7OAP
 
 | | Nanobody H3 AND C1 bound to RBD | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C1 nanobody, CHLORIDE ION, ... | | 著者 | Naismith, J.H, Mikolajek, H. | | 登録日 | 2021-04-19 | | 公開日 | 2021-08-11 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | | 主引用文献 | A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19.
Nat Commun, 12, 2021
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7OAN
 | | Nanobody C5 bound to Spike | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | | 著者 | Naismith, J.H, Weckener, M. | | 登録日 | 2021-04-19 | | 公開日 | 2021-08-11 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19.
Nat Commun, 12, 2021
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7OAY
 | | Nanobody F2 bound to RBD | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, F2 nanobody, Spike protein S1 | | 著者 | Naismith, J.H, Mikolajek, H. | | 登録日 | 2021-04-20 | | 公開日 | 2021-08-11 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19.
Nat Commun, 12, 2021
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7OAU
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6SJ4
 | | Amidohydrolase, AHS with substrate analog | | 分子名称: | 1,2-ETHANEDIOL, 3-(3-hydroxyphenyl)carbonyloxybenzoic acid, Amidohydrolase, ... | | 著者 | Naismith, J.H, Song, H. | | 登録日 | 2019-08-12 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | | 主引用文献 | The Biosynthesis of the Benzoxazole in Nataxazole Proceeds via an Unstable Ester and has Synthetic Utility.
Angew.Chem.Int.Ed.Engl., 59, 2020
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6YQQ
 | | ForT-PRPP complex | | 分子名称: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, CHLORIDE ION, ForT-PRPP complex, ... | | 著者 | Naismith, J.H, Gao, S. | | 登録日 | 2020-04-18 | | 公開日 | 2020-05-20 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Uncovering the chemistry of C-C bond formation in C-nucleoside biosynthesis: crystal structure of a C-glycoside synthase/PRPP complex.
Chem.Commun.(Camb.), 56, 2020
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6Y47
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2VL7
 | | Structure of S. tokodaii Xpd4 | | 分子名称: | PHOSPHATE ION, XPD | | 著者 | Naismith, J.H, Johnson, K.A, Oke, M, McMahon, S.A, Liu, L, White, M.F, Zawadski, M, Carter, L.G. | | 登録日 | 2008-01-08 | | 公開日 | 2008-05-13 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structure of the DNA Repair Helicase Xpd.
Cell(Cambridge,Mass.), 133, 2008
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2VG2
 | | Rv2361 with IPP | | 分子名称: | 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, CHLORIDE ION, DIPHOSPHATE, ... | | 著者 | Naismith, J.H, Wang, W, Dong, C. | | 登録日 | 2007-11-07 | | 公開日 | 2007-11-13 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | The structural basis of chain length control in Rv1086.
J. Mol. Biol., 381, 2008
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2VG3
 | | Rv2361 with citronellyl pyrophosphate | | 分子名称: | CHLORIDE ION, GERANYL DIPHOSPHATE, GLYCEROL, ... | | 著者 | Naismith, J.H, Wang, W, Dong, C. | | 登録日 | 2007-11-08 | | 公開日 | 2008-05-06 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The structural basis of chain length control in Rv1086.
J. Mol. Biol., 381, 2008
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2V7J
 | | PrnB L-tryptophan complex | | 分子名称: | PRNB, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, ... | | 著者 | Naismith, J.H. | | 登録日 | 2007-07-30 | | 公開日 | 2007-08-07 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The Second Enzyme in Pyrrolnitrin Biosynthetic Pathway is Related to the Heme-Dependent Dioxygenase Superfamily
Biochemistry, 46, 2007
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2VG4
 | | Rv2361 native | | 分子名称: | UNDECAPRENYL PYROPHOSPHATE SYNTHETASE | | 著者 | Naismith, J.H, Wang, W, Dong, C. | | 登録日 | 2007-11-08 | | 公開日 | 2007-11-27 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The structural basis of chain length control in Rv1086.
J. Mol. Biol., 381, 2008
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2V82
 | | KDPGal complexed to KDPGal | | 分子名称: | 2-DEHYDRO-3-DEOXY-6-PHOSPHOGALACTONATE ALDOLASE, 2-KETO-DEOXY-GALACTOSE | | 著者 | Naismith, J.H. | | 登録日 | 2007-08-02 | | 公開日 | 2007-08-14 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Characterization and crystal structure of Escherichia coli KDPGal aldolase.
Bioorg. Med. Chem., 16, 2008
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2V7I
 | | PrnB native | | 分子名称: | PRNB, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | | 著者 | Naismith, J.H. | | 登録日 | 2007-07-30 | | 公開日 | 2007-08-07 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | The Second Enzyme in Pyrrolnitrin Biosynthetic Pathway is Related to the Heme-Dependent Dioxygenase Superfamily
Biochemistry, 46, 2007
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2V7L
 | | PrnB 7Cl-L-tryptophan complex | | 分子名称: | 7-CHLOROTRYPTOPHAN, PRNB, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Naismith, J.H. | | 登録日 | 2007-07-30 | | 公開日 | 2007-08-07 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The Second Enzyme in Pyrrolnitrin Biosynthetic Pathway is Related to the Heme-Dependent Dioxygenase Superfamily.
