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7UUJ
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BU of 7uuj by Molmil
Crystal structure of aminoglycoside resistance enzyme ApmA, complex with gentamicin
分子名称: (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, 1,2-ETHANEDIOL, Aminocyclitol acetyltransferase ApmA, ...
著者Stogios, P.J, Evdokimova, E, Osipiuk, J, Di Leo, R, Bordeleau, E, Wright, G.D, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID)
登録日2022-04-28
公開日2023-04-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Crystal structure of aminoglycoside resistance enzyme ApmA, complex with gentamicin
To Be Published
7UUN
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BU of 7uun by Molmil
Crystal structure of aminoglycoside resistance enzyme ApmA, complex with neomycin
分子名称: 1,2-ETHANEDIOL, Aminocyclitol acetyltransferase ApmA, NEOMYCIN
著者Stogios, P.J, Evdokimova, E, Di Leo, R, Osipiuk, J, Bordeleau, E, Wright, G.D, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
登録日2022-04-28
公開日2022-11-02
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.83 Å)
主引用文献Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance.
Nat.Chem.Biol., 20, 2024
7UUO
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BU of 7uuo by Molmil
Crystal structure of aminoglycoside resistance enzyme ApmA H135A mutant, complex with tobramycin and coenzyme A
分子名称: 1,2-ETHANEDIOL, Aminocyclitol acetyltransferase ApmA, COENZYME A, ...
著者Stogios, P.J, Evdokimova, E, Michalska, K, Di Leo, R, Bordeleau, E, Wright, G.D, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
登録日2022-04-28
公開日2022-11-02
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance.
Nat.Chem.Biol., 20, 2024
7UUL
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BU of 7uul by Molmil
Crystal structure of aminoglycoside resistance enzyme ApmA, complex with kanamycin B and coenzyme A
分子名称: (1R,2S,3S,4R,6S)-4,6-DIAMINO-3-[(3-AMINO-3-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-HYDROXYCYCLOHEXYL 2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSIDE, 1,2-ETHANEDIOL, Aminocyclitol acetyltransferase ApmA, ...
著者Stogios, P.J, Evdokimova, E, Di Leo, R, Bordeleau, E, Wright, G.D, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
登録日2022-04-28
公開日2022-11-02
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance.
Nat.Chem.Biol., 20, 2024
7UUM
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BU of 7uum by Molmil
Crystal structure of aminoglycoside resistance enzyme ApmA, complex with paromomycin and coenzyme A
分子名称: Aminocyclitol acetyltransferase ApmA, COENZYME A, GLYCEROL, ...
著者Stogios, P.J, Evdokimova, E, Osipiuk, J, Di Leo, R, Bordeleau, E, Wright, G.D, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
登録日2022-04-28
公開日2022-11-02
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance.
Nat.Chem.Biol., 20, 2024
8SCD
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BU of 8scd by Molmil
Crystal structure of sulfonamide resistance enzyme Sul3 in complex with reaction intermediate
分子名称: 2-amino-6-methylidene-6,7-dihydropteridin-4(3H)-one, 4-AMINOBENZOIC ACID, CHLORIDE ION, ...
著者Stogios, P.J, Venkatesan, M, Michalska, K, Mesa, N, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID), Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2023-04-05
公開日2023-05-03
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics.
Nat Commun, 14, 2023
8SMQ
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BU of 8smq by Molmil
Crystal Structure of the N-terminal Domain of the Cryptic Surface Protein (CD630_25440) from Clostridium difficile.
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ...
著者Minasov, G, Shuvalova, L, Brunzelle, J.S, Kiryukhina, O, Wawrzak, Z, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID), Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2023-04-26
公開日2023-05-10
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Protein target highlights in CASP15: Analysis of models by structure providers.
Proteins, 91, 2023
8EWF
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BU of 8ewf by Molmil
CryoEM structure of Western equine encephalitis virus VLP in complex with the avian MXRA8 receptor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Chimeric MXRA8 receptor: D1 from Duck MXRA8 and D2 from Mouse MXRA8, E1 envelope protein, ...
