2Q6W
The structure of HLA-DRA, DRB3*0101 (DR52a) with bound platelet integrin peptide associated with fetal and neonatal alloimmune thrombocytopenia
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | HLA class II histocompatibility antigen, DR alpha chain | polymer | 182 | 21155.9 | 2 | UniProt (P01903) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (human) | MHC class II antigen DRA |
| 2 | B, E (B, E) | HLA class II histocompatibility antigen, DRB3-1 beta chain | polymer | 190 | 22102.6 | 2 | UniProt (P79483) Pfam (PF00969) Pfam (PF07654) | Homo sapiens (human) | |
| 3 | C, F (C, F) | Integrin beta-3 | polymer | 12 | 1302.4 | 2 | UniProt (P05106) | Homo sapiens | Platelet membrane glycoprotein IIIa, GPIIIa, CD61 antigen |
| 4 | G, H, I, J, K... (A, B, C, D, E...) | water | water | 18.0 | 487 | Chemie (HOH) |
Sequence modifications
C, F: 24 - 35 (UniProt: P05106)
| PDB | External Database | Details |
|---|---|---|
| Arg 26 | Cys 52 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 89121.9 | |
| All* | Total formula weight | 89121.9 |
