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5AC1
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BU of 5ac1 by Molmil
Sheep aldehyde dehydrogenase 1A1 with duocarmycin analog inhibitor
分子名称: 1-[(1S)-1-methyl-5-oxidanyl-1,2-dihydrobenzo[e]indol-3-yl]hexan-1-one, MAGNESIUM ION, RETINAL DEHYDROGENASE 1, ...
著者Koch, M.F, Harteis, S, Blank, I.D, Pestel, G, Tietze, L.F, Ochsenfeld, C, Schneider, S, Sieber, S.A.
登録日2015-08-11
公開日2015-08-26
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues.
Angew.Chem.Int.Ed.Engl., 54, 2015
5BPK
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BU of 5bpk by Molmil
Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases
分子名称: (2S)-amino[(5S)-4,5-dihydro-1,2-oxazol-5-yl]acetic acid, 1,2-ETHANEDIOL, Gamma-glutamyltranspeptidase (Ggt)
著者Bolz, C, Bach, N.C, Meyer, H, Mueller, G, Dawidowski, M, Popowicz, G, Sieber, S.A, Skerra, A, Gerhard, M.
登録日2015-05-28
公開日2016-05-18
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases
To Be Published
6G56
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BU of 6g56 by Molmil
Apo-structure of the alanine racemase from Staphylococcus aureus
分子名称: Alanine racemase 1, GLYCEROL, SULFATE ION
著者Hoegl, A, Sieber, S.A, Schneider, S.
登録日2018-03-29
公開日2018-05-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Mining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics.
Nat Chem, 10, 2018
6G58
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BU of 6g58 by Molmil
Structure of the alanine racemase from Staphylococcus aureus in complex with a pyridoxal 5' phosphate-derivative
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, (6-but-3-ynyl-4-methyl-5-oxidanyl-pyridin-3-yl)methyl dihydrogen phosphate, ...
著者Hoegl, A, Sieber, S.A, Schneider, S.
登録日2018-03-29
公開日2018-05-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Mining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics.
Nat Chem, 10, 2018
6G59
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BU of 6g59 by Molmil
Structure of the alanine racemase from Staphylococcus aureus in complex with an pyridoxal-6- phosphate derivative
分子名称: (6-ethynyl-4-methanoyl-5-oxidanyl-pyridin-3-yl)methyl dihydrogen phosphate, Alanine racemase 1, CHLORIDE ION, ...
著者Hoegl, A, Sieber, S.A, Schneider, S.
登録日2018-03-29
公開日2018-05-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Mining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics.
Nat Chem, 10, 2018
6H23
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BU of 6h23 by Molmil
Crystal structure of the hClpP Y118A mutant with an activating small molecule
分子名称: 1,2-ETHANEDIOL, ATP-dependent Clp protease proteolytic subunit, mitochondrial, ...
著者Kick, L.M, Sieber, S.A, Schneider, S.
登録日2018-07-13
公開日2018-08-29
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (3.089 Å)
主引用文献Selective Activation of Human Caseinolytic Protease P (ClpP).
Angew. Chem. Int. Ed. Engl., 57, 2018
5LIR
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BU of 5lir by Molmil
Structure of the SALTY Sigma cross-reacting protein 27A (SCRP-27A) from Salmonella typhimurium
分子名称: DI(HYDROXYETHYL)ETHER, Sigma cross-reacting protein 27A (SCRP-27A)
著者Schneider, S, Mandel, M, Sieber, S.A.
登録日2016-07-15
公開日2016-09-14
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Natural-Product-Inspired Aminoepoxybenzoquinones Kill Members of the Gram-Negative Pathogen Salmonella by Attenuating Cellular Stress Response.
Angew.Chem.Int.Ed.Engl., 55, 2016
8CIL
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BU of 8cil by Molmil
Crystal structure of Coxiella burnetii Fic protein 2
分子名称: Fic family protein
著者Hoepfner, D, Itzen, A, Pogenberg, V.
登録日2023-02-10
公開日2023-11-15
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献The DNA-binding induced (de)AMPylation activity of a Coxiella burnetii Fic enzyme targets Histone H3.
Commun Biol, 6, 2023
5VZ2
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BU of 5vz2 by Molmil
Structure of ClpP from Staphylococcus aureus in complex with Acyldepsipeptide
分子名称: ATP-dependent Clp protease proteolytic subunit, Acyldepsipeptide
著者Griffith, E.C, Lee, R.E.
登録日2017-05-26
公開日2017-06-21
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Ureadepsipeptides as ClpP Activators.
Acs Infect Dis., 2019
5W18
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BU of 5w18 by Molmil
Staphylococcus aureus ClpP in complex with (S)-N-((2R,6S,8aS,14aS,20S,23aS)-2,6-dimethyl-5,8,14,19,23-pentaoxooctadecahydro-1H,5H,14H,19H-pyrido[2,1-i]dipyrrolo[2,1-c:2',1'-l][1]oxa[4,7,10,13]tetraazacyclohexadecin-20-yl)-3-phenyl-2-(3-phenylureido)propanamide
分子名称: 9V7-PHE-SER-PRO-YCP-ALA-MP8, ATP-dependent Clp protease proteolytic subunit
著者Lee, R.E, Griffith, E.C.
登録日2017-06-02
公開日2017-08-09
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献Ureadepsipeptides as ClpP Activators.
