8H3Z
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8H40
| Cryo-EM structure of the transcription activation complex NtcA-TAC | 分子名称: | DNA (125-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Han, S.J, Jiang, Y.L, You, L.L, Shen, L.Q, Wu, X.X, Yang, F, Kong, W.W, Chen, Z.P, Zhang, Y, Zhou, C.Z. | 登録日 | 2022-10-09 | 公開日 | 2023-10-04 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | DNA looping mediates cooperative transcription activation. Nat.Struct.Mol.Biol., 31, 2024
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8H3V
| Cryo-EM structure of the full transcription activation complex NtcA-NtcB-TAC | 分子名称: | DNA (125-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Han, S.J, Jiang, Y.L, You, L.L, Shen, L.Q, Wu, X.X, Yang, F, Kong, W.W, Chen, Z.P, Zhang, Y, Zhou, C.Z. | 登録日 | 2022-10-09 | 公開日 | 2023-10-04 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | DNA looping mediates cooperative transcription activation. Nat.Struct.Mol.Biol., 31, 2024
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8HLW
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8HLY
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7C6S
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7C6U
| Crystal structure of SARS-CoV-2 complexed with GC376 | 分子名称: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase | 著者 | Fu, L, Feng, Y, Qi, J, Gao, F.G. | 登録日 | 2020-05-22 | 公開日 | 2020-09-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease. Nat Commun, 11, 2020
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7CGW
| Complex structure of PD-1 and tislelizumab Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of tislelizumab Fab, Light chain of tislelizumab Fab, ... | 著者 | Hong, Y, Feng, Y.C, Liu, Y. | 登録日 | 2020-07-02 | 公開日 | 2021-04-07 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Tislelizumab uniquely binds to the CC' loop of PD-1 with slow-dissociated rate and complete PD-L1 blockage. Febs Open Bio, 11, 2021
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7CFP
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7CFQ
| Crystal structure of WDR5 in complex with H3K4me3Q5ser peptide | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, H3K4me3Q5ser peptide, ... | 著者 | Zhao, J, Zhang, X, Zang, J. | 登録日 | 2020-06-27 | 公開日 | 2021-07-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural insights into the recognition of histone H3Q5 serotonylation by WDR5. Sci Adv, 7, 2021
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7D1M
| CRYSTAL STRUCTURE OF THE SARS-CoV-2 MAIN PROTEASE COMPLEXED WITH GC376 | 分子名称: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase, DIMETHYL SULFOXIDE | 著者 | Fu, L.F, Gilski, M, Shabalin, I, Gao, G.F, Qi, J.X. | 登録日 | 2020-09-14 | 公開日 | 2020-10-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease. Nat Commun, 11, 2020
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7EFR
| Structure of SARS-CoV-2 spike receptor-binding domain in complex with high affinity ACE2 mutant (T27W,N330Y) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike glycoprotein | 著者 | Lu, G.W, Ye, F, Lin, X. | 登録日 | 2021-03-23 | 公開日 | 2021-11-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.494 Å) | 主引用文献 | S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis. Signal Transduct Target Ther, 6, 2021
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7EFP
| Structure of SARS-CoV-2 spike receptor-binding domain in complex with high affinity ACE2 mutant (S19W,N330Y) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike glycoprotein | 著者 | Lu, G.W, Ye, F, Lin, X. | 登録日 | 2021-03-22 | 公開日 | 2021-11-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.698 Å) | 主引用文献 | S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis. Signal Transduct Target Ther, 6, 2021
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6IQF
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6IQJ
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6J67
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6KKN
| Crystal structure of RuBisCO accumulation factor Raf1 from Anabaena sp. PCC 7120 | 分子名称: | All5250 protein | 著者 | Xia, L.Y, Jiang, Y.L, Kong, W.W, Chen, Y, Zhou, C.Z. | 登録日 | 2019-07-26 | 公開日 | 2020-05-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Molecular basis for the assembly of RuBisCO assisted by the chaperone Raf1. Nat.Plants, 6, 2020
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6KKM
| Crystal structure of RbcL-Raf1 complex from Anabaena sp. PCC 7120 | 分子名称: | All5250 protein, Ribulose bisphosphate carboxylase large chain | 著者 | Xia, L.Y, Jiang, Y.L, Kong, W.W, Chen, Y, Zhou, C.Z. | 登録日 | 2019-07-26 | 公開日 | 2020-05-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Molecular basis for the assembly of RuBisCO assisted by the chaperone Raf1. Nat.Plants, 6, 2020
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6KFW
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6LRR
| Cryo-EM structure of RuBisCO-Raf1 from Anabaena sp. PCC 7120 | 分子名称: | All5250 protein, Ribulose bisphosphate carboxylase large chain, Ribulose bisphosphate carboxylase small chain | 著者 | Xia, L.Y, Jiang, Y.L, Kong, W.W, Chen, Y, Zhou, C.Z. | 登録日 | 2020-01-16 | 公開日 | 2020-05-13 | 最終更新日 | 2020-07-01 | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | 主引用文献 | Molecular basis for the assembly of RuBisCO assisted by the chaperone Raf1. Nat.Plants, 6, 2020
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6LRC
| Human cGAS catalytic domain bound with the inhibitor PF-06928215 | 分子名称: | (1R,2S)-2-[(7-hydroxy-5-phenylpyrazolo[1,5-a]pyrimidine-3-carbonyl)amino]cyclohexane-1-carboxylic acid, Cyclic GMP-AMP synthase, ZINC ION | 著者 | Zhao, W.F, Xu, Y.C. | 登録日 | 2020-01-15 | 公開日 | 2020-06-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.831 Å) | 主引用文献 | In Silico Screening-Based Discovery of Novel Inhibitors of Human Cyclic GMP-AMP Synthase: A Cross-Validation Study of Molecular Docking and Experimental Testing. J.Chem.Inf.Model., 60, 2020
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7XRP
| Cryo-EM structure of SARS-CoV-2 spike protein in complex with nanobody C5G2 (localized refinement) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C5G2 nanobody, Spike protein S1 | 著者 | Liu, L, Sun, H, Jiang, Y, Liu, X, Zhao, D, Zheng, Q, Li, S, Xia, N. | 登録日 | 2022-05-11 | 公開日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (3.88 Å) | 主引用文献 | A potent synthetic nanobody with broad-spectrum activity neutralizes SARS-CoV-2 virus and the Omicron variant BA.1 through a unique binding mode. J Nanobiotechnology, 20, 2022
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7YHK
| Cryo-EM structure of the HA trimer of A/Beijing/262/1995(H1N1) in complex with neutralizing antibody 12H5 | 分子名称: | 12H5 heavy chain, 12H5 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zheng, Q, Li, S, Li, T, Xue, W, Sun, H. | 登録日 | 2022-07-13 | 公開日 | 2022-08-17 | 最終更新日 | 2023-07-19 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza viruses. Nat Commun, 13, 2022
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6NZR
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6NZH
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