3C1C
 
 | | The effect of H3 K79 dimethylation and H4 K20 trimethylation on nucleosome and chromatin structure | | 分子名称: | Histone 2, H2bf, Histone H2A type 1, ... | | 著者 | Lu, X, Simon, M, Chodaparambil, J, Hansen, J, Shokat, K, Luger, K. | | 登録日 | 2008-01-22 | | 公開日 | 2008-10-07 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure.
Nat.Struct.Mol.Biol., 15, 2008
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2GGR
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5EDS
 | | Crystal structure of human PI3K-gamma in complex with benzimidazole inhibitor 5 | | 分子名称: | 4-azanyl-6-[[(1~{S})-1-[6-fluoranyl-1-(3-methylsulfonylphenyl)benzimidazol-2-yl]ethyl]amino]pyrimidine-5-carbonitrile, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | | 著者 | Whittington, D.A, Tang, J, Yakowec, P. | | 登録日 | 2015-10-21 | | 公開日 | 2015-12-30 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3K delta Inhibitors.
J.Med.Chem., 59, 2016
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2Q7D
 | | Crystal Structure of Human Inositol 1,3,4-Trisphosphate 5/6-kinase (ITPK1) in complex with AMPPNP and Mn2+ | | 分子名称: | Inositol-tetrakisphosphate 1-kinase, MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Chamberlain, P.P, Lesley, S.A, Spraggon, G. | | 登録日 | 2007-06-06 | | 公開日 | 2007-07-03 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Integration of inositol phosphate signaling pathways via human ITPK1.
J.Biol.Chem., 282, 2007
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8DH4
 | | T7 RNA polymerase elongation complex with unnatural base dPa-DsTP pair | | 分子名称: | (7P)-3-{5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-ribofuranosyl}-7-(thiophen-2-yl)-3H-imidazo[4,5-b]pyridine, MAGNESIUM ION, Non-template strand DNA, ... | | 著者 | Oh, J, Wang, D. | | 登録日 | 2022-06-24 | | 公開日 | 2023-02-01 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Nat Commun, 14, 2023
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8DH3
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8DH1
 | | T7 RNA polymerase elongation complex with unnatural base dDs-PaTP pair | | 分子名称: | 1-{5-O-[(S)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-ribofuranosyl}-1H-pyrrole-2-carbaldehyde, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Oh, J, Wang, D. | | 登録日 | 2022-06-24 | | 公開日 | 2023-02-01 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Nat Commun, 14, 2023
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8DH0
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8DH5
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8DH2
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6UPZ
 | | RNA polymerase II elongation complex with 5-guanidinohydantoin lesion in state 3 | | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | | 著者 | Oh, J, Wang, D. | | 登録日 | 2019-10-18 | | 公開日 | 2020-06-10 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | RNA polymerase II stalls on oxidative DNA damage via a torsion-latch mechanism involving lone pair-pi and CH-pi interactions.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6UPY
 | | RNA polymerase II elongation complex with 5-guanidinohydantoin lesion in state 2E | | 分子名称: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... | | 著者 | Oh, J, Wang, D. | | 登録日 | 2019-10-18 | | 公開日 | 2020-06-10 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | RNA polymerase II stalls on oxidative DNA damage via a torsion-latch mechanism involving lone pair-pi and CH-pi interactions.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6L97
 | | Complex of DNA polymerase IV and L-DNA duplex | | 分子名称: | DNA (5'-D(*(0DG)P*(0DG)P*(0DG)P*(0DG)P*(0DG)P*(0DA)P*(0DA)P*(0DG)P*(0DG)P*(0DA)P*(0DT)P*(0DT)P*(0DC)P*(0DC))-3'), DNA (5'-D(P*(0DG)P*(0DG)P*(0DA)P*(0DA)P*(0DT)P*(0DC)P*(0DC)P*(0DT)P*(0DT)P*(0DC)P*(0DC)P*(0DC)P*(0DC)P*(0DC))-3'), DNA polymerase IV | | 著者 | Chung, H.S, An, J, Hwang, D. | | 登録日 | 2019-11-08 | | 公開日 | 2020-07-08 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.362 Å) | | 主引用文献 | The crystal structure of a natural DNA polymerase complexed with mirror DNA.
