1T5X
 
 | | HLA-DR1 in complex with a synthetic peptide (AAYSDQATPLLLSPR) and the superantigen SEC3-3B2 | | 分子名称: | 15-mer peptide fragment of Regulatory protein MIG1, Enterotoxin type C-3, HLA class II histocompatibility antigen, ... | | 著者 | Zavala-Ruiz, Z, Strug, I, Anderson, M.W, Gorski, J, Stern, L.J. | | 登録日 | 2004-05-05 | | 公開日 | 2004-08-17 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | A Polymorphic Pocket at the P10 Position Contributes to Peptide Binding Specificity in Class II MHC Proteins
Chem.Biol., 11, 2004
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1SJH
 | | HLA-DR1 complexed with a 13 residue HIV capsid peptide | | 分子名称: | Enterotoxin type C-3, GAG polyprotein, HLA class II histocompatibility antigen, ... | | 著者 | Zavala-Ruiz, Z, Strug, I, Walker, B.D, Norris, P.J, Stern, L.J. | | 登録日 | 2004-03-03 | | 公開日 | 2004-08-17 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition.
Proc.Natl.Acad.Sci.Usa, 101, 2004
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1T5W
 | | HLA-DR1 in complex with a synthetic peptide (AAYSDQATPLLLSPR) | | 分子名称: | 15-mer peptide fragment of Regulatory protein MIG1, HLA class II histocompatibility antigen, DR alpha chain, ... | | 著者 | Zavala-Ruiz, Z, Strug, I, Anderson, M.W, Gorski, J, Stern, L.J. | | 登録日 | 2004-05-05 | | 公開日 | 2004-08-17 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | A Polymorphic Pocket at the P10 Position Contributes to Peptide Binding Specificity in Class II MHC Proteins
Chem.Biol., 11, 2004
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4I0P
 | | HLA-DO in complex with HLA-DM | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, GLYCEROL, ... | | 著者 | Guce, A.I, Mortimer, S.E, Stern, L.J. | | 登録日 | 2012-11-18 | | 公開日 | 2012-12-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism.
Nat.Struct.Mol.Biol., 20, 2013
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3IK5
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3IOZ
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3TIE
 | | Crystal structure of the vaccinia derived peptide A11R in complex with the murine MHC CLASS I H-2 KB | | 分子名称: | Beta-2-microglobulin, H-2 class I histocompatibility antigen, K-B alpha chain, ... | | 著者 | Nguyen, T.T, Shen, Z.T, Stern, L.J. | | 登録日 | 2011-08-20 | | 公開日 | 2012-08-22 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Disparate epitopes mediating protective heterologous immunity to unrelated viruses share peptide-MHC structural features recognized by cross-reactive T cells.
J.Immunol., 191, 2013
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7KEI
 | | DQA1*01:02/DQB1*06:02 in complex with a hemagglutinin peptide from the H1N1 pandemic flu virus. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HA peptide from 2009 H1N1 pandemic flu virus., ... | | 著者 | Birtley, J.R, Stern, L.J, Mellins, E.D, Jiang, W. | | 登録日 | 2020-10-10 | | 公開日 | 2021-10-13 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Crystal structure of DQA1*01:02/DQB1*06:02 in complex with a flu peptide.
To Be Published
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3TID
 | | Crystal structure of the LCMV derived peptide GP34 in complex with the murine mhc class I H-2 Kb | | 分子名称: | ACETATE ION, Beta-2-microglobulin, H-2 class I histocompatibility antigen, ... | | 著者 | Nguyen, T.T, Shen, Z.T, Stern, L.J. | | 登録日 | 2011-08-20 | | 公開日 | 2012-08-22 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Disparate epitopes mediating protective heterologous immunity to unrelated viruses share peptide-MHC structural features recognized by cross-reactive T cells.
J.Immunol., 191, 2013
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3QXD
 | | F54C HLA-DR1 bound with CLIP peptide | | 分子名称: | HLA class II histocompatibility antigen gamma chain peptide, HLA class II histocompatibility antigen, DR alpha chain, ... | | 著者 | Painter, C.A, Stern, L.J. | | 登録日 | 2011-03-01 | | 公開日 | 2011-11-16 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.302 Å) | | 主引用文献 | Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3QXA
 | | HLA-DR1 bound with CLIP peptide | | 分子名称: | HLA class II histocompatibility antigen gamma chain peptide, HLA class II histocompatibility antigen, DR alpha chain, ... | | 著者 | Painter, C.A, Stern, L.J. | | 登録日 | 2011-03-01 | | 公開日 | 2011-11-16 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.712 Å) | | 主引用文献 | Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3RDT
 | | Crystal Structure of 809.B5 TCR complexed with MHC Class II I-Ab/3k peptide | | 分子名称: | 3K peptide, linker and MHC H-2 class II I-Ab beta chain, H-2 class II histocompatibility antigen, ... | | 著者 | Trenh, P, Huseby, E.S, Stern, L.J. | | 登録日 | 2011-04-01 | | 公開日 | 2011-12-07 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | A role for differential variable gene pairing in creating T cell receptors specific for unique major histocompatibility ligands.
