6W6Z
 
 | | BlsA ground state | | 分子名称: | BLUF domain-containing protein, FLAVIN MONONUCLEOTIDE | | 著者 | Chitrakar, I, French, J.B. | | 登録日 | 2020-03-18 | | 公開日 | 2020-10-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | Structural Basis for the Regulation of Biofilm Formation and Iron Uptake in A. baumannii by the Blue-Light-Using Photoreceptor, BlsA.
Acs Infect Dis., 6, 2020
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6W72
 | | BlsA photo-activated state | | 分子名称: | BLUF domain-containing protein, FLAVIN MONONUCLEOTIDE | | 著者 | Chitrakar, I, French, J.B. | | 登録日 | 2020-03-18 | | 公開日 | 2020-10-07 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Structural Basis for the Regulation of Biofilm Formation and Iron Uptake in A. baumannii by the Blue-Light-Using Photoreceptor, BlsA.
Acs Infect Dis., 6, 2020
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7LBA
 | | E. coli Agmatinase | | 分子名称: | Agmatinase, MANGANESE (II) ION | | 著者 | Chitrakar, I, Ahmed, S.F, Torelli, A.T, French, J.B. | | 登録日 | 2021-01-07 | | 公開日 | 2021-03-31 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure of the E. coli agmatinase, SPEB.
Plos One, 16, 2021
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8U7E
 | | Structure of Sts-1 HP domain with rebamipide derivative | | 分子名称: | N-(4-ethylbenzoyl)-3-(2-oxo-1,2-dihydroquinolin-4-yl)-L-alanine, Ubiquitin-associated and SH3 domain-containing protein B | | 著者 | Aziz, F, Dey, R, French, J.B. | | 登録日 | 2023-09-15 | | 公開日 | 2024-02-07 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | | 主引用文献 | Rebamipide and Derivatives are Potent, Selective Inhibitors of Histidine Phosphatase Activity of the Suppressor of T Cell Receptor Signaling Proteins.
J.Med.Chem., 67, 2024
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8U5M
 | | Structure of Sts-1 HP domain with rebamipide | | 分子名称: | Rebamipide, Ubiquitin-associated and SH3 domain-containing protein B | | 著者 | Azia, F, Dey, R, French, J.B. | | 登録日 | 2023-09-12 | | 公開日 | 2024-02-07 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | Rebamipide and Derivatives are Potent, Selective Inhibitors of Histidine Phosphatase Activity of the Suppressor of T Cell Receptor Signaling Proteins.
J.Med.Chem., 67, 2024
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4P66
 | | Electrostatics of Active Site Microenvironments of E. coli DHFR | | 分子名称: | CALCIUM ION, Dihydrofolate reductase, METHOTREXATE, ... | | 著者 | Liu, C.T, Layfield, J.P, Stewart III, R.J, French, J.B, Hanoian, P, Asbury, J.B, Hammes-Schiffer, S, Benkovic, S.J. | | 登録日 | 2014-03-21 | | 公開日 | 2014-07-16 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Probing the electrostatics of active site microenvironments along the catalytic cycle for Escherichia coli dihydrofolate reductase.
J.Am.Chem.Soc., 136, 2014
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4P68
 | | Electrostatics of Active Site Microenvironments for E. coli DHFR | | 分子名称: | ACETATE ION, CALCIUM ION, Dihydrofolate reductase, ... | | 著者 | Liu, C.T, Layfield, J.P, Stewart III, R.J, French, J.B, Hanoian, P, Asbury, J.B, Hammes-Schiffer, S, Benkovic, S.J. | | 登録日 | 2014-03-22 | | 公開日 | 2014-07-16 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Probing the electrostatics of active site microenvironments along the catalytic cycle for Escherichia coli dihydrofolate reductase.
J.Am.Chem.Soc., 136, 2014
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6NJ0
 | | Wild-type E. coli MenE with bound m phenylether-linked analogue of OSB-AMS | | 分子名称: | 2-succinylbenzoate--CoA ligase, 5'-O-{3-[3-(2-carboxyphenyl)-3-oxopropyl]phenyl}adenosine | | 著者 | Si, Y, Yin, Y, French, J.B, Tonge, P.J. | | 登録日 | 2019-01-02 | | 公開日 | 2019-04-10 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Structure-Based Design, Synthesis, and Biological Evaluation of Non-Acyl Sulfamate Inhibitors of the Adenylate-Forming Enzyme MenE.
Biochemistry, 58, 2019
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6OH9
 | | Yeast Guanine Deaminase | | 分子名称: | NONAETHYLENE GLYCOL, SULFATE ION, Yeast Guanine Deaminase, ... | | 著者 | Shek, R.S, French, J.B. | | 登録日 | 2019-04-05 | | 公開日 | 2019-07-24 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural Determinants for Substrate Selectivity in Guanine Deaminase Enzymes of the Amidohydrolase Superfamily.
Biochemistry, 58, 2019
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6OHC
 | | E. coli Guanine Deaminase | | 分子名称: | GLYCEROL, Guanine deaminase, ZINC ION | | 著者 | Shek, R.S, French, J.B. | | 登録日 | 2019-04-05 | | 公開日 | 2019-07-24 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural Determinants for Substrate Selectivity in Guanine Deaminase Enzymes of the Amidohydrolase Superfamily.
