5X73
| The crystal Structure PDE delta in complex with R-p9 | 分子名称: | (2R)-2-(2-fluorophenyl)-3-phenyl-1,2-dihydroquinazolin-4-one, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | 著者 | Jiang, Y, Zhuang, C, Chen, L, Wang, R, Wang, F, Sheng, C. | 登録日 | 2017-02-23 | 公開日 | 2017-10-04 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Biology-Inspired Discovery of Novel KRAS-PDE delta Inhibitors J. Med. Chem., 60, 2017
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6PVB
| The structure of NTMT1 in complex with compound 6 | 分子名称: | AMINO GROUP-()-(2~{S})-2-azanylpropanal-()-ISOLEUCINE-()-ARGININE-()-LYSINE-()-PROLINE-()-AMINO-ACETALDEHYDE-()-9-(5-{[(3S)-3-amino-3-carboxypropyl](pentyl)amino}-5-deoxy-beta-L-arabinofuranosyl)-9H-purin-6-amine, N-terminal Xaa-Pro-Lys N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Noinaj, N, Chen, D, Huang, R. | 登録日 | 2019-07-20 | 公開日 | 2020-08-19 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogues. J.Med.Chem., 63, 2020
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6WJ7
| The structure of NTMT1 in complex with compound C2A | 分子名称: | 5'-{[(3S)-3-amino-3-carboxypropyl](ethyl)amino}-5'-deoxyadenosine, GLY-PRO-LYS-ARG-ILE-ALA-NH2, N-terminal Xaa-Pro-Lys N-methyltransferase 1 | 著者 | Srinivasan, K, Chen, D, Huang, R, Noinaj, N. | 登録日 | 2020-04-13 | 公開日 | 2020-08-19 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogues. J.Med.Chem., 63, 2020
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6WH8
| The structure of NTMT1 in complex with compound BM-30 | 分子名称: | 4HP-PRO-LYS-ARG-NH2, BM-30, N-terminal Xaa-Pro-Lys N-methyltransferase 1, ... | 著者 | Noinaj, N, Chen, D, Huang, R. | 登録日 | 2020-04-07 | 公開日 | 2020-08-26 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.729 Å) | 主引用文献 | Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies. J.Med.Chem., 63, 2020
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2WIC
| Crystal Structures of the N-terminal Intracellular Domain of FeoB from Klebsiella Pneumoniae in GMPPNP binding state | 分子名称: | FERROUS IRON TRANSPORT PROTEIN B, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 著者 | Hung, K.-W, Chang, Y.-W, Chen, J.-H, Chen, Y.-C, Sun, Y.-J, Hsiao, C.-D, Huang, T.-H. | 登録日 | 2009-05-09 | 公開日 | 2010-05-19 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural Fold, Conservation and Fe(II) Binding of the Intracellular Domain of Prokaryote Feob. J.Struct.Biol., 170, 2010
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2WIA
| Crystal Structures of the N-terminal Intracellular Domain of FeoB from Klebsiella Pneumoniae in Apo Form | 分子名称: | FERROUS IRON TRANSPORT PROTEIN B, MAGNESIUM ION | 著者 | Hung, K.-W, Chang, Y.-W, Chen, J.-H, Chen, Y.-C, Sun, Y.-J, Hsiao, C.-D, Huang, T.-H. | 登録日 | 2009-05-09 | 公開日 | 2010-05-19 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Structural Fold, Conservation and Fe(II) Binding of the Intracellular Domain of Prokaryote Feob. J.Struct.Biol., 170, 2010
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2WIB
| Crystal Structures of the N-terminal Intracellular Domain of FeoB from Klebsiella Pneumoniae in GDP binding state | 分子名称: | FERROUS IRON TRANSPORT PROTEIN B, GUANOSINE-5'-DIPHOSPHATE | 著者 | Hung, K.-W, Chang, Y.-W, Chen, J.-H, Chen, Y.-C, Sun, Y.-J, Hsiao, C.-D, Huang, T.-H. | 登録日 | 2009-05-09 | 公開日 | 2010-05-19 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Structural Fold, Conservation and Fe(II) Binding of the Intracellular Domain of Prokaryote Feob. J.Struct.Biol., 170, 2010
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5UBB
| Crystal structure of human alpha N-terminal protein methyltransferase 1B | 分子名称: | Alpha N-terminal protein methyltransferase 1B, S-ADENOSYLMETHIONINE, UNKNOWN ATOM OR ION | 著者 | Dong, C, Zhu, L, Tempel, W, Dong, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2016-12-20 | 公開日 | 2017-03-22 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2. Commun Biol, 1, 2018
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7K3D
| The structure of NTMT1 in complex with compound DC1-13 | 分子名称: | N-terminal Xaa-Pro-Lys N-methyltransferase 1, N~2~-{(2S)-1-[(naphthalen-1-yl)acetyl]-2,5-dihydro-1H-pyrrole-2-carbonyl}-L-lysyl-L-argininamide, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Chen, D, Huang, R, Noinaj, N. | 登録日 | 2020-09-11 | 公開日 | 2021-04-14 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Structure-based Discovery of Cell-Potent Peptidomimetic Inhibitors for Protein N-Terminal Methyltransferase 1. Acs Med.Chem.Lett., 12, 2021
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6O12
| E. coli cysteine desulfurase SufS H123A | 分子名称: | CHLORIDE ION, Cysteine desulfurase, PYRIDOXAL-5'-PHOSPHATE | 著者 | Dunkle, J.A, Frantom, P.A. | 登録日 | 2019-02-17 | 公開日 | 2019-06-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Direct observation of intermediates in the SufS cysteine desulfurase reaction reveals functional roles of conserved active-site residues. J.Biol.Chem., 294, 2019
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6O13
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6O11
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6O10
| E. coli cysteine desulfurase SufS | 分子名称: | CHLORIDE ION, Cysteine desulfurase, PYRIDOXAL-5'-PHOSPHATE | 著者 | Dunkle, J.A, Frantom, P.A. | 登録日 | 2019-02-17 | 公開日 | 2019-06-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Direct observation of intermediates in the SufS cysteine desulfurase reaction reveals functional roles of conserved active-site residues. J.Biol.Chem., 294, 2019
