1MNQ
| Thioesterase Domain of Picromycin Polyketide Synthase (PICS TE), pH 8.4 | 分子名称: | polyketide synthase IV | 著者 | Tsai, S.-C, Lu, H, Cane, D.E, Khosla, C, Stroud, R.M. | 登録日 | 2002-09-05 | 公開日 | 2003-02-04 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases Biochemistry, 41, 2002
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1MO2
| Thioesterase Domain from 6-Deoxyerythronolide Synthase (DEBS TE), pH 8.5 | 分子名称: | Erythronolide synthase, modules 5 and 6 | 著者 | Tsai, S.-C, Lu, H, Cane, D.E, Khosla, C, Stroud, R.M. | 登録日 | 2002-09-05 | 公開日 | 2003-02-04 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases Biochemistry, 41, 2002
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1AZ5
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1BQ2
| E. COLI THYMIDYLATE SYNTHASE MUTANT N177A | 分子名称: | PHOSPHATE ION, THYMIDYLATE SYNTHASE | 著者 | Reyes, C.L, Sage, C.R, Rutenber, E.E, Finer-Moore, J.S, Stroud, R.M. | 登録日 | 1998-08-20 | 公開日 | 1999-04-27 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Inactivity of N229A thymidylate synthase due to water-mediated effects: isolating a late stage in methyl transfer. J.Mol.Biol., 284, 1998
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1BQ1
| E. COLI THYMIDYLATE SYNTHASE MUTANT N177A IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) | 分子名称: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE | 著者 | Reyes, C.L, Sage, C.R, Rutenber, E.E, Finer-Moore, J.S, Stroud, R.M. | 登録日 | 1998-08-20 | 公開日 | 1999-05-18 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Inactivity of N229A thymidylate synthase due to water-mediated effects: isolating a late stage in methyl transfer. J.Mol.Biol., 284, 1998
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1SQG
| The crystal structure of the E. coli Fmu apoenzyme at 1.65 A resolution | 分子名称: | SUN protein | 著者 | Foster, P.G, Nunes, C.R, Greene, P, Moustakas, D, Stroud, R.M. | 登録日 | 2004-03-18 | 公開日 | 2004-05-18 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | The First Structure of an RNA m5C Methyltransferase,
Fmu, Provides Insight into Catalytic Mechanism
and Specific Binding of RNA Substrate Structure, 11, 2003
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1TJS
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1TDU
| E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE (DURD) | 分子名称: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE, PHOSPHATE ION, ... | 著者 | Stout, T.J, Sage, C.R, Stroud, R.M. | 登録日 | 1997-06-25 | 公開日 | 1998-07-01 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The additivity of substrate fragments in enzyme-ligand binding. Structure, 6, 1998
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1TQY
| The Actinorhodin Ketosynthase/Chain Length Factor | 分子名称: | ACETYL GROUP, Actinorhodin polyketide putative beta-ketoacyl synthase 1, Actinorhodin polyketide putative beta-ketoacyl synthase 2, ... | 著者 | Keatinge-Clay, A.T, Maltby, D.A, Medzihradszky, K.F, Khosla, C, Stroud, R.M. | 登録日 | 2004-06-18 | 公開日 | 2004-07-27 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | An antibiotic factory caught in action. Nat.Struct.Mol.Biol., 11, 2004
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1U7C
| Crystal Structure of AmtB from E.Coli with Methyl Ammonium. | 分子名称: | METHYLAMINE, Probable ammonium transporter | 著者 | Khademi, S, O'Connell III, J, Remis, J, Robles-Colmenares, Y, Miercke, L.J.W, Stroud, R.M. | 登録日 | 2004-08-03 | 公開日 | 2004-09-21 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 A Science, 305, 2004
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1U77
| Crystal Structure of Ammonia Channel AmtB from E. Coli | 分子名称: | Probable ammonium transporter | 著者 | Khademi, S, O'Connell III, J, Remis, J, Robles-Colmenares, Y, Miercke, L.J.W, Stroud, R.M. | 登録日 | 2004-08-02 | 公開日 | 2004-09-21 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 A Science, 305, 2004
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1U7G
| Crystal Structure of Ammonia Channel AmtB from E. Coli | 分子名称: | AMMONIA, AMMONIUM ION, Probable ammonium transporter, ... | 著者 | Khademi, S, O'Connell III, J, Remis, J, Robles-Colmenares, Y, Miercke, L.J.W, Stroud, R.M. | 登録日 | 2004-08-03 | 公開日 | 2004-09-21 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 A Science, 305, 2004
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1R2J
| FkbI for Biosynthesis of Methoxymalonyl Extender Unit of Fk520 Polyketide Immunosuppresant | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, protein FkbI | 著者 | Watanabe, K, Khosla, C, Stroud, R.M, Tsai, S.-C. | 登録日 | 2003-09-28 | 公開日 | 2003-11-25 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal Structure of an Acyl-ACP Dehydrogenase from the FK520 Polyketide Biosynthetic Pathway: Insights into Extender Unit Biosynthesis J.Mol.Biol., 334, 2003
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1TSL
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1TSM
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1SQF
| The crystal structure of E. coli Fmu binary complex with S-Adenosylmethionine at 2.1 A resolution | 分子名称: | S-ADENOSYLMETHIONINE, SUN protein | 著者 | Foster, P.G, Nunes, C.R, Greene, P, Moustakas, D, Stroud, R.M. | 登録日 | 2004-03-18 | 公開日 | 2004-05-18 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The First Structure of an RNA m5C Methyltransferase,
