2RGD
 
 | | Crystal structure of H-RasQ61L-GppNHp | | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Buhrman, G, Wink, G, Mattos, C. | | 登録日 | 2007-10-03 | | 公開日 | 2007-12-18 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Transformation Efficiency of RasQ61 Mutants Linked to Structural Features of the Switch Regions in the Presence of Raf.
Structure, 15, 2007
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6DZH
 | | HRAS G13D bound to GDP (H13GDP) | | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CALCIUM ION, GLYCEROL, ... | | 著者 | Johnson, C.W, Mattos, C. | | 登録日 | 2018-07-04 | | 公開日 | 2019-07-10 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D.
Cell Rep, 28, 2019
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6E6F
 | | KRAS G13D bound to GppNHp (K13GNP) | | 分子名称: | GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | | 著者 | Johnson, C.W, Mattos, C. | | 登録日 | 2018-07-24 | | 公開日 | 2019-07-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3.401 Å) | | 主引用文献 | Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D.
Cell Rep, 28, 2019
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6E6G
 | | KRAS G13D bound to GDP (K13GDP) | | 分子名称: | CALCIUM ION, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Johnson, C.W, Mattos, C. | | 登録日 | 2018-07-24 | | 公開日 | 2019-07-31 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D.
Cell Rep, 28, 2019
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4RSG
 | | Neutron crystal structure of Ras bound to the GTP analogue GppNHp | | 分子名称: | GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | | 著者 | Knihtila, R.R, Holzapfel, G, Weiss, K.L, Meilleur, F, Mattos, C. | | 登録日 | 2014-11-07 | | 公開日 | 2015-11-04 | | 最終更新日 | 2024-02-28 | | 実験手法 | NEUTRON DIFFRACTION (1.907 Å) | | 主引用文献 | Neutron Crystal Structure of RAS GTPase Puts in Question the Protonation State of the GTP gamma-Phosphate.
J.Biol.Chem., 290, 2015
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4XVR
 | | H-Ras Y137F | | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Johnson, C.W, Mattos, C. | | 登録日 | 2015-01-27 | | 公開日 | 2015-06-17 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.031 Å) | | 主引用文献 | Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding.
Faseb J., 29, 2015
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8EM0
 | | HRAS R97V Crystal Form 1 | | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Johnson, C.W, Mattos, C. | | 登録日 | 2022-09-26 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.109 Å) | | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras.
Protein Sci., 32, 2023
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8ELT
 | | HRAS R97G Crystal Form 2 | | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Johnson, C.W, Mattos, C. | | 登録日 | 2022-09-26 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras.
Protein Sci., 32, 2023
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3V4F
 | | H-Ras PEG 400/CaCl2, ordered off | | 分子名称: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, CALCIUM ION, GTPase HRas, ... | | 著者 | Holzapfel, G, Mattos, C. | | 登録日 | 2011-12-14 | | 公開日 | 2012-08-08 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.391 Å) | | 主引用文献 | Shift in the Equilibrium between On and Off States of the Allosteric Switch in Ras-GppNHp Affected by Small Molecules and Bulk Solvent Composition.
Biochemistry, 51, 2012
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2P1H
 | | Rapid Folding and Unfolding of Apaf-1 CARD | | 分子名称: | Apoptotic protease-activating factor 1, ZINC ION | | 著者 | Milam, S.L, Nicely, N.I, Feeney, B, Mattos, C, Clark, A.C. | | 登録日 | 2007-03-05 | | 公開日 | 2007-05-15 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | Rapid Folding and Unfolding of Apaf-1 CARD.
J.Mol.Biol., 369, 2007
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4G3X
 | | Crystal Structure of Q61L H-Ras-GppNHp bound to the RBD of Raf Kinase | | 分子名称: | GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | 著者 | Fetics, S.K, Kearney, B.M, Buhrman, G, Mattos, C. | | 登録日 | 2012-07-15 | | 公開日 | 2013-07-17 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Allosteric Effects of the Oncogenic RasQ61L Mutant on Raf-RBD.
Structure, 23, 2015
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4G0N
 | | Crystal Structure of wt H-Ras-GppNHp bound to the RBD of Raf Kinase | | 分子名称: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, ACETATE ION, CALCIUM ION, ... | | 著者 | Fetics, S.K, Kearney, B.M, Buhrman, G, Mattos, C. | | 登録日 | 2012-07-09 | | 公開日 | 2013-07-17 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Allosteric Effects of the Oncogenic RasQ61L Mutant on Raf-RBD.
