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3P11
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BU of 3p11 by Molmil
anti-EGFR/HER3 Fab DL11 in complex with domains I-III of the HER3 extracellular region
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab DL11 heavy chain, ...
著者Eigenbrot, C, Shia, S.
登録日2010-09-29
公開日2011-10-26
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies.
Cancer Cell, 20, 2011
3P0Y
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BU of 3p0y by Molmil
anti-EGFR/HER3 Fab DL11 in complex with domain III of EGFR extracellular region
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ...
著者Eigenbrot, C, Shia, S.
登録日2010-09-29
公開日2011-10-26
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies.
Cancer Cell, 20, 2011
3P0V
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BU of 3p0v by Molmil
anti-EGFR/HER3 Fab DL11 alone
分子名称: CALCIUM ION, Fab DL11 heavy chain, Fab DL11 light chain
著者Eigenbrot, C, Shia, S.
登録日2010-09-29
公開日2011-10-19
最終更新日2012-03-21
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies.
Cancer Cell, 20, 2011
5KUP
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BU of 5kup by Molmil
Bruton's tyrosine kinase (BTK) with pyridazinone compound 9
分子名称: 2-(2-METHOXYETHOXY)ETHANOL, 6-~{tert}-butyl-8-fluoranyl-2-[3-(hydroxymethyl)-4-[1-methyl-6-oxidanylidene-5-(pyrimidin-4-ylamino)pyridin-3-yl]pyridin-2-yl]phthalazin-1-one, GLYCEROL, ...
著者Eigenbrot, C, Yu, C.
登録日2016-07-13
公開日2016-09-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.389 Å)
主引用文献Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations.
Acs Chem.Biol., 11, 2016
5IXI
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BU of 5ixi by Molmil
Structure of human JAK1 FERM/SH2 in complex with IFNLR1/IL10RA chimera
分子名称: Chimera protein of Interferon lambda receptor 1 and Interleukin-10 receptor subunit alpha, Tyrosine-protein kinase JAK1
著者Ferrao, R, Wallweber, H.J.A, Lupardus, P.J.
登録日2016-03-23
公開日2016-05-18
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献The Structural Basis for Class II Cytokine Receptor Recognition by JAK1.
Structure, 24, 2016
5IXD
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BU of 5ixd by Molmil
Structure of human JAK1 FERM/SH2 in complex with IFN lambda receptor
分子名称: CITRIC ACID, Interferon lambda receptor 1, Tyrosine-protein kinase JAK1
著者Ferrao, R, Wallweber, H.J.A, Lupardus, P.J.
登録日2016-03-23
公開日2016-05-18
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献The Structural Basis for Class II Cytokine Receptor Recognition by JAK1.
Structure, 24, 2016
5WI6
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BU of 5wi6 by Molmil
Human beta-1 tryptase mutant Ile99Cys
分子名称: L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, SULFATE ION, Tryptase alpha/beta-1
著者Eigenbrot, C, Maun, H.R.
登録日2017-07-18
公開日2018-04-25
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.72 Å)
主引用文献Dual functionality of beta-tryptase protomers as both proteases and cofactors in the active tetramer.
J. Biol. Chem., 293, 2018
4G3G
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BU of 4g3g by Molmil
Crystal structure of murine NF-kappaB inducing kinase (NIK) V408L bound to a 2-(aminothiazolyl)phenol (cmp3)
分子名称: 4-fluoro-2-{[4-(pyridin-4-yl)-1,3-thiazol-2-yl]amino}phenol, NF-kappa-beta-inducing kinase
著者Hymowitz, S.
登録日2012-07-13
公開日2012-08-08
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site.
Structure, 20, 2012
4G3E
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BU of 4g3e by Molmil
Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to a 6-alkynylindoline (cmp1)
分子名称: (2R)-4-[1-(2-amino-5-chloropyrimidin-4-yl)-2,3-dihydro-1H-indol-6-yl]-2-(1,3-thiazol-2-yl)but-3-yn-2-ol, NF-kappa-beta-inducing kinase, SULFATE ION
著者Hymowitz, S.G, de Leon-Boenig, G.
登録日2012-07-13
公開日2012-08-15
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site.
Structure, 20, 2012
4G3F
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BU of 4g3f by Molmil
Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to a 2-(aminothiazoly)phenol (cmp2)
分子名称: 3-{2-[(5-fluoro-2-hydroxyphenyl)amino]-1,3-thiazol-4-yl}benzonitrile, NF-kappa-beta-inducing kinase
著者Hymowitz, S.G, de Leon-Boenig, G.
登録日2012-07-13
公開日2012-08-08
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.642 Å)
主引用文献The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site.
Structure, 20, 2012
4G3D
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BU of 4g3d by Molmil
Crystal structure of human NF-kappaB inducing kinase (NIK)
分子名称: MAGNESIUM ION, NF-kappa-beta-inducing kinase
著者Hymowitz, S.G, de Leon-Boenig, G.
登録日2012-07-13
公開日2012-08-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site.
Structure, 20, 2012
4G3C
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BU of 4g3c by Molmil
Crystal structure of apo murine Nf-kappaB inducing kinase (NIK)
分子名称: NF-kappa-beta-inducing kinase, SULFATE ION
著者Hymowitz, S.G, de Leon-Boenig, G.
登録日2012-07-13
公開日2012-08-08
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site.
Structure, 20, 2012
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