6JV3
 
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8JRN
 | | Structure of E6AP-E6 complex in Att1 state | | 分子名称: | Protein E6, Ubiquitin-protein ligase E3A, ZINC ION | | 著者 | Wang, Z, Yu, X. | | 登録日 | 2023-06-17 | | 公開日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structural insights into the functional mechanism of the ubiquitin ligase E6AP.
Nat Commun, 15, 2024
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8JRQ
 | | Structure of E6AP-E6 complex in Det1 state | | 分子名称: | Protein E6, Ubiquitin-protein ligase E3A, ZINC ION | | 著者 | Wang, Z, Yu, X. | | 登録日 | 2023-06-17 | | 公開日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (4.15 Å) | | 主引用文献 | Structural insights into the functional mechanism of the ubiquitin ligase E6AP.
Nat Commun, 15, 2024
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8JRO
 | | Structure of E6AP-E6 complex in Att2 state | | 分子名称: | Protein E6, Ubiquitin-protein ligase E3A, ZINC ION | | 著者 | Wang, Z, Yu, X. | | 登録日 | 2023-06-17 | | 公開日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | | 主引用文献 | Structural insights into the functional mechanism of the ubiquitin ligase E6AP.
Nat Commun, 15, 2024
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8JRP
 | | Structure of E6AP-E6 complex in Att3 state | | 分子名称: | Protein E6, Ubiquitin-protein ligase E3A, ZINC ION | | 著者 | Wang, Z, Yu, X. | | 登録日 | 2023-06-17 | | 公開日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | | 主引用文献 | Structural insights into the functional mechanism of the ubiquitin ligase E6AP.
Nat Commun, 15, 2024
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8JRR
 | | Structure of E6AP-E6 complex in Det2 state | | 分子名称: | Protein E6, Ubiquitin-protein ligase E3A, ZINC ION | | 著者 | Wang, Z, Yu, X. | | 登録日 | 2023-06-17 | | 公開日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (4.35 Å) | | 主引用文献 | Structural insights into the functional mechanism of the ubiquitin ligase E6AP.
Nat Commun, 15, 2024
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2Q15
 | | Structure of BACE complexed to compound 3a | | 分子名称: | (4S)-4-(2-AMINO-6-PHENOXYQUINAZOLIN-3(4H)-YL)-N,4-DICYCLOHEXYL-N-METHYLBUTANAMIDE, Beta-secretase 1 | | 著者 | Sharff, A.J. | | 登録日 | 2007-05-23 | | 公開日 | 2007-08-14 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | 2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-Site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead.
J.Med.Chem., 50, 2007
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2Q11
 | | Structure of BACE complexed to compound 1 | | 分子名称: | 3-(2-AMINO-6-BENZOYLQUINAZOLIN-3(4H)-YL)-N-CYCLOHEXYL-N-METHYLPROPANAMIDE, Beta-secretase 1 | | 著者 | Sharff, A.J. | | 登録日 | 2007-05-23 | | 公開日 | 2007-08-14 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | 2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-Site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead.
J.Med.Chem., 50, 2007
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2HAL
 | | An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors | | 分子名称: | Hepatitis A Protease 3C, N-ACETYL-LEUCYL-PHENYLALANYL-PHENYLALANYL-GLUTAMATE-FLUOROMETHYLKETONE INHIBITOR, N-[(BENZYLOXY)CARBONYL]-L-ALANINE | | 著者 | Yin, J, Cherney, M.M, Bergmann, E.M, James, M.N. | | 登録日 | 2006-06-13 | | 公開日 | 2006-08-08 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | An Episulfide Cation (Thiiranium Ring) Trapped in the Active Site of HAV 3C Proteinase Inactivated by Peptide-based Ketone Inhibitors.
J.Mol.Biol., 361, 2006
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3Q35
 | | Structure of the Rtt109-AcCoA/Vps75 complex and implications for chaperone-mediated histone acetylation | | 分子名称: | 1,2-ETHANEDIOL, ACETYL COENZYME *A, Histone acetyltransferase, ... | | 著者 | Tang, Y, Yuan, H, Meeth, K, Marmorstein, R. | | 登録日 | 2010-12-21 | | 公開日 | 2011-02-02 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structure of the Rtt109-AcCoA/Vps75 Complex and Implications for Chaperone-Mediated Histone Acetylation.
Structure, 19, 2011
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3Q33
 | | Structure of the Rtt109-AcCoA/Vps75 Complex and Implications for Chaperone-Mediated Histone Acetylation | | 分子名称: | 1,2-ETHANEDIOL, ACETYL COENZYME *A, HISTONE H3, ... | | 著者 | Tang, Y, Yuan, H, Meeth, K, Marmorstein, R. | | 登録日 | 2010-12-21 | | 公開日 | 2011-02-02 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure of the Rtt109-AcCoA/Vps75 Complex and Implications for Chaperone-Mediated Histone Acetylation.
