2O2W
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2O31
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2O9S
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2O9V
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9FJL
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7O1N
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6HU9
| III2-IV2 mitochondrial respiratory supercomplex from S. cerevisiae | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 5-(3,7,11,15,19,23-HEXAMETHYL-TETRACOSA-2,6,10,14,18,22-HEXAENYL)-2,3-DIMETHOXY-6-METHYL-BENZENE-1,4-DIOL, CALCIUM ION, ... | 著者 | Hartley, A.M, Pinotsis, N, Marechal, A. | 登録日 | 2018-10-05 | 公開日 | 2018-12-26 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | Structure of yeast cytochrome c oxidase in a supercomplex with cytochrome bc1. Nat. Struct. Mol. Biol., 26, 2019
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8CRF
| Crystal structure of N-terminal SARS-CoV-2 nsp1 in complex with fragment hit 5E11 refined against anomalous diffraction data | 分子名称: | Host translation inhibitor nsp1, ~{N}-methyl-1-(4-thiophen-2-ylphenyl)methanamine | 著者 | Ma, S, Mykhaylyk, V, Pinotsis, N, Bowler, M.W, Kozielski, F. | 登録日 | 2023-03-08 | 公開日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | High-Confidence Placement of Fragments into Electron Density Using Anomalous Diffraction-A Case Study Using Hits Targeting SARS-CoV-2 Non-Structural Protein 1. Int J Mol Sci, 24, 2023
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8CRM
| Crystal structure of N-terminal SARS-CoV-2 nsp1 in complex with fragment hit 11C6 refined against anomalous diffraction data | 分子名称: | 1-[2-(3-chlorophenyl)-1,3-thiazol-4-yl]-~{N}-methyl-methanamine, Host translation inhibitor nsp1 | 著者 | Ma, S, Mikhailik, V, Pinotsis, N, Bowler, M.W, Kozielski, F. | 登録日 | 2023-03-08 | 公開日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | High-Confidence Placement of Fragments into Electron Density Using Anomalous Diffraction-A Case Study Using Hits Targeting SARS-CoV-2 Non-Structural Protein 1. Int J Mol Sci, 24, 2023
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8CRK
| Crystal structure of N-terminal SARS-CoV-2 nsp1 in complex with fragment hit 7H2 refined against anomalous diffraction data | 分子名称: | (1~{R})-1-(4-chlorophenyl)ethanamine, Host translation inhibitor nsp1 | 著者 | Ma, S, Mikhailik, V, Pinotsis, N, Bowler, M.W, Kozielski, F. | 登録日 | 2023-03-08 | 公開日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | High-Confidence Placement of Fragments into Electron Density Using Anomalous Diffraction-A Case Study Using Hits Targeting SARS-CoV-2 Non-Structural Protein 1. Int J Mol Sci, 24, 2023
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2FGO
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7Z10
| Monomeric respiratory complex IV isolated from S. cerevisiae | 分子名称: | COPPER (II) ION, CYTOCHROME C OXIDASE SUBUNIT 3; SYNONYM: CYTOCHROME C OXIDASE POLYPEPTIDE III, COX3, ... | 著者 | Marechal, A, Hartley, A, Ing, G, Pinotsis, N. | 登録日 | 2022-02-24 | 公開日 | 2022-08-03 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | 主引用文献 | Cryo-EM structure of a monomeric yeast S. cerevisiae complex IV isolated with maltosides: Implications in supercomplex formation. Biochim Biophys Acta Bioenerg, 1863, 2022
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8D3B
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7PG5
| Crystal Structure of PI3Kalpha | 分子名称: | GLYCEROL, PHOSPHATE ION, Phosphatidylinositol 3-kinase regulatory subunit alpha, ... | 著者 | Gong, G, Pinotsis, N, Williams, R.L, Vanhaesebroeck, B. | 登録日 | 2021-08-13 | 公開日 | 2022-08-24 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.20029068 Å) | 主引用文献 | A small-molecule PI3K alpha activator for cardioprotection and neuroregeneration. Nature, 618, 2023
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7PG6
