8ZHD
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![BU of 8zhd by Molmil](/molmil-images/mine/8zhd) | SARS-CoV-2 spike trimer (6P) in complex with two R1-26 Fabs | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of R1-26 Fab, ... | 著者 | Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. | 登録日 | 2024-05-10 | 公開日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | 主引用文献 | Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants To Be Published
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8ZHE
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![BU of 8zhe by Molmil](/molmil-images/mine/8zhe) | SARS-CoV-2 spike trimer (6P) in complex with three R1-26 Fabs | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of R1-26 Fab, ... | 著者 | Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. | 登録日 | 2024-05-10 | 公開日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants To Be Published
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8ZHF
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![BU of 8zhf by Molmil](/molmil-images/mine/8zhf) | SARS-CoV-2 spike trimer (6P) in complex with R1-26 Fab, head-to-head aggregate | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of R1-26 Fab, ... | 著者 | Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. | 登録日 | 2024-05-10 | 公開日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (5.26 Å) | 主引用文献 | Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants To Be Published
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8ZHG
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![BU of 8zhg by Molmil](/molmil-images/mine/8zhg) | SARS-CoV-2 spike trimer (6P) in complex with R1-26 Fab, focused refinement of RBD-Fab region | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of R1-26 Fab, Light chain of R1-26 Fab, ... | 著者 | Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. | 登録日 | 2024-05-10 | 公開日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (3.51 Å) | 主引用文献 | Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants To Be Published
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8ZHH
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![BU of 8zhh by Molmil](/molmil-images/mine/8zhh) | SARS-CoV-2 spike trimer (6P) in complex with two H18 Fabs | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of H18 Fab, ... | 著者 | Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. | 登録日 | 2024-05-10 | 公開日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (5.55 Å) | 主引用文献 | Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants To Be Published
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8ZHI
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![BU of 8zhi by Molmil](/molmil-images/mine/8zhi) | SARS-CoV-2 spike trimer (6P) in complex with three H18 Fabs | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of H18 Fab, ... | 著者 | Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. | 登録日 | 2024-05-11 | 公開日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (6.05 Å) | 主引用文献 | Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants To Be Published
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8ZHJ
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![BU of 8zhj by Molmil](/molmil-images/mine/8zhj) | SARS-CoV-2 spike trimer (6P) in complex with three H18 Fabs, head-to-head aggregate (C1 symmetry) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of H18 Fab, ... | 著者 | Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. | 登録日 | 2024-05-11 | 公開日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (8.45 Å) | 主引用文献 | Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants To Be Published
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8ZHK
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![BU of 8zhk by Molmil](/molmil-images/mine/8zhk) | SARS-CoV-2 spike trimer (6P) in complex with three H18 Fabs, head-to-head aggregate (C3 symmetry) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of H18 Fab, ... | 著者 | Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. | 登録日 | 2024-05-11 | 公開日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (6.3 Å) | 主引用文献 | Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants To Be Published
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8ZHL
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![BU of 8zhl by Molmil](/molmil-images/mine/8zhl) | SARS-CoV-2 spike trimer (6P) in complex with two H18 and two R1-32 Fabs | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of H18 Fab, ... | 著者 | Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. | 登録日 | 2024-05-11 | 公開日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (3.96 Å) | 主引用文献 | Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants To Be Published
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8ZHM
