7DPG
 
 | | Cryo-EM structure of Coxsackievirus B1 empty particle | | 分子名称: | VP2, VP3, Virion protein 1 | | 著者 | Li, S, Zhu, R, Xu, L, Cheng, T, Zheng, Q, Xia, N. | | 登録日 | 2020-12-18 | | 公開日 | 2021-05-05 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Cryo-EM structures reveal the molecular basis of receptor-initiated coxsackievirus uncoating.
Cell Host Microbe, 29, 2021
|
|
7DQ7
 | | Cryo-EM structure of Coxsackievirus B1 mature virion in complex with nAb 5F5 | | 分子名称: | 5F5 VH, 5F5 VL, Capsid protein VP4, ... | | 著者 | Li, S, Zhu, R, Xu, L, Cheng, T, Zheng, Q. | | 登録日 | 2020-12-22 | | 公開日 | 2021-05-05 | | 最終更新日 | 2024-11-20 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-EM structures reveal the molecular basis of receptor-initiated coxsackievirus uncoating.
Cell Host Microbe, 29, 2021
|
|
9NGE
 | | The ubiquitin-associated domain of human thirty-eight negative kinase-1 rigidly fused to a double trigger variant of the 1TEL crystallization chaperone | | 分子名称: | DI(HYDROXYETHYL)ETHER, POTASSIUM ION, SODIUM ION, ... | | 著者 | Averett, J.C, Bradford, M.J, Averett, B.J, Hansen, D, Doukov, T, Moody, J.D. | | 登録日 | 2025-02-22 | | 公開日 | 2025-03-26 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | The ubiquitin-associated domain of human thirty-eight negative kinase-1 rigidly fused to a double trigger variant of the 1TEL crystallization chaperone
To Be Published
|
|
8X98
 | | Cryo-EM structure of coxsackievirus A16 mature virion in complex with Fab h1A6.2 | | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | | 著者 | Jiang, Y, Huang, Y, Zhu, R, Zheng, Q, Li, S, Xia, N. | | 登録日 | 2023-11-29 | | 公開日 | 2024-09-04 | | 最終更新日 | 2025-01-15 | | 実験手法 | ELECTRON MICROSCOPY (3.69 Å) | | 主引用文献 | Broadly therapeutic antibody provides cross-serotype protection against enteroviruses via Fc effector functions and by mimicking SCARB2.
Nat Microbiol, 9, 2024
|
|
8X96
 | | Cryo-EM structure of enterovirus A71 A-particle in complex with Fab h1A6.2 | | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3 | | 著者 | Jiang, Y, Huang, Y, Zhu, R, Zheng, Q, Li, S, Xia, N. | | 登録日 | 2023-11-29 | | 公開日 | 2024-09-04 | | 最終更新日 | 2025-01-15 | | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | | 主引用文献 | Broadly therapeutic antibody provides cross-serotype protection against enteroviruses via Fc effector functions and by mimicking SCARB2.
Nat Microbiol, 9, 2024
|
|
8X9B
 | | Cryo-EM structure of coxsackievirus A16 empty particle in complex with Fab h1A6.2 (local refinement) | | 分子名称: | Capsid protein VP1, Genome polyprotein, The heavy chain of Fab h1A6.2, ... | | 著者 | Jiang, Y, Huang, Y, Zhu, R, Zheng, Q, Li, S, Xia, N. | | 登録日 | 2023-11-29 | | 公開日 | 2024-09-04 | | 最終更新日 | 2025-01-15 | | 実験手法 | ELECTRON MICROSCOPY (3.82 Å) | | 主引用文献 | Broadly therapeutic antibody provides cross-serotype protection against enteroviruses via Fc effector functions and by mimicking SCARB2.
Nat Microbiol, 9, 2024
|
|
8X99
 | | Cryo-EM structure of coxsackievirus A16 A-particle in complex with Fab h1A6.2 | | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3 | | 著者 | Jiang, Y, Huang, Y, Zhu, R, Zheng, Q, Li, S, Xia, N. | | 登録日 | 2023-11-29 | | 公開日 | 2024-09-04 | | 最終更新日 | 2025-01-15 | | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | | 主引用文献 | Broadly therapeutic antibody provides cross-serotype protection against enteroviruses via Fc effector functions and by mimicking SCARB2.
