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5ZOJ
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BU of 5zoj by Molmil
Crystal structure of human SMAD2-MAN1 complex
分子名称: Inner nuclear membrane protein Man1, Mothers against decapentaplegic homolog 2
著者Miyazono, K, Ohno, Y, Ito, T, Tanokura, M.
登録日2018-04-13
公開日2018-10-10
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.794 Å)
主引用文献Structural basis for receptor-regulated SMAD recognition by MAN1
Nucleic Acids Res., 46, 2018
6L2N
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BU of 6l2n by Molmil
Crystal structure of the R.PabI(Y68F-K154A)-dsDNA(GTAC-3bp-GTAC) complex
分子名称: DNA (5'-D(*TP*CP*AP*GP*CP*AP*GP*TP*AP*CP*TP*AP*AP*GP*TP*AP*CP*TP*GP*CP*TP*GP*A)-3'), RE_R_Pab1 domain-containing protein
著者Miyazono, K, Wang, D, Ito, T, Tanokura, M.
登録日2019-10-05
公開日2020-03-18
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Distortion of double-stranded DNA structure by the binding of the restriction DNA glycosylase R.PabI.
Nucleic Acids Res., 48, 2020
6L2O
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BU of 6l2o by Molmil
Crystal structure of the R.PabI(Y68F-K154A)-dsDNA(GTAC-5bp-GTAC) complex
分子名称: DNA (5'-D(*CP*A*GP*CP*AP*GP*TP*AP*CP*TP*TP*AP*AP*AP*GP*TP*AP*CP*TP*GP*CP*TP*G)-3'), RE_R_Pab1 domain-containing protein
著者Miyazono, K, Wang, D, Ito, T, Tanokura, M.
登録日2019-10-05
公開日2020-03-18
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Distortion of double-stranded DNA structure by the binding of the restriction DNA glycosylase R.PabI.
Nucleic Acids Res., 48, 2020
6M64
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BU of 6m64 by Molmil
Crystal structure of SMAD2 in complex with CBP
分子名称: CBP, Mothers against decapentaplegic homolog 2
著者Miyazono, K, Ito, T, Wada, H, Tanokura, M.
登録日2020-03-13
公開日2020-11-25
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structural basis for transcriptional coactivator recognition by SMAD2 in TGF-beta signaling.
Sci.Signal., 13, 2020
6M3L
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BU of 6m3l by Molmil
Crystal structure of the R.PabI(Y68F-K154A)-dsDNA(nonspecific) complex
分子名称: DNA (5'-D(*CP*GP*CP*AP*TP*CP*GP*AP*TP*TP*CP*AP*GP*AP*AP*TP*CP*GP*AP*TP*GP*CP*G)-3'), RE_R_Pab1 domain-containing protein
著者Miyazono, K, Wang, D, Ito, T, Tanokura, M.
登録日2020-03-04
公開日2020-03-18
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Distortion of double-stranded DNA structure by the binding of the restriction DNA glycosylase R.PabI.
Nucleic Acids Res., 48, 2020
7CFA
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BU of 7cfa by Molmil
Crystal structure of the restriction DNA glycosylase R.CcoLI
分子名称: R.Pab1 family restriction endonuclease
著者Miyazono, K, Wang, D, Ito, T, Tanokura, M.
登録日2020-06-25
公開日2020-12-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.355 Å)
主引用文献Crystal structure and DNA cleavage mechanism of the restriction DNA glycosylase R.CcoLI from Campylobacter coli.
Sci Rep, 11, 2021
7CO1
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BU of 7co1 by Molmil
Crystal structure of SMAD2 in complex with wild-type CBP
分子名称: CREB-binding protein, Mothers against decapentaplegic homolog 2
著者Miyazono, K, Wada, H, Ito, T, Tanokura, M.
登録日2020-08-03
公開日2020-11-25
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structural basis for transcriptional coactivator recognition by SMAD2 in TGF-beta signaling.
Sci.Signal., 13, 2020
5ZOK
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BU of 5zok by Molmil
Crystal structure of human SMAD1-MAN1 complex.
分子名称: Inner nuclear membrane protein Man1, Mothers against decapentaplegic homolog 1
著者Miyazono, K, Ito, T, Tanokura, M.
