8HLN
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![BU of 8hln by Molmil](/molmil-images/mine/8hln) | Crystal structure of p53/BCL2 fusion complex(complex3) | 分子名称: | Apoptosis regulator Bcl-2, Cellular tumor antigen p53, ZINC ION | 著者 | Guo, M, Wei, H, Wang, H, Chen, Y. | 登録日 | 2022-11-30 | 公開日 | 2023-07-26 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.354 Å) | 主引用文献 | Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Nat Commun, 14, 2023
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6Y9D
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![BU of 6y9d by Molmil](/molmil-images/mine/6y9d) | Crystal structure of the quaternary ammonium Rieske monooxygenase CntA in complex with substrate L-Carnitine | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CARNITINE, Carnitine monooxygenase oxygenase subunit, ... | 著者 | Quareshy, M, Shanmugam, M, Bugg, T.D, Cameron, A, Chen, Y. | 登録日 | 2020-03-06 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Structural basis of carnitine monooxygenase CntA substrate specificity, inhibition, and intersubunit electron transfer. J.Biol.Chem., 296, 2020
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6Y8S
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![BU of 6y8s by Molmil](/molmil-images/mine/6y8s) | Crystal structure of the quaternary ammonium Rieske monooxygenase CntA in complex with substrate gamma-butyrobetaine | 分子名称: | 3-CARBOXY-N,N,N-TRIMETHYLPROPAN-1-AMINIUM, Carnitine monooxygenase oxygenase subunit, FE (III) ION, ... | 著者 | Quareshy, M, Shanmugam, M, Bugg, T.D, Cameron, A, Chen, Y. | 登録日 | 2020-03-05 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.629 Å) | 主引用文献 | Structural basis of carnitine monooxygenase CntA substrate specificity, inhibition, and intersubunit electron transfer. J.Biol.Chem., 296, 2020
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6XD5
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![BU of 6xd5 by Molmil](/molmil-images/mine/6xd5) | Apo KPC-2 N170A mutant at 1.20 A | 分子名称: | Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, SULFATE ION | 著者 | Pemberton, O.A, Chen, Y. | 登録日 | 2020-06-10 | 公開日 | 2020-12-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | KPC-2 beta-lactamase enables carbapenem antibiotic resistance through fast deacylation of the covalent intermediate. J.Biol.Chem., 296, 2020
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7NAQ
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![BU of 7naq by Molmil](/molmil-images/mine/7naq) | Human PA200-20S proteasome complex | 分子名称: | INOSITOL HEXAKISPHOSPHATE, Proteasome activator complex subunit 4, Proteasome subunit alpha type-1, ... | 著者 | Zhao, J, Makhija, S, Huang, B, Cheng, Y. | 登録日 | 2021-06-22 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins. Proc.Natl.Acad.Sci.USA, 119, 2022
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7NAP
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![BU of 7nap by Molmil](/molmil-images/mine/7nap) | Human PA28-20S-PA28 proteasome complex | 分子名称: | Proteasome activator complex subunit 1, Proteasome activator complex subunit 2, Proteasome subunit alpha type-1, ... | 著者 | Zhao, J, Makhija, S, Huang, B, Cheng, Y. | 登録日 | 2021-06-22 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins. Proc.Natl.Acad.Sci.USA, 119, 2022
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7NAO
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![BU of 7nao by Molmil](/molmil-images/mine/7nao) | Human PA28-20S proteasome complex | 分子名称: | Proteasome activator complex subunit 1, Proteasome activator complex subunit 2, Proteasome subunit alpha type-1, ... | 著者 | Zhao, J, Makhija, S, Huang, B, Cheng, Y. | 登録日 | 2021-06-22 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins. Proc.Natl.Acad.Sci.USA, 119, 2022
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7NAN
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![BU of 7nan by Molmil](/molmil-images/mine/7nan) | Human 20S proteasome core particle | 分子名称: | Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ... | 著者 | Zhao, J, Makhija, S, Huang, B, Cheng, Y. | 登録日 | 2021-06-22 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins. Proc.Natl.Acad.Sci.USA, 119, 2022
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6XD7
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![BU of 6xd7 by Molmil](/molmil-images/mine/6xd7) | KPC-2 N170A mutant bound to hydrolyzed ampicillin at 1.65 A | 分子名称: | (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL | 著者 | Pemberton, O.A, Chen, Y. | 登録日 | 2020-06-10 | 公開日 | 2020-12-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | KPC-2 beta-lactamase enables carbapenem antibiotic resistance through fast deacylation of the covalent intermediate. J.Biol.Chem., 296, 2020
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6Y9C
