6UE4
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5UIU
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![BU of 5uiu by Molmil](/molmil-images/mine/5uiu) | Crystal structure of IRAK4 in complex with compound 30 | 分子名称: | 1-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide, Interleukin-1 receptor-associated kinase 4 | 著者 | Han, S, Chang, J.S. | 登録日 | 2017-01-14 | 公開日 | 2017-05-24 | 最終更新日 | 2017-07-26 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. J. Med. Chem., 60, 2017
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2IJN
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6PLM
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![BU of 6plm by Molmil](/molmil-images/mine/6plm) | Legionella pneumophila SidJ/ Calmodulin 2 complex | 分子名称: | ADENOSINE MONOPHOSPHATE, CALCIUM ION, Calmodulin-2, ... | 著者 | Mao, Y, Sulpizio, A, Minelli, M.E, Wu, X. | 登録日 | 2019-07-01 | 公開日 | 2019-11-20 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.592 Å) | 主引用文献 | Protein polyglutamylation catalyzed by the bacterial calmodulin-dependent pseudokinase SidJ. Elife, 8, 2019
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6IWD
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![BU of 6iwd by Molmil](/molmil-images/mine/6iwd) | The PTP domain of human PTPN14 in a complex with the CR3 domain of HPV18 E7 | 分子名称: | CHLORIDE ION, HPV18 E7, PHOSPHATE ION, ... | 著者 | Yun, H.-Y, Kim, S.J, Ku, B. | 登録日 | 2018-12-05 | 公開日 | 2019-07-31 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis for recognition of the tumor suppressor protein PTPN14 by the oncoprotein E7 of human papillomavirus. Plos Biol., 17, 2019
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3G51
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6LSQ
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2PJG
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![BU of 2pjg by Molmil](/molmil-images/mine/2pjg) | Solution structure of rhodostomin D51E mutant | 分子名称: | Rhodostoxin-disintegrin rhodostomin | 著者 | Chuang, W.J, Chen, Y.C, Chen, C.Y, Chou, L.J. | 登録日 | 2007-04-16 | 公開日 | 2007-05-08 | 最終更新日 | 2021-11-10 | 実験手法 | SOLUTION NMR | 主引用文献 | Effect of D to E mutation of the RGD motif in rhodostomin on its activity, structure, and dynamics: Importance of the interactions between the D residue and integrin Proteins, 2009
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2PJF
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![BU of 2pjf by Molmil](/molmil-images/mine/2pjf) | Solution structure of rhodostomin | 分子名称: | Rhodostoxin-disintegrin rhodostomin | 著者 | Chuang, W.J, Chen, Y.C, Chen, C.Y, Chang, Y.T. | 登録日 | 2007-04-16 | 公開日 | 2007-05-08 | 最終更新日 | 2022-03-16 | 実験手法 | SOLUTION NMR | 主引用文献 | Effect of D to E mutation of the RGD motif in rhodostomin on its activity, structure, and dynamics: Importance of the interactions between the D residue and integrin Proteins, 2009
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1MW5
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![BU of 1mw5 by Molmil](/molmil-images/mine/1mw5) | Structure of HI1480 from Haemophilus influenzae | 分子名称: | HYPOTHETICAL PROTEIN HI1480 | 著者 | Lim, K, Sarikaya, E, Howard, A, Galkin, A, Herzberg, O, Structure 2 Function Project (S2F) | 登録日 | 2002-09-27 | 公開日 | 2003-11-18 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Novel structure and nucleotide binding properties of HI1480 from Haemophilus influenzae: a protein with no known sequence homologues PROTEINS: STRUCT.,FUNCT.,GENET., 56, 2004
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3OOB
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![BU of 3oob by Molmil](/molmil-images/mine/3oob) | Structural and functional insights of directly targeting Pin1 by Epigallocatechin-3-gallate | 分子名称: | (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ... | 著者 | Urusova, D.V, Shim, J.-H, Kim, D.-J, Jung, S.K, Zykova, T.A, Bode, A.M, Dong, Z. | 登録日 | 2010-08-30 | 公開日 | 2011-08-17 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Epigallocatechin-gallate suppresses tumorigenesis by directly targeting Pin1. Cancer Prev Res (Phila), 4, 2011