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![BU of 8zhm by Molmil](/molmil-images/mine/8zhm) | SARS-CoV-2 spike trimer (6P) in complex with three H18 and three R1-32 Fabs | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of H18 Fab, ... | 著者 | Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. | 登録日 | 2024-05-11 | 公開日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | 主引用文献 | Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants To Be Published
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8ZHN
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![BU of 8zhn by Molmil](/molmil-images/mine/8zhn) | SARS-CoV-2 spike trimer (6P) in complex with three H18 and three R1-32 Fabs (one RBD rotated) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of H18 Fab, ... | 著者 | Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. | 登録日 | 2024-05-11 | 公開日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (4.12 Å) | 主引用文献 | Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants To Be Published
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8KCP
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![BU of 8kcp by Molmil](/molmil-images/mine/8kcp) | Cryo-EM structure of human gamma-secretase in complex with Crenigacestat | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Guo, X, Li, H, Kai, U, Yan, C, Lei, J, Zhou, R, Shi, Y. | 登録日 | 2023-08-08 | 公開日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs To Be Published
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8KCU
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![BU of 8kcu by Molmil](/molmil-images/mine/8kcu) | Cryo-EM structure of human gamma-secretase in complex with MK-0752 | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Guo, X, Li, H, Kai, U, Yan, C, Lei, J, Zhou, R, Shi, Y. | 登録日 | 2023-08-08 | 公開日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs To Be Published
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8KCT
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![BU of 8kct by Molmil](/molmil-images/mine/8kct) | Cryo-EM structure of human gamma-secretase in complex with Nirogacestat | 分子名称: | (2S)-2-[[(2S)-6,8-bis(fluoranyl)-1,2,3,4-tetrahydronaphthalen-2-yl]amino]-N-[1-[1-(2,2-dimethylpropylamino)-2-methyl-propan-2-yl]imidazol-4-yl]pentanamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Guo, X, Li, H, Kai, U, Yan, C, Lei, J, Zhou, R, Shi, Y. | 登録日 | 2023-08-08 | 公開日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs To Be Published
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8KCS
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![BU of 8kcs by Molmil](/molmil-images/mine/8kcs) | Cryo-EM structure of human gamma-secretase in complex with BMS906024 | 分子名称: | (2S,3R)-N'-[(3S)-1-methyl-2-oxidanylidene-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2,3-bis[3,3,3-tris(fluoranyl)propyl]butanediamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Guo, X, Li, H, Kai, U, Yan, C, Lei, J, Zhou, R, Shi, Y. | 登録日 | 2023-08-08 | 公開日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs To Be Published
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4UIS
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![BU of 4uis by Molmil](/molmil-images/mine/4uis) | The cryoEM structure of human gamma-Secretase complex | 分子名称: | GAMMA-SECRETASE, LYSOZYME | 著者 | Sun, L, Zhao, L, Yang, G, Yan, C, Zhou, R, Zhou, X, Xie, T, Zhao, Y, Wu, S, Li, X, Shi, Y. | 登録日 | 2015-04-03 | 公開日 | 2015-06-10 | 最終更新日 | 2017-08-02 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Structural Basis of Human Gamma-Secretase Assembly. Proc.Natl.Acad.Sci.USA, 112, 2015
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4ZNS
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![BU of 4zns by Molmil](/molmil-images/mine/4zns) | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in complex with a 3-Fluoro-substituted OBHS derivative | 分子名称: | 3-fluorophenyl (1S,2R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonate, Estrogen receptor, Nuclear receptor-interacting peptide | 著者 | Nwachukwu, J.C, Srinivasan, S, Zheng, Y, Wang, S, Min, J, Dong, C, Liao, Z, Cavett, V, Nowak, J, Houtman, R, Carlson, K.E, Josan, J.S, Elemento, O, Katzenellenbogen, J.A, Zhou, H.B, Nettles, K.W. | 登録日 | 2015-05-05 | 公開日 | 2016-05-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Predictive features of ligand-specific signaling through the estrogen receptor. Mol.Syst.Biol., 12, 2016
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8X52
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![BU of 8x52 by Molmil](/molmil-images/mine/8x52) | Cryo-EM structure of human gamma-secretase in complex with Abeta49 | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Guo, X, Yan, C, Lei, J, Zhou, R, Shi, Y. | 登録日 | 2023-11-16 | 公開日 | 2024-05-29 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Molecular mechanism of substrate recognition and cleavage by human gamma-secretase. Science, 384, 2024
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8X53