Nat Microbiol, 9, 2024
|
|
8X95
 | | Cryo-EM structure of enterovirus A71 mature virion in complex with Fab h1A6.2 | | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | | 著者 | Jiang, Y, Huang, Y, Zhu, R, Zheng, Q, Li, S, Xia, N. | | 登録日 | 2023-11-29 | | 公開日 | 2024-09-04 | | 最終更新日 | 2025-01-15 | | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | | 主引用文献 | Broadly therapeutic antibody provides cross-serotype protection against enteroviruses via Fc effector functions and by mimicking SCARB2.
Nat Microbiol, 9, 2024
|
|
8X9A
 | | Cryo-EM structure of coxsackievirus A16 empty particle in complex with Fab h1A6.2 | | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3 | | 著者 | Jiang, Y, Huang, Y, Zhu, R, Zheng, Q, Li, S, Xia, N. | | 登録日 | 2023-11-29 | | 公開日 | 2024-09-04 | | 最終更新日 | 2025-01-15 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | Broadly therapeutic antibody provides cross-serotype protection against enteroviruses via Fc effector functions and by mimicking SCARB2.
Nat Microbiol, 9, 2024
|
|
8X97
 | | Cryo-EM structure of enterovirus A71 empty particle in complex with Fab h1A6.2 | | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3 | | 著者 | Jiang, Y, Huang, Y, Zhu, R, Zheng, Q, Li, S. | | 登録日 | 2023-11-29 | | 公開日 | 2024-09-04 | | 最終更新日 | 2025-01-15 | | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | | 主引用文献 | Broadly therapeutic antibody provides cross-serotype protection against enteroviruses via Fc effector functions and by mimicking SCARB2.
Nat Microbiol, 9, 2024
|
|
7DPF
 | |
8YTJ
 | | Cryo-EM structure of enterovirus A71 mature virion | | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | | 著者 | Jiang, Y, Huang, Y, Zhu, R, Zheng, Q, Li, S, Xia, N. | | 登録日 | 2024-03-26 | | 公開日 | 2024-09-04 | | 最終更新日 | 2025-01-15 | | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | | 主引用文献 | Broadly therapeutic antibody provides cross-serotype protection against enteroviruses via Fc effector functions and by mimicking SCARB2.
Nat Microbiol, 9, 2024
|
|
8YTB
 | | Cryo-EM structure of enterovirus A71 empty particle | | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3 | | 著者 | Jiang, Y, Huang, Y, Zhu, R, Zheng, Q, Li, S, Xia, N. | | 登録日 | 2024-03-25 | | 公開日 | 2024-09-04 | | 最終更新日 | 2025-01-15 | | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | | 主引用文献 | Broadly therapeutic antibody provides cross-serotype protection against enteroviruses via Fc effector functions and by mimicking SCARB2.
Nat Microbiol, 9, 2024
|
|
4DMU
 | |
3FLF
 | | Thermolysin inhibition | | 分子名称: | CALCIUM ION, GLYCEROL, N-[(S)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-valyl-L-leucine, ... | | 著者 | Englert, L, Biela, A, Heine, A, Klebe, G. | | 登録日 | 2008-12-18 | | 公開日 | 2010-01-12 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Displacement of disordered water molecules from hydrophobic pocket creates enthalpic signature: binding of phosphonamidate to the S1'-pocket of thermolysin.
Biochim.Biophys.Acta, 1800, 2010
|
|
8VQQ
 | | Crystal structure of the A/Puerto Rico/8/1934 (H1N1) influenza virus hemagglutinin in complex with small molecule 6S | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, ... | | 著者 | Lin, T.H, Zhu, Y, Wilson, I.A. | | 登録日 | 2024-01-19 | | 公開日 | 2024-06-05 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Ultrapotent influenza hemagglutinin fusion inhibitors developed through SuFEx-enabled high-throughput medicinal chemistry.