| Crystal Structure of PI3Kalpha in complex with the inhibitor NVP-BYL719 | 分子名称: | (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, ... | 著者 | Gong, G, Pinotsis, N, Williams, R.L, Vanhaesebroeck, B. | 登録日 | 2021-08-13 | 公開日 | 2022-08-24 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.49943733 Å) | 主引用文献 | A small-molecule PI3K alpha activator for cardioprotection and neuroregeneration. Nature, 618, 2023
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7QDF
| Hexameric HIV-1 (M-group) CA R120 mutant | 分子名称: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Gag polyprotein, ... | 著者 | Govasli, M.A.L, Pinotsis, N, McAlpine-Scott, S. | 登録日 | 2021-11-26 | 公開日 | 2022-10-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.304 Å) | 主引用文献 | Evasion of cGAS and TRIM5 defines pandemic HIV. Nat Microbiol, 7, 2022
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6T0B
| The III2-IV(5B)2 respiratory supercomplex from S. cerevisiae | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, CALCIUM ION, CARDIOLIPIN, ... | 著者 | Marechal, A, Pinotsis, N, Hartley, A. | 登録日 | 2019-10-02 | 公開日 | 2020-04-22 | 最終更新日 | 2020-05-06 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Rcf2 revealed in cryo-EM structures of hypoxic isoforms of mature mitochondrial III-IV supercomplexes. Proc.Natl.Acad.Sci.USA, 117, 2020
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6T15
| The III2-IV(5B)1 respiratory supercomplex from S. cerevisiae | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, CARDIOLIPIN, COPPER (II) ION, ... | 著者 | Marechal, A, Pinotsis, N, Hartley, A. | 登録日 | 2019-10-03 | 公開日 | 2020-04-22 | 最終更新日 | 2020-05-06 | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | 主引用文献 | Rcf2 revealed in cryo-EM structures of hypoxic isoforms of mature mitochondrial III-IV supercomplexes. Proc.Natl.Acad.Sci.USA, 117, 2020
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8A55
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8AYS
| SARS-CoV-2 non-structural protein-1 (nsp1) in complex with 4-(2-aminothiazol-4-yl)phenol | 分子名称: | 4-(2-amino-1,3-thiazol-4-yl)phenol, Host translation inhibitor nsp1 | 著者 | Ma, S, Damfo, S, Pinotsis, N, Bowler, M.W, Kozielski, F. | 登録日 | 2022-09-03 | 公開日 | 2022-11-23 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | 主引用文献 | Two Ligand-Binding Sites on SARS-CoV-2 Non-Structural Protein 1 Revealed by Fragment-Based X-ray Screening. Int J Mol Sci, 23, 2022
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8AZ8
| SARS-CoV-2 non-structural protein-1 (nsp1) in complex with 2-(benzylamino)ethan-1-ol | 分子名称: | 2-[(phenylmethyl)amino]ethanol, Host translation inhibitor nsp1 | 著者 | Ma, S, Damfo, S, Pinotsis, N, Bowler, M.W, Kozielski, F. | 登録日 | 2022-09-05 | 公開日 | 2022-11-23 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | 主引用文献 | Two Ligand-Binding Sites on SARS-CoV-2 Non-Structural Protein 1 Revealed by Fragment-Based X-ray Screening. Int J Mol Sci, 23, 2022
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8OW2
| Crystal structure of the p110alpha catalytic subunit from homo sapiens in complex with activator 1938 | 分子名称: | 1-[7-[[2-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyridin-4-yl]amino]-2,3-dihydroindol-1-yl]ethanone, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Gong, G.Q, Bellini, D, Vanhaesebroeck, B, Williams, R.L. | 登録日 | 2023-04-26 | 公開日 | 2023-05-24 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | A small-molecule PI3K alpha activator for cardioprotection and neuroregeneration. Nature, 618, 2023
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7T15
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7T14
| Hexameric SIVmac CA | 分子名称: | Capsid protein p24 | 著者 | Jacques, D.A, James, L.C. | 登録日 | 2021-12-01 | 公開日 | 2022-10-19 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Evasion of cGAS and TRIM5 defines pandemic HIV. Nat Microbiol, 7, 2022
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7T13
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