Fmu, Provides Insight into Catalytic Mechanism
and Specific Binding of RNA Substrate Structure, 11, 2003
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1R3F
| Crystal Structure of tRNA Pseudouridine Synthase TruB and Its RNA Complex: RNA-protein Recognition Through a Combination of Rigid Docking and Induced Fit | 分子名称: | tRNA pseudouridine synthase B | 著者 | Pan, H, Agarwalla, S, Moustakas, D.T, Finer-Moore, J, Stroud, R.M. | 登録日 | 2003-10-01 | 公開日 | 2003-11-04 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structure of tRNA Pseudouridine Synthase TruB and Its RNA Complex: RNA Recognition Through a Combination of Rigid Docking and Induced Fit Proc.Natl.Acad.Sci.USA, 100, 2003
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1RC2
| 2.5 Angstrom Resolution X-ray Structure of Aquaporin Z | 分子名称: | 2-O-octyl-beta-D-glucopyranose, Aquaporin Z | 著者 | Savage, D.F, Egea, P.F, Robles, Y.C, O'Connell III, J.D, Stroud, R.M. | 登録日 | 2003-11-03 | 公開日 | 2003-11-25 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Architecture and selectivity in aquaporins: 2.5 a X-ray structure of aquaporin Z Plos Biol., 1, 2003
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1RJ9
| Structure of the heterodimer of the conserved GTPase domains of the Signal Recognition Particle (Ffh) and Its Receptor (FtsY) | 分子名称: | MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, Signal Recognition Protein, ... | 著者 | Egea, P.F, Shan, S.O, Napetschnig, J, Savage, D.F, Walter, P, Stroud, R.M. | 登録日 | 2003-11-18 | 公開日 | 2004-01-27 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Substrate twinning activates the signal recognition particle and its receptor Nature, 427, 2004
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7JX1
| E. coli TSase complex with a bi-substrate reaction intermediate analog | 分子名称: | (2S)-2-({4-[({(6R)-2,4-diamino-5-[(1-{(2R,4S,5R)-4-hydroxy-5-[(phosphonooxy)methyl]tetrahydrofuran-2-yl}-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl}methyl)amino]benzoyl}amino)pentanedioic acid (non-preferred name), N-(4-{[(2,4-diamino-7,8-dihydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino}benzene-1-carbonyl)-L-glutamic acid, PHOSPHATE ION, ... | 著者 | Finer-Moore, J, Kholodar, S.A, Stroud, R.M, Kohen, A. | 登録日 | 2020-08-26 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Caught in Action: X-ray Structure of Thymidylate Synthase with Noncovalent Intermediate Analog. Biochemistry, 60, 2021
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7JXF
| E. coli TSase complex with a bi-substrate reaction intermediate diastereomer analog | 分子名称: | (2S)-2-({4-[({(6S)-2,4-diamino-5-[(1-{(2R,4S,5R)-4-hydroxy-5-[(phosphonooxy)methyl]tetrahydrofuran-2-yl}-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl}methyl)amino]benzoyl}amino)pentanedioic acid (non-preferred name), 5-HYDROXYMETHYLURIDINE-2'-DEOXY-5'-MONOPHOSPHATE, N-[4-({[(6S)-2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl]methyl}amino)benzene-1-carbonyl]-L-glutamic acid, ... | 著者 | Finer-Moore, J, Kholodar, S.A, Stroud, R.M, Kohen, A, Moliner, V, Swiderek, K. | 登録日 | 2020-08-27 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Caught in Action: X-ray Structure of Thymidylate Synthase with Noncovalent Intermediate Analog. Biochemistry, 60, 2021
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7KTX
| Cryo-EM structure of Saccharomyces cerevisiae ER membrane protein complex bound to a Fab in DDM detergent | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ER membrane protein complex subunit 1, ER membrane protein complex subunit 2, ... | 著者 | Miller-Vedam, L.E, Schirle Oakdale, N.S, Braeuning, B, Boydston, E.A, Sevillano, N, Popova, K.D, Bonnar, J.L, Shurtleff, M.J, Prabu, J.R, Stroud, R.M, Craik, C.S, Schulman, B.A, Weissman, J.S, Frost, A. | 登録日 | 2020-11-24 | 公開日 | 2020-12-02 | 最終更新日 | 2020-12-09 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients. Elife, 9, 2020
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7KRA
| Cryo-EM structure of Saccharomyces cerevisiae ER membrane protein complex bound to Fab-DH4 in lipid nanodiscs | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ER membrane protein complex subunit 1, ER membrane protein complex subunit 2, ... | 著者 | Miller-Vedam, L.E, Schirle Oakdale, N.S, Braeuning, B, Boydston, E.A, Sevillano, N, Popova, K.D, Bonnar, J.L, Shurtleff, M.J, Prabu, J.R, Stroud, R.M, Craik, C.S, Schulman, B.A, Weissman, J.S, Frost, A. | 登録日 | 2020-11-19 | 公開日 | 2020-12-02 | 最終更新日 | 2020-12-09 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients. Elife, 9, 2020
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7KP4
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1AID
| STRUCTURE OF A NON-PEPTIDE INHIBITOR COMPLEXED WITH HIV-1 PROTEASE: DEVELOPING A CYCLE OF STRUCTURE-BASED DRUG DESIGN | 分子名称: | 4-(4-CHLORO-PHENYL)-1-{3-[2-(4-FLUORO-PHENYL)-[1,3]DITHIOLAN-2-YL]-PROPYL}-PIPERIDIN-4-OL, CHLORIDE ION, HUMAN IMMUNODEFICIENCY VIRUS PROTEASE | 著者 | Rutenber, E.E, Fauman, E.B, Keenan, R.J, Stroud, R.M. | 登録日 | 1997-04-16 | 公開日 | 1997-10-15 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of a non-peptide inhibitor complexed with HIV-1 protease. Developing a cycle of structure-based drug design. J.Biol.Chem., 268, 1993
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