5EU8
| Structure of FIPV main protease in complex with dual inhibitors | 分子名称: | 1,2-ETHANEDIOL, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE, ZINC ION, ... | 著者 | Wang, F, Chen, C, Liu, X, Yang, K, Xu, X, Yang, H. | 登録日 | 2015-11-18 | 公開日 | 2015-12-30 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.447 Å) | 主引用文献 | Crystal Structure of Feline Infectious Peritonitis Virus Main Protease in Complex with Synergetic Dual Inhibitors J.Virol., 90, 2015
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5VK3
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5H4R
| the complex of Glycoside Hydrolase 5 Lichenase from Caldicellulosiruptor sp. F32 E188Q mutant and cellotetraose | 分子名称: | Beta-1,3-1,4-glucanase, GLYCEROL, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose | 著者 | Dong, S, Zhou, H, Liu, X, Wang, X, Feng, Y. | 登録日 | 2016-11-02 | 公開日 | 2017-09-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.70310438 Å) | 主引用文献 | Structural insights into the substrate specificity of a glycoside hydrolase family 5 lichenase from Caldicellulosiruptor sp. F32 Biochem. J., 474, 2017
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5WAK
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4LSW
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8W1V
| The beta2 adrenergic receptor bound to a bitopic ligand | 分子名称: | (2S)-1-[(3-{1-[4-(4-{(2S)-2-hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)butyl]-1H-1,2,3-triazol-4-yl}propyl)amino]-3-(2-propylphenoxy)propan-2-ol, Beta-2 adrenergic receptor,Endolysin, Lauryl Maltose Neopentyl Glycol, ... | 著者 | Gaiser, B, Danielsen, M, Xu, X, Jorgensen, K, Fronik, P, Marcher-Rorsted, E, Wrobe, T, Hirata, K, Liu, X, Mathiesen, J, Pedersen, D. | 登録日 | 2024-02-19 | 公開日 | 2024-07-17 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Bitopic Ligands Support the Presence of a Metastable Binding Site at the beta 2 Adrenergic Receptor. J.Med.Chem., 67, 2024
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3NYJ
| Crystal Structure Analysis of APP E2 domain | 分子名称: | Amyloid beta A4 protein, OSMIUM ION | 著者 | Ha, Y, Hu, J, Lee, S, Liu, X. | 登録日 | 2010-07-15 | 公開日 | 2011-06-01 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization. Biochemistry, 50, 2011
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4D3E
| Tetramer of IpaD, modified from 2J0O, fitted into negative stain electron microscopy reconstruction of the wild type tip complex from the type III secretion system of Shigella flexneri | 分子名称: | INVASIN IPAD | 著者 | Cheung, M, Shen, D.-K, Makino, F, Kato, T, Roehrich, D, Martinez-Argudo, I, Walker, M.L, Murillo, I, Liu, X, Pain, M, Brown, J, Frazer, G, Mantell, J, Mina, P, Todd, T, Sessions, R.B, Namba, K, Blocker, A.J. | 登録日 | 2014-10-21 | 公開日 | 2014-12-10 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (24 Å) | 主引用文献 | Three-Dimensional Electron Microscopy Reconstruction and Cysteine-Mediated Crosslinking Provide a Model of the T3Ss Needle Tip Complex. Mol.Microbiol., 95, 2015
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5YK9
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3OD5
| Crystal structure of active caspase-6 bound with Ac-VEID-CHO | 分子名称: | CACODYLATE ION, Caspase-6, peptide aldehyde inhibitor AC-VEID-CHO | 著者 | Wang, X.-J, Liu, X, Wang, K.-T, Cao, Q, Su, X.-D. | 登録日 | 2010-08-11 | 公開日 | 2010-10-27 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation Embo Rep., 11, 2010
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3O4O
| Crystal structure of an Interleukin-1 receptor complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-1 beta, ... | 著者 | Wang, X.Q, Wang, D.L, Zhang, S.Y, Li, L, Liu, X, Mei, K.R. | 登録日 | 2010-07-27 | 公開日 | 2010-09-01 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structural insights into the assembly and activation of IL-1beta with its receptors Nat.Immunol., 11, 2010
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3Q0E
| Crystals Structure of Aspartate beta-Semialdehyde Dehydrogenase from Vibrio Cholerae with product of S-allyl-L-cysteine sulfoxide | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Aspartate-semialdehyde dehydrogenase, ... | 著者 | Pavlovsky, A.G, Liu, X, Viola, R.E. | 登録日 | 2010-12-15 | 公開日 | 2012-02-22 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural characterization of inhibitors with selectivity against members of a homologous enzyme family. Chem.Biol.Drug Des., 79, 2012
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3PMR
| Crystal Structure of E2 domain of Human Amyloid Precursor-Like Protein 1 | 分子名称: | Amyloid-like protein 1, PHOSPHATE ION | 著者 | Lee, S, Xue, Y, Hu, J, Wang, Y, Liu, X, Demeler, B, Ha, Y. | 登録日 | 2010-11-17 | 公開日 | 2011-06-01 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization. Biochemistry, 50, 2011
