3M61
 
 | | Crystal structure of complex of urokinase and a upain-1 variant(W3A) in pH4.6 condition | | 分子名称: | Urokinase-type plasminogen activator, upain-1 W3A | | 著者 | Jiang, L, Yuan, C, Wind, T, Andreasen, P.A, Chen, L, Meehan, E.J, Huang, M. | | 登録日 | 2010-03-15 | | 公開日 | 2010-04-07 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | | 主引用文献 | Crystal structure of complex of urokinase and a upain-1 variant(W3A) in pH4.6 condition
TO BE PUBLISHED
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4YOM
 | | Structure of SAD kinase | | 分子名称: | 1,2-ETHANEDIOL, Serine/threonine-protein kinase BRSK2 | | 著者 | Wu, J.X, Wang, J, Chen, L, Wang, Z.X, Wu, J.W. | | 登録日 | 2015-03-12 | | 公開日 | 2015-12-16 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | Structural insight into the mechanism of synergistic autoinhibition of SAD kinases
Nat Commun, 6, 2015
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5XP7
 | | C-Src in complex with ATP-CHCl | | 分子名称: | GLYCEROL, MAGNESIUM ION, Proto-oncogene tyrosine-protein kinase Src, ... | | 著者 | Guo, M, Dai, S, Duan, Y, Chen, L, Chen, Y. | | 登録日 | 2017-06-01 | | 公開日 | 2017-09-06 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.012 Å) | | 主引用文献 | Remarkably Stereospecific Utilization of ATP alpha , beta-Halomethylene Analogues by Protein Kinases.
J. Am. Chem. Soc., 139, 2017
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4OHE
 | | LEOPARD Syndrome-Associated SHP2/G464A mutant | | 分子名称: | Tyrosine-protein phosphatase non-receptor type 11 | | 著者 | Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y. | | 登録日 | 2014-01-17 | | 公開日 | 2014-09-24 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.506 Å) | | 主引用文献 | Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations.
Biochemistry, 53, 2014
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4OHD
 | | LEOPARD Syndrome-Associated SHP2/A461T mutant | | 分子名称: | Tyrosine-protein phosphatase non-receptor type 11 | | 著者 | Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y. | | 登録日 | 2014-01-17 | | 公開日 | 2014-09-24 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations.
Biochemistry, 53, 2014
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3Q47
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3Q49
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3WMB
 | | Crystal structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with naphthalimide derivative Q1 | | 分子名称: | 2-(2-{[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]amino}ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-hexosaminidase | | 著者 | Liu, T, Zhou, Y, Chen, L, Yang, Q. | | 登録日 | 2013-11-16 | | 公開日 | 2014-11-05 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | A crystal structure-guided rational design switching non-carbohydrate inhibitors' specificity between two beta-GlcNAcase homologs
Sci Rep, 4, 2014
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1RYQ
 | | Putative DNA-directed RNA polymerase, subunit e'' from Pyrococcus Furiosus Pfu-263306-001 | | 分子名称: | DNA-directed RNA polymerase, subunit e'', ZINC ION | | 著者 | Liu, Z.-J, Chen, L, Tempel, W, Shah, A, Arendall III, W.B, Rose, J.P, Brereton, P.S, Izumi, M, Jenney Jr, F.E, Lee, H.S, Poole II, F.L, Shah, C, Sugar, F.J, Adams, M.W.W, Richardson, D.C, Richardson, J.S, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | | 登録日 | 2003-12-22 | | 公開日 | 2004-08-10 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | | 主引用文献 | Parameter-space screening: a powerful tool for high-throughput crystal structure determination.
Acta Crystallogr.,Sect.D, 61, 2005
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4OHI
 | | LEOPARD Syndrome-Associated SHP2/Q510E mutant | | 分子名称: | Tyrosine-protein phosphatase non-receptor type 11 | | 著者 | Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y. | | 登録日 | 2014-01-17 | | 公開日 | 2014-09-24 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations.
Biochemistry, 53, 2014
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3Q4A
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3RTP
 | | Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration | | 分子名称: | Mitogen-activated protein kinase 10, N-[4-cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl]-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide | | 著者 | Bowers, S, Truong, A.P, Neitz, R.J, Hom, R.K, Sealy, J.M, Probst, G.D, Quincy, Q, Peterson, B, Chan, W, Galemmo Jr, R.A, Konradi, A.W, Sham, H.L, Pan, H, Lin, M, Yao, N, Artis, D.R, Zhang, H, Chen, L, Dryer, M, Samant, B, Zmolek, W, Wong, K, Lorentzen, C, Goldbach, E, Tonn, G, Quinn, K.P, Sauer, J, Wright, S, Powell, K, Ruslim, L, Ren, Z, Bard, F, Yednock, T.A, Griswold-Prenne, I. | | 登録日 | 2011-05-03 | | 公開日 | 2013-05-08 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.
Bioorg.Med.Chem.Lett., 21, 2011
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4OHH
 | | LEOPARD Syndrome-Associated SHP2/Q506P mutant | | 分子名称: | Tyrosine-protein phosphatase non-receptor type 11 | | 著者 | Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y. | | 登録日 | 2014-01-17 | | 公開日 | 2014-09-24 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations.
Biochemistry, 53, 2014
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4OHL
 | | LEOPARD Syndrome-Associated SHP2/T468M mutant | | 分子名称: | Tyrosine-protein phosphatase non-receptor type 11 | | 著者 | Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y. | | 登録日 | 2014-01-17 | | 公開日 | 2014-09-24 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations.
