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7MFB
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Crystal structure of antibody 10E8v4 Fab - light chain H31F variant
分子名称: Antibody 10E8v4 Fab heavy chain, Antibody 10E8v4 Fab light chain
著者Kwon, Y.D, Kwong, P.D.
登録日2021-04-08
公開日2021-07-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Structures of HIV-1 Neutralizing Antibody 10E8 Delineate the Mechanistic Basis of Its Multi-Peak Behavior on Size-Exclusion Chromatography.
Antibodies, 10, 2021
7MFA
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Crystal structure of antibody 10E8v4-P100fA+P100gA Fab
分子名称: Antibody 10E8v4 Fab heavy chain, Antibody 10E8v4 Fab light chain
著者Kwon, Y.D, Kwong, P.D.
登録日2021-04-08
公開日2021-07-14
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structures of HIV-1 Neutralizing Antibody 10E8 Delineate the Mechanistic Basis of Its Multi-Peak Behavior on Size-Exclusion Chromatography.
Antibodies, 10, 2021
7MF8
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Crystal structure of antibody 10E8v4-P100fA Fab in space group P6422
分子名称: Antibody 10E8v4 Fab heavy chain, Antibody 10E8v4 Fab light chain
著者Kwon, Y.D, Kwong, P.D.
登録日2021-04-08
公開日2021-07-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structures of HIV-1 Neutralizing Antibody 10E8 Delineate the Mechanistic Basis of Its Multi-Peak Behavior on Size-Exclusion Chromatography.
Antibodies, 10, 2021
7MF7
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Crystal structure of antibody 10E8v4-P100gA Fab
分子名称: Antibody 10E8v4 Fab heavy chain, Antibody 10E8v4 Fab light chain
著者Kwon, Y.D, Kwong, P.D.
登録日2021-04-08
公開日2021-07-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structures of HIV-1 Neutralizing Antibody 10E8 Delineate the Mechanistic Basis of Its Multi-Peak Behavior on Size-Exclusion Chromatography.
Antibodies, 10, 2021
7MF9
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Crystal structure of antibody 10E8v4-P100fA Fab in space group C2
分子名称: Antibody 10E8v4 Fab heavy chain, Antibody 10E8v4 Fab light chain
著者Kwon, Y.D, Kwong, P.D.
登録日2021-04-08
公開日2021-07-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献Structures of HIV-1 Neutralizing Antibody 10E8 Delineate the Mechanistic Basis of Its Multi-Peak Behavior on Size-Exclusion Chromatography.
Antibodies, 10, 2021
7LSQ
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BU of 7lsq by Molmil
The Crystal Structure of Q108K:K40E:T53A:R58W:Q38F:Q4F:Y19W Mutant of HCRBPII Bound with LizFluor Chromophore Showing Excited State Intermolecular Proton Transfer
分子名称: 4-{5-[(2E)-but-2-en-2-yl]thiophen-2-yl}-N,N-dimethylaniline, ACETATE ION, Retinol-binding protein 2
著者Ghanbarpour, A, Geiger, J.
登録日2021-02-18
公開日2022-01-12
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.67130542 Å)
主引用文献Design of Large Stokes Shift Fluorescent Proteins Based on Excited State Proton Transfer of an Engineered Photobase.
J.Am.Chem.Soc., 143, 2021
5J2N
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BU of 5j2n by Molmil
HIV-1 reverse transcriptase in complex with DNA that has incorporated EFdA-MP at the P-(post-translocation) site and dTMP at the N-(pre-translocation) site
分子名称: DNA (27-MER), DNA 5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*G)-3', MAGNESIUM ION, ...
著者Salie, Z.L, Kirby, K.A, Sarafianos, S.G.
登録日2016-03-29
公開日2016-08-03
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.896 Å)
主引用文献Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA).
Proc.Natl.Acad.Sci.USA, 113, 2016
5J2Q
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HIV-1 reverse transcriptase in complex with DNA that has incorporated a mismatched EFdA-MP at the N-(pre-translocation) site
分子名称: 2'-deoxy-4'-ethynyl-2-fluoroadenosine 5'-(dihydrogen phosphate), DNA (27-MER), DNA (5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(6FM)P*(6FM))-3'), ...
