketoglutarate-dependent dioxygenase AlkB, DNA (5'-D(*AP*AP*CP*GP*GP*TP*AP*TP*TP*AP*CP*CP*T)-3'), ...
著者Yi, C, Jia, G, Hou, G, Dai, Q, Zhang, W, Zheng, G, Jian, X, Yang, C.-G, Cui, Q, He, C.
登録日2010-07-21
公開日2010-11-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase.
Nature, 468, 2010
3O1R
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BU of 3o1r by Molmil
Iron-Catalyzed Oxidation Intermediates Captured in A DNA Repair Dioxygenase
分子名称: 2-OXOGLUTARIC ACID, Alpha-ketoglutarate-dependent dioxygenase AlkB, DNA (5'-D(*AP*AP*CP*GP*GP*TP*AP*TP*TP*AP*CP*CP*T)-3'), ...
著者Yi, C, Jia, G, Hou, G, Dai, Q, Zhang, W, Zheng, G, Jian, X, Yang, C.-G, Cui, Q, He, C.
登録日2010-07-21
公開日2010-11-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase.
Nature, 468, 2010
3RZH
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BU of 3rzh by Molmil
Duplex Interrogation by a Direct DNA Repair Protein in the Search of Damage
分子名称: 5'-D(*CP*TP*GP*TP*CP*TP*(ME6)P*AP*CP*TP*GP*CP*G)-3', 5'-D(*TP*CP*GP*CP*AP*GP*TP*GP*AP*GP*AP*CP*A)-3', Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, ...
著者Yi, C, Chen, B, Qi, B, Zhang, W, Jia, G, Zhang, L, Li, C, Dinner, A, Yang, C, He, C.
登録日2011-05-11
公開日2012-06-06
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Duplex interrogation by a direct DNA repair protein in search of base damage
Nat.Struct.Mol.Biol., 19, 2012
3RZG
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BU of 3rzg by Molmil
Duplex Interrogation by a Direct DNA Repair Protein in the Search of Damage
分子名称: 5'-D(*CP*TP*GP*TP*CP*AP*TP*CP*AP*CP*TP*GP*CP*G)-3', 5'-D(*TP*CP*GP*CP*AP*GP*TP*GP*AP*TP*GP*AP*CP*A)-3', Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, ...
著者Yi, C, Chen, B, Qi, B, Zhang, W, Jia, G, Zhang, L, Li, C, Dinner, A, Yang, C, He, C.
登録日2011-05-11
公開日2012-06-06
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Duplex interrogation by a direct DNA repair protein in search of base damage
Nat.Struct.Mol.Biol., 19, 2012
3RZM
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BU of 3rzm by Molmil
Duplex Interrogation by a Direct DNA Repair Protein in the Search of Damage
分子名称: 5'-D(*AP*TP*GP*TP*AP*TP*AP*AP*CP*TP*GP*CP*G)-3', 5'-D(*TP*CP*GP*CP*AP*GP*TP*TP*AP*TP*AP*CP*A)-3', Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, ...
著者Yi, C, Chen, B, Qi, B, Zhang, W, Jia, G, Zhang, L, Li, C, Dinner, A, Yang, C, He, C.
登録日2011-05-11
公開日2012-06-06
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.06 Å)
主引用文献Duplex interrogation by a direct DNA repair protein in search of base damage
Nat.Struct.Mol.Biol., 19, 2012
3RZK
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BU of 3rzk by Molmil
Duplex Interrogation by a Direct DNA Repair Protein in the Search of Damage
分子名称: 2-OXOGLUTARIC ACID, 5'-D(*CP*TP*GP*TP*CP*TP*(EDA)P*AP*CP*TP*GP*CP*G)-3', 5'-D(*TP*CP*GP*CP*AP*GP*TP*TP*AP*GP*AP*CP*A)-3', ...
著者Yi, C, Chen, B, Qi, B, Zhang, W, Jia, G, Zhang, L, Li, C, Dinner, A, Yang, C, He, C.
登録日2011-05-11
公開日2012-06-06
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.78 Å)
主引用文献Duplex interrogation by a direct DNA repair protein in search of base damage
Nat.Struct.Mol.Biol., 19, 2012
3RZJ
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BU of 3rzj by Molmil
Duplex Interrogation by a Direct DNA Repair Protein in the Search of Damage
分子名称: 2-OXOGLUTARIC ACID, 5'-D(*CP*TP*GP*TP*CP*TP*(ME6)P*AP*CP*TP*GP*CP*G)-3', 5'-D(*TP*CP*GP*CP*AP*GP*TP*GP*AP*GP*AP*CP*A)-3', ...
著者Yi, C, Chen, B, Qi, B, Zhang, W, Jia, G, Zhang, L, Li, C, Dinner, A, Yang, C, He, C.
登録日2011-05-11
公開日2012-06-06
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Duplex interrogation by a direct DNA repair protein in search of base damage
Nat.Struct.Mol.Biol., 19, 2012
3RZL
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BU of 3rzl by Molmil
Duplex Interrogation by a Direct DNA Repair Protein in the Search of Damage
分子名称: 5'-D(*AP*TP*GP*TP*AP*TP*CP*AP*CP*TP*GP*CP*G)-3', 5'-D(*TP*CP*GP*CP*AP*GP*TP*IP*AP*TP*AP*CP*A)-3', Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, ...
