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3VHD
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BU of 3vhd by Molmil
Hsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor, CH5164840
分子名称: 4-amino-18,20-dimethyl-7-thia-3,5,11,15-tetraazatricyclo[15.3.1.1(2,6)]docosa-1(20),2,4,6(22),17(21),18-hexaene-10,16-dione, Heat shock protein HSP 90-alpha
著者Fukami, T.A, Ono, N.
登録日2011-08-24
公開日2012-07-18
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors
Bioorg.Med.Chem.Lett., 22, 2012
6E56
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BU of 6e56 by Molmil
Human antibody H2214 in complex with influenza hemagglutinin A/Aichi/2/1968 (X-31) (H3N2)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ...
著者McCarthy, K.R, Harrison, S.C.
登録日2018-07-19
公開日2019-05-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism.
Cell, 177, 2019
5IH9
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BU of 5ih9 by Molmil
MELK in complex with NVS-MELK8A
分子名称: 1-methyl-4-[4-(4-{3-[(piperidin-4-yl)methoxy]pyridin-4-yl}-1H-pyrazol-1-yl)phenyl]piperazine, Maternal embryonic leucine zipper kinase
著者Sprague, E.R, Puleo, D.E.
登録日2016-02-29
公開日2016-06-01
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight.
J.Med.Chem., 59, 2016
5IH8
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BU of 5ih8 by Molmil
MELK in complex with NVS-MELK1
分子名称: Maternal embryonic leucine zipper kinase, N-[(pyridin-2-yl)methyl]-4-[4-(pyridin-4-yl)-1H-pyrazol-1-yl]benzamide
著者Sprague, E.R, Puleo, D.E.
登録日2016-02-29
公開日2016-06-01
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight.
J.Med.Chem., 59, 2016
1WWQ
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BU of 1wwq by Molmil
Solution Structure of Mouse ER
分子名称: Enhancer of rudimentary homolog
著者Li, H, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2005-01-12
公開日2006-01-03
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the mouse enhancer of rudimentary protein reveals a novel fold
J.Biomol.Nmr, 32, 2005
3NDR
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BU of 3ndr by Molmil
Crystal structure of tetrameric pyridoxal 4-dehydrogenase from Mesorhizobium loti
分子名称: 3-oxoacyl-(Acyl-carrier protein) reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Chu, H.N.
登録日2010-06-08
公開日2011-06-08
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.88 Å)
主引用文献Crystal structure of tetrameric pyridoxal 4-dehydrogenase from Mesorhizobium loti
To be Published
5X9C
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BU of 5x9c by Molmil
Crystal structure of the cytosolic domain of human MiD51
分子名称: Mitochondrial dynamics protein MID51
著者Sun, F, Pang, X, Ma, J.
登録日2017-03-06
公開日2018-03-21
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献New interfaces on MiD51 for Drp1 recruitment and mitochondrial fission regulation
To Be Published
6LA0
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BU of 6la0 by Molmil
Crystal structure of AoRut
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoside hydrolase family 5
著者Koseki, T, Makabe, K.
登録日2019-11-11
公開日2020-11-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Aspergillus oryzae Rutinosidase: Biochemical and Structural Investigation.
Appl.Environ.Microbiol., 87, 2021
2RLT
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BU of 2rlt by Molmil
phosphorylated CPI-17 (22-120)
分子名称: Protein phosphatase 1 regulatory subunit 14A
著者Eto, M.
登録日2007-08-11
公開日2008-07-15
最終更新日2022-03-16
実験手法SOLUTION NMR
主引用文献Phosphorylation-induced conformational switching of CPI-17 produces a potent myosin phosphatase inhibitor.
Structure, 15, 2007
5YS2
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BU of 5ys2 by Molmil
Structure of the domain IV(D_IV) of Pseudorabies virus glycoprotein B( PRV gB)
分子名称: Envelope glycoprotein B,Envelope glycoprotein B
著者Hu, X.L, Yang, F.L.
登録日2017-11-12
公開日2017-12-27
最終更新日2018-01-17
実験手法X-RAY DIFFRACTION (2.698 Å)
主引用文献Two classes of protective antibodies against Pseudorabies virus variant glycoprotein B: Implications for vaccine design.
