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8YZ7
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BU of 8yz7 by Molmil
Crystal structure of DdrI, a CRP family protein from Deinococcus radiodurans
分子名称: POTASSIUM ION, Transcriptional regulator, FNR/CRP family
著者Zhao, Y, Wang, Y.
登録日2024-04-06
公開日2024-07-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献cAMP-independent DNA binding of the CRP family protein DdrI from Deinococcus radiodurans.
Mbio, 2024
6KZD
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BU of 6kzd by Molmil
Crystal structure of TRKc in complex with 3-((6-(4-aminophenyl)imidazo[1,2-a]pyrazin-3-yl)ethynyl)- N-(3-isopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-2- methylbenzamide
分子名称: 3-[2-[6-(4-aminophenyl)imidazo[1,2-a]pyrazin-3-yl]ethynyl]-2-methyl-~{N}-[3-(4-methylpiperazin-1-yl)-5-propan-2-yl-phenyl]benzamide, NT-3 growth factor receptor, PHOSPHATE ION
著者Wang, Y, Zhang, Z.M.
登録日2019-09-23
公開日2019-10-09
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.708 Å)
主引用文献Design, synthesis and biological evaluation of 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methylbenzamides as potent and selective pan-tropomyosin receptor kinase (TRK) inhibitors.
Eur.J.Med.Chem., 179, 2019
8HXB
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BU of 8hxb by Molmil
Cryo-EM structure of MPXV M2 hexamer in complex with human B7.2
分子名称: NFkB inhibitor, T-lymphocyte activation antigen CD86
著者Wang, Y, Yang, S, Zhao, H, Deng, Z.
登録日2023-01-04
公開日2023-08-30
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2.
Nat Commun, 14, 2023
8HXC
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BU of 8hxc by Molmil
Cryo-EM structure of MPXV M2 heptamer in complex with human B7.2
分子名称: NFkB inhibitor, T-lymphocyte activation antigen CD86
著者Wang, Y, Yang, S, Zhao, H, Deng, Z.
登録日2023-01-04
公開日2023-08-30
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3.12 Å)
主引用文献Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2.
Nat Commun, 14, 2023
8HXA
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BU of 8hxa by Molmil
Cryo-EM structure of MPXV M2 in complex with human B7.1
分子名称: NFkB inhibitor, T-lymphocyte activation antigen CD80
著者Wang, Y, Yang, S, Zhao, H, Deng, Z.
登録日2023-01-04
公開日2023-08-30
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3.04 Å)
主引用文献Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2.
Nat Commun, 14, 2023
6AK4
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BU of 6ak4 by Molmil
Crystal structure of human FTO in complex with small-molecule inhibitors
分子名称: (~{E})-2-cyano-~{N},~{N}-diethyl-3-[3-nitro-4,5-bis(oxidanyl)phenyl]prop-2-enamide, Alpha-ketoglutarate-dependent dioxygenase FTO,Alpha-ketoglutarate-dependent dioxygenase FTO, ZINC ION
著者Wang, Y, Cao, R, Peng, S, Zhang, W, Huang, N.
登録日2018-08-30
公開日2019-07-10
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1.
Sci Transl Med, 11, 2019
1FB9
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BU of 1fb9 by Molmil
EFFECTS OF S-SULFONATION ON THE SOLUTION STRUCTURE OF SALMON CALCITONIN
分子名称: CALCITONIN ANALOGUE
著者Wu, H, Mao, J, Wang, Y, Dou, H.
登録日2000-07-14
公開日2003-07-01
最終更新日2018-06-27
実験手法SOLUTION NMR
主引用文献Solution structure and biological activity of recombinant salmon calcitonin S-sulfonated analog
Biochem.Biophys.Res.Commun., 306, 2003
8SPP
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BU of 8spp by Molmil
Crystal structure of a heme enzyme RufO in rufomycin biosynthesis
分子名称: Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE
著者Wang, Y, Jordan, S, Li, B.
登録日2023-05-03
公開日2023-08-23
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Structural and spectroscopic characterization of RufO indicates a new biological role in rufomycin biosynthesis.
