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6SWQ

N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH iBET-BD2 (GSK046)

This is a non-PDB format compatible entry.
Summary for 6SWQ
Entry DOI10.2210/pdb6swq/pdb
DescriptorBromodomain-containing protein 4, 1,2-ETHANEDIOL, 4-acetamido-3-fluoranyl-~{N}-(4-oxidanylcyclohexyl)-5-[(1~{S})-1-phenylethoxy]benzamide, ... (4 entities in total)
Functional Keywordsinhibitor, histone, epigenetic reader, bromodomain, brd4, bromodomain containing protein4, antagonist, transcription
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight15700.05
Authors
Chung, C. (deposition date: 2019-09-22, release date: 2020-04-01, Last modification date: 2020-05-06)
Primary citationGilan, O.,Rioja, I.,Knezevic, K.,Bell, M.J.,Yeung, M.M.,Harker, N.R.,Lam, E.Y.N.,Chung, C.W.,Bamborough, P.,Petretich, M.,Urh, M.,Atkinson, S.J.,Bassil, A.K.,Roberts, E.J.,Vassiliadis, D.,Burr, M.L.,Preston, A.G.S.,Wellaway, C.,Werner, T.,Gray, J.R.,Michon, A.M.,Gobbetti, T.,Kumar, V.,Soden, P.E.,Haynes, A.,Vappiani, J.,Tough, D.F.,Taylor, S.,Dawson, S.J.,Bantscheff, M.,Lindon, M.,Drewes, G.,Demont, E.H.,Daniels, D.L.,Grandi, P.,Prinjha, R.K.,Dawson, M.A.
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation.
Science, 368:387-394, 2020
Cited by
PubMed: 32193360
DOI: 10.1126/science.aaz8455
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.601 Å)
Structure validation

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