7WG9
| Delta Spike Trimer(1 RBD Up) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Cui, Z. | 登録日 | 2021-12-28 | 公開日 | 2022-06-22 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron. Cell, 185, 2022
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7WGB
| Neutral Omicron Spike Trimer in complex with ACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | 著者 | Cui, Z. | 登録日 | 2021-12-28 | 公開日 | 2022-06-22 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron. Cell, 185, 2022
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7WG8
| Delta Spike Trimer(3 RBD Down) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Cui, Z. | 登録日 | 2021-12-28 | 公開日 | 2022-06-22 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron. Cell, 185, 2022
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7XKC
| Crystal structure of Daucus Carrot hypoglycemic peptide (DCHP) | 分子名称: | DCHP, SULFATE ION | 著者 | Guo, T, Ren, J.Q, Wang, L, Shi, Y.W, Feng, W. | 登録日 | 2022-04-19 | 公開日 | 2022-05-18 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Characterization of a thermostable, protease-tolerant inhibitor of alpha-glycosidase from carrot: A potential oral additive for treatment of diabetes. Int.J.Biol.Macromol., 209, 2022
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8IXU
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8IXT
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7XFR
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7WG6
| Neutral Omicron Spike Trimer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Cui, Z, Wang, X. | 登録日 | 2021-12-28 | 公開日 | 2022-05-18 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron. Cell, 185, 2022
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7V9L
| Cryo-EM structure of the SV1-Gs complex. | 分子名称: | GHRH receptor splice variant 1,GHRH receptor splice variant 1,GHRH receptor splice variant 1,SV1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Cong, Z.T, Zhou, F.L, Zhang, C, Zou, X.Y, Zhang, H.B, Wang, Y.Z, Zhou, Q.T, Cai, X.Q, Liu, Q.F, Li, J, Shao, L.J, Mao, C.Y, Wang, X, Wu, J.H, Xia, T, Zhao, L.H, Jiang, H.L, Zhang, Y, Xu, H.E, Cheng, X, Yang, D.H, Wang, M.W. | 登録日 | 2021-08-26 | 公開日 | 2022-04-06 | 最終更新日 | 2022-05-04 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Constitutive signal bias mediated by the human GHRHR splice variant 1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7YFG
| Structure of the Rat GluN1-GluN2C NMDA receptor in complex with glycine and glutamate (major class in asymmetry) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | 著者 | Zhang, M, Zhang, J, Guo, F, Li, Y, Zhu, S. | 登録日 | 2022-07-08 | 公開日 | 2023-03-29 | 最終更新日 | 2023-05-31 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits. Nat.Struct.Mol.Biol., 30, 2023
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7YFH
| Structure of the Rat GluN1-GluN2C NMDA receptor in complex with glycine, glutamate and (R)-PYD-106 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | 著者 | Zhang, M, Zhang, J, Guo, F, Li, Y, Zhu, S. | 登録日 | 2022-07-08 | 公開日 | 2023-03-29 | 最終更新日 | 2023-05-31 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits. Nat.Struct.Mol.Biol., 30, 2023
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7WGX
| SARS-CoV-2 spike glycoprotein trimer in closed state after treatment with Cathepsin L | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-2-[[5-[(Z)-(3-ethenyl-4-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1H-pyrrol-2-yl]methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid, ... | 著者 | Zhu, Y, Tai, L, Yin, G, Sun, F. | 登録日 | 2021-12-29 | 公開日 | 2023-01-04 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies Cell Discov, 8, 2022
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7WGY
| SARS-CoV-2 spike glycoprotein trimer in Intermediate state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Zhu, Y, Tai, L, Yin, G, Sun, F. | 登録日 | 2021-12-29 | 公開日 | 2023-01-04 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies Cell Discov, 8, 2022
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7WGZ
| SARS-CoV-2 spike glycoprotein trimer in open state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Zhu, Y, Tai, L, Yin, G, Sun, F. | 登録日 | 2021-12-29 | 公開日 | 2023-01-04 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies Cell Discov, 8, 2022
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7WGV
