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4PZA
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BU of 4pza by Molmil
The complex structure of mycobacterial glucosyl-3-phosphoglycerate phosphatase Rv2419c with inorganic phosphate
分子名称: Glucosyl-3-phosphoglycerate phosphatase, PHOSPHATE ION
著者Zhou, W.H, Zheng, Q.Q, Jiang, D.Q, Zhang, W, Zhang, Q.Q, Jin, J, Li, X, Yang, H.T, Shaw, N, Rao, Z.
登録日2014-03-29
公開日2014-06-11
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.776 Å)
主引用文献Mechanism of dephosphorylation of glucosyl-3-phosphoglycerate by a histidine phosphatase
J.Biol.Chem., 289, 2014
4QIH
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BU of 4qih by Molmil
The structure of mycobacterial glucosyl-3-phosphoglycerate phosphatase Rv2419c complexes with VO3
分子名称: Glucosyl-3-phosphoglycerate phosphatase, VANADATE ION
著者Zhou, W.H, Zheng, Q.Q, Jiang, D.Q, Zhang, W, Zhang, Q.Q, Jin, J, Li, X, Yang, H.T, Shaw, N, Rao, Z.
登録日2014-05-30
公開日2014-06-11
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.299 Å)
主引用文献Mechanism of dephosphorylation of glucosyl-3-phosphoglycerate by a histidine phosphatase
J.Biol.Chem., 289, 2014
4HYS
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BU of 4hys by Molmil
Crystal structure of JNK1 in complex with JIP1 peptide and 4-(4-Indazol-1-yl-pyrimidin-2-ylamino)-cyclohexan
分子名称: C-Jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 8, trans-4-{[4-(1H-indazol-1-yl)pyrimidin-2-yl]amino}cyclohexanol
著者Kuglstatter, A, Janson, C.
登録日2012-11-14
公開日2013-10-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.415 Å)
主引用文献Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): kinase profiling guided optimization of a 1,2,3-benzotriazole lead.
Bioorg.Med.Chem.Lett., 23, 2013
5B1R
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BU of 5b1r by Molmil
Crystal structure of mouse CD72a CTLD
分子名称: ACETATE ION, B-cell differentiation antigen CD72, GLYCEROL
著者Shinagawa, K, Numoto, N, Tsubata, T, Ito, N.
登録日2015-12-15
公開日2016-10-19
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP
J.Exp.Med., 213, 2016
4IZY
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BU of 4izy by Molmil
Crystal structure of JNK1 in complex with JIP1 peptide and 4-{4-[4-(4-Methanesulfonyl-piperidin-1-yl)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexan
分子名称: C-Jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 8, trans-4-[(4-{4-[4-(methylsulfonyl)piperidin-1-yl]-1H-indol-1-yl}pyrimidin-2-yl)amino]cyclohexanol
著者Kuglstatter, A, Shao, A.
登録日2013-01-30
公開日2013-12-18
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): optimization for JNK potency and physicochemical properties.
Bioorg.Med.Chem.Lett., 23, 2013
6H16
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BU of 6h16 by Molmil
Structure of LRP6 P3E3P4E4 in complex with VHH L-P2-D07
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Low-density lipoprotein receptor-related protein 6, ...
著者Gros, P, van Scherpenzeel, R.C.
登録日2018-07-11
公開日2019-01-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.
Nat Commun, 10, 2019
1Q1C
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BU of 1q1c by Molmil
Crystal structure of N(1-260) of human FKBP52
分子名称: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, FK506-binding protein 4
著者Wu, B, Li, P, Lou, Z, Ding, Y, Shu, C, Shen, B, Rao, Z.
登録日2003-07-18
公開日2004-06-22
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献3D structure of human FK506-binding protein 52: Implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex
Proc.Natl.Acad.Sci.USA, 101, 2004
4PZ9
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BU of 4pz9 by Molmil
The native structure of mycobacterial glucosyl-3-phosphoglycerate phosphatase Rv2419c
分子名称: Glucosyl-3-phosphoglycerate phosphatase
著者Zhou, W.H, Zheng, Q.Q, Jiang, D.Q, Zhang, W, Zhang, Q.Q, Jin, J, Li, X, Yang, H.T, Shaw, N, Rao, Z.
登録日2014-03-28
公開日2014-06-11
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Mechanism of dephosphorylation of glucosyl-3-phosphoglycerate by a histidine phosphatase
J.Biol.Chem., 289, 2014
6I3U
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BU of 6i3u by Molmil
Optimization of potent and selective ATM inhibitors suitable for a proof-of-concept study in Huntington's disease models
分子名称: 2-morpholin-4-yl-6-[7-[(2~{R})-1-morpholin-4-ylpropan-2-yl]oxy-9~{H}-thioxanthen-4-yl]pyran-4-one, Phosphatidylinositol 3-kinase catalytic subunit type 3
著者Leonard, P.M.