PLoS Pathog., 13, 2017
5YSL
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BU of 5ysl by Molmil
Crystal structure of antibody 1H1 Fab
分子名称: 1H1 heavy chain, 1H1 light chain
著者Hu, X.L, Yang, F.L.
登録日2017-11-14
公開日2017-12-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Two classes of protective antibodies against Pseudorabies virus variant glycoprotein B: Implications for vaccine design.
PLoS Pathog., 13, 2017
5ZQ1
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BU of 5zq1 by Molmil
Crystal structure of spRlmCD with U1939loop RNA at 3.10 angstrom
分子名称: RNA (5'-R(*AP*AP*AP*(MUM)P*UP*CP*CP*U)-3'), S-ADENOSYL-L-HOMOCYSTEINE, Uncharacterized RNA methyltransferase SP_1029
著者Yu, H.L, Jiang, Y.Y.
登録日2018-04-17
公開日2018-10-24
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD
PLoS Pathog., 14, 2018
5ZQ0
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BU of 5zq0 by Molmil
Crystal structure of spRlmCD with U747loop RNA
分子名称: RNA (5'-R(*GP*UP*(MUM)P*GP*AP*AP*AP*A)-3'), S-ADENOSYL-L-HOMOCYSTEINE, Uncharacterized RNA methyltransferase SP_1029
著者Jiang, Y.Y, Yu, H.L.
登録日2018-04-17
公開日2018-10-24
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD
PLoS Pathog., 14, 2018
5XJ2
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BU of 5xj2 by Molmil
Structure of spRlmCD with U747 RNA
分子名称: RNA (5'-R(*GP*GP*CP*AP*CP*GP*UP*GP*CP*U)-3'), S-ADENOSYL-L-HOMOCYSTEINE, Uncharacterized RNA methyltransferase SP_1029, ...
著者Jiang, Y, Gong, Q.
登録日2017-04-28
公開日2017-11-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.84 Å)
主引用文献Structural insights into substrate selectivity of ribosomal RNA methyltransferase RlmCD
PLoS ONE, 12, 2017
5ZQ8
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BU of 5zq8 by Molmil
Crystal structure of spRlmCD with U747 stemloop RNA
分子名称: NICKEL (II) ION, RNA (5'-R(*CP*CP*GP*UP*(MUM)P*GP*AP*AP*AP*AP*GP*G)-3'), S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Jiang, Y.Y, Yu, H.L.
登録日2018-04-17
公開日2018-10-24
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD
PLoS Pathog., 14, 2018
5XJ1
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BU of 5xj1 by Molmil
Crystal structure of spRlmCD
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, HEXAETHYLENE GLYCOL, ...
著者Jiang, Y, Gong, Q.
登録日2017-04-28
公開日2017-11-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.753 Å)
主引用文献Structural insights into substrate selectivity of ribosomal RNA methyltransferase RlmCD
PLoS ONE, 12, 2017
5XJ3
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BU of 5xj3 by Molmil
Complex structure of ipilimumab-scFv and CTLA-4
分子名称: Cytotoxic T-lymphocyte protein 4, ipilimumab-VH, ipilimumab-VL
著者He, M, Chai, Y, Qi, J, Tong, Z, Tan, S, Gao, G.F.
登録日2017-04-29
公開日2018-04-25
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Remarkably similar CTLA-4 binding properties of therapeutic ipilimumab and tremelimumab antibodies
Oncotarget, 8, 2017
5ZTH
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BU of 5zth by Molmil
Crystal structure of spRlmCD with U1939loop RNA at 3.24 angstrom
分子名称: RNA (5'-R(P*AP*AP*AP*(MUM)P*UP*CP*CP*U)-3'), S-ADENOSYL-L-HOMOCYSTEINE, Uncharacterized RNA methyltransferase SP_1029
著者Jiang, Y.Y, Yu, H.L.