Biochemistry, 46, 2007
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2V7K
 | | PrnB D-tryptophan complex | | 分子名称: | D-TRYPTOPHAN, PRNB, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Naismith, J.H. | | 登録日 | 2007-07-30 | | 公開日 | 2007-08-07 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | The Second Enzyme in Pyrrolnitrin Biosynthetic Pathway is Related to the Heme-Dependent Dioxygenase Superfamily
Biochemistry, 46, 2007
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2V7M
 | | PrnB 7-Cl-D-tryptophan complex | | 分子名称: | 7-CL-D-TRYPTOPHAN, PHOSPHATE ION, PRNB, ... | | 著者 | Naismith, J.H. | | 登録日 | 2007-07-30 | | 公開日 | 2007-08-07 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The Second Enzyme in Pyrrolnitrin Biosynthetic Pathway is Related to the Heme-Dependent Dioxygenase Superfamily
Biochemistry, 46, 2007
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7NIH
 | | Wzc-K540M MgADP C8 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Putative transmembrane protein Wzc | | 著者 | Naismith, J.H, Liu, J.W, Yang, Y. | | 登録日 | 2021-02-12 | | 公開日 | 2021-08-25 | | 最終更新日 | 2025-07-09 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | The molecular basis of regulation of bacterial capsule assembly by Wzc.
Nat Commun, 12, 2021
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7NHS
 | | Wzc K540M C8 | | 分子名称: | Putative transmembrane protein Wzc | | 著者 | Naismith, J.H, Liu, J.W, Yang, Y. | | 登録日 | 2021-02-11 | | 公開日 | 2021-08-25 | | 最終更新日 | 2025-07-09 | | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | | 主引用文献 | The molecular basis of regulation of bacterial capsule assembly by Wzc.
Nat Commun, 12, 2021
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7NII
 | | Wzc-K540M MgADP C1 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Putative transmembrane protein Wzc | | 著者 | Naismith, J.H, Liu, J.W, Yang, Y. | | 登録日 | 2021-02-12 | | 公開日 | 2021-08-25 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | | 主引用文献 | The molecular basis of regulation of bacterial capsule assembly by Wzc.
Nat Commun, 12, 2021
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7NI2
 | | Wzc-K540M-4YE C8 | | 分子名称: | Tyrosine-protein kinase | | 著者 | Naismith, J.H, Liu, J.W, Yang, Y. | | 登録日 | 2021-02-11 | | 公開日 | 2021-08-25 | | 最終更新日 | 2025-07-09 | | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | | 主引用文献 | The molecular basis of regulation of bacterial capsule assembly by Wzc.
Nat Commun, 12, 2021
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7NIB
 | | Wzc-K540M-4YE C1 | | 分子名称: | Tyrosine-protein kinase | | 著者 | Naismith, J.H, Liu, J.W, Yang, Y. | | 登録日 | 2021-02-11 | | 公開日 | 2021-08-25 | | 最終更新日 | 2025-07-09 | | 実験手法 | ELECTRON MICROSCOPY (3.51 Å) | | 主引用文献 | The molecular basis of regulation of bacterial capsule assembly by Wzc.
Nat Commun, 12, 2021
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6FI2
 | | VexL: A periplasmic depolymerase provides new insight into ABC transporter-dependent secretion of bacterial capsular polysaccharides | | 分子名称: | 2-acetamido-2-deoxy-alpha-D-galactopyranuronic acid-(1-4)-3-O-acetyl-2-acetamido-2-deoxy-alpha-D-galactopyranuronic acid-(1-4)-3-O-acetyl-2-acetamido-2-deoxy-alpha-D-galactopyranuronic acid, MALONATE ION, VexL | | 著者 | Naismith, J.H, McMahon, S.A, Le Bas, A, Liston, S.D, Whitfield, C. | | 登録日 | 2018-01-16 | | 公開日 | 2018-05-02 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.22 Å) | | 主引用文献 | Periplasmic depolymerase provides insight into ABC transporter-dependent secretion of bacterial capsular polysaccharides.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6ZHD
 | | H11-H4 bound to Spike | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody H11-H4, ... | | 著者 | Clare, D.K, Naismith, J.H, Weckener, M, Vogirala, V.K. | | 登録日 | 2020-06-22 | | 公開日 | 2020-07-29 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | H11-H4 bound to Spike
To Be Published
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6ZH9
 | | Ternary complex CR3022 H11-H4 and RBD (SARS-CoV-2) | | 分子名称: | CR3022 Light chain, CR3022 heavy, Nanobody H11-H4, ... | | 著者 | Naismith, J.H, Mikolajek, H, Le Bas, A. | | 登録日 | 2020-06-21 | | 公開日 | 2020-09-02 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (3.31 Å) | | 主引用文献 | Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2.
Nat.Struct.Mol.Biol., 27, 2020
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