登録日2018-11-07
公開日2019-03-20
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington's Disease Models.
J.Med.Chem., 62, 2019
6MYR
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BU of 6myr by Molmil
Avian mitochondrial complex II with thiapronil bound
分子名称: 1,2-Distearoyl-sn-glycerophosphoethanolamine, DI(HYDROXYETHYL)ETHER, FE2/S2 (INORGANIC) CLUSTER, ...
著者Huang, L.-S, Luemmen, P, Berry, E.A.
登録日2018-11-02
公開日2019-10-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Crystallographic investigation of the ubiquinone binding site of respiratory Complex II and its inhibitors.
Biochim Biophys Acta Proteins Proteom, 1869, 2021
6MYQ
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BU of 6myq by Molmil
Avian mitochondrial complex II with ferulenol bound
分子名称: (~{Z})-2-oxidanylbut-2-enedioic acid, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 4-oxidanyl-3-[(2~{E},6~{E})-3,7,11-trimethyldodeca-2,6,10-trienyl]chromen-2-one, ...
著者Berry, E.A, Huang, L.-S.
登録日2018-11-02
公開日2019-11-06
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Crystallographic investigation of the ubiquinone binding site of respiratory Complex II and its inhibitors.
Biochim Biophys Acta Proteins Proteom, 1869, 2021
6MYP
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BU of 6myp by Molmil
Avian mitochondrial complex II with TTFA (thenoyltrifluoroacetone) bound
分子名称: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 4,4,4-TRIFLUORO-1-THIEN-2-YLBUTANE-1,3-DIONE, BICARBONATE ION, ...
著者Berry, E.A, Huang, L.-S.
登録日2018-11-02
公開日2019-11-06
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystallographic investigation of the ubiquinone binding site of respiratory Complex II and its inhibitors.
Biochim Biophys Acta Proteins Proteom, 1869, 2021
6MYT
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BU of 6myt by Molmil
Avian mitochondrial complex II with Atpenin A5 bound, sidechain in pocket
分子名称: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 3-[(2S,4S,5R)-5,6-DICHLORO-2,4-DIMETHYL-1-OXOHEXYL]-4-HYDROXY-5,6-DIMETHOXY-2(1H)-PYRIDINONE, DI(HYDROXYETHYL)ETHER, ...
著者Berry, E.A, Huang, L.-S.
登録日2018-11-02
公開日2019-11-06
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Crystallographic investigation of the ubiquinone binding site of respiratory Complex II and its inhibitors.
Biochim Biophys Acta Proteins Proteom, 1869, 2021
6MYU
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BU of 6myu by Molmil
Avian mitochondrial complex II crystallized in the presence of HQNO
分子名称: 1,2-Distearoyl-sn-glycerophosphoethanolamine, DI(HYDROXYETHYL)ETHER, FE2/S2 (INORGANIC) CLUSTER, ...
著者Berry, E.A, Huang, L.-S.
登録日2018-11-02
公開日2019-11-06
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Crystallographic investigation of the ubiquinone binding site of respiratory Complex II and its inhibitors.
Biochim Biophys Acta Proteins Proteom, 1869, 2021
6MYO
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BU of 6myo by Molmil
Avian mitochondrial complex II with flutolanyl bound
分子名称: 1,2-Distearoyl-sn-glycerophosphoethanolamine, DI(HYDROXYETHYL)ETHER, FE2/S2 (INORGANIC) CLUSTER, ...
著者Berry, E.A, Huang, L.-S.
登録日2018-11-02
公開日2019-11-06
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystallographic investigation of the ubiquinone binding site of respiratory Complex II and its inhibitors.
Biochim Biophys Acta Proteins Proteom, 1869, 2021
1GIS
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BU of 1gis by Molmil
A TRICHOSANTHIN(TCS) MUTANT(E85Q) COMPLEX STRUCTURE WITH 2'-DEOXY-ADENOSIN-5'-MONOPHOSPHATE
分子名称: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, RIBOSOME-INACTIVATING PROTEIN ALPHA-TRICHOSANTHIN
著者Guo, Q, Liu, Y, Dong, Y, Rao, Z.
登録日2001-03-15
公開日2003-06-03
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Substrate binding and catalysis in trichosanthin occur in different sites as revealed by the complex structures of several E85 mutants.