J.Biol.Chem., 299, 2023
8XAU
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BU of 8xau by Molmil
Cryo-EM structure of HerA
分子名称: ATP-binding protein
著者Wang, Y, Deng, Z.
登録日2023-12-05
公開日2024-06-05
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (3.14 Å)
主引用文献Molecular and structural basis of an ATPase-nuclease dual-enzyme anti-phage defense complex.
Cell Res., 2024
8XAV
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BU of 8xav by Molmil
Cryo-EM structure of an anti-phage defense complex
分子名称: ATP-binding protein, DUF4297
著者Wang, Y, Deng, Z.
登録日2023-12-05
公開日2024-06-05
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (2.87 Å)
主引用文献Molecular and structural basis of an ATPase-nuclease dual-enzyme anti-phage defense complex.
Cell Res., 2024
6LYH
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BU of 6lyh by Molmil
Crystal structure of tea N9-methyltransferase CkTcS in complex with SAH and 1,3,7-trimethyluric acid
分子名称: 1,3,7-trimethyl-9H-purine-2,6,8-trione, N-methyltransferase CkTcS, S-ADENOSYL-L-HOMOCYSTEINE
著者Wang, Y, Zhang, Z.-M.
登録日2020-02-14
公開日2020-03-04
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.15000319 Å)
主引用文献Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea.
Nat Commun, 11, 2020
6LYI
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BU of 6lyi by Molmil
Crystal structure of a N-methyltransferase CkTbS from Camellia assamica var. kucha
分子名称: N-methyltransferase CkTbS
著者Wang, Y, Zhang, Z.M.
登録日2020-02-14
公開日2020-03-04
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea.
Nat Commun, 11, 2020
5H1K
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BU of 5h1k by Molmil
Crystal structure of WD40 repeat domains of Gemin5 in complex with 13-nt U4 snRNA fragment
分子名称: Gem-associated protein 5, U4 snRNA (5'-R(*GP*CP*AP*AP*UP*UP*UP*UP*UP*GP*AP*CP*A)-3')
著者Wang, Y, Jin, W, Liu, C.P, Yang, N, Jin, M, Cong, Y, Wang, M, Xu, R.M.
登録日2016-10-10
公開日2016-11-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5
Genes Dev., 30, 2016
139D
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BU of 139d by Molmil
SOLUTION STRUCTURE OF A PARALLEL-STRANDED G-QUADRUPLEX DNA
分子名称: DNA (5'-D(*TP*TP*GP*GP*GP*GP*T)-3')
著者Patel, D.J, Wang, Y.
登録日1993-09-28
公開日1994-01-31
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution structure of a parallel-stranded G-quadruplex DNA.
J.Mol.Biol., 234, 1993
7DAD
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BU of 7dad by Molmil
EPD in complex with tubulin
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ...
著者Wang, Y, Wu, C.
登録日2020-10-16
公開日2021-03-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献High-resolution X-ray structure of three microtubule-stabilizing agents in complex with tubulin provide a rationale for drug design.
Biochem.Biophys.Res.Commun., 534, 2021
7CE2
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BU of 7ce2 by Molmil
The Crystal structure of TeNT Hc complexed with neutralizing antibody
分子名称: Tetanus toxin, neutralizing antibody heavy chain, neutralizing antibody light chain
著者Wang, X, Wang, Y, Wu, C, Yu, J, Liao, H.
登録日2020-06-21
公開日2021-04-07
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structural basis of tetanus toxin neutralization by native human monoclonal antibodies.
Cell Rep, 35, 2021
7PEM
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BU of 7pem by Molmil
Cryo-EM structure of phophorylated Drs2p-Cdc50p in a PS and ATP-bound E2P state
分子名称: (2R)-1-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Timcenko, M, Wang, Y, Lyons, J.A, Nissen, P, Lindorff-Larsen, K.
登録日2021-08-10
公開日2022-08-24
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Substrate Transport and Specificity in a Phospholipid Flippase
To Be Published
5K13
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BU of 5k13 by Molmil
Crystal structure of the RAR alpha ligand-binding domain in complex with an antagonist
分子名称: 4-{5-(3-tert-butylphenyl)-1-[4-(methylsulfonyl)phenyl]-1H-pyrazol-3-yl}benzoic acid, Retinoic acid receptor alpha
著者Wang, Y, Stout, S.L.
