3DN9
 
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3DG1
 | | Segment SSTNVG derived from IAPP | | 分子名称: | SSTNVG from Islet Amyloid Polypeptide | | 著者 | Wiltzius, J.J, Sievers, S.A, Sawaya, M.R, Cascio, D, Eisenberg, D. | | 登録日 | 2008-06-12 | | 公開日 | 2008-07-01 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | Atomic structure of the cross-beta spine of islet amyloid polypeptide (amylin).
Protein Sci., 17, 2008
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8G4H
 | | KRAS G13C complex with GDP imaged on a cryo-EM imaging scaffold | | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Castells-Graells, R, Sawaya, M.R, Yeates, T.O. | | 登録日 | 2023-02-09 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-09-27 | | 実験手法 | ELECTRON MICROSCOPY (2.87 Å) | | 主引用文献 | Cryo-EM structure determination of small therapeutic protein targets at 3 angstrom -resolution using a rigid imaging scaffold.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8G2V
 | | Cryo-EM structure of recombinant human LECT2 amyloid fibril core | | 分子名称: | Leukocyte cell-derived chemotaxin-2 | | 著者 | Richards, L.S, Flores, M.D, Zink, S, Schibrowsky, N.A, Sawaya, M.R, Rodriguez, J.A. | | 登録日 | 2023-02-06 | | 公開日 | 2023-08-16 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.715 Å) | | 主引用文献 | Cryo-EM structure of a human LECT2 amyloid fibril reveals a network of polar ladders at its core.
Structure, 31, 2023
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8FQ7
 | | Nanobody with WIW inserted in CDR3 loop to Inhibit Growth of Alzheimer's Tau fibrils | | 分子名称: | GLYCEROL, Nanobody with WIW insert in CDR3 loop to target tau fibrils | | 著者 | Abskharon, R, Sawaya, M.R, Cascio, D.C, Eisenberg, D.S. | | 登録日 | 2023-01-05 | | 公開日 | 2023-10-04 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils.
Proc.Natl.Acad.Sci.USA, 120, 2023
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5K7R
 | | MicroED structure of trypsin at 1.7 A resolution | | 分子名称: | CALCIUM ION, Cationic trypsin | | 著者 | de la Cruz, M.J, Hattne, J, Shi, D, Seidler, P, Rodriguez, J, Reyes, F.E, Sawaya, M.R, Cascio, D, Eisenberg, D, Gonen, T. | | 登録日 | 2016-05-26 | | 公開日 | 2017-04-05 | | 最終更新日 | 2018-08-22 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.7 Å) | | 主引用文献 | Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED.
Nat. Methods, 14, 2017
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5K7Q
 | | MicroED structure of thaumatin at 2.5 A resolution | | 分子名称: | Thaumatin-1 | | 著者 | de la Cruz, M.J, Hattne, J, Shi, D, Seidler, P, Rodriguez, J, Reyes, F.E, Sawaya, M.R, Cascio, D, Eisenberg, D, Gonen, T. | | 登録日 | 2016-05-26 | | 公開日 | 2017-04-05 | | 最終更新日 | 2018-08-22 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (2.5 Å) | | 主引用文献 | Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED.
Nat. Methods, 14, 2017
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5K7T
 | | MicroED structure of thermolysin at 2.5 A resolution | | 分子名称: | CALCIUM ION, DIMETHYL SULFOXIDE, ISOPROPYL ALCOHOL, ... | | 著者 | de la Cruz, M.J, Hattne, J, Shi, D, Seidler, P, Rodriguez, J, Reyes, F.E, Sawaya, M.R, Cascio, D, Eisenberg, D, Gonen, T. | | 登録日 | 2016-05-26 | | 公開日 | 2017-04-05 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (2.5 Å) | | 主引用文献 | Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED.
Nat. Methods, 14, 2017
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5K7O
 | | MicroED structure of lysozyme at 1.8 A resolution | | 分子名称: | CHLORIDE ION, Lysozyme C, SODIUM ION | | 著者 | de la Cruz, M.J, Hattne, J, Shi, D, Seidler, P, Rodriguez, J, Reyes, F.E, Sawaya, M.R, Cascio, D, Eisenberg, D, Gonen, T. | | 登録日 | 2016-05-26 | | 公開日 | 2017-04-05 | | 最終更新日 | 2018-08-22 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.8 Å) | | 主引用文献 | Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED.
