4LUC
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![BU of 4luc by Molmil](/molmil-images/mine/4luc) | Crystal Structure of small molecule disulfide 6 bound to K-Ras G12C | 分子名称: | CALCIUM ION, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. | 登録日 | 2013-07-25 | 公開日 | 2013-11-27 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | 主引用文献 | K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
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4M22
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![BU of 4m22 by Molmil](/molmil-images/mine/4m22) | Crystal Structure of small molecule acrylamide 16 covalently bound to K-Ras G12C | 分子名称: | 1-{4-[(2,4-dichlorophenoxy)acetyl]piperazin-1-yl}propan-1-one, GUANOSINE-5'-DIPHOSPHATE, K-Ras GTPase, ... | 著者 | Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. | 登録日 | 2013-08-05 | 公開日 | 2013-11-27 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
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4M1T
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![BU of 4m1t by Molmil](/molmil-images/mine/4m1t) | Crystal Structure of small molecule vinylsulfonamide 14 covalently bound to K-Ras G12C | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, K-Ras GTPase, N-{1-[(2,4-dichlorophenoxy)acetyl]piperidin-4-yl}ethanesulfonamide | 著者 | Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. | 登録日 | 2013-08-04 | 公開日 | 2013-11-27 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.703 Å) | 主引用文献 | K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
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4M04
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![BU of 4m04 by Molmil](/molmil-images/mine/4m04) | Human DNA Polymerase Mu ternary complex | 分子名称: | 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Moon, A.F, Pryor, J.M, Ramsden, D.A, Kunkel, T.A, Bebenek, K, Pedersen, L.C. | 登録日 | 2013-08-01 | 公開日 | 2014-02-05 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.898 Å) | 主引用文献 | Sustained active site rigidity during synthesis by human DNA polymerase mu. Nat.Struct.Mol.Biol., 21, 2014
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4JZQ
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![BU of 4jzq by Molmil](/molmil-images/mine/4jzq) | |
4K0N
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![BU of 4k0n by Molmil](/molmil-images/mine/4k0n) | Crystal structure of human CLIC1 C24A mutant | 分子名称: | Chloride intracellular channel protein 1, MALONATE ION | 著者 | Phang, J.M, Harrop, S.J, Duff, A.P, Wilk, K.E, Curmi, P.M.G. | 登録日 | 2013-04-04 | 公開日 | 2014-04-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Crystal structure analysis of CLIC1 C24 mutants To be Published
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4K8I
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![BU of 4k8i by Molmil](/molmil-images/mine/4k8i) | Crystal Structure of Staphylococcal Nuclease mutant I92V/V99L | 分子名称: | Thermonuclease | 著者 | Sanders, J.M, Latimer, E.C, Roeser, J.R, Janowska, K, Sakon, J, Stites, W.E. | 登録日 | 2013-04-18 | 公開日 | 2013-05-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Hydrophobic core mutants of Staphylococcal nuclease To be Published
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3W35
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![BU of 3w35 by Molmil](/molmil-images/mine/3w35) | Crystal structure of apo-type bacterial Vanadium-dependent chloroperoxidase | 分子名称: | NapH1 | 著者 | Liscombe, D.K, Miyanaga, A, Fielding, E, Bernhardt, P, Li, A, Winter, J.M, Gilson, M.K, Noel, J.P, Moore, B.S. | 登録日 | 2012-12-11 | 公開日 | 2013-12-11 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural Basis of Stereospecific Vanadium-Dependent Haloperoxidase Family Enzymes in Napyradiomycin Biosynthesis. Biochemistry, 2022
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4LRW
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![BU of 4lrw by Molmil](/molmil-images/mine/4lrw) | Crystal Structure of K-Ras G12C (cysteine-light), GDP-bound | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | 著者 | Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. | 登録日 | 2013-07-21 | 公開日 | 2013-11-27 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.151 Å) | 主引用文献 | K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
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3UEG