Structure, 23, 2015
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3ITN
 | | Crystal structure of Pseudo-activated Procaspase-3 | | 分子名称: | ACETYL-ASP-GLU-VAL-ASP-CHLOROMETHYL KETONE inhibitor, Caspase-3 | | 著者 | Walters, J, Pop, C, Scott, F.L, Drag, M, Swartz, P.D, Mattos, C, Salvesen, G.S, Clark, A.C. | | 登録日 | 2009-08-28 | | 公開日 | 2010-03-02 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | | 主引用文献 | A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis.
Biochem.J., 424, 2009
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6E6P
 | | HRAS G13D bound to GppNHp (Ha,b,c13GNP) | | 分子名称: | CALCIUM ION, GLYCEROL, GTPase HRas, ... | | 著者 | Johnson, C.W, Mattos, C. | | 登録日 | 2018-07-25 | | 公開日 | 2019-07-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D.
Cell Rep, 28, 2019
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6E6C
 | | HRAS G13D bound to GppNHp (H13GNP) | | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Johnson, C.W, Mattos, C. | | 登録日 | 2018-07-24 | | 公開日 | 2019-07-31 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D.
Cell Rep, 28, 2019
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6E6H
 | | NRAS G13D bound to GppNHp (N13GNP) | | 分子名称: | GTPase NRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | | 著者 | Johnson, C.W, Mattos, C. | | 登録日 | 2018-07-24 | | 公開日 | 2019-07-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D.
Cell Rep, 28, 2019
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5UHV
 | | wild-type NRas bound to GppNHp | | 分子名称: | GLYCEROL, GTPase NRas, MAGNESIUM ION, ... | | 著者 | Reid, D, Johnson, C, Salter, S, Mattos, C. | | 登録日 | 2017-01-12 | | 公開日 | 2017-06-28 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.672 Å) | | 主引用文献 | The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects.
J. Biol. Chem., 292, 2017
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1U8Y
 | | CRystal structures of Ral-GppNHp and Ral-GDP reveal two novel binding sites that are also present in Ras and Rap | | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Ral-A | | 著者 | Nicely, N.I, Kosak, J, de Serrano, V, Mattos, C. | | 登録日 | 2004-08-09 | | 公開日 | 2004-11-23 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Crystal Structures of Ral-GppNHp and Ral-GDP Reveal Two Binding Sites that Are Also Present in Ras and Rap
Structure, 12, 2004
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1U8Z
 | | Crystal structures of Ral-GppNHp and Ral-GDP reveal two novel binding sites that are also present in Ras and Rap | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Ral-A | | 著者 | Nicely, N.I, Kosak, J, de Serrano, V, Mattos, C. | | 登録日 | 2004-08-09 | | 公開日 | 2004-11-23 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Crystal Structures of Ral-GppNHp and Ral-GDP Reveal Two Binding Sites that Are Also Present in Ras and Rap
Structure, 12, 2004
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1U90
 | | Crystal structures of Ral-GppNHp and Ral-GDP reveal two novel binding sites that are also present in Ras and Rap | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Ral-A | | 著者 | Nicely, N.I, Kosak, J, de Serrano, V, Mattos, C. | | 登録日 | 2004-08-09 | | 公開日 | 2004-11-23 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structures of Ral-GppNHp and Ral-GDP Reveal Two Binding Sites that Are Also Present in Ras and Rap
Structure, 12, 2004
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8FG3
 | | HRAS R97L Crystal Form 2 | | 分子名称: | GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | | 著者 | Fetics, S, Johnson, C.W, Mattos, C. | | 登録日 | 2022-12-12 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras.
Protein Sci., 32, 2023
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8FG4
 | | HRAS R97L Crystal Form 1 | | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Fetics, S, Johnson, C.W, Mattos, C. | | 登録日 | 2022-12-12 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras.
Protein Sci., 32, 2023
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8ELY
 | | HRAS R97M Crystal Form 2 | | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Johnson, C.W, Mattos, C. | | 登録日 | 2022-09-26 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras.
Protein Sci., 32, 2023
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8ELV
 | | HRAS R97I Crystal Form 2 | | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Johnson, C.W, Mattos, C. | | 登録日 | 2022-09-26 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.153 Å) | | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras.
Protein Sci., 32, 2023
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8ELS
 | | HRAS R97A Crystal Form 1 R-state | | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Davis, D, Johnson, C.W, Mattos, C. | | 登録日 | 2022-09-26 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.267 Å) | | 主引用文献 | Allosteric site variants affect GTP hydrolysis on Ras.
Protein Sci., 32, 2023
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