8ZGH
 
 | | Human lysine O-link glycosylation complex, LH3/ColGalT1 in its apo state | | 分子名称: | 2-OXOGLUTARIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Peng, J, Li, W, Yao, D, Xia, Y, Wang, Q, Cai, Y, Li, S, Cao, M, Shen, Y, Ma, P, Liao, R, Qin, A, Cao, Y. | | 登録日 | 2024-05-09 | | 公開日 | 2025-03-19 | | 最終更新日 | 2025-03-26 | | 実験手法 | ELECTRON MICROSCOPY (3.93 Å) | | 主引用文献 | The structural basis for the human procollagen lysine hydroxylation and dual-glycosylation.
Nat Commun, 16, 2025
|
|
8ZGE
 | | Human lysine O-link glycosylation complex, LH3/ColGalT1 tetramer with bound UDP-galactose | | 分子名称: | 2-OXOGLUTARIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Peng, J, Li, W, Yao, D, Xia, Y, Wang, Q, Cai, Y, Li, S, Cao, M, Shen, Y, Ma, P, Liao, R, Qin, A, Cao, Y. | | 登録日 | 2024-05-09 | | 公開日 | 2025-03-19 | | 最終更新日 | 2025-03-26 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | The structural basis for the human procollagen lysine hydroxylation and dual-glycosylation.
Nat Commun, 16, 2025
|
|
8ZGG
 | | Human lysine O-link glycosylation complex, LH3/ColGalT1 with bound UDP-glucose | | 分子名称: | 2-OXOGLUTARIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Peng, J, Li, W, Yao, D, Xia, Y, Wang, Q, Cai, Y, Li, S, Cao, M, Shen, Y, Ma, P, Liao, R, Qin, A, Cao, Y. | | 登録日 | 2024-05-09 | | 公開日 | 2025-03-19 | | 最終更新日 | 2025-03-26 | | 実験手法 | ELECTRON MICROSCOPY (3.75 Å) | | 主引用文献 | The structural basis for the human procollagen lysine hydroxylation and dual-glycosylation.
Nat Commun, 16, 2025
|
|
8ZGC
 | | Human lysine O-link glycosylation complex, LH3/ColGalT1 with bound UDP-galactose | | 分子名称: | 2-OXOGLUTARIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Peng, J, Li, W, Yao, D, Xia, Y, Wang, Q, Cai, Y, Li, S, Cao, M, Shen, Y, Ma, P, Liao, R, Qin, A, Cao, Y. | | 登録日 | 2024-05-09 | | 公開日 | 2025-03-19 | | 最終更新日 | 2025-03-26 | | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | | 主引用文献 | The structural basis for the human procollagen lysine hydroxylation and dual-glycosylation.
Nat Commun, 16, 2025
|
|
4IT8
 | | A sperm whale myoglobin mutant L29H Mb with two distal histidines | | 分子名称: | Myoglobin, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Lin, Y.-W, Tan, X.-S, Li, W, Sun, M.-H, Wen, G.-B, Liu, J.-H. | | 登録日 | 2013-01-18 | | 公開日 | 2013-04-10 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural and nitrite reductase activity comparisons of myoglobins with one to three distal histidines.
RSC Adv, 2013
|
|
8K1X
 | | Biochemical and structural characterization of a multifunctional cytochrome P450 SpcN in staurosporine biosynthesis | | 分子名称: | 13-(3-Amino-2,3,6-trideoxy-alpha-L-ribo-hexopyranosyl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Xiao, F, Dong, S, Feng, Y, Li, W. | | 登録日 | 2023-07-11 | | 公開日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Molecular Basis for the P450-Catalyzed sp3 C-N Glycosidic Bond Formation in Staurosporine Biosynthesis.
Acs Catalysis, 14, 2024
|
|
6BFU
 | | Glycan shield and fusion activation of a deltacoronavirus spike glycoprotein fine-tuned for enteric infections | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein, ... | | 著者 | Xiong, X, Tortorici, M.A, Snijder, S, Yoshioka, C, Walls, A.C, Li, W, Seattle Structural Genomics Center for Infectious Disease (SSGCID), McGuire, A.T, Rey, F.A, Bosch, B.J, Veesler, D. | | 登録日 | 2017-10-27 | | 公開日 | 2017-11-22 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Glycan Shield and Fusion Activation of a Deltacoronavirus Spike Glycoprotein Fine-Tuned for Enteric Infections.
J. Virol., 92, 2018
|
|
6BGN
 | | Crystal Structure of 4-Oxalocrotonate Tautomerase After Incubation with 5-Fluoro-2-hydroxy-2,4-pentadienoate | | 分子名称: | 2-hydroxymuconate tautomerase, 5-fluoranyl-2-oxidanylidene-pentanoic acid, GLYCEROL, ... | | 著者 | Zhang, Y, Li, W, Stack, T. | | 登録日 | 2017-10-29 | | 公開日 | 2018-02-21 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | | 主引用文献 | Inactivation of 4-Oxalocrotonate Tautomerase by 5-Halo-2-hydroxy-2,4-pentadienoates.
Biochemistry, 57, 2018
|
|
8ILV
 | | Cryo-EM structure of PI3Kalpha in complex with compound 18 | | 分子名称: | N-[(2R)-1-(ethylamino)-1-oxidanylidene-3-[3-(2-quinoxalin-6-ylethynyl)phenyl]propan-2-yl]-2,3-dimethyl-quinoxaline-6-carboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Zhou, Q, Liu, X, Neri, D, Li, W, Favalli, N, Bassi, G, Yang, S, Yang, D, Vogt, P.K, Wang, M.-W. | | 登録日 | 2023-03-04 | | 公開日 | 2023-09-06 | | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | | 主引用文献 | Structural insights into the interaction of three Y-shaped ligands with PI3K alpha.
Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8ILS
 | | Cryo-EM structure of PI3Kalpha in complex with compound 17 | | 分子名称: | N-[(2R)-1-(ethylamino)-1-oxidanylidene-3-[4-(2-quinoxalin-6-ylethynyl)phenyl]propan-2-yl]-2,3-dimethyl-quinoxaline-6-carboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Zhou, Q, Liu, X, Neri, D, Li, W, Favalli, N, Bassi, G, Yang, S, Yang, D, Vogt, P.K, Wang, M.-W. | | 登録日 | 2023-03-04 | | 公開日 | 2023-09-13 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural insights into the interaction of three Y-shaped ligands with PI3K alpha.
Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8JTN
 | | Tudor domain of TDRD3 in complex with a small molecule | | 分子名称: | 2-propyl-2-azoniatricyclo[7.3.0.0^{3,7}]dodeca-1(9),2,7-trien-8-amine, Tudor domain-containing protein 3 | | 著者 | Chen, M, Wang, Z, Li, W, Shang, X, Liu, Y. | | 登録日 | 2023-06-22 | | 公開日 | 2023-08-09 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of Tudor domain of TDRD3 in complex with a small molecule antagonist.
Biochim Biophys Acta Gene Regul Mech, 1866, 2023
|
|
8ILR
 | | Cryo-EM structure of PI3Kalpha in complex with compound 16 | | 分子名称: | N-[(2S)-1-(ethylamino)-1-oxidanylidene-3-[4-(2-quinoxalin-6-ylethynyl)phenyl]propan-2-yl]-2,3-dimethyl-quinoxaline-6-carboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Zhou, Q, Liu, X, Neri, D, Li, W, Favalli, N, Bassi, G, Yang, S, Yang, D, Vogt, P.K, Wang, M.-W. | | 登録日 | 2023-03-04 | | 公開日 | 2023-08-30 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Structural insights into the interaction of three Y-shaped ligands with PI3K alpha.
Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
6KMJ
 | | Crystal structure of Sth1 bromodomain in complex with H3K14Ac | | 分子名称: | GLYCEROL, Histone H3, Nuclear protein STH1/NPS1 | | 著者 | Chen, G, Li, W, Yan, F, Wang, D, Chen, Y. | | 登録日 | 2019-07-31 | | 公開日 | 2019-11-27 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | The Structural Basis for Specific Recognition of H3K14 Acetylation by Sth1 in the RSC Chromatin Remodeling Complex.
Structure, 28, 2020
|
|
6KMB
 | | Crystal structure of Sth1 bromodomain | | 分子名称: | GLYCEROL, Nuclear protein STH1/NPS1 | | 著者 | Chen, G, Li, W, Yan, F, Wang, D, Chen, Y. | | 登録日 | 2019-07-31 | | 公開日 | 2019-10-30 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The Structural Basis for Specific Recognition of H3K14 Acetylation by Sth1 in the RSC Chromatin Remodeling Complex.
Structure, 28, 2020
|
|
7E4P
 | | Crystal structure of tubulin in complex with Ansamitocin P3 | | 分子名称: | (1S,2S,3S,5S,6S,16Z,18Z,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl 2-methylpropanoate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | 著者 | Wang, Y, Li, W. | | 登録日 | 2021-02-14 | | 公開日 | 2022-02-16 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | C3 Ester Side Chain Plays a Pivotal Role in the Antitumor Activity of Maytansinoids
To Be Published
|
|
7E4Y
 | | Crystal structure of tubulin in complex with L-DM4-SMe | | 分子名称: | (1S,2S,3S,5R,6S,16E,18E,20S,21R)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl (2S)-2-{methyl[3-methyl-3-(methyldisulfanyl)butanoyl]amino}propanoate (non-preferred name), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | 著者 | Wang, Y, Li, W. | | 登録日 | 2021-02-16 | | 公開日 | 2022-02-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.708 Å) | | 主引用文献 | C3 Ester Side Chain Plays a Pivotal Role in the Antitumor Activity of Maytansinoids
To Be Published
|
|
4LGJ
 | | Crystal structure and mechanism of a type III secretion protease | | 分子名称: | Uncharacterized protein, ZINC ION | | 著者 | Li, W.Q, Liu, Y.X, Sheng, X.L, Yan, C.Y, Wang, J.W. | | 登録日 | 2013-06-28 | | 公開日 | 2014-01-15 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Structure and mechanism of a type III secretion protease, NleC
Acta Crystallogr.,Sect.D, 70, 2014
|
|
5D6J
 | | Crystal structure of a mycobacterial protein | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Acyl-CoA synthase, MAGNESIUM ION, ... | | 著者 | Li, W.J, Bi, L.J. | | 登録日 | 2015-08-12 | | 公開日 | 2016-03-02 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Crystal structure of FadD32, an enzyme essential for mycolic acid biosynthesis in mycobacteria.
Sci Rep, 5, 2015
|
|
3DPC
 | |
6LOI
 | |
4ZM9
 | | Crystal structure of circularly permuted human asparaginase-like protein 1 | | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, BETA-MERCAPTOETHANOL, CITRATE ANION, ... | | 著者 | Li, W.Z, Zhang, Y. | | 登録日 | 2015-05-02 | | 公開日 | 2016-02-17 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | Intramolecular Cleavage of the hASRGL1 Homodimer Occurs in Two Stages.
Biochemistry, 55, 2016
|
|
3FSH
 | |
8HY0
 | |
8HXX
 | |
8HXY
 | |