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![BU of 3ueg by Molmil](/molmil-images/mine/3ueg) | Crystal structure of human Survivin K62A mutant | 分子名称: | 1,2-ETHANEDIOL, Baculoviral IAP repeat-containing protein 5, TETRAETHYLENE GLYCOL, ... | 著者 | Niedzialkowska, E, Porebski, P.J, Wang, F, Higgins, J.M, Stukenberg, P.T, Minor, W. | 登録日 | 2011-10-30 | 公開日 | 2012-03-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres. Mol.Biol.Cell, 23, 2012
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4LQR
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![BU of 4lqr by Molmil](/molmil-images/mine/4lqr) | Structure of CBM32-3 from a family 31 glycoside hydrolase from Clostridium perfringens | 分子名称: | CALCIUM ION, Glycosyl hydrolase, family 31/fibronectin type III domain protein | 著者 | Grondin, J.M, Furness, H.S, Duan, D, Spencer, C.A, Allingham, J.S, Smith, S.P. | 登録日 | 2013-07-19 | 公開日 | 2014-07-23 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Diverse modes of galacto-specific carbohydrate recognition by a family 31 glycoside hydrolase from Clostridium perfringens. Plos One, 12, 2017
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4LXK
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![BU of 4lxk by Molmil](/molmil-images/mine/4lxk) | Crystal Structure of Human Beta Secretase in Complex with compound 11d | 分子名称: | (1R,3S,4S,5R)-3-(4-amino-3-fluoro-5-{[(2R)-1,1,1-trifluoro-3-methoxypropan-2-yl]oxy}benzyl)-5-[(3-tert-butylbenzyl)amino]tetrahydro-2H-thiopyran-4-ol 1-oxide, Beta-secretase 1, GLYCEROL | 著者 | Rondeau, J.M, Bourgier, E. | 登録日 | 2013-07-30 | 公開日 | 2013-08-28 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective beta-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid beta-peptides. Bioorg.Med.Chem.Lett., 23, 2013
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4M1S
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![BU of 4m1s by Molmil](/molmil-images/mine/4m1s) | Crystal Structure of small molecule vinylsulfonamide 13 covalently bound to K-Ras G12C | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, K-Ras GTPase, N-{1-[N-(2,4-dichlorophenyl)glycyl]piperidin-4-yl}ethanesulfonamide | 著者 | Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. | 登録日 | 2013-08-04 | 公開日 | 2013-11-27 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.552 Å) | 主引用文献 | K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
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4M7I
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![BU of 4m7i by Molmil](/molmil-images/mine/4m7i) | Crystal Structure of GSK6157 Bound to PERK (R587-R1092, delete A660-T867) at 2.34A Resolution | 分子名称: | 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-1H-indol-1-yl]-2-(6-methylpyridin-2-yl)ethanone, Eukaryotic translation initiation factor 2-alpha kinase 3 | 著者 | Gampe, R.T, Axten, J.M. | 登録日 | 2013-08-12 | 公開日 | 2014-09-03 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Discovery of 5-{4-fluoro-1-[(6-methyl-2-pyridinyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2656157), a Potent and Selective PERK Inhibitor Selected for Preclinical Development To be Published
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3UEC
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![BU of 3uec by Molmil](/molmil-images/mine/3uec) | Crystal structure of human Survivin bound to histone H3 phosphorylated on threonine-3. | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Baculoviral IAP repeat-containing protein 5, ... | 著者 | Niedzialkowska, E, Porebski, P.J, Cooper, D.R, Chruszcz, M, Wang, F, Higgins, J.M, Stukenberg, P.T, Minor, W. | 登録日 | 2011-10-30 | 公開日 | 2012-03-07 | 最終更新日 | 2022-04-13 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres. Mol.Biol.Cell, 23, 2012
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3UEI
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![BU of 3uei by Molmil](/molmil-images/mine/3uei) | Crystal structure of human Survivin E65A mutant | 分子名称: | Baculoviral IAP repeat-containing protein 5, ZINC ION | 著者 | Niedzialkowska, E, Porebski, P.J, Wang, F, Higgins, J.M, Stukenberg, P.T, Minor, W. | 登録日 | 2011-10-30 | 公開日 | 2012-03-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres. Mol Biol Cell, 23, 2012
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3UIE
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3UFB
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![BU of 3ufb by Molmil](/molmil-images/mine/3ufb) | Crystal structure of a modification subunit of a putative type I restriction enzyme from Vibrio vulnificus YJ016 | 分子名称: | Type I restriction-modification system methyltransferase subunit | 著者 | Park, S.Y, Lee, H.J, Sun, J, Nishi, K, Song, J.M, Kim, J.S. | 登録日 | 2011-11-01 | 公開日 | 2012-11-07 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural characterization of a modification subunit of a putative type I restriction enzyme from Vibrio vulnificus YJ016 Acta Crystallogr.,Sect.D, 68, 2012
