6SCT
| Cryo-EM structure of the consensus triskelion hub of the clathrin coat complex | 分子名称: | Clathrin heavy chain, Clathrin light chain | 著者 | Morris, K.L, Cameron, A.D, Sessions, R, Smith, C.J. | 登録日 | 2019-07-25 | 公開日 | 2019-10-02 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.69 Å) | 主引用文献 | Cryo-EM of multiple cage architectures reveals a universal mode of clathrin self-assembly. Nat.Struct.Mol.Biol., 26, 2019
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6SCM
| SOS1 in Complex with Inhibitor BI-3406 | 分子名称: | 1,2-ETHANEDIOL, IMIDAZOLE, Son of sevenless homolog 1, ... | 著者 | Kessler, D, Fischer, G, Ramharter, J. | 登録日 | 2019-07-24 | 公開日 | 2020-08-26 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.866 Å) | 主引用文献 | BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition. Cancer Discov, 11, 2021
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6SO5
| Homo sapiens WRB/CAML heterotetramer in complex with a TRC40 dimer | 分子名称: | ATPase ASNA1, Calcium signal-modulating cyclophilin ligand, Tail-anchored protein insertion receptor WRB, ... | 著者 | McDowell, M.A, Heimes, M, Wild, K, Flemming, D, Sinning, I. | 登録日 | 2019-08-29 | 公開日 | 2020-09-09 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex. Mol.Cell, 80, 2020
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6SLE
| Structure of Reductive Aminase from Neosartorya fumigata in complex with NADP+ | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxidoreductase, putative | 著者 | Sharma, M, Mangas-Sanchez, J, Turner, N.J, Grogan, G. | 登録日 | 2019-08-19 | 公開日 | 2020-06-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases. Chem Sci, 11, 2020
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6SWN
| N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH iBET-BD1 (GSK778) | 分子名称: | 1,2-ETHANEDIOL, 4-[2-(methoxymethyl)-1-[(1~{R})-1-phenylethyl]-8-[[(3~{S})-pyrrolidin-3-yl]methoxy]imidazo[4,5-c]quinolin-7-yl]-3,5-dimethyl-1,2-oxazole, Bromodomain-containing protein 4, ... | 著者 | Chung, C. | 登録日 | 2019-09-22 | 公開日 | 2020-04-01 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | 主引用文献 | Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation. Science, 368, 2020
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6SWQ
| N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH iBET-BD2 (GSK046) | 分子名称: | 1,2-ETHANEDIOL, 4-acetamido-3-fluoranyl-~{N}-(4-oxidanylcyclohexyl)-5-[(1~{S})-1-phenylethoxy]benzamide, Bromodomain-containing protein 4 | 著者 | Chung, C. | 登録日 | 2019-09-22 | 公開日 | 2020-04-01 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | 主引用文献 | Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation. Science, 368, 2020
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6SWP
| C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH iBET-BD2 (GSK046) | 分子名称: | 1,2-ETHANEDIOL, 4-acetamido-3-fluoranyl-~{N}-(4-oxidanylcyclohexyl)-5-[(1~{S})-1-phenylethoxy]benzamide, Bromodomain-containing protein 2 | 著者 | Chung, C. | 登録日 | 2019-09-22 | 公開日 | 2020-04-01 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.604 Å) | 主引用文献 | Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation. Science, 368, 2020
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6T3H
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6TQ3
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6T46
| Structure of the Rap conjugation gene regulator of the plasmid pLS20 in complex with the Phr* peptide | 分子名称: | CHLORIDE ION, Quorum-sensing secretion protein (processed), Response regulator aspartate phosphatase, ... | 著者 | Crespo, I, Bernardo, N, Meijer, W.J.J, Boer, D.R. | 登録日 | 2019-10-12 | 公開日 | 2020-06-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Inactivation of the dimeric RappLS20 anti-repressor of the conjugation operon is mediated by peptide-induced tetramerization. Nucleic Acids Res., 48, 2020
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6TQ8
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6TQ5
| Alcohol dehydrogenase from Candida magnoliae DSMZ 70638 (ADHA): complex with NADP+ | 分子名称: | Enzyme subunit, GLYCEROL, ISOPROPYL ALCOHOL, ... | 著者 | Rovida, S, Aalbers, F.S, Fraaije, M.W, Mattevi, A. | 登録日 | 2019-12-16 | 公開日 | 2020-04-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Approaching boiling point stability of an alcohol dehydrogenase through computationally-guided enzyme engineering. Elife, 9, 2020