Nat. Methods, 14, 2017
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5K7N
 | | MicroED structure of tau VQIVYK peptide at 1.1 A resolution | | 分子名称: | VQIVYK | | 著者 | de la Cruz, M.J, Hattne, J, Shi, D, Seidler, P, Rodriguez, J, Reyes, F.E, Sawaya, M.R, Cascio, D, Eisenberg, D, Gonen, T. | | 登録日 | 2016-05-26 | | 公開日 | 2017-04-05 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.1 Å) | | 主引用文献 | Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED.
Nat. Methods, 14, 2017
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5K7S
 | | MicroED structure of proteinase K at 1.6 A resolution | | 分子名称: | CALCIUM ION, Proteinase K | | 著者 | de la Cruz, M.J, Hattne, J, Shi, D, Seidler, P, Rodriguez, J, Reyes, F.E, Sawaya, M.R, Cascio, D, Eisenberg, D, Gonen, T. | | 登録日 | 2016-05-26 | | 公開日 | 2017-04-05 | | 最終更新日 | 2018-08-22 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.6 Å) | | 主引用文献 | Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED.
Nat. Methods, 14, 2017
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5KO0
 | | Human Islet Amyloid Polypeptide Segment 15-FLVHSSNNFGA-25 Determined by MicroED | | 分子名称: | THIOCYANATE ION, hIAPP(15-25)WT | | 著者 | Krotee, P.A.L, Rodriguez, J.A, Sawaya, M.R, Cascio, D, Shi, D, Nannenga, B.L, Hattne, J, Reyes, F.E, Gonen, T, Eisenberg, D.S. | | 登録日 | 2016-06-28 | | 公開日 | 2016-12-21 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.4 Å) | | 主引用文献 | Atomic structures of fibrillar segments of hIAPP suggest tightly mated beta-sheets are important for cytotoxicity.
Elife, 6, 2017
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5K7P
 | | MicroED structure of xylanase at 2.3 A resolution | | 分子名称: | Endo-1,4-beta-xylanase 2, IODIDE ION | | 著者 | de la Cruz, M.J, Hattne, J, Shi, D, Seidler, P, Rodriguez, J, Reyes, F.E, Sawaya, M.R, Cascio, D, Eisenberg, D, Gonen, T. | | 登録日 | 2016-05-26 | | 公開日 | 2017-04-05 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (2.3 Å) | | 主引用文献 | Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED.
Nat. Methods, 14, 2017
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5KNZ
 | | Human Islet Amyloid Polypeptide Segment 19-SGNNFGAILSS-29 with Early Onset S20G Mutation Determined by MicroED | | 分子名称: | hIAPP(residues 19-29)S20G | | 著者 | Krotee, P.A.L, Rodriguez, J.A, Sawaya, M.R, Cascio, D, Shi, D, Nannenga, B.L, Hattne, J, Reyes, F.E, Gonen, T, Eisenberg, D.S. | | 登録日 | 2016-06-28 | | 公開日 | 2016-12-21 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.9 Å) | | 主引用文献 | Atomic structures of fibrillar segments of hIAPP suggest tightly mated beta-sheets are important for cytotoxicity.
Elife, 6, 2017
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1Y67
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8SPA
 | | Structural insights into cellular control of the human CPEB3 prion, functionally regulated by a labile-amyloid-forming segment | | 分子名称: | Cytoplasmic polyadenylation element-binding protein 3 | | 著者 | Flores, M.D, Sawaya, M.R, Boyer, D.R, Zink, S, Fioriti, L, Rodriguez, J.A. | | 登録日 | 2023-05-02 | | 公開日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structure of a reversible amyloid fibril formed by the CPEB3 prion-like domain reveals a core sequence involved in translational regulation
To Be Published
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8TER
 | | Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) P285L mutant, amyloid fiber | | 分子名称: | TRK-fused gene protein Low Complexity Domain P285L mutant | | 著者 | Rosenberg, G.M, Sawaya, M.R, Boyer, D.R, Ge, P, Abskharon, R, Eisenberg, D.S. | | 登録日 | 2023-07-06 | | 公開日 | 2023-12-20 | | 最終更新日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (2.59 Å) | | 主引用文献 | Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method.