Immunity, 35, 2011
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4P23
 | | J809.B5 TCR bound to IAb/3K | | 分子名称: | 3K peptide and MHC IAb beta chain,H-2 class II histocompatibility antigen, A beta chain, H-2 class II histocompatibility antigen, ... | | 著者 | Stadinski, B.D, Huseby, E.S, Trenh, P, Stern, L. | | 登録日 | 2014-02-28 | | 公開日 | 2014-05-28 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Effect of CDR3 Sequences and Distal V Gene Residues in Regulating TCR-MHC Contacts and Ligand Specificity.
J Immunol., 192, 2014
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8CGP
 | | Insulin regulated aminopeptidase (IRAP) in complex with an allosteric aryl sulfonamide inhibitor | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Mpakali, A, Stratikos, E, Giastas, P. | | 登録日 | 2023-02-06 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | | 主引用文献 | Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase.
J.Mol.Biol., 436, 2024
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8CGW
 | | Insulin-regulated aminopeptidase (IRAP) in complex with an allosteric benzopyran-based inhibitor | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Mpakali, A, Stratikos, E, Giastas, P. | | 登録日 | 2023-02-06 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3.03 Å) | | 主引用文献 | Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase.
J.Mol.Biol., 436, 2024
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6YDX
 | | Insulin-regulated aminopeptidase complexed with a macrocyclic peptidic inhibitor | | 分子名称: | 1,2-ETHANEDIOL, 2-[2-[[[(4~{R},8~{S},11~{S})-11-azanyl-8-[(4-hydroxyphenyl)methyl]-6,10-bis(oxidanylidene)-1,2-dithia-5,9-diazacyclotridec-4-yl]carbonylamino]methyl]phenyl]ethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Mpakali, A, Saridakis, E, Giastas, P, Stratikos, E. | | 登録日 | 2020-03-21 | | 公開日 | 2020-07-22 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor.
Acs Med.Chem.Lett., 11, 2020
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6MKD
 | | 4699 TCR bound to I-Ab Padi4 | | 分子名称: | 4699 TCR alpha chain, 4699 TCR beta chain, H-2 class II histocompatibility antigen, ... | | 著者 | Stadinski, B.D, Blevins, S.J, Huseby, E.S. | | 登録日 | 2018-09-25 | | 公開日 | 2019-07-03 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3+Tregcell development.
Nat.Immunol., 20, 2019
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6MNO
 | | 6235 TCR bound to I-Ab Padi4 | | 分子名称: | 6235 TCR alpha chain, 6235 TCR beta chain, H-2 class II histocompatibility antigen, ... | | 著者 | Stadinski, B.D, Blevins, S.J, Huseby, E.S. | | 登録日 | 2018-10-02 | | 公開日 | 2019-07-03 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3+Tregcell development.
Nat.Immunol., 20, 2019
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6MKR
 | | 5287 TCR bound to IAb Padi4 | | 分子名称: | 5287 TCR alpha chain, 5287 TCR beta chain, H-2 class II histocompatibility antigen, ... | | 著者 | Stadinski, B.D, Blevins, S.J, Huseby, E.S. | | 登録日 | 2018-09-26 | | 公開日 | 2019-07-03 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.355 Å) | | 主引用文献 | A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3+Tregcell development.
Nat.Immunol., 20, 2019
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6MNN
 | | 6236 TCR bound to I-Ab Padi4 | | 分子名称: | 6236 TCR alpha chain, 6236 TCR beta chain, H-2 class II histocompatibility antigen, ... | | 著者 | Blevins, S.J, Stadinski, B.D, Huseby, E.S. | | 登録日 | 2018-10-02 | | 公開日 | 2019-07-03 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | | 主引用文献 | A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3+Tregcell development.
Nat.Immunol., 20, 2019
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6MNM
 | | 6256 TCR bound to I-Ab Padi4 | | 分子名称: | 6256 TCR alpha chain, 6256 TCR beta chain, H-2 class II histocompatibility antigen, ... | | 著者 | Blevins, S.J, Stadinski, B.D, Huseby, E.S. | | 登録日 | 2018-10-02 | | 公開日 | 2019-07-03 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3+Tregcell development.
Nat.Immunol., 20, 2019
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6MNG
 | | 4738 TCR bound to IAb Padi4 | | 分子名称: | 4738 TCR alpha chain, 4738 TCR beta chain, H-2 class II histocompatibility antigen, ... | | 著者 | Blevins, S.J, Stadinski, B.D, Huseby, E.S. | | 登録日 | 2018-10-01 | | 公開日 | 2019-07-03 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.662 Å) | | 主引用文献 | A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3+Tregcell development.
Nat.Immunol., 20, 2019
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2Q6W
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1ESF
 | | STAPHYLOCOCCAL ENTEROTOXIN A | | 分子名称: | CADMIUM ION, STAPHYLOCOCCAL ENTEROTOXIN A | | 著者 | Schad, E.M, Svensson, L.A. | | 登録日 | 1995-05-25 | | 公開日 | 1996-07-11 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of the superantigen staphylococcal enterotoxin type A.
EMBO J., 14, 1995
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4GKZ
 | | HA1.7, a MHC class II restricted TCR specific for haemagglutinin | | 分子名称: | 1,2-ETHANEDIOL, Alpha chain of Class II TCR, Beta Chain of Class II TCR, ... | | 著者 | Holland, C.J, Rizkallah, P.J, Cole, D.K, Sewell, A.K, Godkin, A.J. | | 登録日 | 2012-08-13 | | 公開日 | 2012-11-07 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers.
Sci Rep, 2, 2012
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