8XCY
 
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8XCP
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8XD3
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8XCT
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8XCZ
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1VDJ
 | | Solution structure of actin-binding domain of troponin in Ca2+-bound state | | 分子名称: | Troponin I, fast skeletal muscle | | 著者 | Murakami, K, Yumoto, F, Ohki, S, Yasunaga, T, Tanokura, M, Wakabayashi, T. | | 登録日 | 2004-03-22 | | 公開日 | 2005-09-06 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Basis for Ca(2+)-regulated Muscle Relaxation at Interaction Sites of Troponin with Actin and Tropomyosin
J.Mol.Biol., 352, 2005
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1VDI
 | | Solution structure of actin-binding domain of troponin in Ca2+-free state | | 分子名称: | Troponin I, fast skeletal muscle | | 著者 | Murakami, K, Yumoto, F, Ohki, S, Yasunaga, T, Tanokura, M, Wakabayashi, T. | | 登録日 | 2004-03-22 | | 公開日 | 2005-09-06 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Basis for Ca(2+)-regulated Muscle Relaxation at Interaction Sites of Troponin with Actin and Tropomyosin
J.Mol.Biol., 352, 2005
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1DEJ
 | | CRYSTAL STRUCTURE OF A DICTYOSTELIUM/TETRAHYMENA CHIMERA ACTIN (MUTANT 646: Q228K/T229A/A230Y/A231K/S232E/E360H) IN COMPLEX WITH HUMAN GELSOLIN SEGMENT 1 | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, CHIMERIC ACTIN, ... | | 著者 | Matsuura, Y, Stewart, M, Kawamoto, M, Kamiya, N, Saeki, K, Yasunaga, T, Wakabayashi, T. | | 登録日 | 1999-11-15 | | 公開日 | 2000-03-01 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for the higher Ca(2+)-activation of the regulated actin-activated myosin ATPase observed with Dictyostelium/Tetrahymena actin chimeras.
J.Mol.Biol., 296, 2000
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6KLU
 | | Troponin of cardiac thin filament in high-calcium state | | 分子名称: | CALCIUM ION, Troponin C, slow skeletal and cardiac muscles, ... | | 著者 | Oda, T, Yanagisawa, H, Wakabayashi, T. | | 登録日 | 2019-07-30 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (12 Å) | | 主引用文献 | Cryo-EM structures of cardiac thin filaments reveal the 3D architecture of troponin.
J.Struct.Biol., 209, 2020
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6KLL
 | | F-actin of cardiac thin filament in low-calcium state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | 著者 | Oda, T, Yanagisawa, H, Wakabayashi, T. | | 登録日 | 2019-07-30 | | 公開日 | 2020-01-15 | | 最終更新日 | 2020-03-11 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Cryo-EM structures of cardiac thin filaments reveal the 3D architecture of troponin.
J.Struct.Biol., 209, 2020
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6KLN
 | | F-actin of cardiac thin filament in high-calcium state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | 著者 | Oda, T, Yanagisawa, H, Wakabayashi, T. | | 登録日 | 2019-07-30 | | 公開日 | 2020-01-15 | | 最終更新日 | 2020-03-11 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Cryo-EM structures of cardiac thin filaments reveal the 3D architecture of troponin.
J.Struct.Biol., 209, 2020
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6KLP
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6KLT
 | | Troponin of cardiac thin filament in low-calcium state | | 分子名称: | CALCIUM ION, Troponin C, slow skeletal and cardiac muscles, ... | | 著者 | Oda, T, Yanagisawa, H, Wakabayashi, T. | | 登録日 | 2019-07-30 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (12 Å) | | 主引用文献 | Cryo-EM structures of cardiac thin filaments reveal the 3D architecture of troponin.
J.Struct.Biol., 209, 2020
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6KLQ
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1C0G
 | | CRYSTAL STRUCTURE OF 1:1 COMPLEX BETWEEN GELSOLIN SEGMENT 1 AND A DICTYOSTELIUM/TETRAHYMENA CHIMERA ACTIN (MUTANT 228: Q228K/T229A/A230Y/E360H) | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, PROTEIN (CHIMERIC ACTIN), ... | | 著者 | Matsuura, Y, Stewart, M, Kawamoto, M, Kamiya, N, Saeki, K, Yasunaga, T, Wakabayashi, T. | | 登録日 | 1999-07-16 | | 公開日 | 2000-03-01 | | 最終更新日 | 2022-12-21 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis for the higher Ca(2+)-activation of the regulated actin-activated myosin ATPase observed with Dictyostelium/Tetrahymena actin chimeras.
