2Q6W
The structure of HLA-DRA, DRB3*0101 (DR52a) with bound platelet integrin peptide associated with fetal and neonatal alloimmune thrombocytopenia
Summary for 2Q6W
Entry DOI | 10.2210/pdb2q6w/pdb |
Descriptor | HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB3-1 beta chain, Integrin beta-3, ... (4 entities in total) |
Functional Keywords | drb3, peptide-class ii mhc complex, fetal-maternal alloimmune thrombocytopenia, thrombocytopenia purpura, myasthenia gravis, beta 11 arginine, autoimmunity, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein: P01903 P79483 Membrane; Single-pass type I membrane protein: P05106 |
Total number of polymer chains | 6 |
Total formula weight | 89121.91 |
Authors | Parry, C.S. (deposition date: 2007-06-05, release date: 2007-07-24, Last modification date: 2023-08-30) |
Primary citation | Parry, C.S.,Gorski, J.,Stern, L.J. Crystallographic Structure of the Human Leukocyte Antigen DRA, DRB3*0101: Models of a Directional Alloimmune Response and Autoimmunity J.Mol.Biol., 371:435-446, 2007 Cited by PubMed: 17583734DOI: 10.1016/j.jmb.2007.05.025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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