| SARS-CoV-2 spike glycoprotein trimer in closed state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-2-[[5-[(Z)-(3-ethenyl-4-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1H-pyrrol-2-yl]methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid, ... | 著者 | Zhu, Y, Tai, L, Yin, G, Sun, F. | 登録日 | 2021-12-29 | 公開日 | 2023-01-04 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies Cell Discov, 8, 2022
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7YFI
| Structure of the Rat tri-heteromeric GluN1-GluN2A-GluN2C NMDA receptor in complex with glycine and glutamate | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | 著者 | Zhang, M, Zhang, J, Guo, F, Li, Y, Zhu, S. | 登録日 | 2022-07-08 | 公開日 | 2023-03-29 | 最終更新日 | 2023-07-26 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits. Nat.Struct.Mol.Biol., 30, 2023
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7V9M
| Cryo-EM structure of the GHRH-bound human GHRHR splice variant 1 complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Cong, Z.T, Zhou, F.L, Zhang, C, Zou, X.Y, Zhang, H.B, Wang, Y.Z, Zhou, Q.T, Cai, X.Q, Liu, Q.F, Li, J, Shao, L.J, Mao, C.Y, Wang, X, Wu, J.H, Xia, T, Zhao, L.H, Jiang, H.L, Zhang, Y, Xu, H.E, Chen, X, Yang, D.H, Wang, M.W. | 登録日 | 2021-08-26 | 公開日 | 2021-10-20 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | 主引用文献 | Constitutive signal bias mediated by the human GHRHR splice variant 1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7WK4
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7WK5
| Cryo-EM structure of Omicron S-ACE2, C2 state | 分子名称: | Angiotensin-converting enzyme 2, Spike glycoprotein | 著者 | Han, W.Y, Wang, Y.F. | 登録日 | 2022-01-08 | 公開日 | 2022-02-02 | 最終更新日 | 2022-03-09 | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | 主引用文献 | Molecular basis of SARS-CoV-2 Omicron variant receptor engagement and antibody evasion and neutralization Biorxiv, 2022
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7WK6
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3QLH
| HIV-1 Reverse Transcriptase in Complex with Manicol at the RNase H Active Site and TMC278 (Rilpivirine) at the NNRTI Binding Pocket | 分子名称: | (2S)-5,7-dihydroxy-9-methyl-2-(prop-1-en-2-yl)-1,2,3,4-tetrahydro-6H-benzo[7]annulen-6-one, 1,2-ETHANEDIOL, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... | 著者 | Himmel, D.M, Wojtak, K, Bauman, J.D, Arnold, E. | 登録日 | 2011-02-02 | 公開日 | 2011-12-21 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Synthesis, activity, and structural analysis of novel alpha-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H. J.Med.Chem., 54, 2011
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7WVN
| SARS-CoV-2 Omicron S-open | 分子名称: | Spike glycoprotein | 著者 | Li, J.W, Cong, Y. | 登録日 | 2022-02-10 | 公開日 | 2022-03-02 | 最終更新日 | 2022-05-04 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Molecular basis of receptor binding and antibody neutralization of Omicron. Nature, 604, 2022
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7WVO
| SARS-CoV-2 Omicron S-open-2 | 分子名称: | Spike glycoprotein | 著者 | Li, J.W, Cong, Y. | 登録日 | 2022-02-10 | 公開日 | 2022-03-02 | 最終更新日 | 2022-05-04 | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | 主引用文献 | Molecular basis of receptor binding and antibody neutralization of Omicron. Nature, 604, 2022
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7XAF
| The crystal structure of TrkA kinase in complex with 4^6,14-dimethyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-10-oxo-5-oxa-11,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclo- tetradecaphan-2-yne-45-carboxamide | 分子名称: | 4^6,14-dimethyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-10-oxo-5-oxa-11,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclo-tetradecaphan-2-yne-45-carboxamide, High affinity nerve growth factor receptor | 著者 | Zhang, Z.M, Wang, Y.J. | 登録日 | 2022-03-17 | 公開日 | 2022-06-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.001182 Å) | 主引用文献 | Discovery of the First Highly Selective and Broadly Effective Macrocycle-Based Type II TRK Inhibitors that Overcome Clinically Acquired Resistance. J.Med.Chem., 65, 2022
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7YFF
| Structure of GluN1a-GluN2D NMDA receptor in complex with agonist glycine and competitive antagonist CPP. | 分子名称: | (2R)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhang, J.L, Zhu, S.J, Zhang, M. | 登録日 | 2022-07-08 | 公開日 | 2023-04-12 | 最終更新日 | 2023-08-02 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits. Nat.Struct.Mol.Biol., 30, 2023
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