6MK6
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5UWV
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![BU of 5uwv by Molmil](/molmil-images/mine/5uwv) | Crystal structure of Mycobacterium abscessus L,D-transpeptidase 2 | 分子名称: | L,D-TRANSPEPTIDASE 2 | 著者 | Kumar, P, Ginell, S.L, Lamichhane, G. | 登録日 | 2017-02-21 | 公開日 | 2017-08-16 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | Mycobacterium abscessus l,d-Transpeptidases Are Susceptible to Inactivation by Carbapenems and Cephalosporins but Not Penicillins. Antimicrob. Agents Chemother., 61, 2017
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3VAE
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![BU of 3vae by Molmil](/molmil-images/mine/3vae) | Crystal Structure of M. tuberculosis LD-transpeptidase type 2 with Modified Catalytic Cysteine (C354) | 分子名称: | DI(HYDROXYETHYL)ETHER, LD-transpeptidase type 2 | 著者 | Erdemli, S, Bianchet, M.A, Gupta, R, Lamichhane, G, Amzel, L.M. | 登録日 | 2011-12-29 | 公開日 | 2012-12-12 | 最終更新日 | 2018-04-04 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Targeting the Cell Wall of Mycobacterium tuberculosis: Structure and Mechanism of L,D-Transpeptidase 2. Structure, 20, 2012
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5D7H
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![BU of 5d7h by Molmil](/molmil-images/mine/5d7h) | X-RAY CRYSTAL STRUCTURE OF L,D TRANSPEPTIDASE 2 FROM MYCOBACTERIUM TUBERCULOSIS | 分子名称: | GLYCEROL, L,D-transpeptidase 2, SULFATE ION | 著者 | Saavedra, H, Basta, L.A, Lamichhane, G, Bianchet, M.A. | 登録日 | 2015-08-13 | 公開日 | 2016-09-28 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem. BMC Biochem., 18, 2017
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8B2Y
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![BU of 8b2y by Molmil](/molmil-images/mine/8b2y) | Structure of the weakly red fluorescent protein csiFP4 from Clytia simplex | 分子名称: | CHLORIDE ION, CsiFP4 chain A, SULFATE ION | 著者 | Depernet, H, Engilberge, S, Lambert, G, Gotthard, G, Shaner, N, Royant, A. | 登録日 | 2022-09-15 | 公開日 | 2023-09-27 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | Structure of the weakly red fluorescent protein csiFP4 from Clytia simplex To Be Published
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3TUR
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![BU of 3tur by Molmil](/molmil-images/mine/3tur) | Crystal Structure of M. tuberculosis LD-transpeptidase type 2 complexed with a peptidoglycan fragment | 分子名称: | 6-CARBOXYLYSINE, D-GLUTAMIC ACID, Di-mu-iodobis(ethylenediamine)diplatinum(II), ... | 著者 | Bianchet, M.A, Erdemli, S.B, Gupta, R, Lamichhane, G, Amzel, L.M. | 登録日 | 2011-09-17 | 公開日 | 2012-12-05 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Targeting the Cell Wall of Mycobacterium tuberculosis: Structure and Mechanism of L,D-Transpeptidase 2. Structure, 20, 2012
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3U1Q
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![BU of 3u1q by Molmil](/molmil-images/mine/3u1q) | Crystal Structure of M. tuberculosis LD-transpeptidase type 2 with 2-Mercaptoethanol | 分子名称: | BETA-MERCAPTOETHANOL, DI(HYDROXYETHYL)ETHER, Mycobacteria Tuberculosis LD-transpeptidase type 2 | 著者 | Erdemli, S, Bianchet, M.A, Gupta, R, Lamichhane, G, Amzel, L.M. | 登録日 | 2011-09-30 | 公開日 | 2012-12-05 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | The Structure of Mycobacterium tuberculosis L,D-transpeptidase 2 provides insights into targeting the cell wall of persisters to be published
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3U1P
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![BU of 3u1p by Molmil](/molmil-images/mine/3u1p) | Crystal Structure of M. tuberculosis LD-transpeptidase type 2 with Modified Catalytic Cysteine (C354) | 分子名称: | DI(HYDROXYETHYL)ETHER, Mycobacteria Tuberculosis LD-transpeptidase type 2 | 著者 | Erdemli, S, Bianchet, M.A, Gupta, R, Lamichhane, G, Amzel, L.M. | 登録日 | 2011-09-30 | 公開日 | 2012-12-05 | 最終更新日 | 2018-04-04 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Targeting the Cell Wall of Mycobacterium tuberculosis: Structure and Mechanism of L,D-Transpeptidase 2. Structure, 20, 2012
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5DVP