J.Mol.Biol., 296, 2000
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1C0F
 | | CRYSTAL STRUCTURE OF DICTYOSTELIUM CAATP-ACTIN IN COMPLEX WITH GELSOLIN SEGMENT 1 | | 分子名称: | ACTIN, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... | | 著者 | Matsuura, Y, Stewart, M, Kawamoto, M, Kamiya, N, Saeki, K, Yasunaga, T, Wakabayashi, T. | | 登録日 | 1999-07-16 | | 公開日 | 2000-03-01 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for the higher Ca(2+)-activation of the regulated actin-activated myosin ATPase observed with Dictyostelium/Tetrahymena actin chimeras
J.Mol.Biol., 296, 2000
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3A5M
 | | Crystal Structure of a Dictyostelium P109I Mg2+-Actin in Complex with Human Gelsolin Segment 1 | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Gelsolin, ... | | 著者 | Murakami, K, Yasunaga, T, Noguchi, T.Q, Uyeda, T.Q, Wakabayashi, T. | | 登録日 | 2009-08-09 | | 公開日 | 2010-10-27 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for actin assembly, activation of ATP hydrolysis, and delayed phosphate release
Cell(Cambridge,Mass.), 143, 2010
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3A5L
 | | Crystal Structure of a Dictyostelium P109A Mg2+-Actin in Complex with Human Gelsolin Segment 1 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Gelsolin, ... | | 著者 | Murakami, K, Yasunaga, T, Noguchi, T.Q, Uyeda, T.Q, Wakabayashi, T. | | 登録日 | 2009-08-09 | | 公開日 | 2010-10-27 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for actin assembly, activation of ATP hydrolysis, and delayed phosphate release
Cell(Cambridge,Mass.), 143, 2010
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2Z5I
 | | Crystal structure of the head-to-tail junction of tropomyosin | | 分子名称: | General control protein GCN4 and Tropomyosin alpha-1 chain, MAGNESIUM ION, Tropomyosin alpha-1 chain and General control protein GCN4 | | 著者 | Murakami, K, Nozawa, K, Tomii, K, Kudou, N, Igarashi, N, Shirakihara, Y, Wakatsuki, S, Stewart, M, Yasunaga, T, Wakabayashi, T. | | 登録日 | 2007-07-12 | | 公開日 | 2008-04-22 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T
Proc.Natl.Acad.Sci.USA, 105, 2008
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2Z5H
 | | Crystal structure of the head-to-tail junction of tropomyosin complexed with a fragment of TnT | | 分子名称: | General control protein GCN4 and Tropomyosin alpha-1 chain, Tropomyosin alpha-1 chain and General control protein GCN4, Troponin T, ... | | 著者 | Murakami, K, Nozawa, K, Tomii, K, Kudou, N, Igarashi, N, Shirakihara, Y, Wakatsuki, S, Stewart, M, Yasunaga, T, Wakabayashi, T. | | 登録日 | 2007-07-12 | | 公開日 | 2008-04-22 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | | 主引用文献 | Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T
Proc.Natl.Acad.Sci.USA, 105, 2008
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3A5O
 | | Crystal Structure of a Dictyostelium P109I Ca2+-Actin in Complex with Human Gelsolin Segment 1 | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Gelsolin, ... | | 著者 | Murakami, K, Yasunaga, T, Noguchi, T.Q, Uyeda, T.Q, Wakabayashi, T. | | 登録日 | 2009-08-09 | | 公開日 | 2010-10-27 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for actin assembly, activation of ATP hydrolysis, and delayed phosphate release
Cell(Cambridge,Mass.), 143, 2010
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3A5N
 | | Crystal Structure of a Dictyostelium P109A Ca2+-Actin in Complex with Human Gelsolin Segment 1 | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Gelsolin, ... | | 著者 | Murakami, K, Yasunaga, T, Noguchi, T.Q, Uyeda, T.Q, Wakabayashi, T. | | 登録日 | 2009-08-09 | | 公開日 | 2010-10-27 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | | 主引用文献 | Structural basis for actin assembly, activation of ATP hydrolysis, and delayed phosphate release
Cell(Cambridge,Mass.), 143, 2010
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6E0R
 | | hALK in complex with compound 7 N-((1S)-1-(5-fluoropyridin-2-yl)ethyl)-1-(5-methyl-1H-pyrazol-3-yl)-3-(oxetan-3-ylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-6-amine | | 分子名称: | ALK tyrosine kinase receptor, N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-1-(5-methyl-1H-pyrazol-3-yl)-3-[(oxetan-3-yl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-6-amine | | 著者 | Lane, W, Saikatendu, K. | | 登録日 | 2018-07-06 | | 公開日 | 2019-05-01 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.303 Å) | | 主引用文献 | Discovery of Potent, Selective, and Brain-Penetrant 1 H-Pyrazol-5-yl-1 H-pyrrolo[2,3- b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors.
J.Med.Chem., 62, 2019
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6EDL
 | | hALK in complex with compound 1 (S)-N-(1-(2,4-difluorophenyl)ethyl)-3-(3-methyl-1H-pyrazol-5-yl)imidazo[1,2-b]pyridazin-6-amine | | 分子名称: | ALK tyrosine kinase receptor, N-[(1S)-1-(2,4-difluorophenyl)ethyl]-3-(5-methyl-1H-pyrazol-3-yl)imidazo[1,2-b]pyridazin-6-amine | | 著者 | Lane, W, Saikatendu, K. | | 登録日 | 2018-08-09 | | 公開日 | 2019-05-01 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.799 Å) | | 主引用文献 | Discovery of Potent, Selective, and Brain-Penetrant 1 H-Pyrazol-5-yl-1 H-pyrrolo[2,3- b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors.
J.Med.Chem., 62, 2019
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1VOM
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