8U7E

Structure of Sts-1 HP domain with rebamipide derivative

Summary for 8U7E

Entry DOI	10.2210/pdb8u7e/pdb
Related	8U5M
Descriptor	Ubiquitin-associated and SH3 domain-containing protein B, N-(4-ethylbenzoyl)-3-(2-oxo-1,2-dihydroquinolin-4-yl)-L-alanine (3 entities in total)
Functional Keywords	sts-1, histidine phosphatase, inhibitor, ubash3b, tula-2, hydrolase-hydrolase inhibitor complex, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	6
Total formula weight	193679.68
Authors	Aziz, F.,Dey, R.,French, J.B. (deposition date: 2023-09-15, release date: 2024-02-07, Last modification date: 2024-02-21)
Primary citation	Aziz, F.,Reddy, K.,Fernandez Vega, V.,Dey, R.,Hicks, K.A.,Rao, S.,Jordan, L.O.,Smith, E.,Shumate, J.,Scampavia, L.,Carpino, N.,Spicer, T.P.,French, J.B. Rebamipide and Derivatives are Potent, Selective Inhibitors of Histidine Phosphatase Activity of the Suppressor of T Cell Receptor Signaling Proteins. J.Med.Chem., 67:1949-1960, 2024 Cited by PubMed: 38252624 DOI: 10.1021/acs.jmedchem.3c01763 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.63 Å)

Structure validation