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![BU of 8x53 by Molmil](/molmil-images/mine/8x53) | Cryo-EM structure of human gamma-secretase in complex with Abeta46 | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Guo, X, Yan, C, Lei, J, Zhou, R, Shi, Y. | 登録日 | 2023-11-16 | 公開日 | 2024-05-29 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular mechanism of substrate recognition and cleavage by human gamma-secretase. Science, 384, 2024
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8X54
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![BU of 8x54 by Molmil](/molmil-images/mine/8x54) | Cryo-EM structure of human gamma-secretase in complex with APP-C99 | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Guo, X, Yan, C, Lei, J, Zhou, R, Shi, Y. | 登録日 | 2023-11-16 | 公開日 | 2024-05-29 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Molecular mechanism of substrate recognition and cleavage by human gamma-secretase. Science, 384, 2024
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4ZNU
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![BU of 4znu by Molmil](/molmil-images/mine/4znu) | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in complex with a 2-Methyl-substituted OBHS derivative | 分子名称: | 2-methylphenyl (1S,2R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonate, Estrogen receptor, Nuclear receptor-interacting peptide | 著者 | Nwachukwu, J.C, Srinivasan, S, Zheng, Y, Wang, S, Min, J, Dong, C, Liao, Z, Cavett, V, Nowak, J, Houtman, R, Carlson, K.E, Josan, J.S, Elemento, O, Katzenellenbogen, J.A, Zhou, H.B, Nettles, K.W. | 登録日 | 2015-05-05 | 公開日 | 2016-05-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Predictive features of ligand-specific signaling through the estrogen receptor. Mol.Syst.Biol., 12, 2016
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4ZNW
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![BU of 4znw by Molmil](/molmil-images/mine/4znw) | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in complex with a 4-Bromo-substituted OBHS derivative | 分子名称: | 4-bromophenyl (1S,2R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonate, Estrogen receptor, Nuclear receptor-interacting peptide | 著者 | Nwachukwu, J.C, Srinivasan, S, Zheng, Y, Wang, S, Min, J, Dong, C, Liao, Z, Cavett, V, Nowak, J, Houtman, R, Carlson, K.E, Josan, J.S, Elemento, O, Katzenellenbogen, J.A, Zhou, H.B, Nettles, K.W. | 登録日 | 2015-05-05 | 公開日 | 2016-05-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Predictive features of ligand-specific signaling through the estrogen receptor. Mol.Syst.Biol., 12, 2016
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4ZNH
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![BU of 4znh by Molmil](/molmil-images/mine/4znh) | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in complex with a 2-Fluoro-substituted OBHS derivative | 分子名称: | 2-fluorophenyl (1S,2R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonate, Estrogen receptor, Nuclear receptor-interacting peptide | 著者 | Nwachukwu, J.C, Srinivasan, S, Zheng, Y, Wang, S, Min, J, Dong, C, Liao, Z, Cavett, V, Nowak, J, Houtman, R, Carlson, K.E, Josan, J.S, Elemento, O, Katzenellenbogen, J.A, Zhou, H.B, Nettles, K.W. | 登録日 | 2015-05-04 | 公開日 | 2016-05-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.933 Å) | 主引用文献 | Predictive features of ligand-specific signaling through the estrogen receptor. Mol.Syst.Biol., 12, 2016
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4ZNT
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![BU of 4znt by Molmil](/molmil-images/mine/4znt) | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in complex with a 3-Bromo-substituted OBHS derivative | 分子名称: | 3-bromophenyl (1S,2R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonate, Estrogen receptor, Nuclear receptor-interacting peptide | 著者 | Nwachukwu, J.C, Srinivasan, S, Zheng, Y, Wang, S, Min, J, Dong, C, Liao, Z, Cavett, V, Nowak, J, Houtman, R, Carlson, K.E, Josan, J.S, Elemento, O, Katzenellenbogen, J.A, Zhou, H.B, Nettles, K.W. | 登録日 | 2015-05-05 | 公開日 | 2016-05-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.903 Å) | 主引用文献 | Predictive features of ligand-specific signaling through the estrogen receptor. Mol.Syst.Biol., 12, 2016
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4ZN7
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![BU of 4zn7 by Molmil](/molmil-images/mine/4zn7) | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in complex with Diethylstilbestrol | 分子名称: | DIETHYLSTILBESTROL, Estrogen receptor, Nuclear receptor coactivator 2 | 著者 | Nwachukwu, J.C, Srinivasan, S, Zheng, Y, Wang, S, Min, J, Dong, C, Liao, Z, Cavett, V, Nowak, J, Houtman, R, Carlson, K.E, Josan, J.S, Elemento, O, Katzenellenbogen, J.A, Zhou, H.B, Nettles, K.W. | 登録日 | 2015-05-04 | 公開日 | 2016-05-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.934 Å) | 主引用文献 | Predictive features of ligand-specific signaling through the estrogen receptor. Mol.Syst.Biol., 12, 2016
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