7DNH
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![BU of 7dnh by Molmil](/molmil-images/mine/7dnh) | 2-fold subparticles refinement of human papillomavirus type 58 pseudovirus in complexed with the Fab fragment of 2H3 | 分子名称: | Major capsid protein L1, The heavy chain of 2H3 Fab fragment, The light chain of 2H3 Fab fragment | 著者 | He, M.Z, Chi, X, Zha, Z.H, Zheng, Q.B, Gu, Y, Li, S.W, Xia, N.S. | 登録日 | 2020-12-09 | 公開日 | 2020-12-30 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | 主引用文献 | Structural basis for the shared neutralization mechanism of three classes of human papillomavirus type 58 antibodies with disparate modes of binding. J.Virol., 95, 2021
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6X2J
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![BU of 6x2j by Molmil](/molmil-images/mine/6x2j) | Structure of human TRPA1 in complex with agonist GNE551 | 分子名称: | 5-amino-1-[(4-bromo-2-fluorophenyl)methyl]-N-(2,5-dimethoxyphenyl)-1H-1,2,3-triazole-4-carboxamide, Transient receptor potential cation channel subfamily A member 1 | 著者 | Rohou, A, Rouge, L, Chen, H. | 登録日 | 2020-05-20 | 公開日 | 2020-11-18 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel. Neuron, 109, 2021
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7DNK
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![BU of 7dnk by Molmil](/molmil-images/mine/7dnk) | 2-fold subparticles refinement of human papillomavirus type 58 pseudovirus in complexed with the Fab fragment of 5G9 | 分子名称: | Major capsid protein L1, The heavy chain of 5G9 Fab fragment, The light chain of 5G9 Fab fragment | 著者 | He, M.Z, Chi, X, Zha, Z.H, Zheng, Q.B, Gu, Y, Li, S.W, Xia, N.S. | 登録日 | 2020-12-09 | 公開日 | 2020-12-30 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (6.41 Å) | 主引用文献 | Structural basis for the shared neutralization mechanism of three classes of human papillomavirus type 58 antibodies with disparate modes of binding. J.Virol., 95, 2021
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7DNL
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![BU of 7dnl by Molmil](/molmil-images/mine/7dnl) | 2-fold subparticles refinement of human papillomavirus type 58 pseudovirus in complexed with the Fab fragment of A4B4 | 分子名称: | Major capsid protein L1, The heavy chain of 2H3 Fab fragment, The light chain of A4B4 Fab fragment | 著者 | He, M.Z, Chi, X, Zha, Z.H, Zheng, Q.B, Gu, Y, Li, S.W, Xia, N.S. | 登録日 | 2020-12-09 | 公開日 | 2020-12-30 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (4.19 Å) | 主引用文献 | Structural basis for the shared neutralization mechanism of three classes of human papillomavirus type 58 antibodies with disparate modes of binding. J.Virol., 95, 2021
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8JEL
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![BU of 8jel by Molmil](/molmil-images/mine/8jel) | Crystal structure of TIGIT in complexed with Ociperlimab, crystal form I | 分子名称: | T-cell immunoreceptor with Ig and ITIM domains, antibody heavy chain, antibody light chain | 著者 | Sun, J, Zhang, X.X, Song, J. | 登録日 | 2023-05-16 | 公開日 | 2024-02-28 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab. Structure, 32, 2024
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8JEQ
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![BU of 8jeq by Molmil](/molmil-images/mine/8jeq) | Crystal structure of Tiragolumab | 分子名称: | antibody heavy chain, antibody light chain | 著者 | Sun, J, Zhang, X.X, Song, J. | 登録日 | 2023-05-16 | 公開日 | 2024-02-28 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab. Structure, 32, 2024
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8JEP
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![BU of 8jep by Molmil](/molmil-images/mine/8jep) | Crystal structure of Ociperlimab | 分子名称: | antibody heavy chain, antibody light chain | 著者 | Sun, J, Zhang, X.X, Song, J. | 登録日 | 2023-05-16 | 公開日 | 2024-02-28 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab. Structure, 32, 2024
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8JEO
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![BU of 8jeo by Molmil](/molmil-images/mine/8jeo) | |
8JEN