Protein Eng., 16, 2003
3NZ0
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BU of 3nz0 by Molmil
Non-phosphorylated TYK2 kinase with CMP6
分子名称: 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE, Non-receptor tyrosine-protein kinase TYK2
著者Eigenbrot, C, Ultsch, M.
登録日2010-07-15
公開日2010-10-20
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A new regulatory switch in a JAK protein kinase.
Proteins, 79, 2011
6MYS
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BU of 6mys by Molmil
Avian mitochondrial complex II with Atpenin A5 bound, sidechain outside
分子名称: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 3-[(2S,4S,5R)-5,6-DICHLORO-2,4-DIMETHYL-1-OXOHEXYL]-4-HYDROXY-5,6-DIMETHOXY-2(1H)-PYRIDINONE, FE2/S2 (INORGANIC) CLUSTER, ...
著者Berry, E.A, Huang, L.-S.
登録日2018-11-02
公開日2019-11-06
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Crystallographic investigation of the ubiquinone binding site of respiratory Complex II and its inhibitors.
Biochim Biophys Acta Proteins Proteom, 1869, 2021
3NYX
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BU of 3nyx by Molmil
Non-phosphorylated TYK2 JH1 domain with Quinoline-Thiadiazole-Thiophene Inhibitor
分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, N-{5-[(7-chloroquinolin-4-yl)sulfanyl]-1,3,4-thiadiazol-2-yl}thiophene-2-carboxamide, Non-receptor tyrosine-protein kinase TYK2
著者Eigenbrot, C, Ultsch, M.
登録日2010-07-15
公開日2010-10-20
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A new regulatory switch in a JAK protein kinase.
Proteins, 79, 2011
3MW1
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BU of 3mw1 by Molmil
p38 kinase Crystal structure in complex with small molecule inhibitor
分子名称: 8-(2,6-dichlorophenyl)-4-(2,4-difluorophenyl)-2-piperidin-4-yl-1,7-naphthyridine 7-oxide, Mitogen-activated protein kinase 14
著者Segarra, V, Caturla, F, Lumeras, W, Roca, R, Fisher, M, Lamers, M.
登録日2010-05-05
公開日2011-04-27
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献1,7-Naphthyridine 1-Oxides as Novel Potent and Selective Inhibitors of p38 Mitogen Activated Protein Kinase
J.Med.Chem., 54, 2011
1H0C
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BU of 1h0c by Molmil
The crystal structure of human alanine:glyoxylate aminotransferase
分子名称: (AMINOOXY)ACETIC ACID, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, ...
著者Zhang, X, Danpure, C.J, Roe, S.M, Pearl, L.H.
登録日2002-06-17
公開日2003-06-12
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of Alanine:Glyoxylate Aminotransferase and the Relationship between Genotype and Enzymatic Phenotype in Primary Hyperoxaluria Type 1.
J.Mol.Biol., 331, 2003
1GIU
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BU of 1giu by Molmil
A TRICHOSANTHIN(TCS) MUTANT(E85R) COMPLEX STRUCTURE WITH ADENINE
分子名称: ADENINE, RIBOSOME-INACTIVATING PROTEIN ALPHA-TRICHOSANTHIN
著者Guo, Q, Liu, Y, Dong, Y, Rao, Z.
登録日2001-03-15
公開日2003-06-03
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Substrate binding and catalysis in trichosanthin occur in different sites as revealed by the complex structures of several E85 mutants.
Protein Eng., 16, 2003
1GH2
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BU of 1gh2 by Molmil
Crystal structure of the catalytic domain of a new human thioredoxin-like protein
分子名称: THIOREDOXIN-LIKE PROTEIN
著者Jin, J, Chen, X, Guo, Q, Yuan, J, Qiang, B, Rao, Z.
登録日2000-11-01
公開日2001-05-01
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Crystal structure of the catalytic domain of a human thioredoxin-like protein.
Eur.J.Biochem., 269, 2002
1QZ2
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BU of 1qz2 by Molmil
Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90
分子名称: 5-mer peptide from Heat shock protein HSP 90, FK506-binding protein 4
著者Wu, B, Li, P, Lou, Z, Liu, Y, Ding, Y, Shu, C, Shen, B, Rao, Z.
登録日2003-09-15
公開日2004-06-22
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献3D structure of human FK506-binding protein 52: Implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex.
Proc.Natl.Acad.Sci.USA, 101, 2004
8OVJ
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BU of 8ovj by Molmil
CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : PARENTAL STRAIN
分子名称: 40S ribosomal protein S12, 40S ribosomal protein S14, 40S ribosomal protein S19-like protein, ...
著者Rajan, K.S, Yonath, A.
登録日2023-04-26
公開日2024-05-08
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Cell Rep, 43, 2024

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