8FBQ
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![BU of 8fbq by Molmil](/molmil-images/mine/8fbq) | Crystal structure of Plasmodium vivax glycylpeptide N-tetradecanoyltransferase (N-myristoyltransferase, NMT) bound to myristoyl-CoA and inhibitor 12b | 分子名称: | 1-[(3M)-3-{3-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethoxy]pyridin-2-yl}phenyl]piperazine, ACETATE ION, CHLORIDE ION, ... | 著者 | Fenwick, M.K, Staker, B.L, Lovell, S.W, Phan, I.Q, Early, J, Myler, P.J, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | 登録日 | 2022-11-29 | 公開日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts. Nat Commun, 14, 2023
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1EJ0
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![BU of 1ej0 by Molmil](/molmil-images/mine/1ej0) | FTSJ RNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLMETHIONINE, MERCURY DERIVATIVE | 分子名称: | FTSJ, MERCURY (II) ION, S-ADENOSYLMETHIONINE | 著者 | Bugl, H, Fauman, E.B, Staker, B.L, Zheng, F, Kushner, S.R, Saper, M.A, Bardwell, J.C.A, Jakob, U. | 登録日 | 2000-02-29 | 公開日 | 2000-08-30 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | RNA methylation under heat shock control. Mol.Cell, 6, 2000
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1EIZ
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![BU of 1eiz by Molmil](/molmil-images/mine/1eiz) | FTSJ RNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLMETHIONINE | 分子名称: | FTSJ, S-ADENOSYLMETHIONINE | 著者 | Bugl, H, Fauman, E.B, Staker, B.L, Zheng, F, Kushner, S.R, Saper, M.A, Bardwell, J.C.A, Jakob, U. | 登録日 | 2000-02-29 | 公開日 | 2000-08-30 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | RNA methylation under heat shock control. Mol.Cell, 6, 2000
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1TL8
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![BU of 1tl8 by Molmil](/molmil-images/mine/1tl8) | Human DNA topoisomerase I (70 kDa) in complex with the indenoisoquinoline AI-III-52 and covalent complex with a 22 base pair DNA duplex | 分子名称: | 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM, 5'-D(*(TPC)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', ... | 著者 | Ioanoviciu, A, Antony, S, Pommier, Y, Staker, B.L, Stewart, L, Cushman, M. | 登録日 | 2004-06-09 | 公開日 | 2005-06-21 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA-Enzyme-Inhibitor Complex As Determined by X-ray Crystallographic Analysis J.Med.Chem., 48, 2005
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1RRJ
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![BU of 1rrj by Molmil](/molmil-images/mine/1rrj) | Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I | 分子名称: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID, 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', ... | 著者 | Chrencik, J.E, Staker, B.L, Burgin, A.B, Stewart, L, Redinbo, M.R. | 登録日 | 2003-12-08 | 公開日 | 2004-07-06 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Mechanisms of camptothecin resistance by human topoisomerase I mutations J.Mol.Biol., 339, 2004
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1RR8
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![BU of 1rr8 by Molmil](/molmil-images/mine/1rr8) | Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I | 分子名称: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID, 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', ... | 著者 | Chrencik, J.E, Staker, B.L, Burgin, A.B, Stewart, L, Redinbo, M.R. | 登録日 | 2003-12-08 | 公開日 | 2004-07-06 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Mechanisms of camptothecin resistance by human topoisomerase I mutations J.Mol.Biol., 339, 2004
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3GMT
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![BU of 3gmt by Molmil](/molmil-images/mine/3gmt) | Crystal structure of adenylate kinase from burkholderia pseudomallei | 分子名称: | Adenylate kinase, SULFATE ION | 著者 | Abendroth, J, Staker, B.L, Robinson, H, Buchko, G.W, Hewitt, S.N, Napuli, A.J, Van Voorhis, W, Stacy, R, Myler, P.J, Stewart, L, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | 登録日 | 2009-03-15 | 公開日 | 2009-06-02 | 最終更新日 | 2013-10-30 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural characterization of Burkholderia pseudomallei adenylate kinase (Adk): profound asymmetry in the crystal structure of the 'open' state. Biochem.Biophys.Res.Commun., 394, 2010
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4EGF
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3IEF
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![BU of 3ief by Molmil](/molmil-images/mine/3ief) | |
3MEQ
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![BU of 3meq by Molmil](/molmil-images/mine/3meq) | Crystal structure of alcohol dehydrogenase from Brucella melitensis | 分子名称: | 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Alcohol dehydrogenase, ... | 著者 | Arakaki, T.L, Staker, B.L, Gardberg, A, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | 登録日 | 2010-03-31 | 公開日 | 2010-04-28 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of alcohol dehydrogenase from Brucella melitensis To be Published
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3T80
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![BU of 3t80 by Molmil](/molmil-images/mine/3t80) | Crystal structure of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Salmonella typhimurium bound to cytidine | 分子名称: | 1,2-ETHANEDIOL, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, 4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE, ... | 著者 | Seattle Structural Genomics Center for Infectious Disease (SSGCID), Staker, B.L, Edwards, T.E. | 登録日 | 2011-07-31 | 公開日 | 2011-09-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Salmonella typhimurium bound to cytidine To be Published