Biochemistry, 58, 2019
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5VR6
 | | Structure of Human Sts-1 histidine phosphatase domain with sulfate bound | | 分子名称: | SULFATE ION, Ubiquitin-associated and SH3 domain-containing protein B | | 著者 | Zhou, W, Yin, Y, Weinheimer, A.W, Kaur, N, Carpino, N, French, J.B. | | 登録日 | 2017-05-10 | | 公開日 | 2017-08-16 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Structural and Functional Characterization of the Histidine Phosphatase Domains of Human Sts-1 and Sts-2.
Biochemistry, 56, 2017
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5W5G
 | | Structure of Human Sts-1 histidine phosphatase domain | | 分子名称: | Ubiquitin-associated and SH3 domain-containing protein B | | 著者 | Zhou, W, Yin, Y, Weinheimer, A.W, Kaur, N, Carpino, N, French, J.B. | | 登録日 | 2017-06-15 | | 公開日 | 2017-08-16 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Structural and Functional Characterization of the Histidine Phosphatase Domains of Human Sts-1 and Sts-2.
Biochemistry, 56, 2017
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5WDI
 | | Structure of Human Sts-2 histidine phosphatase domain | | 分子名称: | SULFATE ION, Ubiquitin-associated and SH3 domain-containing protein A | | 著者 | Zhou, W, Yin, Y, Weinheimer, A.W, Kaur, N, Carpino, N, French, J.B. | | 登録日 | 2017-07-05 | | 公開日 | 2017-08-16 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | | 主引用文献 | Structural and Functional Characterization of the Histidine Phosphatase Domains of Human Sts-1 and Sts-2.
Biochemistry, 56, 2017
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6B2W
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6B10
 | | C. Jejuni Agmatine Deiminase | | 分子名称: | PHOSPHATE ION, POTASSIUM ION, Putative peptidyl-arginine deiminase family protein | | 著者 | Shek, R, Hicks, K.A, French, J.B. | | 登録日 | 2017-09-15 | | 公開日 | 2017-12-13 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Structural and Functional Basis for Targeting Campylobacter jejuni Agmatine Deiminase To Overcome Antibiotic Resistance.
Biochemistry, 56, 2017
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6OHB
 | | E. coli Guanine Deaminase | | 分子名称: | Guanine deaminase, ZINC ION | | 著者 | Shek, R.S, French, J.B. | | 登録日 | 2019-04-05 | | 公開日 | 2019-07-24 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural Determinants for Substrate Selectivity in Guanine Deaminase Enzymes of the Amidohydrolase Superfamily.
Biochemistry, 58, 2019
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6OHA
 | | Yeast Guanine Deaminase | | 分子名称: | PENTAETHYLENE GLYCOL, Probable guanine deaminase, SULFATE ION, ... | | 著者 | Shek, R.S, French, J.B. | | 登録日 | 2019-04-05 | | 公開日 | 2019-07-24 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Structural Determinants for Substrate Selectivity in Guanine Deaminase Enzymes of the Amidohydrolase Superfamily.
Biochemistry, 58, 2019
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5C5H
 | | R195K E. coli MenE with bound OSB-AMS | | 分子名称: | 2-succinylbenzoate--CoA ligase, 5'-O-{[4-(2-carboxyphenyl)-4-oxobutanoyl]sulfamoyl}adenosine, MAGNESIUM ION | | 著者 | Matarlo, J.S, Shek, R, Rajashankar, K.R, Tonge, P.J, French, J.B. | | 登録日 | 2015-06-19 | | 公開日 | 2015-10-07 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | | 主引用文献 | Mechanism of MenE Inhibition by Acyl-Adenylate Analogues and Discovery of Novel Antibacterial Agents.
Biochemistry, 54, 2015
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4GRD
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4YL5
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4YWR
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6O55
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8EEB
 | | Cryo-EM structure of human ABCA7 in Digitonin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Phospholipid-transporting ATPase ABCA7, ... | | 著者 | Alam, A, Le, L.T.M, Thompson, J.R. | | 登録日 | 2022-09-06 | | 公開日 | 2022-12-21 | | 最終更新日 | 2023-02-15 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Cryo-EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms.
Embo J., 42, 2023
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8EE6
 | | Cryo-EM Structure of human ABCA7 in PE/Ch nanodiscs | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Phospholipid-transporting ATPase ABCA7, ... | | 著者 | Alam, A, Le, L.T.M, Thompson, J.R. | | 登録日 | 2022-09-06 | | 公開日 | 2022-12-21 | | 最終更新日 | 2023-02-15 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Cryo-EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms.
Embo J., 42, 2023
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8EDW
 | | Cryo-EM Structure of human ABCA7 in BPL/Ch Nanodiscs | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | 著者 | Alam, A, Le, L.T.M, Thompson, J.R. | | 登録日 | 2022-09-06 | | 公開日 | 2022-12-21 | | 最終更新日 | 2023-02-15 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Cryo-EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms.
Embo J., 42, 2023
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