Acs Infect Dis., 2019
4JCQ
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BU of 4jcq by Molmil
ClpP1 from Listeria monocytogenes
分子名称: ATP-dependent Clp protease proteolytic subunit
著者Zeiler, E, List, A, Alte, F, Gersch, M, Wachtel, R, Groll, M, Sieber, S.
登録日2013-02-22
公開日2013-06-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad.
Proc.Natl.Acad.Sci.USA, 110, 2013
4JCT
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BU of 4jct by Molmil
ClpP2 from Listeria monocytogenes
分子名称: ATP-dependent Clp protease proteolytic subunit
著者Zeiler, E, List, A, Alte, F, Gersch, M, Wachtel, R, Groll, M, Sieber, S.
登録日2013-02-22
公開日2013-06-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad.
Proc.Natl.Acad.Sci.USA, 110, 2013
4JCR
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BU of 4jcr by Molmil
ClpP1 N165D mutant from Listeria monocytogenes
分子名称: ATP-dependent Clp protease proteolytic subunit
著者Zeiler, E, List, A, Alte, F, Gersch, M, Wachtel, R, Groll, M, Sieber, S.
登録日2013-02-22
公開日2013-06-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad.
Proc.Natl.Acad.Sci.USA, 110, 2013
3V5E
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BU of 3v5e by Molmil
Crystal structure of ClpP from Staphylococcus aureus in the active, extended conformation
分子名称: ATP-dependent Clp protease proteolytic subunit
著者Gersch, M, List, A, Groll, M, Sieber, S.
登録日2011-12-16
公開日2012-02-08
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Insights into structural network responsible for oligomerization and activity of bacterial virulence regulator caseinolytic protease P (ClpP) protein.
J.Biol.Chem., 287, 2012
3V5I
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BU of 3v5i by Molmil
The crystal structure of the mutant ClpP S98A (Staphylococcus aureus)
分子名称: ATP-dependent Clp protease proteolytic subunit
著者List, A, Gersch, M, Groll, M, Sieber, S.
登録日2011-12-16
公開日2012-02-08
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Insights into structural network responsible for oligomerization and activity of bacterial virulence regulator caseinolytic protease P (ClpP) protein.
J.Biol.Chem., 287, 2012
6S8Z
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BU of 6s8z by Molmil
Elongation Factor P from Corynebacterium glutamicum
分子名称: 1,2-ETHANEDIOL, ACETATE ION, Elongation factor P, ...
著者Schneider, S, Scheidler, C.M.
登録日2019-07-11
公開日2020-02-26
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure and Function of an Elongation Factor P Subfamily in Actinobacteria.
Cell Rep, 30, 2020
6SFW
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BU of 6sfw by Molmil
Cryo-EM Structure of the ClpX component of the ClpXP1/2 degradation machinery.
分子名称: ATP-dependent Clp protease ATP-binding subunit ClpX
著者Gatsogiannis, C, Merino, F, Raunser, S.
登録日2019-08-02
公開日2019-10-16
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (6 Å)
主引用文献Cryo-EM structure of the ClpXP protein degradation machinery.
Nat.Struct.Mol.Biol., 26, 2019
6SFX
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BU of 6sfx by Molmil
Cryo-EM structure of ClpP1/2 in the LmClpXP1/2 complex
分子名称: ATP-dependent Clp protease proteolytic subunit
著者Gatsogiannis, C, Merino, F, Raunser, S.
登録日2019-08-02
公開日2019-10-16
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Cryo-EM structure of the ClpXP protein degradation machinery.
Nat.Struct.Mol.Biol., 26, 2019
5DL1
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BU of 5dl1 by Molmil
ClpP from Staphylococcus aureus in complex with AV145
分子名称: 1-(propan-2-yl)-N-{[2-(thiophen-2-yl)-1,3-oxazol-4-yl]methyl}-1H-pyrazolo[3,4-b]pyridine-5-carboxamide, ATP-dependent Clp protease proteolytic subunit
著者Vielberg, M.-T, Groll, M.
登録日2015-09-04
公開日2015-11-25
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association.
Angew.Chem.Int.Ed.Engl., 54, 2015
6CFD
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BU of 6cfd by Molmil
ADEP4 bound to E. faecium ClpP
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ATP-dependent Clp protease proteolytic subunit, N-[(6aS,12S,15aS,17R,21R,23aS)-17,21-dimethyl-6,11,15,20,23-pentaoxooctadecahydro-2H,6H,11H,15H-pyrido[2,1-i]dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13]oxatetraazacyclohexadecin-12-yl]-3,5-difluoro-Nalpha-[(2E)-hept-2-enoyl]-L-phenylalaninamide
著者Lee, R.E, Griffith, E.C.
登録日2018-02-14
公開日2018-05-16
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献In VivoandIn VitroEffects of a ClpP-Activating Antibiotic against Vancomycin-Resistant Enterococci.
Antimicrob. Agents Chemother., 62, 2018
5LP2
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BU of 5lp2 by Molmil
Adhesin domain of the type 1 HopQ of Helicobacter pylori strain G27
分子名称: HopQ
著者Moonens, K, Kruse, T, Gerhard, M, Remaut, H.
登録日2016-08-11
公開日2016-10-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs.
Nat Microbiol, 2, 2016
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