7RXO
| Crystal structure of CDK2 liganded with compound WN333 | 分子名称: | 1,2-ETHANEDIOL, 2-{[2-(1H-indol-3-yl)ethyl]amino}-5-(methoxycarbonyl)benzoic acid, Cyclin-dependent kinase 2 | 著者 | Sun, L, Schonbrunn, E. | 登録日 | 2021-08-23 | 公開日 | 2022-08-31 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice. J.Med.Chem., 66, 2023
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7S7A
| Crystal structure of CDK2 liganded with compound EF3019 | 分子名称: | 1,2-ETHANEDIOL, 2-{[2-(2H-indazol-3-yl)ethyl]amino}-5-(trifluoromethyl)benzoic acid, Cyclin-dependent kinase 2 | 著者 | Sun, L, Schonbrunn, E. | 登録日 | 2021-09-15 | 公開日 | 2022-09-28 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice. J.Med.Chem., 66, 2023
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7S4T
| Crystal structure of CDK2 liganded with compound EF2252 | 分子名称: | 1,2-ETHANEDIOL, 2-{[2-(6-chloro-1H-indol-3-yl)ethyl]amino}-5-nitrobenzoic acid, Cyclin-dependent kinase 2 | 著者 | Sun, L, Schonbrunn, E. | 登録日 | 2021-09-09 | 公開日 | 2022-09-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice. J.Med.Chem., 66, 2023
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4XOH
| Mechanistic insights into anchorage of the contractile ring from yeast to humans | 分子名称: | Division mal foutue 1 protein | 著者 | Chen, Z, Wu, J.-Q, Wang, J, Guan, R, Sun, L, Lee, I.-J, Liu, Y, Chen, M. | 登録日 | 2015-01-16 | 公開日 | 2015-07-15 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.801 Å) | 主引用文献 | Mechanistic insights into the anchorage of the contractile ring by anillin and mid1 Dev.Cell, 33, 2015
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7S84
| Crystal structure of CDK2 liganded with compound TW8972 | 分子名称: | 2-{[2-(1H-indol-3-yl)ethyl]amino}-5-(trifluoromethyl)benzoic acid, Cyclin-dependent kinase 2 | 著者 | Sun, L, Schonbrunn, E. | 登録日 | 2021-09-17 | 公開日 | 2022-09-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding. Nat Commun, 14, 2023
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7RWE
| Crystal structure of CDK2 liganded with compound GPHR787 | 分子名称: | 5-nitro-2-[(3-phenylpropyl)amino]benzoic acid, Cyclin-dependent kinase 2 | 著者 | Sun, L, Schonbrunn, E. | 登録日 | 2021-08-19 | 公開日 | 2022-08-24 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice. J.Med.Chem., 66, 2023
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8GQ6
| Cryo-EM Structure of the KBTBD2-CUL3-Rbx1 dimeric complex | 分子名称: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | 著者 | Sun, L, Chen, Z, Hu, Y, Mao, Q. | 登録日 | 2022-08-29 | 公開日 | 2023-09-06 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.96 Å) | 主引用文献 | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2. Nat.Struct.Mol.Biol., 31, 2024
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7MPH
| GRB2 SH2 Domain with Compound 7 | 分子名称: | (4-{(10R,11E,14S,18S)-18-(2-amino-2-oxoethyl)-14-[(naphthalen-1-yl)methyl]-8,17,20-trioxo-7,16,19-triazaspiro[5.14]icos-11-en-10-yl}phenyl)acetic acid, 1,2-ETHANEDIOL, Growth factor receptor-bound protein 2, ... | 著者 | Sun, L, Schonbrunn, E. | 登録日 | 2021-05-04 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Synthesis and structural characterization of a monocarboxylic inhibitor for GRB2 SH2 domain. Bioorg.Med.Chem.Lett., 51, 2021
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7RWF
| Crystal structure of CDK2 in complex with TW8672 | 分子名称: | 1,2-ETHANEDIOL, 2-{[2-(1H-indol-3-yl)ethyl]amino}-5-nitrobenzoic acid, Cyclin-dependent kinase 2 | 著者 | Sun, L, Schonbrunn, E. | 登録日 | 2021-08-19 | 公開日 | 2022-08-24 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding. Nat Commun, 14, 2023
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6LYP
| Cryo-EM structure of AtMSL1 wild type | 分子名称: | Mechanosensitive ion channel protein 1, mitochondrial | 著者 | Sun, L. | 登録日 | 2020-02-15 | 公開日 | 2020-04-15 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural Insights into a Plant Mechanosensitive Ion Channel MSL1. Cell Rep, 30, 2020
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5U6K
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4OFB
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7Y9U
| Structure of the auxin exporter PIN1 in Arabidopsis thaliana in the NPA-bound state | 分子名称: | 2-(naphthalen-1-ylcarbamoyl)benzoic acid, Auxin efflux carrier component 1, nanobody | 著者 | Sun, L, Liu, X, Yang, Z, Xia, J. | 登録日 | 2022-06-26 | 公開日 | 2022-09-07 | 最終更新日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural insights into auxin recognition and efflux by Arabidopsis PIN1. Nature, 609, 2022
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7Y9V