登録日2018-04-13
公開日2018-10-17
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Structural basis for receptor-regulated SMAD recognition by MAN1
Nucleic Acids Res., 46, 2018
5WR9
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BU of 5wr9 by Molmil
Crystal structure of hen egg-white lysozyme
分子名称: CHLORIDE ION, Lysozyme C, SODIUM ION
著者Sugahara, M, Suzuki, M, Masuda, T, Inoue, S, Nango, E.
登録日2016-12-01
公開日2017-12-06
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Hydroxyethyl cellulose matrix applied to serial crystallography
Sci Rep, 7, 2017
5WR2
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BU of 5wr2 by Molmil
Thermolysin, SFX liganded form with oil-based carrier
分子名称: CALCIUM ION, N-[(benzyloxy)carbonyl]-L-aspartic acid, Thermolysin, ...
著者Kunishima, N, Naitow, H, Matsuura, Y.
登録日2016-11-29
公開日2017-08-16
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Protein-ligand complex structure from serial femtosecond crystallography using soaked thermolysin microcrystals and comparison with structures from synchrotron radiation
Acta Crystallogr D Struct Biol, 73, 2017
6P4V
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BU of 6p4v by Molmil
1.65 Angstrom ternary complex of Deoxyhypusine synthase with cofactor NAD and spermidine mimic inhibitor GC7
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1-GUANIDINIUM-7-AMINOHEPTANE, Deoxyhypusine synthase, ...
著者Klein, M.G, Ambrus-Aikelin, G.
登録日2019-05-28
公開日2020-04-01
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase.
J.Med.Chem., 63, 2020
6PGR
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BU of 6pgr by Molmil
Cocomplex structure of Deoxyhypusine synthase with inhibitor 6-BROMO-N-(1H-INDOL-4-YL)-1-BENZOTHIOPHENE-2-CARBOXAMIDE
分子名称: 6-bromo-N-(1H-indol-4-yl)-1-benzothiophene-2-carboxamide, Deoxyhypusine synthase
著者Klein, M.G, Ambrus-Aikelin, G.
登録日2019-06-24
公開日2020-04-01
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase.
J.Med.Chem., 63, 2020
6XOG
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BU of 6xog by Molmil
Structure of SUMO1-ML786519 adduct bound to SAE
分子名称: SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ...
著者Sintchak, M, Lane, W, Bump, N.
登録日2020-07-07
公開日2021-03-10
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer.
J.Med.Chem., 64, 2021
6XOH
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BU of 6xoh by Molmil
Structure of SUMO1-ML00789344 adduct bound to SAE
分子名称: SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ...
著者Sintchak, M, Lane, W, Bump, N.
登録日2020-07-07
公開日2021-03-24
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.226 Å)
主引用文献Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer.
J.Med.Chem., 64, 2021
6XOI
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BU of 6xoi by Molmil
Structure of SUMO1-ML00752641 adduct bound to SAE
分子名称: SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ...
著者Sintchak, M, Lane, W, Bump, N.
登録日2020-07-07
公開日2021-03-24
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer.
J.Med.Chem., 64, 2021
6T39
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BU of 6t39 by Molmil
Crystal structure of rsEGFP2 in its off-state determined by SFX
分子名称: Green fluorescent protein
著者Woodhouse, J, Coquelle, N, Adam, V, Barends, T.R.M, De La Mora, E, Bourgeois, D, Colletier, J.P, Schlichting, I, Weik, M.
登録日2019-10-10
公開日2020-02-19
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Photoswitching mechanism of a fluorescent protein revealed by time-resolved crystallography and transient absorption spectroscopy.
Nat Commun, 11, 2020
6T3A
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BU of 6t3a by Molmil
Difference-refined structure of rsEGFP2 10 ns following 400-nm laser irradiation of the off-state determined by SFX
分子名称: Green fluorescent protein
著者Woodhouse, J, Coquelle, N, Adam, V, Barends, T.R.M, De La Mora, E, Bourgeois, D, Colletier, J.P, Schlichting, I, Weik, M.
登録日2019-10-10
公開日2020-02-19
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Photoswitching mechanism of a fluorescent protein revealed by time-resolved crystallography and transient absorption spectroscopy.
