5J61
 
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7Q5P
 | | Structure of VgrG1 from Pseudomonas protegens. | | 分子名称: | Type VI secretion protein VgrG | | 著者 | Guenther, P, Quentin, D, Ahmad, S, Sachar, K, Gatsogiannis, C, Whitney, J.C, Raunser, S. | | 登録日 | 2021-11-04 | | 公開日 | 2021-12-15 | | 最終更新日 | 2022-02-02 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure of a bacterial Rhs effector exported by the type VI secretion system.
Plos Pathog., 18, 2022
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7Q97
 | | Structure of the bacterial type VI secretion system effector RhsA. | | 分子名称: | Rhs family protein | | 著者 | Guenther, P, Quentin, D, Ahmad, S, Sachar, K, Gatsogiannis, C, Whitney, J.C, Raunser, S. | | 登録日 | 2021-11-12 | | 公開日 | 2021-12-22 | | 最終更新日 | 2022-02-02 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure of a bacterial Rhs effector exported by the type VI secretion system.
Plos Pathog., 18, 2022
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7JL3
 | | Cryo-EM structure of RIG-I:dsRNA filament in complex with RIPLET PrySpry domain (trimer) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Antiviral innate immune response receptor RIG-I, E3 ubiquitin-protein ligase RNF135, ... | | 著者 | Kato, K, Ahmad, S, Hur, S. | | 登録日 | 2020-07-29 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.
Mol.Cell, 81, 2021
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7JL0
 | | Cryo-EM structure of MDA5-dsRNA in complex with TRIM65 PSpry domain (Monomer) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, MAGNESIUM ION, ... | | 著者 | Kato, K, Ahmad, S, Hur, S. | | 登録日 | 2020-07-29 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.
Mol.Cell, 81, 2021
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7JL1
 | | Cryo-EM structure of RIG-I:dsRNA in complex with RIPLET PrySpry domain (monomer) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Antiviral innate immune response receptor RIG-I, E3 ubiquitin-protein ligase RNF135, ... | | 著者 | Kato, K, Ahmad, S, Hur, S. | | 登録日 | 2020-07-29 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.
Mol.Cell, 81, 2021
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7JL4
 | | Crystal structure of TRIM65 PSpry domain | | 分子名称: | GLYCEROL, Tripartite motif-containing protein 65 | | 著者 | Kato, K, Ahmad, S, Hur, S. | | 登録日 | 2020-07-29 | | 公開日 | 2020-12-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.
Mol.Cell, 81, 2021
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7JL2
 | | Cryo-EM structure of MDA5-dsRNA filament in complex with TRIM65 PSpry domain (Trimer) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, MAGNESIUM ION, ... | | 著者 | Kato, K, Ahmad, S, Hur, S. | | 登録日 | 2020-07-29 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.
Mol.Cell, 81, 2021
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6VYC
 | | Crystal structure of WD-repeat domain of human WDR91 | | 分子名称: | UNKNOWN ATOM OR ION, WD repeat-containing protein 91 | | 著者 | Halabelian, L, Hutchinson, A, Li, Y, Seitova, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC) | | 登録日 | 2020-02-26 | | 公開日 | 2020-03-25 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning.
J.Med.Chem., 66, 2023
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6OTT
 | | Structure of PurF in complex with ppApp | | 分子名称: | Amidophosphoribosyltransferase, PurF, MAGNESIUM ION, ... | | 著者 | Grant, R.A, Wang, B, Laub, M.T. | | 登録日 | 2019-05-03 | | 公開日 | 2019-11-06 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp.
Nature, 575, 2019
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8T55
 | | Co-crystal structure of the WD-repeat domain of human WDR91 in complex with MR46654 | | 分子名称: | 1,2-ETHANEDIOL, N-[3-(4-chlorophenyl)oxetan-3-yl]-1-propanoyl-1,2,3,4-tetrahydroquinoline-5-carboxamide, WD repeat-containing protein 91 | | 著者 | Ahmad, H, Zeng, H, Dong, A, Li, Y, Yen, H, Seitova, A, Xu, J, Feng, J.W, Brown, P.J, Santhakumar, V, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | 登録日 | 2023-06-12 | | 公開日 | 2023-07-05 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning.
J.Med.Chem., 66, 2023
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8SHJ
 | | Crystal structure of the WD-repeat domain of human WDR91 in complex with MR45279 | | 分子名称: | N-[3-(4-chlorophenyl)oxetan-3-yl]-4-[(3S)-3-hydroxypyrrolidin-1-yl]benzamide, WD repeat-containing protein 91 | | 著者 | Ahmad, H, Zeng, H, Dong, A, Li, Y, Hutchinson, A, Seitova, A, Xu, J, Feng, J.W, Brown, P.J, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | 登録日 | 2023-04-14 | | 公開日 | 2023-07-05 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning.
J.Med.Chem., 66, 2023
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5HV9
 | | Human LTC4S mutant-S36E | | 分子名称: | GLUTATHIONE, Leukotriene C4 synthase, SULFATE ION | | 著者 | Thulasingam, M, Ahmad, H.R.S, Rinaldo-Matthis, A, Haeggstrom, J.Z. | | 登録日 | 2016-01-28 | | 公開日 | 2016-07-13 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Phosphorylation of Leukotriene C4 Synthase at Serine 36 Impairs Catalytic Activity.
J.Biol.Chem., 291, 2016
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4RRR
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4RRQ
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3D2A
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3D2C
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3D2B
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2QXT
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2QXU
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6H3L
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5MDN
 | | Structure of the family B DNA polymerase from the hyperthermophilic archaeon Pyrobaculum calidifontis | | 分子名称: | DNA polymerase, MAGNESIUM ION | | 著者 | Guo, J, Zhang, W, Coker, A.R, Wood, S.P, Cooper, J.B, Rashid, N, Akhtar, M. | | 登録日 | 2016-11-12 | | 公開日 | 2016-12-14 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure of the family B DNA polymerase from the hyperthermophilic archaeon Pyrobaculum calidifontis.
Acta Crystallogr D Struct Biol, 73, 2017
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5MIO
 | | KIF2C-DARPIN FUSION PROTEIN BOUND TO TUBULIN | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF2C,KIF2C FUSED TO A DARPIN,KIF2C FUSED TO A DARPIN, ... | | 著者 | Wang, W, Gigant, B. | | 登録日 | 2016-11-28 | | 公開日 | 2017-07-19 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | | 主引用文献 | Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin.
Nat Commun, 8, 2017
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7RT7
 | | Crystal structure of the RhsP2 C-terminal toxin domain in complex with its immunity protein, RhsI2 | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, RhsI2, RhsP2 | | 著者 | Bullen, N.P, Prehna, G, Whitney, J.C. | | 登録日 | 2021-08-12 | | 公開日 | 2022-08-17 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | An ADP-ribosyltransferase toxin kills bacterial cells by modifying structured non-coding RNAs.
Mol.Cell, 82, 2022
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8QK2
 | | Structure of K.pneumoniae LpxH in complex with EBL-3339 | | 分子名称: | MANGANESE (II) ION, UDP-2,3-diacylglucosamine hydrolase, ~{N}-[4-[4-(4-cyano-6-methyl-pyrimidin-2-yl)piperazin-1-yl]sulfonylphenyl]-2-[methyl(methylsulfonyl)amino]benzamide | | 著者 | Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L. | | 登録日 | 2023-09-14 | | 公開日 | 2024-04-17 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
Proc.Natl.Acad.Sci.USA, 121, 2024
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