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![BU of 8jen by Molmil](/molmil-images/mine/8jen) | Crystal structure of TIGIT in complexed with Ociperlimab, crystal form II | 分子名称: | T-cell immunoreceptor with Ig and ITIM domains, antibody heavy chain, antibody light chain | 著者 | Sun, J, Zhang, X.X, Song, J. | 登録日 | 2023-05-16 | 公開日 | 2024-02-28 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab. Structure, 32, 2024
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7CM3
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![BU of 7cm3 by Molmil](/molmil-images/mine/7cm3) | Cryo-EM structure of human NALCN in complex with FAM155A | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wu, J, Yan, Z, Ke, M. | 登録日 | 2020-07-24 | 公開日 | 2020-11-11 | 最終更新日 | 2020-12-02 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of the human sodium leak channel NALCN in complex with FAM155A. Nat Commun, 11, 2020
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8J5U
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![BU of 8j5u by Molmil](/molmil-images/mine/8j5u) | Crystal structure of Mycobacterium tuberculosis OppA complexed with an endogenous oligopeptide | 分子名称: | Endogenous oligopeptide, Uncharacterized protein Rv1280c | 著者 | Yang, X, Hu, T, Zhang, B, Rao, Z. | 登録日 | 2023-04-24 | 公開日 | 2024-04-03 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | An oligopeptide permease, OppABCD, requires an iron-sulfur cluster domain for functionality. Nat.Struct.Mol.Biol., 2024
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8J5S
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![BU of 8j5s by Molmil](/molmil-images/mine/8j5s) | Cryo-EM structure of Mycobacterium tuberculosis OppABCD in the pre-catalytic intermediate state | 分子名称: | Endogenous oligopeptide, IRON/SULFUR CLUSTER, MAGNESIUM ION, ... | 著者 | Yang, X, Hu, T, Zhang, B, Rao, Z. | 登録日 | 2023-04-24 | 公開日 | 2024-04-03 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | An oligopeptide permease, OppABCD, requires an iron-sulfur cluster domain for functionality. Nat.Struct.Mol.Biol., 2024
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8J5R
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![BU of 8j5r by Molmil](/molmil-images/mine/8j5r) | Cryo-EM structure of Mycobacterium tuberculosis OppABCD in the resting state | 分子名称: | IRON/SULFUR CLUSTER, Putative peptide transport permease protein Rv1282c, Putative peptide transport permease protein Rv1283c, ... | 著者 | Yang, X, Hu, T, Zhang, B, Rao, Z. | 登録日 | 2023-04-24 | 公開日 | 2024-04-03 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | 主引用文献 | An oligopeptide permease, OppABCD, requires an iron-sulfur cluster domain for functionality. Nat.Struct.Mol.Biol., 2024
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8J5T
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![BU of 8j5t by Molmil](/molmil-images/mine/8j5t) | Cryo-EM structure of Mycobacterium tuberculosis OppABCD in the catalytic intermediate state | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, IRON/SULFUR CLUSTER, MAGNESIUM ION, ... | 著者 | Yang, X, Hu, T, Zhang, B, Rao, Z. | 登録日 | 2023-04-24 | 公開日 | 2024-04-03 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | An oligopeptide permease, OppABCD, requires an iron-sulfur cluster domain for functionality. Nat.Struct.Mol.Biol., 2024
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8J5Q
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![BU of 8j5q by Molmil](/molmil-images/mine/8j5q) | Cryo-EM structure of Mycobacterium tuberculosis OppABCD in the pre-translocation state | 分子名称: | Endogenous oligopeptide, IRON/SULFUR CLUSTER, Putative peptide transport permease protein Rv1282c, ... | 著者 | Yang, X, Hu, T, Zhang, B, Rao, Z. | 登録日 | 2023-04-24 | 公開日 | 2024-04-03 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | An oligopeptide permease, OppABCD, requires an iron-sulfur cluster domain for functionality. Nat.Struct.Mol.Biol., 2024
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7XP6