登録日2016-05-17
公開日2016-06-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Identification of potent and selective retinoic acid receptor gamma (RAR gamma ) antagonists for the treatment of osteoarthritis pain using structure based drug design.
Bioorg.Med.Chem.Lett., 26, 2016
8HN9
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BU of 8hn9 by Molmil
Human SIRT3 Recognizing CCNE2K348la peptide
分子名称: CCNE2 peptide, IMIDAZOLE, NAD-dependent protein deacetylase sirtuin-3, ...
著者Wang, Y, Ding, W.
登録日2022-12-07
公開日2023-05-10
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献SIRT3-dependent delactylation of cyclin E2 prevents hepatocellular carcinoma growth.
Embo Rep., 24, 2023
5IY4
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BU of 5iy4 by Molmil
Crystal structure of human PCNA in complex with the PIP box of DVC1
分子名称: DVC1 PIP box, Proliferating cell nuclear antigen
著者Jiang, T, Xu, M, Wang, Y.
登録日2016-03-24
公開日2016-06-08
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.945 Å)
主引用文献Crystal structure of human PCNA in complex with the PIP box of DVC1
Biochem.Biophys.Res.Commun., 474, 2016
3NYL
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BU of 3nyl by Molmil
The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain
分子名称: Amyloid beta (A4) protein (Peptidase nexin-II, Alzheimer disease), isoform CRA_b
著者Ha, Y, Hu, J, Lee, S, Liu, X, Wang, Y.
登録日2010-07-15
公開日2011-07-13
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain.
Mol.Cell, 15, 2004
5D8Q
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BU of 5d8q by Molmil
2.20A resolution structure of BfrB (L68A) from Pseudomonas aeruginosa
分子名称: ARSENIC, Ferroxidase, MAGNESIUM ION, ...
著者Lovell, S, Battaile, K.P, Wang, Y, Yao, H, Rivera, M.
登録日2015-08-17
公開日2015-09-23
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Characterization of the Bacterioferritin/Bacterioferritin Associated Ferredoxin Protein-Protein Interaction in Solution and Determination of Binding Energy Hot Spots.
Biochemistry, 54, 2015
5D8P
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BU of 5d8p by Molmil
2.35A resolution structure of iron bound BfrB (wild-type, C2221 form) from Pseudomonas aeruginosa
分子名称: ACETATE ION, FE (II) ION, Ferroxidase, ...
著者Lovell, S, Battaile, K.P, Wang, Y, Yao, H, Rivera, M.
登録日2015-08-17
公開日2015-09-23
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Characterization of the Bacterioferritin/Bacterioferritin Associated Ferredoxin Protein-Protein Interaction in Solution and Determination of Binding Energy Hot Spots.
Biochemistry, 54, 2015
5D8S
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BU of 5d8s by Molmil
2.55A resolution structure of BfrB (E85A) from Pseudomonas aeruginosa
分子名称: Ferroxidase, POTASSIUM ION, PROTOPORPHYRIN IX CONTAINING FE
著者Lovell, S, Battaile, K.P, Wang, Y, Yao, H, Rivera, M.
登録日2015-08-17
公開日2015-09-23
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Characterization of the Bacterioferritin/Bacterioferritin Associated Ferredoxin Protein-Protein Interaction in Solution and Determination of Binding Energy Hot Spots.
Biochemistry, 54, 2015
5D8R
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BU of 5d8r by Molmil
2.50A resolution structure of BfrB (E81A) from Pseudomonas aeruginosa
分子名称: Ferroxidase, POTASSIUM ION, PROTOPORPHYRIN IX CONTAINING FE
著者Lovell, S, Battaile, K.P, Wang, Y, Yao, H, Rivera, M.
登録日2015-08-17
公開日2015-09-23
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Characterization of the Bacterioferritin/Bacterioferritin Associated Ferredoxin Protein-Protein Interaction in Solution and Determination of Binding Energy Hot Spots.
Biochemistry, 54, 2015

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