Nat Commun, 11, 2020
6KG2
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BU of 6kg2 by Molmil
Human MTHFD2 in complex with Compound 18
分子名称: Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, N-[2-chloranyl-4-[[7-methyl-8-(4-methylpiperazin-1-yl)-5-oxidanylidene-2,4-dihydro-1H-chromeno[3,4-c]pyridin-3-yl]carbonyl]phenyl]methanesulfonamide, ...
著者Suzuki, M, Matsui, Y, Ota, M, Kawai, J.
登録日2019-07-10
公開日2019-11-13
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity.
J.Med.Chem., 62, 2019
5V8Q
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BU of 5v8q by Molmil
Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs): Part III
分子名称: 4-[(2S,3S)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile, Androgen receptor, GLYCEROL
著者Wilson, K.P.
登録日2017-03-22
公開日2017-05-24
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.44 Å)
主引用文献Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate.
Bioorg. Med. Chem., 25, 2017
4WRI
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BU of 4wri by Molmil
Crystal structure of okadaic acid binding protein 2.1
分子名称: OKADAIC ACID, Okadaic acid binding protein 2-alpha
著者Ehara, H, Makino, M, Kodama, K, Ito, T, Sekine, S, Fukuzawa, S, Yokoyama, S, Tachibana, K.
登録日2014-10-24
公開日2015-05-27
最終更新日2020-02-05
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Crystal Structure of Okadaic Acid Binding Protein 2.1: A Sponge Protein Implicated in Cytotoxin Accumulation
Chembiochem, 16, 2015
4W4Q
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BU of 4w4q by Molmil
Glucose isomerase structure determined by serial femtosecond crystallography at SACLA
分子名称: CALCIUM ION, Xylose isomerase
著者Nango, E, Tanaka, T, Sugahara, M, Suzuki, M, Iwata, S.
登録日2014-08-15
公開日2014-11-05
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Grease matrix as a versatile carrier of proteins for serial crystallography
Nat.Methods, 12, 2015
1KDJ
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BU of 1kdj by Molmil
OXIDIZED FORM OF PLASTOCYANIN FROM DRYOPTERIS CRASSIRHIZOMA
分子名称: COPPER (II) ION, PLASTOCYANIN
著者Inoue, T, Gotowda, M, Hamada, K, Kohzuma, T, Yoshizaki, F, Sugimura, Y, Kai, Y.
登録日1998-05-08
公開日1999-05-11
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The structure and unusual pH dependence of plastocyanin from the fern Dryopteris crassirhizoma. The protonation of an active site histidine is hindered by pi-pi interactions.
J.Biol.Chem., 274, 1999
1KDI
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BU of 1kdi by Molmil
REDUCED FORM OF PLASTOCYANIN FROM DRYOPTERIS CRASSIRHIZOMA
分子名称: COPPER (II) ION, PLASTOCYANIN
著者Inoue, T, Gotowda, M, Hamada, K, Kohzuma, T, Yoshizaki, F, Sugimura, Y, Kai, Y.
登録日1998-05-08
公開日1999-05-11
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The structure and unusual pH dependence of plastocyanin from the fern Dryopteris crassirhizoma. The protonation of an active site histidine is hindered by pi-pi interactions.
J.Biol.Chem., 274, 1999
5OER
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BU of 5oer by Molmil
Hen egg-white lysozyme refined against 5000 9 keV diffraction patterns
分子名称: 10-((2R)-2-HYDROXYPROPYL)-1,4,7,10-TETRAAZACYCLODODECANE 1,4,7-TRIACETIC ACID, GADOLINIUM ATOM, Lysozyme C, ...
著者Gorel, A, Schlichting, I.
登録日2017-07-09
公開日2017-10-25
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Multi-wavelength anomalous diffraction de novo phasing using a two-colour X-ray free-electron laser with wide tunability.
Nat Commun, 8, 2017
5AZD
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BU of 5azd by Molmil
Crystal structure of thermophilic rhodopsin.
分子名称: Bacteriorhodopsin
著者Mizutani, K, Hashimoto, N, Tsukamoto, T, Yamashita, K, Yamamoto, M, Sudo, Y, Murata, T.
登録日2015-09-30
公開日2016-04-27
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献X-ray crystallographic structure of thermophilic rhodopsin: implications for high thermal stability and optogenetic availability.
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件を2024-09-11に公開中

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