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5X72
| The crystal Structure PDE delta in complex with (rac)-p9 | 分子名称: | (2R)-2-(2-fluorophenyl)-3-phenyl-1,2-dihydroquinazolin-4-one, (2S)-2-(2-fluorophenyl)-3-phenyl-1,2-dihydroquinazolin-4-one, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | 著者 | Jiang, Y, Zhuang, C, Chen, L, Wang, R, Wang, F, Sheng, C. | 登録日 | 2017-02-23 | 公開日 | 2017-10-04 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural Biology-Inspired Discovery of Novel KRAS-PDE delta Inhibitors J. Med. Chem., 60, 2017
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6DTN
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6IMB
| Crystal structure of PDE4D complexed with a novel inhibitor | 分子名称: | 1,2-ETHANEDIOL, 6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde, MAGNESIUM ION, ... | 著者 | Zhang, X, Su, H, Xu, Y. | 登録日 | 2018-10-22 | 公開日 | 2019-10-23 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.549 Å) | 主引用文献 | Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent. J.Med.Chem., 62, 2019
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6IMI
| Crystal structure of PDE4D complexed with a novel inhibitor | 分子名称: | 1,2-ETHANEDIOL, 6-ethoxy-7-methoxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde, MAGNESIUM ION, ... | 著者 | Zhang, X, Su, H, Xu, Y. | 登録日 | 2018-10-23 | 公開日 | 2019-10-23 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent. J.Med.Chem., 62, 2019
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6IMD
| Crystal structure of PDE4D complexed with a novel inhibitor | 分子名称: | 1,2-ETHANEDIOL, 6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde, MAGNESIUM ION, ... | 著者 | Zhang, X, Su, H, Xu, Y. | 登録日 | 2018-10-22 | 公開日 | 2019-10-23 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.499 Å) | 主引用文献 | Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent. J.Med.Chem., 62, 2019
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6IM6
| Crystal structure of PDE4D complexed with a novel inhibitor | 分子名称: | 1,2-ETHANEDIOL, 7-ethoxy-6-methoxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde, MAGNESIUM ION, ... | 著者 | Zhang, X.L, Su, H.X, Xu, Y.C. | 登録日 | 2018-10-22 | 公開日 | 2019-10-23 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.702 Å) | 主引用文献 | Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent. J.Med.Chem., 62, 2019
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6IMT
| Crystal structure of PDE4D complexed with a novel inhibitor | 分子名称: | (1S)-1-[2-(6-fluoro-1H-indol-3-yl)ethyl]-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde, 1,2-ETHANEDIOL, MAGNESIUM ION, ... | 著者 | Zhang, X.L, Su, H.X, Xu, Y.C. | 登録日 | 2018-10-23 | 公開日 | 2019-10-23 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.483 Å) | 主引用文献 | Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent. J.Med.Chem., 62, 2019
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6IND
| Crystal structure of PDE4D complexed with a novel inhibitor | 分子名称: | (1S)-6,7-dimethoxy-1-[2-(6-methyl-1H-indol-3-yl)ethyl]-3,4-dihydroisoquinoline-2(1H)-carbaldehyde, 1,2-ETHANEDIOL, MAGNESIUM ION, ... | 著者 | Zhang, X.L, Su, H.X, Xu, Y.C. | 登録日 | 2018-10-24 | 公開日 | 2019-10-23 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.872 Å) | 主引用文献 | Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent. J.Med.Chem., 62, 2019
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6INM
| Crystal structure of PDE4D complexed with a novel inhibitor | 分子名称: | (1S)-1-[2-(1H-indol-3-yl)ethyl]-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde, 1,2-ETHANEDIOL, MAGNESIUM ION, ... | 著者 | Zhang, X.L, Su, H.X, Xu, Y.C. | 登録日 | 2018-10-26 | 公開日 | 2019-10-23 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.999 Å) | 主引用文献 | Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent. J.Med.Chem., 62, 2019
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6IMR
| Crystal structure of PDE4D complexed with a novel inhibitor | 分子名称: | (1S)-1-[3-(1H-indol-3-yl)propyl]-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde, 1,2-ETHANEDIOL, MAGNESIUM ION, ... | 著者 | Zhang, X.L, Su, H.X, Xu, Y.C. | 登録日 | 2018-10-23 | 公開日 | 2019-10-23 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.503 Å) | 主引用文献 | Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent. J.Med.Chem., 62, 2019
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6INK
| Crystal structure of PDE4D complexed with a novel inhibitor | 分子名称: | (1S)-1-[2-(1H-indol-3-yl)ethyl]-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde, 1,2-ETHANEDIOL, MAGNESIUM ION, ... | 著者 | Zhang, X.L, Su, H.X, Xu, Y.C. | 登録日 | 2018-10-25 | 公開日 | 2019-10-23 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent. J.Med.Chem., 62, 2019
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6IMO
| Crystal structure of PDE4D complexed with a novel inhibitor | 分子名称: | (1S)-1-[(1H-indol-3-yl)methyl]-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde, 1,2-ETHANEDIOL, MAGNESIUM ION, ... | 著者 | Zhang, X.L, Su, H.X, Xu, Y.C. | 登録日 | 2018-10-23 | 公開日 | 2019-10-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent. J.Med.Chem., 62, 2019
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