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3UI7
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BU of 3ui7 by Molmil
Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia
分子名称: 6-methoxy-3,8-dimethyl-4-(morpholin-4-ylmethyl)-1H-pyrazolo[3,4-b]quinoline, MAGNESIUM ION, ZINC ION, ...
著者Yang, S, Smotryski, J, Mcelroy, W, Ho, G, Tulshian, D, Greenlee, W.J, Hodgson, R, Xiao, L, Hruza, A.
登録日2011-11-04
公開日2011-12-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia.
Bioorg.Med.Chem.Lett., 22, 2012
4YGH
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BU of 4ygh by Molmil
Crystal Structure of R111K:Y134F:T54V:R132Q:P39Y:R59Y mutant of human Cellular Retinoic Acid Binding Protein II with Retinal at 2.1 Angstrom resolution - UV irradiated crystal - 2nd cycle
分子名称: Cellular retinoic acid-binding protein 2, RETINAL
著者Nosrati, M, Geiger, J.H.
登録日2015-02-26
公開日2016-03-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A Photoisomerizing Rhodopsin Mimic Observed at Atomic Resolution.
J.Am.Chem.Soc., 138, 2016
4YH0
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BU of 4yh0 by Molmil
Crystal structure of the R111K:Y134F:T54V:R132Q:P39Y:R59Y mutant of human Cellular Retinoic Acid Binding Protein II in complex with Retinal at 2.14 angstrom resolution - UV irradiated crystal - 3rd cycle
分子名称: Cellular retinoic acid-binding protein 2, RETINAL
著者Nosrati, M, Geiger, J.H.
登録日2015-02-26
公開日2016-03-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.144 Å)
主引用文献A Photoisomerizing Rhodopsin Mimic Observed at Atomic Resolution.
J.Am.Chem.Soc., 138, 2016
4YGG
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BU of 4ygg by Molmil
CRYSTAL STRUCTURE OF R111K:Y134F:T54V:R132Q:P39Y:R59Y MUTANT OF HUMAN CELLULAR RETINOIC ACID BINDING PROTEIN II WITH RETINAL AT 1.9 ANGSTROM RESOLUTION - VISIBLE LIGHT IRRADIATED CRYSTAL - 2ND CYCLE
分子名称: Cellular retinoic acid-binding protein 2, RETINAL
著者Nosrati, M, Geiger, J.H.
登録日2015-02-26
公開日2016-03-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A Photoisomerizing Rhodopsin Mimic Observed at Atomic Resolution.
J.Am.Chem.Soc., 138, 2016
4YCE
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BU of 4yce by Molmil
Crystal structure of the R111K:Y134F:T54V:R132Q:P39Q:R59Y mutant of human cellular retinoic acid binding proteinii with retinal at 1.95 angstrom- visible light irradiated crystal for 1 hour - 2nd cycle
分子名称: Cellular retinoic acid-binding protein 2, RETINAL
著者Nosrati, M, Geiger, J.H.
登録日2015-02-19
公開日2016-02-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.953 Å)
主引用文献A Photoisomerizing Rhodopsin Mimic Observed at Atomic Resolution.
J.Am.Chem.Soc., 138, 2016
4YFR
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BU of 4yfr by Molmil
Crystal structure of the R111K:Y134F:T54V:R132Q:P39Y:R59Y mutant of human Cellular Retinoic Acid Binding Protein II with Retinal at 1.95 Angstrom Resolution - UV irradiated crystal for 30 minutes - 1st Cycle
分子名称: Cellular retinoic acid-binding protein 2, RETINAL
著者Nosrati, M, Geiger, J.H.
登録日2015-02-25
公開日2016-03-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.952 Å)
主引用文献A Photoisomerizing Rhodopsin Mimic Observed at Atomic Resolution.
J.Am.Chem.Soc., 138, 2016
4YKM
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BU of 4ykm by Molmil
Crystal structure of the R111K:Y134F:T54V:R132Q:P39Q:R59Y:A32W:F3Q mutant of human Cellular Retinoic Acid Binding Protein II with Retinal at 1.58 angstrom resolution
分子名称: Cellular retinoic acid-binding protein 2, RETINAL
著者Nosrati, M, Geiger, J.H.
登録日2015-03-04
公開日2016-03-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献A Photoisomerizing Rhodopsin Mimic Observed at Atomic Resolution.
J.Am.Chem.Soc., 138, 2016
4EFG
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BU of 4efg by Molmil
Crystal Structure of the Q108K:K40L:T51V:T53C:Y19W:R58W:T29L Mutant of Cellular Retinol Binding Protein Type II in Complex with All-trans-Retinal at 1.58 Angstrom Resolution
分子名称: ACETATE ION, RETINAL, Retinol-binding protein 2
著者Nossoni, Z, Geiger, J.H.
登録日2012-03-29
公開日2012-12-26
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Tuning the electronic absorption of protein-embedded all-trans-retinal.