Structure, 19, 2011
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8X73
 | | Crystal structure of Peroxiredoxin I in complex with compound 19-069 | | 分子名称: | Peroxiredoxin-1, methyl (2~{S})-2-[[(2~{R},4~{a}~{S},6~{a}~{R},6~{a}~{S},14~{a}~{S},14~{b}~{R})-2,4~{a},6~{a},6~{a},9,14~{a}-hexamethyl-10-oxidanyl-11-oxidanylidene-1,3,4,5,6,13,14,14~{b}-octahydropicen-2-yl]carbamoylamino]-3-oxidanyl-propanoate | | 著者 | Zhang, H, Luo, C. | | 登録日 | 2023-11-22 | | 公開日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | | 主引用文献 | Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors.
J.Med.Chem., 67, 2024
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8X71
 | | Crystal structure of Peroxiredoxin I in complex with compound 19-064 | | 分子名称: | Peroxiredoxin-1, methyl 3-[[(2~{R},4~{a}~{S},6~{a}~{R},6~{a}~{S},14~{a}~{S},14~{b}~{R})-2,4~{a},6~{a},6~{a},9,14~{a}-hexamethyl-10-oxidanyl-11-oxidanylidene-1,3,4,5,6,13,14,14~{b}-octahydropicen-2-yl]carbamoylamino]oxetane-3-carboxylate | | 著者 | Zhang, H, Luo, C. | | 登録日 | 2023-11-22 | | 公開日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors.
J.Med.Chem., 67, 2024
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5VXC
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5VXO
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5VXS
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5WUU
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7V7W
 | | Crystal Structure of the Heterodimeric HIF-3a:ARNT Complex with oleoylethanolamide (OEA) | | 分子名称: | (Z)-N-(2-hydroxyethyl)octadec-9-enamide, Aryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 3-alpha | | 著者 | Diao, X, Ren, X, Li, F.W, Zhang, M, Sun, X, Wu, D. | | 登録日 | 2021-08-21 | | 公開日 | 2022-05-18 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.507 Å) | | 主引用文献 | Identification of oleoylethanolamide as an endogenous ligand for HIF-3 alpha.
Nat Commun, 13, 2022
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3UO7
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3UOB
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7V7L
 | | Crystal Structure of the Heterodimeric HIF-3a:ARNT Complex | | 分子名称: | Aryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 3-alpha | | 著者 | Diao, X, Ren, X, Li, F.W, Sun, X, Wu, D. | | 登録日 | 2021-08-21 | | 公開日 | 2022-05-18 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Identification of oleoylethanolamide as an endogenous ligand for HIF-3 alpha.
Nat Commun, 13, 2022
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7VD4
 | | Crystal structure of BPTF-BRD with ligand TP248 bound | | 分子名称: | 6-[4-[3-(dimethylamino)propoxy]phenyl]-N-methyl-2-methylsulfonyl-pyrimidin-4-amine, Nucleosome-remodeling factor subunit BPTF | | 著者 | Lu, T, Lu, H.B. | | 登録日 | 2021-09-06 | | 公開日 | 2022-09-14 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.85659146 Å) | | 主引用文献 | Discovery of a highly potent CECR2 bromodomain inhibitor with 7H-pyrrolo[2,3-d] pyrimidine scaffold.
Bioorg.Chem., 123, 2022
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7YHW
 | | Cryo-EM structure of SARS-CoV-2 Omicron BA.2.12.1 RBD in complex with human ACE2 (local refinement) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, Z.N, Xie, Y.F, Qi, J.X, Gao, G.F. | | 登録日 | 2022-07-14 | | 公開日 | 2023-07-19 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | | 主引用文献 | Structural basis for receptor binding and broader interspecies receptor recognition of currently circulating Omicron sub-variants.
Nat Commun, 14, 2023
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5VZ2
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5W18
 | | Staphylococcus aureus ClpP in complex with (S)-N-((2R,6S,8aS,14aS,20S,23aS)-2,6-dimethyl-5,8,14,19,23-pentaoxooctadecahydro-1H,5H,14H,19H-pyrido[2,1-i]dipyrrolo[2,1-c:2',1'-l][1]oxa[4,7,10,13]tetraazacyclohexadecin-20-yl)-3-phenyl-2-(3-phenylureido)propanamide | | 分子名称: | 9V7-PHE-SER-PRO-YCP-ALA-MP8, ATP-dependent Clp protease proteolytic subunit | | 著者 | Lee, R.E, Griffith, E.C. | | 登録日 | 2017-06-02 | | 公開日 | 2017-08-09 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | Ureadepsipeptides as ClpP Activators.
Acs Infect Dis., 2019
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