3UW4
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![BU of 3uw4 by Molmil](/molmil-images/mine/3uw4) | Crystal structure of cIAP1 BIR3 bound to GDC0152 | 分子名称: | Baculoviral IAP repeat-containing protein 2, Baculoviral IAP repeat-containing protein 4, GDC0152, ... | 著者 | Maurer, B, Hymowitz, S. | 登録日 | 2011-11-30 | 公開日 | 2012-02-22 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152). J.Med.Chem., 55, 2012
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3UW5
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![BU of 3uw5 by Molmil](/molmil-images/mine/3uw5) | Crystal structure of the BIR domain of MLIAP bound to GDC0152 | 分子名称: | Baculoviral IAP repeat-containing protein 7, Baculoviral IAP repeat-containing protein 4, GDC-0152, ... | 著者 | Maurer, B, Hymowitz, S.G. | 登録日 | 2011-11-30 | 公開日 | 2012-02-22 | 最終更新日 | 2017-08-02 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152). J.Med.Chem., 55, 2012
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7CBT
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![BU of 7cbt by Molmil](/molmil-images/mine/7cbt) | The crystal structure of SARS-CoV-2 main protease in complex with GC376 | 分子名称: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase | 著者 | Shi, Y, Peng, G. | 登録日 | 2020-06-13 | 公開日 | 2020-09-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.346 Å) | 主引用文献 | The preclinical inhibitor GS441524 in combination with GC376 efficaciously inhibited the proliferation of SARS-CoV-2 in the mouse respiratory tract. Emerg Microbes Infect, 10, 2021
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8SK5
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![BU of 8sk5 by Molmil](/molmil-images/mine/8sk5) | Crystal structure of the SARS-CoV-2 neutralizing VHH 7A9 bound to the spike receptor binding domain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, anti-SARS-CoV-2 receptor binding domain VHH | 著者 | Noland, C.L, Pande, K, Zhang, L, Zhou, H, Galli, J, Eddins, M, Gomez-Llorente, Y. | 登録日 | 2023-04-18 | 公開日 | 2023-08-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.011 Å) | 主引用文献 | Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants. Sci Rep, 13, 2023
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8JHF
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![BU of 8jhf by Molmil](/molmil-images/mine/8jhf) | Native SUV420H1 bound to 167-bp nucleosome | 分子名称: | DNA (160-MER), Histone H2A.Z, Histone H2B type 1-K, ... | 著者 | Lin, F, Li, W. | 登録日 | 2023-05-23 | 公開日 | 2023-11-15 | 最終更新日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | 主引用文献 | Structural basis of nucleosomal H4K20 recognition and methylation by SUV420H1 methyltransferase. Cell Discov, 9, 2023
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8JHG
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![BU of 8jhg by Molmil](/molmil-images/mine/8jhg) | Native SUV420H1 bound to 167-bp nucleosome | 分子名称: | DNA (160-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | 著者 | Lin, F, Li, W. | 登録日 | 2023-05-23 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | 主引用文献 | Structural basis of nucleosomal H4K20 recognition and methylation by SUV420H1 methyltransferase. Cell Discov, 9, 2023
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7END
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![BU of 7end by Molmil](/molmil-images/mine/7end) | |
7EN9
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![BU of 7en9 by Molmil](/molmil-images/mine/7en9) | Crystal structure of SARS-CoV-2 3CLpro in complex with the non-covalent inhibitor WU-02 | 分子名称: | 3C-like proteinase, 5-bromanyl-~{N}-methyl-3-nitro-2-[(4~{R},5~{S})-2-(7-oxidanylisoquinolin-4-yl)carbonyl-4-phenyl-2,7-diazaspiro[4.4]nonan-7-yl]benzamide | 著者 | Hou, N, Peng, C, Hu, Q. | 登録日 | 2021-04-16 | 公開日 | 2022-07-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Development of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 3CLpro. Acs Cent.Sci., 9, 2023
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7EN8