著者Zimmerman, M.I, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
登録日2022-10-22
公開日2023-10-25
実験手法ELECTRON MICROSCOPY (3.92 Å)
主引用文献Alternate domain repeat usage in an alphavirus entry receptor enables host species expansion
To Be Published
7SUA
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BU of 7sua by Molmil
Crystal Structure of the Hypothetical Protein (ACX60_00475) from Acinetobacter baumannii
分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, DUF4175 domain-containing protein
著者Minasov, G, Shuvalova, L, Dubrovska, I, Kiryukhina, O, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID)
登録日2021-11-16
公開日2022-11-30
最終更新日2023-02-01
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal Structure of the Hypothetical Protein (ACX60_00475) from Acinetobacter baumannii
To be Published
8DAN
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BU of 8dan by Molmil
CryoEM structure of Western equine encephalitis virus VLP in complex with the avian MXRA8 receptor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, E1 envelope glycoprotein, E2 envelope glycoprotein, ...
著者Zimmerman, M.I, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
登録日2022-06-13
公開日2023-12-20
実験手法ELECTRON MICROSCOPY (4.74 Å)
主引用文献Alternate domain repeat usage in an alphavirus entry receptor enables host species expansion
To Be Published
7SWW
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BU of 7sww by Molmil
SARS-CoV-2 Spike NTD in complex with neutralizing Fab SARS2-57 (local refinement)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SARS2-57 Fv heavy chain, ...
著者Adams, L.J, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
登録日2021-11-21
公開日2022-11-23
最終更新日2023-02-01
実験手法ELECTRON MICROSCOPY (3.13 Å)
主引用文献A protective antibody targeting the N-terminal domain of SARS-CoV-2 spike recognizes most emerging variants
To Be Published
7SWX
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BU of 7swx by Molmil
SARS-CoV-2 Spike in complex with neutralizing Fab SARS2-57 (three down conformation)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SARS2-57 Fv heavy chain, ...
著者Adams, L.J, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
登録日2021-11-21
公開日2022-11-23
最終更新日2023-02-01
実験手法ELECTRON MICROSCOPY (3.13 Å)
主引用文献A protective antibody targeting the N-terminal domain of SARS-CoV-2 spike recognizes most emerging variants
To Be Published
8DAQ
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BU of 8daq by Molmil
CryoEM structure of Western equine encephalitis virus VLP
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, E1 envelope glycoprotein, E2 envelope glycoprotein
著者Zimmerman, M.I, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
登録日2022-06-13
公開日2023-12-20
実験手法ELECTRON MICROSCOPY (4.35 Å)
主引用文献Alternate repeat domain usage in an alphavirus entry receptor enables host species expansion
To Be Published
8F4Y
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BU of 8f4y by Molmil
Crystal Structure of SARS-CoV-2 2'-O-Methyltransferase in Complex with Compound 5a covalently bound to nsp16 and nsp10
分子名称: 2'-O-methyltransferase, 4-[(E)-2-(2,4-dichlorophenyl)ethenyl]-6-(trifluoromethyl)pyrimidin-2-ol, 4-[2-(2,4-dichlorophenyl)ethyl]-6-(trifluoromethyl)pyrimidin-2-ol, ...
著者Minasov, G, Shuvalova, L, Brunzelle, J.S, Rosas-Lemus, M, Kiryukhina, O, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID)
登録日2022-11-11
公開日2023-10-18
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Discovery of a Druggable, Cryptic Pocket in SARS-CoV-2 nsp16 Using Allosteric Inhibitors.
Acs Infect Dis., 9, 2023
8F4S
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BU of 8f4s by Molmil
Crystal Structure of the SARS-CoV-2 2'-O-Methyltransferase with Compound 5a bound to the Cryptic Pocket of nsp16
分子名称: 2'-O-methyltransferase, 4-[(E)-2-(2,4-dichlorophenyl)ethenyl]-6-(trifluoromethyl)pyrimidin-2-ol, FORMIC ACID, ...
著者Minasov, G, Shuvalova, L, Brunzelle, J.S, Rosas-Lemus, M, Kiryukhina, O, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID)
登録日2022-11-11
公開日2023-10-18
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Discovery of a Druggable, Cryptic Pocket in SARS-CoV-2 nsp16 Using Allosteric Inhibitors.
Acs Infect Dis., 9, 2023
8SQN
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BU of 8sqn by Molmil
CryoEM structure of Western equine encephalitis virus VLP in complex with the chimeric Du-D1-Mo-D2 MXRA8 receptor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DuD1MoD2 chimeric MXRA8, E1 envelope glycoprotein, ...
著者Zimmerman, M.I, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
登録日2023-05-04
公開日2023-12-20
実験手法ELECTRON MICROSCOPY (3.89 Å)
主引用文献Vertebrate-class-specific binding modes of the alphavirus receptor MXRA8.