登録日2018-05-03
公開日2018-10-24
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.24 Å)
主引用文献Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD
PLoS Pathog., 14, 2018
1MKW
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BU of 1mkw by Molmil
THE CO-CRYSTAL STRUCTURE OF UNLIGANDED BOVINE ALPHA-THROMBIN AND PRETHROMBIN-2: MOVEMENT OF THE YPPW SEGMENT AND ACTIVE SITE RESIDUES UPON LIGAND BINDING
分子名称: ALPHA-THROMBIN, PRETHROMBIN-2
著者Malkowski, M.G, Edwards, B.F.P.
登録日1997-03-13
公開日1997-07-07
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding.
Protein Sci., 6, 1997
2RSD
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BU of 2rsd by Molmil
Solution structure of the plant homeodomain (PHD) of the E3 SUMO ligase Siz1 from rice
分子名称: E3 SUMO-protein ligase SIZ1, ZINC ION
著者Shindo, H, Tsuchiya, W, Suzuki, R, Yamazaki, T.
登録日2012-01-12
公開日2012-08-15
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献PHD finger of the SUMO ligase Siz/PIAS family in rice reveals specific binding for methylated histone H3 at lysine 4 and arginine 2
Febs Lett., 586, 2012
6UIN
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BU of 6uin by Molmil
Role of Beta-hairpin motifs in the DNA duplex opening by the Rad4/XPC nucleotide excision repair complex
分子名称: DNA (5'-D(*AP*TP*TP*GP*TP*AP*GP*NP*NP*NP*NP*GP*GP*AP*TP*GP*TP*CP*GP*AP*GP*TP*CP*A)-3'), DNA (5'-D(*TP*TP*GP*AP*CP*TP*CP*(G47)P*AP*CP*AP*TP*CP*CP*CP*CP*CP*CP*CP*TP*AP*CP*AP*A)-3'), DNA repair protein RAD4, ...
著者Paul, D, Min, J.-H.
登録日2019-10-01
公開日2020-10-14
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.348 Å)
主引用文献Tethering-facilitated DNA 'opening' and complementary roles of beta-hairpin motifs in the Rad4/XPC DNA damage sensor protein
Nucleic Acids Res., 48, 2021
4FJZ
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BU of 4fjz by Molmil
Crystal structure of PI3K-gamma in complex with pyrrolo-pyridine inhibitor 63
分子名称: 1'-[7-fluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-yl]-6'-(morpholin-4-yl)-1',2,2',3,5,6-hexahydrospiro[pyran-4,3'-pyrrolo[3,2-b]pyridine], Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION
著者Whittington, D.A, Tang, J, Yakowec, P.
登録日2012-06-12
公開日2012-10-24
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Discovery and in Vivo Evaluation of Dual PI3K-beta/delta inhibitors
J.Med.Chem., 55, 2012
4FJY
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BU of 4fjy by Molmil
Crystal structure of PI3K-gamma in complex with quinoline-indoline inhibitor 24f
分子名称: 4-[3,3-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1H-indol-1-yl]-7-fluoro-3-methyl-2-(pyridin-3-yl)quinoline, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION
著者Whittington, D.A, Tang, J, Yakowec, P.
登録日2012-06-12
公開日2012-10-24
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Discovery and in Vivo Evaluation of Dual PI3K-beta/delta inhibitors
J.Med.Chem., 55, 2012
5B6F
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BU of 5b6f by Molmil
Crystal structure of the Fab fragment of an anti-Leukotriene C4 monoclonal antibody complexed with LTC4
分子名称: (5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-[[(4~{S})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-3-(2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SULFATE ION, ...
著者Sugahara, M, Ago, H, Saino, H, Miyano, M.
登録日2016-05-27
公開日2017-05-31
最終更新日2019-07-24
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of the Fab fragment of an anti-Leukotriene C4 monoclonal antibody complexed with LTC4
To Be Published
5B86
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BU of 5b86 by Molmil
Crystal structure of M-Sec
分子名称: Tumor necrosis factor alpha-induced protein 2
著者Yamashita, M, Sato, Y, Yamagata, A, Fukai, S.
登録日2016-06-12
公開日2016-10-12
最終更新日2020-02-26
実験手法X-RAY DIFFRACTION (3.017 Å)
主引用文献Distinct Roles for the N- and C-terminal Regions of M-Sec in Plasma Membrane Deformation during Tunneling Nanotube Formation.
Sci Rep, 6, 2016

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