| Structure of the auxin exporter PIN1 in Arabidopsis thaliana in the IAA-bound state | 分子名称: | 1H-INDOL-3-YLACETIC ACID, Auxin efflux carrier component 1, nanobody | 著者 | Sun, L, Liu, X, Yang, Z, Xia, J. | 登録日 | 2022-06-26 | 公開日 | 2022-09-07 | 最終更新日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insights into auxin recognition and efflux by Arabidopsis PIN1. Nature, 609, 2022
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7Y9T
| Structure of the auxin exporter PIN1 in Arabidopsis thaliana in the apo state | 分子名称: | Auxin efflux carrier component 1, nanobody | 著者 | Sun, L, Liu, X, Yang, Z, Xia, J. | 登録日 | 2022-06-26 | 公開日 | 2022-09-07 | 最終更新日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insights into auxin recognition and efflux by Arabidopsis PIN1. Nature, 609, 2022
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6IJZ
| Structure of a plant cation channel | 分子名称: | Calcium permeable stress-gated cation channel 1 | 著者 | Sun, L, Wang, J, Liu, X. | 登録日 | 2018-10-12 | 公開日 | 2018-12-12 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | 主引用文献 | Structure of the hyperosmolality-gated calcium-permeable channel OSCA1.2. Nat Commun, 9, 2018
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7WNQ
| Cryo-EM structure of AtSLAC1 S59A mutant | 分子名称: | Guard cell S-type anion channel SLAC1 | 著者 | Sun, L, Liu, X, Li, Y. | 登録日 | 2022-01-19 | 公開日 | 2022-04-13 | 最終更新日 | 2022-10-26 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structure of the Arabidopsis guard cell anion channel SLAC1 suggests activation mechanism by phosphorylation. Nat Commun, 13, 2022
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7YKS
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7YKR
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8JMM
| Structure of XBB spike protein (S) dimer-trimer in complex with bispecific antibody G7-Fc at 3.75 Angstroms resolution. | 分子名称: | 7F3 Fv, GW01 Fv, Spike glycoprotein | 著者 | Hao, A, Mao, Q, Chen, Z, Huang, J, Sun, L. | 登録日 | 2023-06-05 | 公開日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.75 Å) | 主引用文献 | Structure of XBB spike protein (S) dimer-trimer in complex with bispecific antibody G7-Fc at 3.75 Angstroms resolution. To Be Published
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2QTH
| Crystal structure of a GTP-binding protein from the hyperthermophilic archaeon Sulfolobus solfataricus in complex with GDP | 分子名称: | ACETATE ION, CADMIUM ION, GTP-binding protein, ... | 著者 | Wu, H, Sun, L, Brouns, S.J, Fu, S, Rao, Z, Van der Oost, J. | 登録日 | 2007-08-02 | 公開日 | 2008-08-19 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of a GTP-binding protein from the hyperthermophilic archaeon Sulfolobus solfataricus. To be Published
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2QTF
| Crystal structure of a GTP-binding protein from the hyperthermophilic archaeon Sulfolobus solfataricus | 分子名称: | ACETATE ION, CADMIUM ION, GTP-binding protein, ... | 著者 | Wu, H, Sun, L, Brouns, S.J, Fu, S, Rao, Z, Van der Oost, J. | 登録日 | 2007-08-02 | 公開日 | 2008-08-19 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of a GTP-binding protein from the hyperthermophilic archaeon Sulfolobus solfataricus. To be Published
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8H34
| Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 hexameric complex | 分子名称: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | 著者 | Hu, Y, Mao, Q, Chen, Z, Sun, L. | 登録日 | 2022-10-07 | 公開日 | 2023-10-11 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (7.99 Å) | 主引用文献 | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2. Nat.Struct.Mol.Biol., 31, 2024
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8H33
| Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 tetrameric complex | 分子名称: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | 著者 | Hu, Y, Mao, Q, Chen, Z, Sun, L. | 登録日 | 2022-10-07 | 公開日 | 2023-10-11 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (7.86 Å) | 主引用文献 | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2. Nat.Struct.Mol.Biol., 31, 2024
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8H3Q
| Cryo-EM Structure of the CAND1-Cul3-Rbx1 complex | 分子名称: | Cullin-3, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... | 著者 | Hu, Y, Mao, Q, Chen, Z, Sun, L. | 登録日 | 2022-10-09 | 公開日 | 2023-10-11 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.76 Å) | 主引用文献 | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2. Nat.Struct.Mol.Biol., 31, 2024
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