著者Yi, C, Chen, B, Qi, B, Zhang, W, Jia, G, Zhang, L, Li, C, Dinner, A, Yang, C, He, C.
登録日2011-05-11
公開日2012-06-06
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Duplex interrogation by a direct DNA repair protein in search of base damage
Nat.Struct.Mol.Biol., 19, 2012
3S5A
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BU of 3s5a by Molmil
ABH2 cross-linked to undamaged dsDNA-2 with cofactors
分子名称: 2-OXOGLUTARIC ACID, 5'-D(*CP*TP*GP*TP*CP*TP*CP*AP*CP*TP*GP*TP*CP*G)-3', 5'-D(*TP*CP*GP*AP*CP*AP*GP*TP*GP*AP*GP*AP*CP*A)-3', ...
著者Yi, C, Chen, B, Qi, B, Ramirez, B, Zhang, W, Jia, G, Zhang, L, Li, C.Q, Dinner, A.R, Yang, C.-G, He, C.
登録日2011-05-21
公開日2012-06-06
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Duplex interrogation by a direct DNA repair protein in search of base damage
Nat.Struct.Mol.Biol., 19, 2012
3S57
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BU of 3s57 by Molmil
ABH2 cross-linked with undamaged dsDNA-1 containing cofactors
分子名称: 2-OXOGLUTARIC ACID, 5'-D(*CP*TP*GP*TP*CP*AP*TP*CP*AP*CP*TP*GP*CP*G)-3', 5'-D(*TP*CP*GP*CP*AP*GP*TP*GP*AP*TP*GP*AP*CP*A)-3', ...
著者Yi, C, Chen, B, Qi, B, Ramirez, B, Zhang, W, Jia, G, Zhang, L, Li, C.Q, Dinner, A.R, Yang, C.-G, He, C.
登録日2011-05-20
公開日2012-06-06
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Duplex interrogation by a direct DNA repair protein in search of base damage
Nat.Struct.Mol.Biol., 19, 2012
5HLH
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BU of 5hlh by Molmil
Crystal structure of the overoxidized AbfR bound to DNA
分子名称: DNA (5'-D(*TP*AP*AP*CP*TP*CP*AP*AP*TP*CP*GP*CP*GP*CP*GP*CP*GP*AP*TP*TP*GP*AP*GP*T)-3'), MarR family transcriptional regulator
著者Liu, G, Liu, X, Gan, J, Yang, C.-G.
登録日2016-01-15
公開日2017-01-25
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR.
J. Am. Chem. Soc., 139, 2017
5HLI
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BU of 5hli by Molmil
Structure of Disulfide formed AbfR
分子名称: CHLORIDE ION, COPPER (II) ION, MarR family transcriptional regulator
著者Liu, G, Liu, X, Gan, J, Yang, C.-G.
登録日2016-01-15
公開日2017-01-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR.
J. Am. Chem. Soc., 139, 2017
5DAJ
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BU of 5daj by Molmil
Crystal structure of NalD, the secondary repressor of MexAB-OprM multidrug efflux pump in Pseudomonas aeruginosa
分子名称: NalD
著者Chen, W.Z, Wang, D, Huang, S.Q, Hu, Q.Y, Liu, X.C, Gan, J.H, Chen, H.
登録日2015-08-20
公開日2016-04-20
最終更新日2023-04-12
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Novobiocin binding to NalD induces the expression of the MexAB-OprM pump in Pseudomonas aeruginosa
Mol.Microbiol., 100, 2016
7DFT
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BU of 7dft by Molmil
Crystal structure of Xanthomonas oryzae ClpP
分子名称: ATP-dependent Clp protease proteolytic subunit, CHLORIDE ION
著者Yang, C.-G, Yang, T.
登録日2020-11-09
公開日2021-05-19
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Dysregulation of ClpP by Small-Molecule Activators Used Against Xanthomonas oryzae pv. oryzae Infections.
J.Agric.Food Chem., 69, 2021
7DFU
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BU of 7dfu by Molmil
Crystal structure of Xanthomonas oryzae ClpP S68Y in complex with ADEP4.
分子名称: ATP-dependent Clp protease proteolytic subunit, CHLORIDE ION, MAGNESIUM ION, ...
著者Yang, C.-G, Yang, T.
登録日2020-11-09
公開日2021-05-19
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.901 Å)
主引用文献Dysregulation of ClpP by Small-Molecule Activators Used Against Xanthomonas oryzae pv. oryzae Infections.
J.Agric.Food Chem., 69, 2021
6AKW
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BU of 6akw by Molmil
Crystal structure of RNA dioxygenase bound with an inhibitor
分子名称: 2-OXOGLUTARIC ACID, 2-[[2,6-bis(chloranyl)-4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]amino]benzoic acid, Alpha-ketoglutarate-dependent dioxygenase FTO
著者Yang, C.-G, Huang, Y, Gan, J.
登録日2018-09-04
公開日2019-05-29
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Cancer Cell, 35, 2019
5VZ2
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BU of 5vz2 by Molmil
Structure of ClpP from Staphylococcus aureus in complex with Acyldepsipeptide
分子名称: ATP-dependent Clp protease proteolytic subunit, Acyldepsipeptide
著者Griffith, E.C, Lee, R.E.
登録日2017-05-26
公開日2017-06-21
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Ureadepsipeptides as ClpP Activators.
Acs Infect Dis., 2019

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