著者Salie, Z.L, Kirby, K.A, Sarafianos, S.G.
登録日2016-03-29
公開日2016-08-03
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.789 Å)
主引用文献Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA).
Proc.Natl.Acad.Sci.USA, 113, 2016
5WEV
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Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model
分子名称: N-[2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide, Tyrosine-protein kinase JAK2
著者Ultsch, M.H, Magnuson, S.
登録日2017-07-10
公開日2017-09-06
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.854 Å)
主引用文献Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.
Bioorg. Med. Chem. Lett., 27, 2017
6EE0
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BU of 6ee0 by Molmil
Crystal Structure of SNX23 PX domain
分子名称: Kinesin-like protein KIF16B
著者Chandra, M, Collins, B.M.
登録日2018-08-12
公開日2018-08-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.518 Å)
主引用文献Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities.
Nat Commun, 10, 2019
6ECM
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BU of 6ecm by Molmil
Crystal Structure of SNX15 PX domain in domain swapped conformation
分子名称: SULFATE ION, Sorting nexin-15
著者Chandra, M, Collins, B.M.
登録日2018-08-08
公開日2018-08-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.353 Å)
主引用文献Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities.
Nat Commun, 10, 2019
7LUI
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Crystal structure of Vibrio cholerae DsbA in complex with bile salt taurocholate
分子名称: GLYCEROL, TAUROCHOLIC ACID, Thiol:disulfide interchange protein DsbA
著者Wang, G, Heras, B.
登録日2021-02-22
公開日2021-12-29
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Selective Binding of Small Molecules to Vibrio cholerae DsbA Offers a Starting Point for the Design of Novel Antibacterials.
Chemmedchem, 17, 2022
7LSM
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Crystal structure of E.coli DsbA in complex with bile salt taurocholate
分子名称: DI(HYDROXYETHYL)ETHER, TAUROCHOLIC ACID, Thiol:disulfide interchange protein DsbA
著者Wang, G, Heras, B.
登録日2021-02-18
公開日2021-12-29
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.786 Å)
主引用文献Selective Binding of Small Molecules to Vibrio cholerae DsbA Offers a Starting Point for the Design of Novel Antibacterials.
Chemmedchem, 17, 2022
7LUH
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BU of 7luh by Molmil
Burkholderia pseudomallei Disulfide bond forming protein A (DsbA) liganded with fragment bromophenoxy propanamide
分子名称: (2~{R})-2-(4-bromanylphenoxy)propanamide, Thiol:disulfide interchange protein
著者Petit, G.A, Martin, J.L, McMahon, R.M.
登録日2021-02-22
公開日2022-01-05
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Identification and characterization of two drug-like fragments that bind to the same cryptic binding pocket of Burkholderia pseudomallei DsbA.
Acta Crystallogr D Struct Biol, 78, 2022
7LUJ
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Burkholderia pseudomallei Disulfide bond forming protein A (DsbA) liganded with fragment 4-methoxy-N-phenylbenzenesulfonamide
分子名称: 4-methoxy-~{N}-phenyl-benzenesulfonamide, SULFATE ION, Thiol:disulfide interchange protein
著者Petit, G.A, Martin, J.L, McMahon, R.M.
登録日2021-02-22
公開日2022-01-05
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Identification and characterization of two drug-like fragments that bind to the same cryptic binding pocket of Burkholderia pseudomallei DsbA.
Acta Crystallogr D Struct Biol, 78, 2022
6E51
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Crystal structure of the apo domain-swapped dimer Q108K:K40L:T51W mutant of human cellular retinol binding protein II
分子名称: Retinol-binding protein 2
著者Ghanbarpour, A, Geiger, J.
登録日2018-07-19
公開日2019-10-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.256 Å)
主引用文献Engineering the hCRBPII Domain-Swapped Dimer into a New Class of Protein Switches.