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![BU of 7en8 by Molmil](/molmil-images/mine/7en8) | Crystal structure of SARS-CoV-2 3CLpro in complex with the non-covalent inhibitor WU-04 | 分子名称: | 3C-like proteinase, GLYCEROL, ~{N}-[(1~{S},2~{R})-2-[[4-bromanyl-2-(methylcarbamoyl)-6-nitro-phenyl]amino]cyclohexyl]isoquinoline-4-carboxamide | 著者 | Hou, N, Peng, C, Hu, Q. | 登録日 | 2021-04-16 | 公開日 | 2022-07-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Development of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 3CLpro. Acs Cent.Sci., 9, 2023
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7ENE
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![BU of 7ene by Molmil](/molmil-images/mine/7ene) | |
4R1E
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![BU of 4r1e by Molmil](/molmil-images/mine/4r1e) | Crystal Structure of MTIP from Plasmodium falciparum in complex with a peptide-fragment chimera | 分子名称: | 5-{[(2-aminoethyl)sulfanyl]methyl}furan-2-carbaldehyde, Myosin A tail domain interacting protein, Myosin-A | 著者 | Douse, C.H, Vrielink, N, Cota, E, Tate, E.W. | 登録日 | 2014-08-05 | 公開日 | 2014-11-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Targeting a Dynamic Protein-Protein Interaction: Fragment Screening against the Malaria Myosin A Motor Complex. Chemmedchem, 10, 2015
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4MBJ
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![BU of 4mbj by Molmil](/molmil-images/mine/4mbj) | |
7YRD
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![BU of 7yrd by Molmil](/molmil-images/mine/7yrd) | histone methyltransferase | 分子名称: | DNA (146-MER), Histone H2A.Z, Histone H2B 1.1, ... | 著者 | Li, H, Wang, W.Y. | 登録日 | 2022-08-09 | 公開日 | 2023-08-16 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insight into H4K20 methylation on H2A.Z-nucleosome by SUV420H1. Mol.Cell, 83, 2023
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7YRG
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![BU of 7yrg by Molmil](/molmil-images/mine/7yrg) | histone methyltransferase | 分子名称: | DNA (146-MER), Histone H2A.Z, Histone H2B 1.1, ... | 著者 | Li, H, Wang, W.Y. | 登録日 | 2022-08-09 | 公開日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structural insight into H4K20 methylation on H2A.Z-nucleosome by SUV420H1. Mol.Cell, 83, 2023
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7WGX
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![BU of 7wgx by Molmil](/molmil-images/mine/7wgx) | SARS-CoV-2 spike glycoprotein trimer in closed state after treatment with Cathepsin L | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-2-[[5-[(Z)-(3-ethenyl-4-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1H-pyrrol-2-yl]methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid, ... | 著者 | Zhu, Y, Tai, L, Yin, G, Sun, F. | 登録日 | 2021-12-29 | 公開日 | 2023-01-04 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies Cell Discov, 8, 2022
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7WGY
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![BU of 7wgy by Molmil](/molmil-images/mine/7wgy) | SARS-CoV-2 spike glycoprotein trimer in Intermediate state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Zhu, Y, Tai, L, Yin, G, Sun, F. | 登録日 | 2021-12-29 | 公開日 | 2023-01-04 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies Cell Discov, 8, 2022
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7WGZ
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![BU of 7wgz by Molmil](/molmil-images/mine/7wgz) | SARS-CoV-2 spike glycoprotein trimer in open state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Zhu, Y, Tai, L, Yin, G, Sun, F. | 登録日 | 2021-12-29 | 公開日 | 2023-01-04 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies Cell Discov, 8, 2022
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7WGV
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![BU of 7wgv by Molmil](/molmil-images/mine/7wgv) | SARS-CoV-2 spike glycoprotein trimer in closed state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-2-[[5-[(Z)-(3-ethenyl-4-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1H-pyrrol-2-yl]methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid, ... | 著者 | Zhu, Y, Tai, L, Yin, G, Sun, F. | 登録日 | 2021-12-29 | 公開日 | 2023-01-04 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies Cell Discov, 8, 2022
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