5AK2
Oxyphenylpropenoic acids as Oral Selective Estrogen Receptor Down- Regulators.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | ESTROGEN RECEPTOR | polymer | 268 | 30581.6 | 2 | UniProt (P03372) Pfam (PF00104) In PDB | HOMO SAPIENS (HUMAN) | ER, ER-ALPHA, ESTRADIOL RECEPTOR, NUCLEAR RECEPTOR SUBFAMILY 3 GROUP A MEMBER 1, ESTROGEN RECEPTOR ALPHA |
2 | A, B | (E)-3-[4-[[3-(4-fluoranyl-2-methyl-phenyl)-7-oxidanyl-2-oxidanylidene-chromen-4-yl]methyl]phenyl]prop-2-enoic acid | non-polymer | 430.4 | 2 | Chemie (85Z) | |||
3 | water | water | 18.0 | 142 | Chemie (HOH) |
Sequence modifications
A, B: 307 - 554 (UniProt: P03372)
PDB | External Database | Details |
---|---|---|
Met 287 | - | expression tag |
His 288 | - | expression tag |
His 289 | - | expression tag |
His 290 | - | expression tag |
His 291 | - | expression tag |
His 292 | - | expression tag |
His 293 | - | expression tag |
Gly 294 | - | expression tag |
Gly 295 | - | expression tag |
Gly 296 | - | expression tag |
Glu 297 | - | expression tag |
Asn 298 | - | expression tag |
Leu 299 | - | expression tag |
Tyr 300 | - | expression tag |
Phe 301 | - | expression tag |
Gln 302 | - | expression tag |
Gly 303 | - | expression tag |
Ser 304 | - | expression tag |
His 305 | - | expression tag |
Met 306 | - | expression tag |
Ser 381 | Cys 381 | engineered mutation |
Ser 417 | Cys 417 | engineered mutation |
Ser 530 | Cys 530 | engineered mutation |
Ser 536 | Leu 536 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 61163.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 860.8 | |
All* | Total formula weight | 62024.0 |