J.Am.Chem.Soc., 141, 2019
6E50
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Crystal structure of the apo domain-swapped dimer Q108K:K40L:T51F mutant of human Cellular Retinol Binding Protein II
分子名称: ACETATE ION, Retinol-binding protein 2
著者Ghanbarpour, A, Geiger, J.
登録日2018-07-18
公開日2019-10-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.965 Å)
主引用文献Engineering the hCRBPII Domain-Swapped Dimer into a New Class of Protein Switches.
J.Am.Chem.Soc., 141, 2019
6E7M
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BU of 6e7m by Molmil
Crystal structure of the holo retinal-bound domain-swapped dimer Q108K:T51D:A28C mutant of human Cellular Retinol Binding Protein II
分子名称: ACETATE ION, GLYCEROL, RETINAL, ...
著者Ghanbarpour, A, Geiger, J.
登録日2018-07-26
公開日2019-10-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Engineering the hCRBPII Domain-Swapped Dimer into a New Class of Protein Switches.
J.Am.Chem.Soc., 141, 2019
6E5R
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BU of 6e5r by Molmil
Crystal structure of the apo domain-swapped dimer Q108K:T51D:A28C mutant of human Cellular Retinol Binding Protein II
分子名称: ACETATE ION, GLYCEROL, Retinol-binding protein 2
著者Ghanbarpour, A, Geiger, J.
登録日2018-07-22
公開日2019-08-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.592 Å)
主引用文献Engineering the hCRBPII Domain-Swapped Dimer into a New Class of Protein Switches.
J.Am.Chem.Soc., 141, 2019
5IVL
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CshA Helicase
分子名称: DEAD-box ATP-dependent RNA helicase CshA, SULFATE ION
著者Huen, J, Lin, C.-L, Yi, W.-L, Li, C.-L, Yuan, H.
登録日2016-03-21
公開日2017-03-22
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Insights into a Unique Dimeric DEAD-Box Helicase CshA that Promotes RNA Decay.
Structure, 25, 2017
6E5S
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BU of 6e5s by Molmil
Crystal structure of holo retinal-bound domain-swapped dimer Q108K:T51D mutant of human Cellular Retinol Binding Protein II
分子名称: RETINAL, Retinol-binding protein 2
著者Nosrati, M, Ghanbarpour, A, Geiger, J.
登録日2018-07-22
公開日2019-07-24
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.061 Å)
主引用文献Engineering the hCRBPII Domain-Swapped Dimer into a New Class of Protein Switches.
J.Am.Chem.Soc., 141, 2019
6E6L
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BU of 6e6l by Molmil
Crystal structure of the holo retinal-bound domain-swapped dimer Q108K:K40L:T51F:Y60A mutant of human cellular retinol binding protein II
分子名称: ACETATE ION, RETINAL, Retinol-binding protein 2
著者Ghanbarpour, A, Geiger, J.
登録日2018-07-25
公開日2019-10-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Engineering the hCRBPII Domain-Swapped Dimer into a New Class of Protein Switches.
J.Am.Chem.Soc., 141, 2019
7C01
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Molecular basis for a potent human neutralizing antibody targeting SARS-CoV-2 RBD
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CB6 heavy chain, CB6 light chain, ...
著者Shi, R, Qi, J, Wang, Q, Gao, F.G, Yan, J.
登録日2020-04-29
公開日2020-05-27
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.88 Å)
主引用文献A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2.
Nature, 584, 2020
4LST
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BU of 4lst by Molmil
Crystal structure of broadly and potently neutralizing antibody VRC01 in complex with HIV-1 clade C strain ZM176.66 gp120
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C, HEAVY CHAIN OF ANTIBODY VRC01, ...
著者Zhou, T, Moquin, S, Kwong, P.D.
登録日2013-07-23
公開日2013-08-21
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
6ZNO
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The pointed end complex of dynactin with the p150 projection docked
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ARP1 actin related protein 1 homolog A, ...
著者Lau, C.K, Lacey, S.E, Carter, A.P.
登録日2020-07-06
公開日2020-07-29
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (6.8 Å)
主引用文献Cryo-EM reveals the complex architecture of dynactin's shoulder region and pointed end.
Embo J., 40, 2021

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