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5UIS
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![BU of 5uis by Molmil](/molmil-images/mine/5uis) | Crystal structure of IRAK4 in complex with compound 12 | 分子名称: | 4-{[(3R)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide, Interleukin-1 receptor-associated kinase 4 | 著者 | Han, S, Chang, J.S. | 登録日 | 2017-01-14 | 公開日 | 2017-05-24 | 最終更新日 | 2017-07-26 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. J. Med. Chem., 60, 2017
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5UIQ
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![BU of 5uiq by Molmil](/molmil-images/mine/5uiq) | Crystal structure of IRAK4 in complex with compound 9 | 分子名称: | 2-[(propan-2-yl)oxy]benzamide, Interleukin-1 receptor-associated kinase 4 | 著者 | Han, S, Chang, J.S. | 登録日 | 2017-01-14 | 公開日 | 2017-05-24 | 最終更新日 | 2017-07-26 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. J. Med. Chem., 60, 2017
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5UIR
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![BU of 5uir by Molmil](/molmil-images/mine/5uir) | Crystal structure of IRAK4 in complex with compound 11 | 分子名称: | 5-(4-cyanophenyl)-3-[(propan-2-yl)oxy]naphthalene-2-carboxamide, Interleukin-1 receptor-associated kinase 4 | 著者 | Han, S, Chang, J.S. | 登録日 | 2017-01-14 | 公開日 | 2017-05-24 | 最終更新日 | 2017-07-26 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. J. Med. Chem., 60, 2017
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5UIT
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![BU of 5uit by Molmil](/molmil-images/mine/5uit) | Crystal structure of IRAK4 in complex with compound 14 | 分子名称: | 1-{[(2S)-5-oxopyrrolidin-2-yl]methoxy}-7-[(propan-2-yl)oxy]isoquinoline-6-carboxamide, Interleukin-1 receptor-associated kinase 4 | 著者 | Han, S, Chang, J.S. | 登録日 | 2017-01-14 | 公開日 | 2017-05-24 | 最終更新日 | 2017-07-26 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. J. Med. Chem., 60, 2017
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7X4S
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7X4V
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7X4Z
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1C3E
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![BU of 1c3e by Molmil](/molmil-images/mine/1c3e) | NEW INSIGHTS INTO INHIBITOR DESIGN FROM THE CRYSTAL STRUCTURE AND NMR STUDIES OF E. COLI GAR TRANSFORMYLATE IN COMPLEX WITH BETA-GAR AND 10-FORMYL-5,8,10-TRIDEAZAFOLIC ACID. | 分子名称: | 2-{4-[2-(2-AMINO-4-HYDROXY-QUINAZOLIN-6-YL)-1-CARBOXY-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, GLYCINAMIDE RIBONUCLEOTIDE, GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE | 著者 | Greasley, S.E, Yamashita, M.M, Cai, H, Benkovic, S.J, Boger, D.L, Wilson, I.A. | 登録日 | 1999-07-27 | 公開日 | 1999-12-29 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | New insights into inhibitor design from the crystal structure and NMR studies of Escherichia coli GAR transformylase in complex with beta-GAR and 10-formyl-5,8,10-trideazafolic acid. Biochemistry, 38, 1999
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1C2T
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![BU of 1c2t by Molmil](/molmil-images/mine/1c2t) | NEW INSIGHTS INTO INHIBITOR DESIGN FROM THE CRYSTAL STRUCTURE AND NMR STUDIES OF E. COLI GAR TRANSFORMYLASE IN COMPLEX WITH BETA-GAR AND 10-FORMYL-5,8,10-TRIDEAZAFOLIC ACID. | 分子名称: | 10-FORMYL-5,8,10-TRIDEAZAFOLIC ACID, GLYCINAMIDE RIBONUCLEOTIDE, GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE | 著者 | Greasley, S.E, Yamashita, M.M, Cai, H, Benkovic, S.J, Boger, D.L, Wilson, I.A. | 登録日 | 1999-07-26 | 公開日 | 2000-01-05 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | New insights into inhibitor design from the crystal structure and NMR studies of Escherichia coli GAR transformylase in complex with beta-GAR and 10-formyl-5,8,10-trideazafolic acid. Biochemistry, 38, 1999
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2KIU
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5W0T
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