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![BU of 7xp6 by Molmil](/molmil-images/mine/7xp6) | Cryo-EM structure of a class T GPCR in active state | 分子名称: | Endoglucanase H,Taste receptor type 2 member 46,Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, Z.J, Hua, T, Xu, W.X, Wu, L.J. | 登録日 | 2022-05-03 | 公開日 | 2022-10-12 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Structural basis for strychnine activation of human bitter taste receptor TAS2R46. Science, 377, 2022
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7XP4
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![BU of 7xp4 by Molmil](/molmil-images/mine/7xp4) | Cryo-EM structure of a class T GPCR in apo state | 分子名称: | Endoglucanase H,Taste receptor type 2 member 46,Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, Z.J, Hua, T, Xu, W.X, Wu, L.J. | 登録日 | 2022-05-03 | 公開日 | 2022-10-12 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Structural basis for strychnine activation of human bitter taste receptor TAS2R46. Science, 377, 2022
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7XP5
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![BU of 7xp5 by Molmil](/molmil-images/mine/7xp5) | Cryo-EM structure of a class T GPCR in ligand-free state | 分子名称: | Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, Z.J, Hua, T, Xu, W.X, Wu, L.J. | 登録日 | 2022-05-03 | 公開日 | 2022-10-12 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Structural basis for strychnine activation of human bitter taste receptor TAS2R46. Science, 377, 2022
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7X81
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![BU of 7x81 by Molmil](/molmil-images/mine/7x81) | The crystal structure of PloI4-C16M/D46A/I137V in complex with exo-2+2 adduct | 分子名称: | (4S,4aS,6aR,8R,9R,11E,12aR,14aS,17E,18aR,18bR)-9-ethyl-4,8,19-trihydroxy-11,12a,13,18a-tetramethyl-2,3,4,4a,6a,7,8,9,10,12a,13,14,18a,18b-tetradecahydro-14a,17-(metheno)cyclobuta[b]naphtho[2,1-j][1]azacyclotetradecine-16,18(1H,15H)-dione, PloI4 | 著者 | Li, M, Pan, L.F. | 登録日 | 2022-03-10 | 公開日 | 2023-02-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.104 Å) | 主引用文献 | A cyclase that catalyses competing 2 + 2 and 4 + 2 cycloadditions. Nat.Chem., 15, 2023
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7X80
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![BU of 7x80 by Molmil](/molmil-images/mine/7x80) | |
7X7Z
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![BU of 7x7z by Molmil](/molmil-images/mine/7x7z) | |
7X86
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![BU of 7x86 by Molmil](/molmil-images/mine/7x86) | The crystal structure of PloI4-F124L in complex with endo-4+2 adduct | 分子名称: | (4S,4aS,6aR,8R,9R,10aS,13S,14aS,18aR,18bR,E)-9-ethyl-4,8,19-trihydroxy-10a,12,13,18a-tetramethyl-2,3,4,4a,6a,7,8,9,10,10a,13,14,18a,18b-tetradecahydro-14a,17-(metheno)benzo[b]naphtho[2,1-h][1]azacyclododecine-16,18(1H,15H)-dione, PloI4 | 著者 | Li, M, Pan, L.F. | 登録日 | 2022-03-11 | 公開日 | 2023-02-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.303 Å) | 主引用文献 | A cyclase that catalyses competing 2 + 2 and 4 + 2 cycloadditions. Nat.Chem., 15, 2023
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3TJC
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![BU of 3tjc by Molmil](/molmil-images/mine/3tjc) | Co-crystal structure of jak2 with thienopyridine 8 | 分子名称: | 4-amino-N-methyl-2-[4-(morpholin-4-yl)phenyl]thieno[3,2-c]pyridine-7-carboxamide, Tyrosine-protein kinase JAK2 | 著者 | Huang, X. | 登録日 | 2011-08-24 | 公開日 | 2011-11-30 | 最終更新日 | 2011-12-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Discovery of potent and highly selective thienopyridine janus kinase 2 inhibitors. J.Med.Chem., 54, 2011
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5XFN
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![BU of 5xfn by Molmil](/molmil-images/mine/5xfn) | |
3R4P
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![BU of 3r4p by Molmil](/molmil-images/mine/3r4p) | Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide | 分子名称: | 2-amino-4-{2,4-dichloro-6-[2-(1H-pyrazol-1-yl)ethoxy]phenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide, Heat shock protein HSP 90-alpha, PHOSPHATE ION | 著者 | Gajiwala, K.S. | 登録日 | 2011-03-17 | 公開日 | 2011-04-27 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide. J.Med.Chem., 54, 2011
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