Science, 338, 2012
4EXZ
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BU of 4exz by Molmil
Crystal Structure of the Q108K:K40L Mutant of Cellular Retinol Binding Protein Type II in Complex with All-trans-Retinal at 1.7 Angstrom Resolution
分子名称: ACETATE ION, RETINAL, Retinol-binding protein 2
著者Nossoni, Z, Geiger, J.H.
登録日2012-05-01
公開日2012-12-26
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.608 Å)
主引用文献Tuning the electronic absorption of protein-embedded all-trans-retinal.
Science, 338, 2012
4YDA
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BU of 4yda by Molmil
Crystal structure of R111K:Y134F:T54V:R132Q:P39Q:R59Y mutant of human cellular retinoic acid binding proteinii with retinal at 1.95 angstrom - after 1hour visible light irradiation - 3rd cycle
分子名称: Cellular retinoic acid-binding protein 2, RETINAL
著者Nosrati, M, Geiger, J.H.
登録日2015-02-21
公開日2016-02-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.951 Å)
主引用文献A Photoisomerizing Rhodopsin Mimic Observed at Atomic Resolution.
J.Am.Chem.Soc., 138, 2016
4YDB
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BU of 4ydb by Molmil
Crystal structure of the R111K:Y134F:T54V:R132Q:P39Q:R59Y mutant of human Cellular Retinoic Acid Binding Protein II in complex with Retinal at 2.03 angstrom -UV irradiated crystal- 3rd cycle
分子名称: Cellular retinoic acid-binding protein 2, RETINAL
著者Nosrati, M, Geiger, J.H.
登録日2015-02-21
公開日2016-02-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献A Photoisomerizing Rhodopsin Mimic Observed at Atomic Resolution.
J.Am.Chem.Soc., 138, 2016
4YFQ
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BU of 4yfq by Molmil
CRYSTAL STRUCTURE OF THE R111K:Y134F:T54V:R132Q:P39Y:R59Y MUTANT OF HUMAN CELLULAR RETINOIC ACID BINDING PROTEINII WITH RETINAL AFTER 24 HOURS INCUBATION AT 1.62 ANGSTROM RESOLUTION - Thermodynamic product - 1st cycle
分子名称: Cellular retinoic acid-binding protein 2, RETINAL
著者Nosrati, M, Geiger, J.H.
登録日2015-02-25
公開日2016-03-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献A Photoisomerizing Rhodopsin Mimic Observed at Atomic Resolution.
J.Am.Chem.Soc., 138, 2016
4YFP
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BU of 4yfp by Molmil
CRYSTAL STRUCTURE OF THE R111K:Y134F:T54V:R132Q:P39Y:R59Y MUTANT OF HUMAN CELLULAR RETINOIC ACID BINDING PROTEIN II WITH RETINAL AFTER 20 MINUTES INCUBATION AT 1.95 ANGSTROM RESOLUTION-Kinetic Product
分子名称: Cellular retinoic acid-binding protein 2, RETINAL
著者Nosrati, M, Geiger, J.H.
登録日2015-02-25
公開日2016-03-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.951 Å)
主引用文献A Photoisomerizing Rhodopsin Mimic Observed at Atomic Resolution.
J.Am.Chem.Soc., 138, 2016
4GKC
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BU of 4gkc by Molmil
Crystal structure of Q108K:K40L:T51V:T53C:R58W:T29L:Y19W:Q4A mutant of cellular retinol binding protein II complex with all-trans-retinal at 1.33
分子名称: RETINAL, Retinol-binding protein 2
著者Nossoni, Z, Geiger, J.H.
登録日2012-08-10
公開日2012-12-26
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Tuning the electronic absorption of protein-embedded all-trans-retinal.
Science, 338, 2012
4EDE
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BU of 4ede by Molmil
Crystal Structure of the Q108K:K40L:T51V:T53C:Y19W:R58W:T29L:A33W Mutant of Cellular Retinol Binding Protein Type II in Complex with All-trans-Retinal at 1.4 Angstrom Resolution
分子名称: ACETATE ION, RETINAL, Retinol-binding protein 2
著者Nossoni, Z, Geiger, J.H.
登録日2012-03-27
公開日2012-12-26
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Tuning the electronic absorption of protein-embedded all-trans-retinal.
Science, 338, 2012
4EEJ
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BU of 4eej by Molmil
Crystal Structure of the Q108K:K40L:T51V:T53C:Y19W:R58W:T29L:Q4R Mutant of Cellular Retinol Binding Protein Type II in Complex with All-trans-Retinal at 1.5 Angstrom Resolution
分子名称: ACETATE ION, RETINAL, Retinol-binding protein 2
著者Nossoni, Z, Geiger, J.H.
登録日2012-03-28
公開日2012-12-26
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.501 Å)
主引用文献Tuning the electronic absorption of protein-embedded all-trans-retinal.
Science, 338, 2012
4QGW
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BU of 4qgw by Molmil
Crystal sturcture of the R132K:R111L:L121D mutant of Cellular Retinoic Acid Binding ProteinII complexed with a synthetic ligand (Merocyanine) at 1.77 angstrom resolution
分子名称: (2E,4E,6E)-3-methyl-6-(1,3,3-trimethyl-1,3-dihydro-2H-indol-2-ylidene)hexa-2,4-dienal, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cellular retinoic acid-binding protein 2
著者Nosrati, M, Yapici, I, Geiger, J.H.