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![BU of 6y9c by Molmil](/molmil-images/mine/6y9c) | The structure of a quaternary ammonium Rieske monooxygenase reveals insights into carnitine oxidation by gut microbiota and inter-subunit electron transfer | 分子名称: | CARNITINE, Carnitine monooxygenase oxygenase subunit, FE (III) ION, ... | 著者 | Quareshy, M, Shanmugam, M, Bugg, T.D, Cameron, A, Chen, Y. | 登録日 | 2020-03-06 | 公開日 | 2021-03-31 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Characterisation of an unusual cysteine pair in the Rieske carnitine monooxygenase CntA catalytic site. Febs J., 2023
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6XJ8
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![BU of 6xj8 by Molmil](/molmil-images/mine/6xj8) | KPC-2 N170A mutant bound to hydrolyzed imipenem at 2.05 A | 分子名称: | (2R)-2-[(2S,3R)-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-(2-methanimidamidoethylsulfanyl)-2,3-dihydro-1H-pyrrole -5-carboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC | 著者 | Pemberton, O.A, Chen, Y. | 登録日 | 2020-06-23 | 公開日 | 2020-12-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | KPC-2 beta-lactamase enables carbapenem antibiotic resistance through fast deacylation of the covalent intermediate. J.Biol.Chem., 296, 2020
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6Y8J
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![BU of 6y8j by Molmil](/molmil-images/mine/6y8j) | Crystal structure of the apo form of a quaternary ammonium Rieske monooxygenase CntA | 分子名称: | Carnitine monooxygenase oxygenase subunit, FE2/S2 (INORGANIC) CLUSTER | 著者 | Quareshy, M, Shanmugam, M, Bugg, T.D, Cameron, A, Chen, Y. | 登録日 | 2020-03-05 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural basis of carnitine monooxygenase CntA substrate specificity, inhibition, and intersubunit electron transfer. J.Biol.Chem., 296, 2020
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5K5T
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![BU of 5k5t by Molmil](/molmil-images/mine/5k5t) | Crystal structure of the inactive form of human calcium-sensing receptor extracellular domain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Extracellular calcium-sensing receptor, ... | 著者 | Geng, Y, Mosyak, L, Kurinov, I, Zuo, H, Sturchler, E, Cheng, T.C, Subramanyam, P, Brown, A.P, Brennan, S.C, Mun, H.-C, Bush, M, Chen, Y, Nguyen, T, Cao, B, Chang, D, Quick, M, Conigrave, A, Colecraft, H.M, McDonald, P, Fan, Q.R. | 登録日 | 2016-05-23 | 公開日 | 2016-08-03 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural mechanism of ligand activation in human calcium-sensing receptor. Elife, 5, 2016
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5DI0
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![BU of 5di0 by Molmil](/molmil-images/mine/5di0) | Crystal structure of Dln1 | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Jia, N, Jiang, Y.L, Cheng, W, Wang, H.W, Zhou, C.Z, Chen, Y. | 登録日 | 2015-08-31 | 公開日 | 2016-02-03 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein. Embo Rep., 17, 2016
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1VBT
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![BU of 1vbt by Molmil](/molmil-images/mine/1vbt) | Structure of cyclophilin complexed with sulfur-substituted tetrapeptide AAPF | 分子名称: | CYCLOPHILIN A, SULFUR-SUBSTITUTED TETRAPEPTIDE | 著者 | Zhao, Y, Chen, Y, Schutkowski, M, Fischer, G, Ke, H. | 登録日 | 1998-06-16 | 公開日 | 1999-01-13 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Insight Into Conversion of Substrate to Inhibitor To be Published
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8HN6
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![BU of 8hn6 by Molmil](/molmil-images/mine/8hn6) | Crystal structure of monoclonal antibody complexed with SARS-CoV-2 RBD | 分子名称: | Heavy chain of monoclonal antibody 3G10, Light chain of monoclonal antibody 3G10, Spike protein S1 | 著者 | Qi, J, Chen, Y. | 登録日 | 2022-12-07 | 公開日 | 2023-05-17 | 最終更新日 | 2023-06-07 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Characterization of RBD-specific cross-neutralizing antibodies responses against SARS-CoV-2 variants from COVID-19 convalescents. Front Immunol, 14, 2023
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8HN7
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![BU of 8hn7 by Molmil](/molmil-images/mine/8hn7) | Crystal structure of monoclonal antibody complexed with SARS-CoV-2 RBD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of monoclonal antibody 3C11, Light chain of monoclonal antibody 3C11, ... | 著者 | Qi, J, Chen, Y. | 登録日 | 2022-12-07 | 公開日 | 2023-05-17 | 最終更新日 | 2023-06-07 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Characterization of RBD-specific cross-neutralizing antibodies responses against SARS-CoV-2 variants from COVID-19 convalescents. Front Immunol, 14, 2023