Biochemistry, 53, 2014
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3WZF
 | | Crystal structure of human cytoplasmic aspartate aminotransferase | | 分子名称: | Aspartate aminotransferase, cytoplasmic | | 著者 | Jiang, X, Chang, H, Zhou, Y, Chen, L, Yang, Q. | | 登録日 | 2014-09-24 | | 公開日 | 2015-10-07 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.991 Å) | | 主引用文献 | Recombinant expression, purification and Preliminary crystallographic studies of human cytoplasmic aspartate aminotransferase
To be Published
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3GUT
 | | Crystal structure of a higher-order complex of p50:RelA bound to the HIV-1 LTR | | 分子名称: | HIV-LTR Core Forward Strand, HIV-LTR Core Reverse Strand, Nuclear factor NF-kappa-B p105 subunit, ... | | 著者 | Stroud, J.C, Oltman, A.J, Han, A, Bates, D.L, Chen, L. | | 登録日 | 2009-03-30 | | 公開日 | 2009-09-08 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.59 Å) | | 主引用文献 | Structural basis of HIV-1 activation by NF-kappaB--a higher-order complex of p50:RelA bound to the HIV-1 LTR.
J.Mol.Biol., 393, 2009
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4EWE
 | | Study on structure and function relationships in human Pirin with Manganese ion | | 分子名称: | 1,2-ETHANEDIOL, MANGANESE (II) ION, Pirin | | 著者 | Liu, F, Rehmani, I, Fu, R, Esaka, S, Chen, L, Serrano, V, Liu, A. | | 登録日 | 2012-04-26 | | 公開日 | 2013-05-29 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | Pirin is an iron-dependent redox regulator of NF-kappa B.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4EWD
 | | Study on structure and function relationships in human Pirin with Mn ion | | 分子名称: | MANGANESE (II) ION, Pirin | | 著者 | Liu, F, Rehmani, I, Chen, L, Fu, R, Serrano, V, Wilson, D.W, Liu, A. | | 登録日 | 2012-04-26 | | 公開日 | 2013-05-29 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Pirin is an iron-dependent redox regulator of NF-kappa B.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4R4X
 | | Structure of PNGF-II in C2 space group | | 分子名称: | PNGF-II, ZINC ION | | 著者 | Sun, G, Yu, X, Celimuge, Wang, L, Li, M, Gan, J, Qu, D, Ma, J, Chen, L. | | 登録日 | 2014-08-20 | | 公開日 | 2015-01-28 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Identification and
Characterization of a Novel Prokaryotic Peptide: N-glycosidase from
Elizabethkingia meningoseptica
J.Biol.Chem., 2015
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4R4Z
 | | Structure of PNGF-II in P21 space group | | 分子名称: | PNGF-II | | 著者 | Sun, G, Yu, X, Celimuge, Wang, L, Li, M, Gan, J, Qu, D, Ma, J, Chen, L. | | 登録日 | 2014-08-20 | | 公開日 | 2015-01-28 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Identification and
Characterization of a Novel Prokaryotic Peptide: N-glycosidase from
Elizabethkingia meningoseptica
J.Biol.Chem., 2015
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4ERO
 | | Study on structure and function relationships in human Pirin with Cobalt ion | | 分子名称: | 1,2-ETHANEDIOL, COBALT (II) ION, Pirin | | 著者 | Liu, F, Rehmani, I, Fu, R, Esaka, S, Chen, L, Serrano, V, Liu, A. | | 登録日 | 2012-04-20 | | 公開日 | 2013-05-29 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Pirin is an iron-dependent redox regulator of NF-kappa B.
Proc.Natl.Acad.Sci.USA, 110, 2013
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7XUZ
 | | Crystal structure of a HDAC4-MEF2A-DNA ternary complex | | 分子名称: | DNA (5'-D(*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3'), DNA (5'-D(P*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*A)-3'), Histone deacetylase 4, ... | | 著者 | Dai, S.Y, Guo, L, Dey, R, Guo, M, Bates, D, Cayford, J, Chen, X.J, Wei, X.D, Chen, L, Chen, Y.H. | | 登録日 | 2022-05-20 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-06-12 | | 実験手法 | X-RAY DIFFRACTION (3.591 Å) | | 主引用文献 | Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation.
Nucleic Acids Res., 52, 2024
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6BZ1
 | | MEF2 Chimera D83V mutant/DNA complex | | 分子名称: | DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), DNA (5'-D(P*TP*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3'), MEF2 CHIMERA | | 著者 | Lei, X, Chen, L. | | 登録日 | 2017-12-21 | | 公開日 | 2018-02-07 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.97 Å) | | 主引用文献 | The Cancer Mutation D83V Induces an alpha-Helix to beta-Strand Conformation Switch in MEF2B.
J. Mol. Biol., 430, 2018
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6BYY
 | | MEF2 CHIMERA/DNA Complex | | 分子名称: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 3,3',3''-phosphanetriyltripropanoic acid, DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), ... | | 著者 | Lei, X, Chen, L. | | 登録日 | 2017-12-21 | | 公開日 | 2018-01-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The Cancer Mutation D83V Induces an alpha-Helix to beta-Strand Conformation Switch in MEF2B.
J. Mol. Biol., 430, 2018
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6C9L
 | | MEF2B Apo Protein Structure | | 分子名称: | Myocyte-specific enhancer factor 2B | | 著者 | Lei, X, Chen, L. | | 登録日 | 2018-01-26 | | 公開日 | 2018-02-07 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal Structure of Apo MEF2B Reveals New Insights in DNA Binding and Cofactor Interaction.
Biochemistry, 57, 2018
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