Chem.Commun.(Camb.), 56, 2020
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8TVP
 | | Cryo-EM structure of CPD-stalled Pol II in complex with Rad26 (open state) | | 分子名称: | DNA (NTS), DNA (TS), DNA repair and recombination protein RAD26, ... | | 著者 | Sarsam, R.D, Lahiri, I, Leschziner, A.E. | | 登録日 | 2023-08-18 | | 公開日 | 2024-01-24 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8TVV
 | | Cryo-EM structure of backtracked Pol II | | 分子名称: | DNA (NTS), DNA (TS), DNA-directed RNA polymerase II subunit RPB1, ... | | 著者 | Sarsam, R.D, Lahiri, I, Leschziner, A.E. | | 登録日 | 2023-08-18 | | 公開日 | 2024-01-24 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8TVQ
 | | Cryo-EM structure of CPD stalled 10-subunit Pol II in complex with Rad26 | | 分子名称: | DNA (NTS), DNA (TS), DNA repair and recombination protein RAD26, ... | | 著者 | Sarsam, R.D, Lahiri, I, Leschziner, A.E. | | 登録日 | 2023-08-18 | | 公開日 | 2024-01-24 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8TVX
 | | Cryo-EM structure of CPD-stalled Pol II (Conformation 2) | | 分子名称: | DNA (NTS), DNA (TS), DNA-directed RNA polymerase II subunit RPB1, ... | | 著者 | Sarsam, R.D, Lahiri, I, Leschziner, A.E. | | 登録日 | 2023-08-18 | | 公開日 | 2024-01-24 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8TVY
 | | Cryo-EM structure of CPD lesion containing RNA Polymerase II elongation complex with Rad26 and Elf1 (closed state) | | 分子名称: | DNA (NTS), DNA (TS), DNA-directed RNA polymerase II subunit RPB1, ... | | 著者 | Sarsam, R.D, Lahiri, I, Leschziner, A.E. | | 登録日 | 2023-08-18 | | 公開日 | 2024-01-24 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8TVW
 | | Cryo-EM structure of CPD-stalled Pol II (conformation 1) | | 分子名称: | DNA (NTS), DNA (TS), DNA-directed RNA polymerase II subunit RPB1, ... | | 著者 | Sarsam, R.D, Lahiri, I, Leschziner, A.E. | | 登録日 | 2023-08-18 | | 公開日 | 2024-01-24 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8TVS
 | | Cryo-EM structure of backtracked Pol II in complex with Rad26 | | 分子名称: | DNA (NTS), DNA (TS), DNA repair and recombination protein RAD26, ... | | 著者 | Sarsam, R.D, Lahiri, I, Leschziner, A.E. | | 登録日 | 2023-08-18 | | 公開日 | 2024-01-24 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8TUG
 | | Cryo-EM structure of CPD-stalled Pol II in complex with Rad26 (engaged state) | | 分子名称: | DNA (NTS), DNA (TS), DNA repair and recombination protein RAD26, ... | | 著者 | Sarsam, R.D, Lahiri, I, Leschziner, A.E. | | 登録日 | 2023-08-16 | | 公開日 | 2024-01-24 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8TOC
 | | Acinetobacter phage AP205 | | 分子名称: | Coat protein, Maturation protein, RNA (4269-MER) | | 著者 | Meng, R, Xing, Z, Chang, J, Zhang, J. | | 登録日 | 2023-08-03 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | | 主引用文献 | Structural basis of Acinetobacter type IV pili targeting by an RNA virus.
Nat Commun, 15, 2024
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4KDL
 | | Crystal structure of p97/VCP N in complex with OTU1 UBXL | | 分子名称: | Transitional endoplasmic reticulum ATPase, Ubiquitin thioesterase OTU1 | | 著者 | Kim, S.J, Kim, E.E. | | 登録日 | 2013-04-25 | | 公開日 | 2014-03-19 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | | 主引用文献 | Structural Basis for Ovarian Tumor Domain-containing Protein 1 (OTU1) Binding to p97/Valosin-containing Protein (VCP).
J.Biol.Chem., 289, 2014
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4KDI
 | | Crystal structure of p97/VCP N in complex with OTU1 UBXL | | 分子名称: | Transitional endoplasmic reticulum ATPase, Ubiquitin thioesterase OTU1 | | 著者 | Kim, S.J, Kim, E.E. | | 登録日 | 2013-04-25 | | 公開日 | 2014-03-19 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Structural Basis for Ovarian Tumor Domain-containing Protein 1 (OTU1) Binding to p97/Valosin-containing Protein (VCP).
J.Biol.Chem., 289, 2014
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8TW2
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