登録日2014-05-26
公開日2015-01-28
最終更新日2015-02-11
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献"Turn-on" protein fluorescence: in situ formation of cyanine dyes.
J.Am.Chem.Soc., 137, 2015
8CGT
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BU of 8cgt by Molmil
STRUCTURE OF CYCLODEXTRIN GLYCOSYLTRANSFERASE COMPLEXED WITH A THIO-MALTOHEXAOSE
分子名称: CALCIUM ION, PROTEIN (CYCLODEXTRIN-GLYCOSYLTRANSFERASE), alpha-D-glucopyranose-(1-4)-4-thio-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-4-thio-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-4-thio-alpha-D-glucopyranose
著者Schmidt, A.K, Schulz, G.E.
登録日1998-09-27
公開日1998-10-14
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Substrate binding to a cyclodextrin glycosyltransferase and mutations increasing the gamma-cyclodextrin production.
Eur.J.Biochem., 255, 1998
2GAR
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BU of 2gar by Molmil
A PH-DEPENDENT STABLIZATION OF AN ACTIVE SITE LOOP OBSERVED FROM LOW AND HIGH PH CRYSTAL STRUCTURES OF MUTANT MONOMERIC GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE
分子名称: GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE, PHOSPHATE ION
著者Su, Y, Yamashita, M.M, Greasley, S.E, Mullen, C.A, Shim, J.H, Jennings, P.A, Benkovic, S.J, Wilson, I.A.
登録日1998-05-13
公開日1998-08-12
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A pH-dependent stabilization of an active site loop observed from low and high pH crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 A.
J.Mol.Biol., 281, 1998
6MOP
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BU of 6mop by Molmil
Crystal Structure of the All-trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121E Mutant of Human Cellular Retinoic Acid Binding Protein II in the Dark at 1.9 Angstrom Resolution
分子名称: Cellular retinoic acid-binding protein 2, RETINAL
著者Ghanbarpour, A, Geiger, J.
登録日2018-10-04
公開日2019-01-09
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Mimicking Microbial Rhodopsin Isomerization in a Single Crystal.
J. Am. Chem. Soc., 141, 2019
6MPK
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BU of 6mpk by Molmil
Crystal Structure of the 13-cis Retinal-Bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121E:A32Y Mutant of Human Cellular Retinoic Acid Binding Protein II in the Dark at 1.58 Angstrom Resolution
分子名称: Cellular retinoic acid-binding protein 2, GLYCEROL, RETINAL
著者Ghanbarpour, A, Geiger, J.
登録日2018-10-07
公開日2019-01-09
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Mimicking Microbial Rhodopsin Isomerization in a Single Crystal.
J. Am. Chem. Soc., 141, 2019
6MQY
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BU of 6mqy by Molmil
Crystal Structure of the 13-cis Product of All-trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121E Mutant of Human Cellular Retinoic Acid Binding Protein II Irradiated with 400 nm Laser (30 seconds) at 1.9 Angstrom
分子名称: Cellular retinoic acid-binding protein 2, GLYCEROL, RETINAL
著者Ghanbarpour, A, Geiger, J.
登録日2018-10-11
公開日2019-01-09
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Mimicking Microbial Rhodopsin Isomerization in a Single Crystal.
J. Am. Chem. Soc., 141, 2019
6MQJ
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BU of 6mqj by Molmil
Crystal Structure of the All-Trans Retinal bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121Q mutant of Human Cellular Retinoic Acid Binding Protein II Irradiated with 532 nm Laser for 10 minutes at 2.1 Angstrom Resolution
分子名称: Cellular retinoic acid-binding protein 2, RETINAL
著者Ghanbarpour, A, Geiger, J.
登録日2018-10-09
公開日2019-01-09
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.125 Å)
主引用文献Mimicking Microbial Rhodopsin Isomerization in a Single Crystal.
J. Am. Chem. Soc., 141, 2019
6MOQ
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BU of 6moq by Molmil
Crystal Structure of the All-trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121W Mutant of Human Cellular Retinoic Acid Binding Protein II in the Dark at 2.2 Angstrom Resolution
分子名称: Cellular retinoic acid-binding protein 2, RETINAL
著者Ghanbarpour, A, Geiger, J.
登録日2018-10-04
公開日2019-01-09
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.198 Å)
主引用文献Mimicking Microbial Rhodopsin Isomerization in a Single Crystal.
J. Am. Chem. Soc., 141, 2019
6MOV
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BU of 6mov by Molmil
Crystal Structure of the All-trans Retinal bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121Q Human Cellular Retinoic Acid Binding Protein II in the Dark at 1.75 Angstrom Resolution
分子名称: Cellular retinoic acid-binding protein 2, RETINAL
著者Ghanbarpour, A, Geiger, J.
登録日2018-10-04
公開日2019-01-09
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.752 Å)
主引用文献Mimicking Microbial Rhodopsin Isomerization in a Single Crystal.
J. Am. Chem. Soc., 141, 2019

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