Pnas Nexus, 2, 2023
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8TEQ
 | | Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) G269V mutant, amyloid fiber | | 分子名称: | TRK-fused gene protein Low Complexity Domain G269V mutant | | 著者 | Rosenberg, G.M, Sawaya, M.R, Boyer, D.R, Ge, P, Abskharon, R, Eisenberg, D.S. | | 登録日 | 2023-07-06 | | 公開日 | 2023-12-20 | | 最終更新日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | | 主引用文献 | Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method.
Pnas Nexus, 2, 2023
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8UMP
 | | T33-ml35 - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms | | 分子名称: | T33-ml35-redesigned-CutA-fold, T33-ml35-redesigned-TPR-domain-fold | | 著者 | Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O. | | 登録日 | 2023-10-18 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | | 主引用文献 | A suite of designed protein cages using machine learning and protein fragment-based protocols.
Structure, 32, 2024
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8UF0
 | | T33-ml23 - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms | | 分子名称: | T33-ml23-redesigned-CutA-fold, T33-ml23-redesigned-tandem-BMC-T-fold | | 著者 | Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O. | | 登録日 | 2023-10-03 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.02 Å) | | 主引用文献 | A suite of designed protein cages using machine learning and protein fragment-based protocols.
Structure, 32, 2024
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8UI2
 | | T33-ml28 - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms | | 分子名称: | T33-ml28-redesigned-CutA-fold, T33-ml28-redesigned-tandem-BMC-T-fold | | 著者 | Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O. | | 登録日 | 2023-10-09 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.73 Å) | | 主引用文献 | A suite of designed protein cages using machine learning and protein fragment-based protocols.
Structure, 32, 2024
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8UKM
 | | T33-ml30 - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms | | 分子名称: | T33-ml30-redesigned-4-OT-fold, T33-ml30-redesigned-tandem-BMC-T-fold | | 著者 | Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O. | | 登録日 | 2023-10-14 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | A suite of designed protein cages using machine learning and protein fragment-based protocols.
Structure, 32, 2024
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8UN1
 | | T33-ml23 Assembly Intermediate - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms | | 分子名称: | T33-ml23-redesigned-CutA-fold, T33-ml23-redesigned-tandem-BMC-T-fold | | 著者 | Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O. | | 登録日 | 2023-10-18 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | A suite of designed protein cages using machine learning and protein fragment-based protocols.
Structure, 32, 2024
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8UMR
 | | T33-ml35 Assembly Intermediate - Designed Tetrahedral Protein Cage Using Machine Learning Algorithms | | 分子名称: | T33-ml35-redesigned-CutA-fold, T33-ml35-redesigned-TPR-domain-fold | | 著者 | Castells-Graells, R, Meador, K, Sawaya, M.R, Yeates, T.O. | | 登録日 | 2023-10-18 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.42 Å) | | 主引用文献 | A suite of designed protein cages using machine learning and protein fragment-based protocols.
Structure, 32, 2024
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8V9O
 | | Imaging scaffold engineered to bind the therapeutic protein target BARD1 | | 分子名称: | CALCIUM ION, Tetrahedral Nanocage Cage Component Fused to Anti-BARD1 Darpin, Tetrahedral Nanocage Cage, ... | | 著者 | Agdanowski, M.P, Castells-Graells, R, Sawaya, M.R, Yeates, T.O, Arbing, M.A. | | 登録日 | 2023-12-08 | | 公開日 | 2024-05-15 | | 最終更新日 | 2024-06-12 | | 実験手法 | X-RAY DIFFRACTION (3.81 Å) | | 主引用文献 | X-ray crystal structure of a designed rigidified imaging scaffold in the ligand-free conformation.
Acta Crystallogr.,Sect.F, 80, 2024
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