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3PYL
| Crystal structure of aspartate beta-semialdehide dehydrogenase from Streptococcus pneumoniae with D-2,3-diaminopropionate | 分子名称: | 3-amino-D-alanine, Aspartate-semialdehyde dehydrogenase | 著者 | Pavlovsky, A.G, Liu, X, Faehnle, C.R, Potente, N, Viola, R.E. | 登録日 | 2010-12-13 | 公開日 | 2012-01-04 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural Characterization of Inhibitors with Selectivity against Members of a Homologous Enzyme Family. Chem.Biol.Drug Des., 79, 2012
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3NR2
| Crystal structure of Caspase-6 zymogen | 分子名称: | Caspase-6 | 著者 | Su, X.-D, Wang, X.-J, Liu, X, Mi, W, Wang, K.-T. | 登録日 | 2010-06-30 | 公開日 | 2010-10-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation Embo Rep., 11, 2010
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4MH1
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8H3G
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) E166V Mutant in Complex with Inhibitor Enstrelvir | 分子名称: | 3C-like proteinase nsp5, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione, GLYCEROL | 著者 | Wang, H, Lin, M, Duan, Y, Zhang, X, Zhou, H, Bian, Q, Liu, X, Rao, Z, Yang, H. | 登録日 | 2022-10-08 | 公開日 | 2023-10-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Nature, 622, 2023
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8H3L
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) Double Mutant (T21I and E166V) in Complex with Inhibitor Enstrelvir | 分子名称: | 3C-like proteinase nsp5, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione | 著者 | Wang, H, Lin, M, Duan, Y, Zhang, X, Zhou, H, Bian, Q, Liu, X, Rao, Z, Yang, H. | 登録日 | 2022-10-08 | 公開日 | 2023-10-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Nature, 622, 2023
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8H3K
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) Double Mutant (L50F and E166V) in Complex with Inhibitor Enstrelvir | 分子名称: | 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, 3C-like proteinase nsp5, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione, ... | 著者 | Wang, H, Lin, M, Duan, Y, Zhang, X, Zhou, H, Bian, Q, Liu, X, Rao, Z, Yang, H. | 登録日 | 2022-10-08 | 公開日 | 2023-10-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Nature, 622, 2023
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5D5B
| In meso X-ray crystallography structure of the Beta2-adrenergic receptor at 100 K | 分子名称: | (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, 1,4-BUTANEDIOL, ACETAMIDE, ... | 著者 | Huang, C.-Y, Olieric, V, Liu, X, Kobilka, B, Wang, M, Caffrey, M. | 登録日 | 2015-08-10 | 公開日 | 2016-01-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures. Acta Crystallogr D Struct Biol, 72, 2016
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5D5A
| In meso in situ serial X-ray crystallography structure of the Beta2-adrenergic receptor at 100 K | 分子名称: | (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, 1,4-BUTANEDIOL, ACETAMIDE, ... | 著者 | Huang, C.-Y, Olieric, V, Warshamanage, R, Liu, X, Kobilka, B, Kay Diederichs, K, Wang, M, Caffrey, M. | 登録日 | 2015-08-10 | 公開日 | 2016-01-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.4826 Å) | 主引用文献 | In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures. Acta Crystallogr D Struct Biol, 72, 2016
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8H6I
| The crystal structure of SARS-CoV-2 3C-like protease Double Mutant (L50F and E166V) in complex with a traditional Chinese Medicine Inhibitors | 分子名称: | (1beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14R,16beta)-1,6,7,14-tetrahydroxy-7,20-epoxykauran-15-one, 3C-like proteinase nsp5 | 著者 | Lin, M, Liu, X. | 登録日 | 2022-10-17 | 公開日 | 2023-10-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Nature, 622, 2023
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8H7K
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8H51
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) Double Mutant (T21I and E166V) in Complex with Inhibitor Nirmatrelvir | 分子名称: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | 著者 | Lin, M, Liu, X. | 登録日 | 2022-10-11 | 公開日 | 2023-10-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Nature, 622, 2023
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8H5P
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) Double Mutant (L50F and E166V) in Complex with Inhibitor Nirmatrelvir | 分子名称: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | 著者 | Lin, M, Liu, X. | 登録日 | 2022-10-13 | 公開日 | 2023-10-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Nature, 622, 2023
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