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![BU of 5dvp by Molmil](/molmil-images/mine/5dvp) | Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 2 with Doripenem adduct | 分子名称: | (2S,3R,4S)-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-4-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-3,4-dihydro-2H-pyrrole-5-carboxylic acid, L,D-transpeptidase 2, PHOSPHONOACETALDEHYDE, ... | 著者 | Kumar, P, Lamichhane, G. | 登録日 | 2015-09-21 | 公開日 | 2016-09-28 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Non-classical transpeptidases yield insight into new antibacterials. Nat. Chem. Biol., 13, 2017
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5E1G
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![BU of 5e1g by Molmil](/molmil-images/mine/5e1g) | Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 2 with carbapenem drug T208 | 分子名称: | (2~{S},3~{R},4~{R})-4-(2-cyclohexyloxy-2-oxidanylidene-ethyl)sulfanyl-3-methyl-2-[(2~{S},3~{R})-3-oxidanyl-1-oxidanylidene-butan-2-yl]-3,4-dihydro-2~{H}-pyrrole-5-carboxylic acid, L,D-transpeptidase 2 | 著者 | Kumar, P, Lamichhane, G, Ginell, S.L. | 登録日 | 2015-09-29 | 公開日 | 2016-10-12 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.852 Å) | 主引用文献 | Non-classical transpeptidases yield insight into new antibacterials. Nat. Chem. Biol., 13, 2017
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5DZP
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![BU of 5dzp by Molmil](/molmil-images/mine/5dzp) | Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 2 with carbapenem drug T206 in conformation B | 分子名称: | (2~{R},3~{R},4~{R})-4-methyl-3-(2-oxidanylidene-2-propoxy-ethyl)sulfanyl-5-[(2~{S},3~{R})-3-oxidanyl-1-oxidanylidene-butan-2-yl]-3,4-dihydro-2~{H}-pyrrole-2-carboxylic acid, L,D-transpeptidase 2 | 著者 | Kumar, P, Ginell, S.L, Lamichhane, G. | 登録日 | 2015-09-25 | 公開日 | 2016-10-05 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Non-classical transpeptidases yield insight into new antibacterials. Nat. Chem. Biol., 13, 2017
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5E5L
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5E51
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![BU of 5e51 by Molmil](/molmil-images/mine/5e51) | Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 1 with Faropenem adduct | 分子名称: | (3R)-3-hydroxybutanal, L,D-transpeptidase 1 | 著者 | Kumar, P, Lamichhane, G, Ginell, S.L. | 登録日 | 2015-10-07 | 公開日 | 2016-10-26 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Non-classical transpeptidases yield insight into new antibacterials. Nat. Chem. Biol., 13, 2017
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7F8P
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![BU of 7f8p by Molmil](/molmil-images/mine/7f8p) | Crystal structure of the Mycobacterium tuberculosis L,D-transpeptidase-2 (LdtMt2) with new carbapenem drug T203 | 分子名称: | (2R,3R)-3-methyl-4-(2-oxidanylidene-2-propan-2-yloxy-ethyl)sulfanyl-2-[(2R)-3-oxidanyl-1-oxidanylidene-butan-2-yl]-2,3-dihydro-1H-pyrrole-5-carboxylic acid, (4R,5S,6S)-6-((R)-1-hydroxyethyl)-3-((2-isopropoxy-2-oxoethyl)thio)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, GLUTAMIC ACID, ... | 著者 | Kumar, P, Lamichhane, G. | 登録日 | 2021-07-02 | 公開日 | 2022-05-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Allosteric cooperation in beta-lactam binding to a non-classical transpeptidase. Elife, 11, 2022
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7F71
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![BU of 7f71 by Molmil](/molmil-images/mine/7f71) | Crystal structure of the Mycobacterium tuberculosis L,D-transpeptidase-2 (LdtMt2) with peptidoglycan sugar moiety and glutamate | 分子名称: | GLUTAMIC ACID, GLYCEROL, L,D-transpeptidase 2, ... | 著者 | Kumar, P, Lamichhane, G. | 登録日 | 2021-06-26 | 公開日 | 2022-05-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Allosteric cooperation in beta-lactam binding to a non-classical transpeptidase. Elife, 11, 2022
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6DGM
