2Z5H

Crystal structure of the head-to-tail junction of tropomyosin complexed with a fragment of TnT

Summary for 2Z5H

Entry DOI	10.2210/pdb2z5h/pdb
Descriptor	General control protein GCN4 and Tropomyosin alpha-1 chain, Tropomyosin alpha-1 chain and General control protein GCN4, Troponin T, fast skeletal muscle isoforms, ... (4 entities in total)
Functional Keywords	actin, troponin, tropomyosin, cytoskeleton, cardiomyopathy, four-helix bundle, contractile protein
Biological source	Saccharomyces cerevisiae (baker's yeast, rabbit) More
Cellular location	Cytoplasm, cytoskeleton: P58772 Nucleus: P03069
Total number of polymer chains	10
Total formula weight	59657.50
Authors	Murakami, K.,Nozawa, K.,Tomii, K.,Kudou, N.,Igarashi, N.,Shirakihara, Y.,Wakatsuki, S.,Stewart, M.,Yasunaga, T.,Wakabayashi, T. (deposition date: 2007-07-12, release date: 2008-04-22, Last modification date: 2024-03-13)
Primary citation	Murakami, K.,Stewart, M.,Nozawa, K.,Tomii, K.,Kudou, N.,Igarashi, N.,Shirakihara, Y.,Wakatsuki, S.,Yasunaga, T.,Wakabayashi, T. Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T Proc.Natl.Acad.Sci.USA, 105:7200-7205, 2008 Cited by PubMed: 18483193 DOI: 10.1073/pnas.0801950105 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.89 Å)

Structure validation