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5MS1
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![BU of 5ms1 by Molmil](/molmil-images/mine/5ms1) | Cowpea mosaic virus top component (CPMV-T) - naturally occurring empty particles | 分子名称: | Large subunit of Cowpea music virus, Small subunit of cowpea mosaic virus | 著者 | Hesketh, E.L, Meshcheriakova, Y, Thompson, R.F, Lomonossoff, G.P, Ranson, N.A. | 登録日 | 2016-12-29 | 公開日 | 2017-07-19 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.25 Å) | 主引用文献 | The structures of a naturally empty cowpea mosaic virus particle and its genome-containing counterpart by cryo-electron microscopy. Sci Rep, 7, 2017
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5MSH
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![BU of 5msh by Molmil](/molmil-images/mine/5msh) | Cowpea mosaic virus top component (CPMV-T) - naturally occurring empty particles | 分子名称: | Cowpea mosaic virus large subunit, Cowpea mosaic virus small subunit | 著者 | Hesketh, E.L, Meshcheriakova, Y, Thompson, R.F, Lomonossoff, G.P, Ranson, N.A. | 登録日 | 2017-01-04 | 公開日 | 2017-07-19 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.25 Å) | 主引用文献 | The structures of a naturally empty cowpea mosaic virus particle and its genome-containing counterpart by cryo-electron microscopy. Sci Rep, 7, 2017
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4XSQ
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![BU of 4xsq by Molmil](/molmil-images/mine/4xsq) | Structure of a variable lymphocyte receptor-like protein Bf66946 from Branchiostoma floridae | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, variable lymphocyte receptor-like protein Bf66946 | 著者 | Cao, D.D, Cheng, W, Jiang, Y.L, Wang, W.J, Li, Q, Chen, Y, Zhou, C.Z. | 登録日 | 2015-01-22 | 公開日 | 2016-03-23 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Structure of a variable lymphocyte receptor-like protein from the amphioxus Branchiostoma floridae. Sci Rep, 6, 2016
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8V6V
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![BU of 8v6v by Molmil](/molmil-images/mine/8v6v) | Cryo-EM structure of doubly-bound SNF2h-nucleosome complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Histone H2A type 1, Histone H2B, ... | 著者 | Chio, U.S, Palovcak, E, Armache, J.P, Narlikar, G.J, Cheng, Y. | 登録日 | 2023-12-03 | 公開日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking. Nat Commun, 15, 2024
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8V4Y
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![BU of 8v4y by Molmil](/molmil-images/mine/8v4y) | Cryo-EM structure of singly-bound SNF2h-nucleosome complex with SNF2h at inactive SHL2 (conformation 1) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Histone H2A type 1, ... | 著者 | Chio, U.S, Palovcak, E, Armache, J.P, Narlikar, G.J, Cheng, Y. | 登録日 | 2023-11-29 | 公開日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking. Nat Commun, 15, 2024
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8V7L
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![BU of 8v7l by Molmil](/molmil-images/mine/8v7l) | Cryo-EM structure of singly-bound SNF2h-nucleosome complex with SNF2h at inactive SHL2 (conformation 2) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Histone H2A type 1, Histone H2B, ... | 著者 | Chio, U.S, Palovcak, E, Armache, J.P, Narlikar, G.J, Cheng, Y. | 登録日 | 2023-12-04 | 公開日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking. Nat Commun, 15, 2024
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6NE3
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![BU of 6ne3 by Molmil](/molmil-images/mine/6ne3) | Cryo-EM structure of singly-bound SNF2h-nucleosome complex with SNF2h bound at SHL-2 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (156-MER), Histone H2A type 1, ... | 著者 | Armache, J.-P, Gamarra, N, Johnson, S.L, Leonard, J.D, Wu, S, Narlikar, G.N, Cheng, Y. | 登録日 | 2018-12-16 | 公開日 | 2019-07-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome. Elife, 8, 2019
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6CZ1
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![BU of 6cz1 by Molmil](/molmil-images/mine/6cz1) | Crystal structure of ATPase domain of Human GRP78 bound to Ver155008 | 分子名称: | 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile, Endoplasmic reticulum chaperone BiP, MAGNESIUM ION | 著者 | Antoshchenko, T, Chen, Y, Hughes, S, Park, H. | 登録日 | 2018-04-07 | 公開日 | 2019-04-10 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Crystallographic selection of adenosine analogs that fit the mold of the active site of human GRP78 and beyond To be Published
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