Proc.Natl.Acad.Sci.USA, 121, 2024
|
|
8VQN
 | | Crystal structure of the A/Puerto Rico/8/1934 (H1N1) influenza virus hemagglutinin in complex with small molecule 6R | | 分子名称: | (S~1~S,3R)-N-{3-chloro-4-[(2S)-2-phenylmorpholine-4-carbonyl]phenyl}-3-(dimethylamino)pyrrolidine-1-sulfonimidoyl fluoride, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, ... | | 著者 | Lin, T.H, Zhu, Y, Wilson, I.A. | | 登録日 | 2024-01-18 | | 公開日 | 2024-06-05 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Ultrapotent influenza hemagglutinin fusion inhibitors developed through SuFEx-enabled high-throughput medicinal chemistry.
Proc.Natl.Acad.Sci.USA, 121, 2024
|
|
8VQL
 | | Crystal structure of the A/Puerto Rico/8/1934 (H1N1) influenza virus hemagglutinin in complex with small molecule 6S prime | | 分子名称: | (S~1~S,3S)-N-{3,5-dichloro-4-[(2S)-2-phenylmorpholine-4-carbonyl]phenyl}-3-(dimethylamino)pyrrolidine-1-sulfonimidoyl fluoride, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Lin, T.H, Zhu, Y, Wilson, I.A. | | 登録日 | 2024-01-18 | | 公開日 | 2024-06-05 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Ultrapotent influenza hemagglutinin fusion inhibitors developed through SuFEx-enabled high-throughput medicinal chemistry.
Proc.Natl.Acad.Sci.USA, 121, 2024
|
|
8VQM
 | | Crystal structure of the A/Puerto Rico/8/1934 (H1N1) influenza virus hemagglutinin in complex with small molecule 6R prime | | 分子名称: | (S~1~S,3R)-N-{3,5-dichloro-4-[(2S)-2-phenylmorpholine-4-carbonyl]phenyl}-3-(dimethylamino)pyrrolidine-1-sulfonimidoyl fluoride, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Lin, T.H, Zhu, Y, Wilson, I.A. | | 登録日 | 2024-01-18 | | 公開日 | 2024-06-05 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Ultrapotent influenza hemagglutinin fusion inhibitors developed through SuFEx-enabled high-throughput medicinal chemistry.
Proc.Natl.Acad.Sci.USA, 121, 2024
|
|
3FV4
 | | Thermolysin inhibition | | 分子名称: | CALCIUM ION, DIMETHYL SULFOXIDE, GLYCEROL, ... | | 著者 | Englert, L, Biela, A, Heine, A, Klebe, G. | | 登録日 | 2009-01-15 | | 公開日 | 2010-02-09 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | Displacement of disordered water molecules from hydrophobic pocket creates enthalpic signature: binding of phosphonamidate to the S1'-pocket of thermolysin.
Biochim.Biophys.Acta, 1800, 2010
|
|
3FVP
 | | Thermolysin inhibition | | 分子名称: | CALCIUM ION, DIMETHYL SULFOXIDE, GLYCEROL, ... | | 著者 | Englert, L, Biela, A, Heine, A, Klebe, G. | | 登録日 | 2009-01-16 | | 公開日 | 2010-02-09 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | | 主引用文献 | Thermolysin inhibition
To be Published
|
|
7XJG
 | | Cryo-EM structure of E.coli retron-Ec86 in complex with its effector at 2.5 angstrom | | 分子名称: | DNA (105-MER), MAGNESIUM ION, RNA (14-MER), ... | | 著者 | Wang, Y.J, Guan, Z.Y, Zou, T.T. | | 登録日 | 2022-04-17 | | 公開日 | 2022-09-14 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.51 Å) | | 主引用文献 | Cryo-EM structures of Escherichia coli Ec86 retron complexes reveal architecture and defence mechanism.
Nat Microbiol, 7, 2022
|
|
3OBK
 | |
5U8K
 | | RitR mutant - C128S | | 分子名称: | Response regulator | | 著者 | Silvaggi, N.R, Han, L. | | 登録日 | 2016-12-14 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | RitR is an archetype for a novel family of redox sensors in the streptococci that has evolved from two-component response regulators and is required for pneumococcal colonization.
PLoS Pathog., 14, 2018
|
|
7VCK
 | |
