6JXK
 
 | | Rb+-bound E2-MgF state of the gastric proton pump (Wild-type) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, MAGNESIUM ION, ... | | 著者 | Abe, K, Irie, K, Yamamoto, K. | | 登録日 | 2019-04-23 | | 公開日 | 2019-08-14 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | | 主引用文献 | A single K + -binding site in the crystal structure of the gastric proton pump.
Elife, 8, 2019
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3A1R
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6LHM
 | | Structure of human PYCR2 | | 分子名称: | Pyrroline-5-carboxylate reductase 2 | | 著者 | Baburajendran, N. | | 登録日 | 2019-12-09 | | 公開日 | 2020-10-28 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2.
Neuron, 107, 2020
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3WPK
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3WU8
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3WU7
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3WUA
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3WPL
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3WPJ
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3WU9
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7CEP
 | | Crystal structure of L-cycloserine-bound form of cysteine desulfurase SufS from Bacillus subtilis | | 分子名称: | (5-hydroxy-6-methyl-4-{[(3-oxo-2,3-dihydro-1,2-oxazol-4-yl)amino]methyl}pyridin-3-yl)methyl dihydrogen phosphate, Cysteine desulfurase SufS, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Nakamura, R, Yasuhiro, T, Fujishiro, T. | | 登録日 | 2020-06-24 | | 公開日 | 2021-06-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Cycloserine enantiomers inhibit PLP-dependent cysteine desulfurase SufS via distinct mechanisms.
Febs J., 2022
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7JXQ
 | | EGFR kinase (T790M/V948R) in complex with allosteric inhibitor JBJ-09-063 | | 分子名称: | (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ... | | 著者 | Beyett, T.S, Eck, M.J. | | 登録日 | 2020-08-27 | | 公開日 | 2021-09-08 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer.
Nat Cancer, 3, 2022
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2CU7
 | | Solution structure of the SANT domain of human KIAA1915 protein | | 分子名称: | KIAA1915 protein | | 著者 | Yoneyama, M, Umehara, T, Saito, K, Tochio, N, Koshiba, S, Inoue, M, Tanaka, A, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2005-05-25 | | 公開日 | 2005-11-25 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural and Functional Differences of SWIRM Domain Subtypes
J.Mol.Biol., 369, 2007
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2CUJ
 | | Solution structure of SWIRM domain of mouse transcriptional adaptor 2-like | | 分子名称: | transcriptional adaptor 2-like | | 著者 | Yoneyama, M, Umehara, T, Sato, M, Tochio, N, Koshiba, S, Inoue, M, Tanaka, A, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2005-05-26 | | 公開日 | 2005-11-26 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural and Functional Differences of SWIRM Domain Subtypes
J.Mol.Biol., 369, 2007
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7V5P
 | | The dimeric structure of G80A/H81A myoglobin | | 分子名称: | Myoglobin, OXYGEN ATOM, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Xie, C, Nagao, S, Shibata, N, Higuchi, Y, Hirota, S. | | 登録日 | 2021-08-17 | | 公開日 | 2022-06-29 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.16 Å) | | 主引用文献 | Experimental and theoretical study on converting myoglobin into a stable domain-swapped dimer by utilizing a tight hydrogen bond network at the hinge region.
Rsc Adv, 11, 2021
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9BJK
 | | Inactive mu opioid receptor bound to Nb6, naloxone and NAM | | 分子名称: | Mu-type opioid receptor, Naloxone, Nalpha-[({(1M)-1-[5-(benzyloxy)pyridin-3-yl]naphthalen-2-yl}sulfanyl)acetyl]-3-methoxy-N,4-dimethyl-L-phenylalaninamide, ... | | 著者 | O'Brien, E.S, Wang, H, Kaavya Krishna, K, Zhang, C, Kobilka, B.K. | | 登録日 | 2024-04-25 | | 公開日 | 2024-07-17 | | 最終更新日 | 2024-08-14 | | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | | 主引用文献 | A mu-opioid receptor modulator that works cooperatively with naloxone.
Nature, 631, 2024
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2DCE
 | | Solution structure of the SWIRM domain of human KIAA1915 protein | | 分子名称: | KIAA1915 protein | | 著者 | Yoneyama, M, Tochio, N, Umehara, T, Koshiba, S, Inoue, M, Tanaka, A, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2006-01-06 | | 公開日 | 2006-07-06 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural and Functional Differences of SWIRM Domain Subtypes
J.Mol.Biol., 369, 2007
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7CBF
 | | Crystal structure of benzophenone synthase from Garcinia mangostana L. pericarps reveals basis for substrate specificity and catalysis | | 分子名称: | 2,4,6-trihydroxybenzophenone synthase, GLYCEROL, IMIDAZOLE, ... | | 著者 | Songsiriritthigul, C, Nualkaew, N, Chen, C.-J. | | 登録日 | 2020-06-12 | | 公開日 | 2020-12-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.301 Å) | | 主引用文献 | Crystal structure of benzophenone synthase from Garcinia mangostana L. pericarps reveals basis for substrate specificity and catalysis.
Acta Crystallogr.,Sect.F, 76, 2020
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2OH4
 | | Crystal structure of Vegfr2 with a benzimidazole-urea inhibitor | | 分子名称: | METHYL (5-{4-[({[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-1H-BENZIMIDAZOL-2-YL)CARBAMATE, SULFATE ION, Vascular endothelial growth factor receptor 2 | | 著者 | Nolte, R.T, Wang, L. | | 登録日 | 2007-01-09 | | 公開日 | 2007-09-18 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Discovery of Novel Benzimidazoles as Potent Inhibitors of TIE-2 and VEGFR-2 Tyrosine Kinase Receptors.
J.Med.Chem., 50, 2007
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5X1A
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5X1D
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7M2U
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5X1C
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5Z5S
 | | Crystal structure of the PPARgamma-LBD complexed with compound 13ab | | 分子名称: | 3-{[6-(4-chloro-3-fluorophenoxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoic acid, CHLORIDE ION, Peptide from Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, ... | | 著者 | Matsui, Y, Hanzawa, H. | | 登録日 | 2018-01-19 | | 公開日 | 2018-10-17 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Discovery of DS-6930, a potent selective PPAR gamma modulator. Part I: Lead identification.
Bioorg. Med. Chem., 26, 2018
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7YU1
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