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4LZD
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![BU of 4lzd by Molmil](/molmil-images/mine/4lzd) | Human DNA polymerase mu- Apoenzyme | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DNA-directed DNA/RNA polymerase mu, ... | 著者 | Moon, A.F, Pryor, J.M, Ramsden, D.A, Kunkel, T.A, Bebenek, K, Pedersen, L.C. | 登録日 | 2013-07-31 | 公開日 | 2014-02-05 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.849 Å) | 主引用文献 | Sustained active site rigidity during synthesis by human DNA polymerase mu. Nat.Struct.Mol.Biol., 21, 2014
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3UJA
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![BU of 3uja by Molmil](/molmil-images/mine/3uja) | Phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with phosphoethanolamine | 分子名称: | PHOSPHORIC ACID MONO-(2-AMINO-ETHYL) ESTER, Phosphoethanolamine N-methyltransferase | 著者 | Lee, S.G, Kim, Y, Alpert, T.D, Nagata, A, Jez, J.M. | 登録日 | 2011-11-07 | 公開日 | 2011-11-30 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.466 Å) | 主引用文献 | Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum: an antiparasitic drug target. J.Biol.Chem., 287, 2012
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4M29
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![BU of 4m29 by Molmil](/molmil-images/mine/4m29) | Structure of a GH39 Beta-xylosidase from Caulobacter crescentus | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-xylosidase | 著者 | Polo, C.C, Santos, C.R, Correa, J.M, Simao, R.C.G, Seixas, F.A.V, Murakami, M.T. | 登録日 | 2013-08-05 | 公開日 | 2013-08-14 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure of a GH39 Beta-xylosidase from Caulobacter crescentus Thesis
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3UEF
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![BU of 3uef by Molmil](/molmil-images/mine/3uef) | Crystal structure of human Survivin bound to histone H3 (C2 space group). | 分子名称: | 1,2-ETHANEDIOL, Baculoviral IAP repeat-containing protein 5, N-terminal fragment of histone H3, ... | 著者 | Niedzialkowska, E, Porebski, P.J, Wang, F, Higgins, J.M, Stukenberg, P.T, Minor, W. | 登録日 | 2011-10-30 | 公開日 | 2012-03-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres. Mol.Biol.Cell, 23, 2012
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4IW0
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![BU of 4iw0 by Molmil](/molmil-images/mine/4iw0) | Crystal structure and mechanism of activation of TBK1 | 分子名称: | N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1 | 著者 | Larabi, A, Devos, J.M, Ng, S.-L, Nanao, M.H, Round, A, Maniatis, T, Panne, D. | 登録日 | 2013-01-23 | 公開日 | 2013-03-13 | 最終更新日 | 2013-05-22 | 実験手法 | X-RAY DIFFRACTION (4 Å) | 主引用文献 | Crystal structure and mechanism of activation of TANK-binding kinase 1. Cell Rep, 3, 2013
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4IHK
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![BU of 4ihk by Molmil](/molmil-images/mine/4ihk) | Crystal structure of the Collagen VI alpha3 N5 domain R1061Q | 分子名称: | Collagen alpha3(VI) | 著者 | Mikolajek, H, Becker, A.K.A, Paulsson, M, Wagener, R, Werner, J.M. | 登録日 | 2012-12-19 | 公開日 | 2013-12-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | A structure of a collagen VI VWA domain displays N and C termini at opposite sides of the protein Structure, 22, 2014
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4IKH
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![BU of 4ikh by Molmil](/molmil-images/mine/4ikh) | Crystal structure of a glutathione transferase family member from Pseudomonas fluorescens pf-5, target efi-900003, with two glutathione bound | 分子名称: | CHLORIDE ION, GLUTATHIONE, Glutathione S-transferase | 著者 | Vetting, M.W, Sauder, J.M, Morisco, L.L, Wasserman, S.R, Sojitra, S, Imker, H.J, Burley, S.K, Armstrong, R.N, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) | 登録日 | 2012-12-26 | 公開日 | 2013-01-16 | 最終更新日 | 2021-02-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of a glutathione transferase family member from Pseudomonas fluorescens pf-5, target efi-900003, with two glutathione bound To be Published
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