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3U0B
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![BU of 3u0b by Molmil](/molmil-images/mine/3u0b) | Crystal structure of an oxidoreductase from Mycobacterium smegmatis | 分子名称: | Oxidoreductase, short chain dehydrogenase/reductase family protein, SODIUM ION | 著者 | Arakaki, T.L, Staker, B.L, Clifton, M.C, Abendroth, J, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | 登録日 | 2011-09-28 | 公開日 | 2011-10-05 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
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3U0A
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![BU of 3u0a by Molmil](/molmil-images/mine/3u0a) | Crystal structure of an Acyl-CoA thioesterase II TesB2 from Mycobacterium marinum | 分子名称: | Acyl-CoA thioesterase II TesB2, GLYCEROL, SODIUM ION, ... | 著者 | Arakaki, T.L, Staker, B.L, Clifton, M.C, Sankaran, B, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | 登録日 | 2011-09-28 | 公開日 | 2011-10-05 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
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3STH
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![BU of 3sth by Molmil](/molmil-images/mine/3sth) | Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Toxoplasma gondii | 分子名称: | 1,2-ETHANEDIOL, Glyceraldehyde-3-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Seattle Structural Genomics Center for Infectious Disease (SSGCID), Staker, B.L, Edwards, T.E, Sankaran, B. | 登録日 | 2011-07-10 | 公開日 | 2011-08-03 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Membrane skeletal association and post-translational allosteric regulation of Toxoplasma gondii GAPDH1. Mol.Microbiol., 103, 2017
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3SI9
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![BU of 3si9 by Molmil](/molmil-images/mine/3si9) | Crystal structure of Dihydrodipicolinate Synthase from Bartonella Henselae | 分子名称: | 1,2-ETHANEDIOL, Dihydrodipicolinate synthase | 著者 | Seattle Structural Genomics Center for Infectious Disease (SSGCID), Staker, B.L, Abendroth, J, Sankaran, B. | 登録日 | 2011-06-17 | 公開日 | 2011-06-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Cloning, expression, purification, crystallization and X-ray diffraction analysis of dihydrodipicolinate synthase from the human pathogenic bacterium Bartonella henselae strain Houston-1 at 2.1 angstrom resolution. Acta Crystallogr F Struct Biol Commun, 72, 2016
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3GRP
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![BU of 3grp by Molmil](/molmil-images/mine/3grp) | |
3U0G
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![BU of 3u0g by Molmil](/molmil-images/mine/3u0g) | |
3KCQ
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![BU of 3kcq by Molmil](/molmil-images/mine/3kcq) | |
3OUJ
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![BU of 3ouj by Molmil](/molmil-images/mine/3ouj) | PHD2 with 2-Oxoglutarate | 分子名称: | 2-OXOGLUTARIC ACID, Egl nine homolog 1, FE (II) ION, ... | 著者 | Staker, B.L, Arakaki, T.L. | 登録日 | 2010-09-14 | 公開日 | 2010-12-01 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues. ACS Med Chem Lett, 1, 2010
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5EJ2
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![BU of 5ej2 by Molmil](/molmil-images/mine/5ej2) | |
3CXK
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![BU of 3cxk by Molmil](/molmil-images/mine/3cxk) | 1.7 A Crystal structure of methionine-R-sulfoxide reductase from Burkholderia pseudomallei: crystallization in a microfluidic crystal card. | 分子名称: | ACETATE ION, Methionine-R-sulfoxide reductase, ZINC ION | 著者 | Lovell, S, Gerdts, C, Staker, B, Craigen, D, Stewart, L, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), Seattle Structural Genomics Center for Infectious Disease (SSGCID) | 登録日 | 2008-04-24 | 公開日 | 2008-05-27 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The plug-based nanovolume Microcapillary Protein Crystallization System (MPCS). Acta Crystallogr.,Sect.D, 64, 2008
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4W5K
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![BU of 4w5k by Molmil](/molmil-images/mine/4w5k) | |
5QBV
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![BU of 5qbv by Molmil](/molmil-images/mine/5qbv) | Crystal structure of human Cathepsin-S with bound ligand | 分子名称: | Cathepsin S, N-[2-chloro-5-(1-{3-[4-(6-chloro-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]propyl}-6-oxo-1,6-dihydropyridazin-3-yl)benzyl]benzamide | 著者 | Bembenek, S.D, Ameriks, M.K, Mirzadegan, T, Yang, H, Shao, C, Burley, S.K. | 登録日 | 2017-08-04 | 公開日 | 2017-12-20 | 最終更新日 | 2021-11-17 | 実験手法 | X-RAY DIFFRACTION (1.796 Å) | 主引用文献 | Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors Bioorg.Med.Chem.Lett., 20, 2010
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5QBY
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![BU of 5qby by Molmil](/molmil-images/mine/5qby) | Crystal structure of human Cathepsin-S with bound ligand | 分子名称: | Cathepsin S, N-[2-chloro-5-(1-{3-[4-(6-chloro-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]propyl}-6-oxo-1,6-dihydropyrimidin-5-yl)benzyl]-4-fluorobenzamide | 著者 | Bembenek, S.D, Ameriks, M.K, Mirzadegan, T, Yang, H, Shao, C, Burley, S.K. | 登録日 | 2017-08-04 | 公開日 | 2017-12-20 | 最終更新日 | 2021-11-17 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors Bioorg.Med.Chem.Lett., 20, 2010
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6WE5
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![BU of 6we5 by Molmil](/molmil-images/mine/6we5) | |