Cell, 186, 2023
7ROA
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BU of 7roa by Molmil
Crystal structure of EntV136 from Enterococcus faecalis
分子名称: EntV
著者Stogios, P.J, Evdokimova, E, Kim, Y, Garsin, D, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
登録日2021-07-30
公開日2022-10-12
最終更新日2023-01-25
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Structural and functional analysis of EntV reveals a 12 amino acid fragment protective against fungal infections.
Nat Commun, 13, 2022
8T28
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BU of 8t28 by Molmil
The crystal structure of SrtC2 sortase from Actinomyces oris
分子名称: CHLORIDE ION, Class C sortase, PHOSPHATE ION
著者Osipiuk, J, Chang, C, Ton-That, H.L, Ton-That, H, Joachimiak, A, Center for Structural Biology of Infectious Diseases (CSBID)
登録日2023-06-05
公開日2024-04-17
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Molecular basis for dual functions in pilus assembly modulated by the lid of a pilus-specific sortase.
J.Biol.Chem., 300, 2024
7S2I
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BU of 7s2i by Molmil
Crystal structure of sulfonamide resistance enzyme Sul1 in complex with 6-hydroxymethylpterin
分子名称: 6-HYDROXYMETHYLPTERIN, CHLORIDE ION, GLYCEROL, ...
著者Stogios, P.J, Skarina, T, Kim, Y, Venkatesan, M, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID), Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2021-09-03
公開日2023-05-03
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics.
Nat Commun, 14, 2023
7S2M
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BU of 7s2m by Molmil
Crystal structure of sulfonamide resistance enzyme Sul3 in complex with 6-hydroxymethylpterin
分子名称: 6-HYDROXYMETHYLPTERIN, Sul3
著者Stogios, P.J, Skarina, T, Venkatesan, M, Michalska, K, Mesa, N, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID), Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2021-09-03
公開日2023-05-03
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics.
Nat Commun, 14, 2023
7S2J
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BU of 7s2j by Molmil
Crystal structure of sulfonamide resistance enzyme Sul2 apoenzyme
分子名称: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者Stogios, P.J, Skarina, T, Michalska, K, Venkatesan, M, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID), Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2021-09-03
公開日2023-05-03
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics.
Nat Commun, 14, 2023
7S2K
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BU of 7s2k by Molmil
Crystal structure of sulfonamide resistance enzyme Sul2 in complex with 7,8-dihydropteroate, magnesium, and pyrophosphate
分子名称: 4-AMINOBENZOIC ACID, 7,8-DIHYDROPTEROATE, CHLORIDE ION, ...
著者Stogios, P.J, Skarina, T, Michalska, K, Venkatesan, M, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID), Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2021-09-03
公開日2023-05-03
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics.
Nat Commun, 14, 2023
7S2L
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BU of 7s2l by Molmil
Crystal structure of sulfonamide resistance enzyme Sul3 apoenzyme
分子名称: CHLORIDE ION, GLYCEROL, SULFATE ION, ...
著者Stogios, P.J, Venkatesan, M, Michalska, K, Mesa, N, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID), Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2021-09-03
公開日2023-05-03
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics.
Nat Commun, 14, 2023
8F09
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BU of 8f09 by Molmil
Crystal structure of a trimethoprim-resistant dihydrofolate reductase (DHFR) enzyme from an uncultured soil bacterium
分子名称: Dihydrofolate reductase, SULFATE ION
著者Stogios, P.J, Evdokimova, D, Borek, D, Di Leo, R, Semper, C, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID)
登録日2022-11-02
公開日2022-11-16
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Crystal structure of a trimethoprim-resistant dihydrofolate reductase (DHFR) enzyme from an uncultured soil bacterium
To Be Published
8UFB
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BU of 8ufb by Molmil
Eastern equine encephalitis virus (PE-6) VLP in complex with full-length VLDLR (asymmetric unit)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Capsid protein, ...
著者Adams, L.J, Fremont, D.H, Center for Structural Biology of Infectious Diseases (CSBID)
登録日2023-10-04
公開日2024-01-17
最終更新日2024-01-31
実験手法ELECTRON MICROSCOPY (3.89 Å)
主引用文献Structural and functional basis of VLDLR usage by Eastern equine encephalitis virus.
Cell, 187, 2024

222036

件を2024-07-03に公開中

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