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![BU of 6dgm by Molmil](/molmil-images/mine/6dgm) | Streptococcus pyogenes phosphoglycerol transferase GacH in complex with sn-glycerol-1-phosphate | 分子名称: | CALCIUM ION, MANGANESE (II) ION, Phosphoglycerol transferase GacH, ... | 著者 | Edgar, R.J, Korotkova, N, Korotkov, K.V. | 登録日 | 2018-05-17 | 公開日 | 2018-06-06 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides. Nat.Chem.Biol., 15, 2019
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6DQ3
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![BU of 6dq3 by Molmil](/molmil-images/mine/6dq3) | Streptococcus pyogenes deacetylase PplD in complex with acetate | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, IMIDAZOLE, ... | 著者 | Li, J, Korotkova, N, Korotkov, K.V. | 登録日 | 2018-06-10 | 公開日 | 2019-05-01 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides Nat Commun, 13, 2022
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6WQL
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6WQJ
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![BU of 6wqj by Molmil](/molmil-images/mine/6wqj) | |
7O70
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![BU of 7o70 by Molmil](/molmil-images/mine/7o70) | KRasG12C ligand complex | 分子名称: | 1-[(4R,7S)-12-chloro-14-fluoro-13-(2-fluoro-6-hydroxyphenyl)-4-methyl-10-oxa-2,5,16,18-tetrazatetracyclo[9.7.1.0^(2,7).0^(15,19)]nonadeca-1(18),11,13,15(19),16-pentaen-5-en-1-one-yl]prop-2, CALCIUM ION, GTPase KRas, ... | 著者 | Phillips, C. | 登録日 | 2021-04-12 | 公開日 | 2022-04-20 | 最終更新日 | 2022-05-25 | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | 主引用文献 | Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS G12C . J.Med.Chem., 65, 2022
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7O83
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![BU of 7o83 by Molmil](/molmil-images/mine/7o83) | KRasG12C ligand complex | 分子名称: | 1-[(7S)-11-chloro-12-(5-methyl-1H-indazol-4-yl)-9-oxa-2,5,15,17-tetrazatetracyclo[8.7.1.02,7.014,18]octadeca-1(17),10,12,14(18),15-pentaen-5-yl]prop-2-en-1-one, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Phillips, C, Breed, J. | 登録日 | 2021-04-14 | 公開日 | 2022-04-20 | 最終更新日 | 2022-05-25 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS G12C . J.Med.Chem., 65, 2022
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7OO7
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![BU of 7oo7 by Molmil](/molmil-images/mine/7oo7) | KRasG12C ligand complex | 分子名称: | 1-[(6aS)-3-chloro-2-(5-methyl-1H-indazol-4-yl)-5,6,6a,7,9,10-hexahydro-8H-pyrazino[1',2':5,6][1,5]oxazocino[4,3,2-de]quinazolin-8-yl]-2-propen-1-one, CALCIUM ION, GTPase KRas, ... | 著者 | Phillips, C. | 登録日 | 2021-05-26 | 公開日 | 2022-04-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS G12C . J.Med.Chem., 65, 2022
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5AK2
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![BU of 5ak2 by Molmil](/molmil-images/mine/5ak2) | Oxyphenylpropenoic acids as Oral Selective Estrogen Receptor Down- Regulators. | 分子名称: | (E)-3-[4-[[3-(4-fluoranyl-2-methyl-phenyl)-7-oxidanyl-2-oxidanylidene-chromen-4-yl]methyl]phenyl]prop-2-enoic acid, ESTROGEN RECEPTOR | 著者 | Degorce, S, Bailey, A, Callis, R, De Savi, C, Ducray, R, Lamot, P, MacFaul, P, Maudet, M, Norman, R.A, Scott, J.S, Phillips, C. | 登録日 | 2015-02-27 | 公開日 | 2015-04-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Investigation of (E)-3-[4-(2-Oxo-3-Aryl-Chromen-4-Yl)Oxyphenyl]Acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators. J.Med.Chem., 58, 2015
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6BOI
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![BU of 6boi by Molmil](/molmil-images/mine/6boi) | Crystal Structure of LdtMt2 (56-408) with a panipenem adduct at the active site cysteine-354 | 分子名称: | (3S,5R)-5-[(2R,3R)-1,3-dihydroxybutan-2-yl]-3-({(3R)-1-[(1E)-ethanimidoyl]pyrrolidin-3-yl}sulfanyl)-L-proline, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Saavedra, H, Bianchet, M.A. | 登録日 | 2017-11-20 | 公開日 | 2018-04-11 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.102 Å) | 主引用文献 | Structures and Mechanism of Inhibition of Mycobacterium tuberculosis L,D-transpeptidase 2 by Panipenem To Be Published
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5U9Z
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![BU of 5u9z by Molmil](/molmil-images/mine/5u9z) | |