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6SKX
| Structure of Reductive Aminase from Neosartorya fumigata | 分子名称: | Oxidoreductase, putative | 著者 | Sharma, M, Mangas-Sanchez, J, Turner, N.J, Grogan, G. | 登録日 | 2019-08-16 | 公開日 | 2020-06-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases. Chem Sci, 11, 2020
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6SLH
| Conformational flexibility within the small domain of human serine racemase. | 分子名称: | MAGNESIUM ION, SODIUM ION, Serine racemase, ... | 著者 | Koulouris, C.R, Bax, B, Atack, J, Roe, S.M. | 登録日 | 2019-08-19 | 公開日 | 2020-02-12 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Conformational flexibility within the small domain of human serine racemase. Acta Crystallogr.,Sect.F, 76, 2020
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6SWO
| C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH iBET-BD1 (GSK778) | 分子名称: | 1,2-ETHANEDIOL, 4-[2-(methoxymethyl)-1-[(1~{R})-1-phenylethyl]-8-[[(3~{S})-pyrrolidin-3-yl]methoxy]imidazo[4,5-c]quinolin-7-yl]-3,5-dimethyl-1,2-oxazole, Bromodomain-containing protein 2 | 著者 | Chung, C. | 登録日 | 2019-09-22 | 公開日 | 2020-04-01 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | 主引用文献 | Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation. Science, 368, 2020
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6U38
| PCSK9 in complex with a Fab and compound 8 | 分子名称: | 2-fluoro-4-{[(1R)-1-methyl-6-{[(2S)-oxan-2-yl]methoxy}-1-{2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}benzoic acid, Fab Heavy Chain, Fab Light Chain, ... | 著者 | Lu, J, Soisson, S. | 登録日 | 2019-08-21 | 公開日 | 2019-11-06 | 最終更新日 | 2020-01-29 | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | 主引用文献 | From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9. Cell Chem Biol, 27, 2020
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6UBI
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6U2N
| PCSK9 in complex with compound 4 | 分子名称: | 4-{[(1R)-6-methoxy-1-methyl-1-{2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}benzoic acid, Proprotein convertase subtilisin/kexin type 9 | 著者 | Lu, J, Soisson, S. | 登録日 | 2019-08-20 | 公開日 | 2019-11-06 | 最終更新日 | 2020-01-29 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9. Cell Chem Biol, 27, 2020
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6TSC
| OphMA I407P complex with SAH | 分子名称: | GLY-PHE-PRO-TRP-MVA-ILE-MVA-VAL-GLY-VAL-PRO-GLY, Peptide N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Song, H, Naismith, J.H. | 登録日 | 2019-12-20 | 公開日 | 2020-06-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Substrate Plasticity of a Fungal Peptide alpha-N-Methyltransferase. Acs Chem.Biol., 15, 2020
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6TAV
| Crystal structure of endopeptidase-induced alpha2-macroglobulin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... | 著者 | Gomis-Ruth, F.X, Duquerroy, S, Trapani, S, Marrero, A, Goulas, T, Guevara, T, Andersen, G.A, Sottrup-Jensen, L, Navaza, J. | 登録日 | 2019-10-30 | 公開日 | 2021-05-12 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | 主引用文献 | Cryo-EM structures shows the mechanistic basis of pan-peptidase inhibition by human alpha2-macroglobulin Proc.Natl.Acad.Sci.USA, 2022
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6U3K
| The crystal structure of 4-(pyridin-2-yl)benzoate-bound CYP199A4 | 分子名称: | 4-(pyridin-2-yl)benzoic acid, CHLORIDE ION, Cytochrome P450, ... | 著者 | Podgorski, M.N, Bruning, J.B, Bell, S.G. | 登録日 | 2019-08-21 | 公開日 | 2020-02-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Biophysical Techniques for Distinguishing Ligand Binding Modes in Cytochrome P450 Monooxygenases. Biochemistry, 59, 2020
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6UCG
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6UH8
| Crystal structure of DAD2 N242I mutant | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Decreased Apical Dominance 2, GLYCEROL, ... | 著者 | Sharma, P, Hamiaux, C, Snowden, K.C. | 登録日 | 2019-09-27 | 公開日 | 2020-02-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Flexibility of the petunia strigolactone receptor DAD2 promotes its interaction with signaling partners. J.Biol.Chem., 295, 2020
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6TA8
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2HHM
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