5AK2

Oxyphenylpropenoic acids as Oral Selective Estrogen Receptor Down- Regulators.

Summary for 5AK2

Entry DOI	10.2210/pdb5ak2/pdb
Descriptor	ESTROGEN RECEPTOR, (E)-3-[4-[[3-(4-fluoranyl-2-methyl-phenyl)-7-oxidanyl-2-oxidanylidene-chromen-4-yl]methyl]phenyl]prop-2-enoic acid (3 entities in total)
Functional Keywords	signaling protein
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
Total number of polymer chains	2
Total formula weight	62024.02
Authors	Degorce, S.,Bailey, A.,Callis, R.,De Savi, C.,Ducray, R.,Lamot, P.,MacFaul, P.,Maudet, M.,Norman, R.A.,Scott, J.S.,Phillips, C. (deposition date: 2015-02-27, release date: 2015-04-22, Last modification date: 2018-04-25)
Primary citation	Degorce, S.L.,Bailey, A.,Callis, R.,De Savi, C.,Ducray, R.,Lamont, G.,Macfaul, P.,Maudet, M.,Martin, S.,Morgentin, R.,Norman, R.A.,Peru, A.,Pink, J.H.,Ple, P.A.,Roberts, B.,Scott, J.S. Investigation of (E)-3-[4-(2-Oxo-3-Aryl-Chromen-4-Yl)Oxyphenyl]Acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators. J.Med.Chem., 58:3522-, 2015 Cited by PubMed: 25790336 DOI: 10.1021/ACS.JMEDCHEM.5B00066 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.19 Å)

Structure validation